<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Reverse Transcriptase Inhibitors

Subtype A
Gene RT
Mutation V90I
Rx >= 1 NNRTI
(+/- NRTI)
IncludeMixtures No
References 23
Patients 61
Isolates 64
 
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# NRTIs NNRTIsNRTIDRMs NNRTIDRMs OtherMutSubtype
Eshleman (2004)ESH_Pat29ESH838AY435371NoneNVP  P4S, K11T, K20R, V21I, V35T, T39R, V90I, D123S, S162D, K173S, D177E, V179I, E194D, I202V, Q207A, R211S, V245Q, E248D, T286A, E291D, V292VI, I293V, P294T, E312N, I326NA
Non-B Workgroup (2005)TK3029TK3029 AZT, 3TC, D4T, DDI, ABCEFVM41L, D67N, K70R, V75M, L210LW, T215F, K219QK103N, G190AE6D, K20R, V35T, K49R, V60I, V90I, I94L, S117A, K122E, D123S, I135T, S162D, K173S, Q174K, D177E, V179I, Q207A, R211N, D218E, L228H, V245K, D250E, A272G, T286A, E291D, I293V, P294T, E312DA
  TK3029a AZT, 3TC, D4T, DDI, ABCEFV  E6D, T7S, V35T, K49R, V60I, V90I, K122E, D123S, T131TA, I135T, S162D, K173S, Q174K, D177E, V179I, T200A, Q207A, R211S, V245E, D250E, A272G, T286A, E291D, I293V, P294TA
Weber (2005)F56326F56326AY6775293TC, D4T, AZT, DDI, ABCNVPM41L, M184V, L210W, T215YK103NK11T, V35T, T39R, K43KE, V90I, K102KR, V118VI, D121H, K122E, I135V, S162A, K173S, D177EG, T200A, I202IV, Q207D, V245Q, A272P, L283I, I293V, E312DA
 M36781M36781-1AY677542D4T, DDI, Unknown, AZT, 3TCNVP, Unknown, EFVV75I, M184V, T215FK103NV35T, V90I, A98AS, K122E, D123N, I132L, I135T, S162H, K173A, D177E, V179I, T200A, Q207A, R211N, V245M, D250DE, K281R, E291D, I293V, P294T, E298EG, E312N, S322AA
  M36781-2AY714403D4T, DDI, Unknown, AZT, 3TC, TDFNVP, Unknown, EFVM41L, V75I, M184V, T215FK103NV35T, V90I, A98S, K122E, D123N, I132L, I135T, S162H, K173A, D177E, T200A, Q207A, R211N, V245M, K281R, E291D, I293V, P294T, E298G, E312N, S322AA
 M55405M55405AY6775643TC, D4TNVPM184VK101E, G190AP4S, K11T, K20R, V21I, V35T, T39K, S68G, V90I, A98S, K122E, D123N, T165I, K166R, K173S, D177E, V179I, T200A, I202V, Q207A, R211K, V245Q, E248D, T286A, E291D, V292I, I293V, E297EA, E312DYA
 F87084F87084AY677580D4T, 3TC, AZTNVPM41L, M184V, T215YA98G, G190AP14A, V35T, T39A, E44ED, V90I, K122E, D123S, I135T, S162Y, K173L, Q174K, D177E, V179I, T200A, Q207E, R211S, V245E, D250E, A272G, I274IV, E291D, V292I, I293V, E312D, Y318X, Y319XA
Ndembi (2010)15017D_P115017GQ409572AZT, 3TCNVPM184VK101KE, G190AE6D, V35T, K49R, I50V, V60I, V90I, K122E, D123N, I135T, K173S, Q174K, D177E, V179I, V189D, I202V, E203D, R206S, Q207D, R211S, Q242EA
Charpentier (2011)30CP001399 D4T, 3TCNVPK65R, D67H, T69D, K219EGK103N, Y181C, G190AE6D, K11T, K20R, V35T, T39KR, K43E, S68G, V90I, D121H, K122E, I135M, I142V, S162A, K173A, Q174K, D177E, I178L, T200A, E204K, Q207A, R211S, F214L, L228R, V245E, T286A, E291D, V292I, I293V, E297K, A304E, P313T, I329VA
Fokam (2011)CIRCB-4899CIRCB-4899JQ796151AZT, 3TCNVPD67DN, M184VK103KN, K238TE6D, K11T, E29EG, V35T, T39K, K43E, S68G, V90I, D121H, K122E, I135T, S162H, K173S, Q174K, D177E, D186DE, G196E, T200A, Q207A, R211S, V245Q, T286A, I293V, E297KA
Dvali (2012)R149R149FJ456914D4T, 3TCNVPA62V, K65R, M184IK101E, Y181YC, G190SK30Q, K32G, A33C, L34T, V35L, E36N, I37F, T39K, V90I, K122E, D123N, A158S, K173L, Q174K, T200A, Q207A, R211S, V245MA
 R144R144FJ456910AZT, 3TCEFVA62V, M184VA98AG, V179DE, G190SK30Q, K32G, A33C, L34T, V35L, E36N, I37F, T39K, V90I, K122E, D123N, I135T, E138A, K173L, Q174K, Q207A, R211S, V245KA
Reynolds (2012)J0747J0747-1JN652203AZT, 3TCNVPM184V, T215TFISG190A, M230MLP14PL, V35T, E40D, K49R, K64KE, F87FL, V90I, H96HR, K122E, D123N, I135T, S162SN, K173S, V179I, T200A, Q207A, R211S, V245Q, E291D, P294TA
Avidor (2013)1976_FT1976_FTKC184308AZT, 3TCEFVA62V K30Q, K32G, A33C, L34T, V35L, E36N, I37F, T39K, V90I, K122E, D123NS, K173L, Q174K, T200A, Q207A, R211NSA
Pircher (2013)B1110B1110JX110211D4T, 3TC, AZTNVPK70R, M184V, K219QK103NT27S, V35T, T39KN, V60I, V90I, K122E, D123S, I135T, S162Y, K173A, Q174K, T200A, Q207D, R211K, D218E, L228H, V245Q, E248D, Q258EA
Rawizza (2013)LM3929LM3929KF241482NRTINNRTID67N, K70R, M184V, T215F, K219EV108VI, Y181CP4S, T27S, V35T, T39K, K43A, T69TN, V90I, K102Q, V111I, D123E, I142V, S162Y, K173S, D177DE, V179I, T200A, Q207A, R211K, P243PS, V245T, E248D, T286A, E291D, I293V, P294PTA
Theys (2013)4365143651KC221286TDF, FTCEFVM184IVK103N, P225HE53D, V60I, V90I, D121H, K122E, D123S, I135T, S162H, K173L, Q174R, D177E, I178L, V179I, T200A, Q207D, R211KA
 4064140641KC221204NRTI, TDFNNRTI K103N, Y188C, P225HV90I, D121H, K122E, I135V, A158S, K173A, Q174K, D177E, V179VI, T200A, Q207A, R211KA
 4053040530KC221199NRTI, TDFNNRTID67N, K70R, M184MI, T215DE, K219QK103H, Y181C, G190AK43KR, T69TN, V90I, K101Q, K122E, D123N, S134R, A158S, T165TI, R172K, K173S, Q174K, D177E, I178M, T200A, Q207A, R211SA
Van Zyl (2013)O15522995KC423922ABC, 3TCEFVL74V, Y115F, M184VL100LI, K103N, V108VIW88S, V90I, K102Q, K122E, I135T, S162N, S163T, T165I, K173T, Q174K, D177E, V179I, T200A, I202V, Q207A, R211K, H221Y, V241VA, V245E, D250EA
Aghokeng (2014)TG-3-659TG-3-659KC350315NRTINNRTIM184VK103N, Y181CM16MT, V35T, V90I, K122E, D123N, I135T, A158S, S162A, S163T, T165I, K173S, Q174K, V179I, T200A, Q207A, F214L, H221Y, V245Q, A272P, V292I, I293V, P294T, L295M, E312D, V317A, I326V, G335D, R356K, M357K, G359S, T369V, A371V, I375V, A376I, T386A, K390R, A400T, T403M, E404D, W410YA
 TG-4-638TG-4-638KC350297NRTINNRTIM41L, M184VY181CK11T, K20R, V35T, T39N, V90I, K122E, D123S, I135T, S162Y, K173S, D177E, V179I, Q207A, F214L, H221Y, V245Q, K281R, T286A, E291D, V292I, I293V, P294T, E312D, I326V, R356K, M357K, G359S, K366R, T369V, A371V, I375V, A376V, A400T, T403M, W410C, E432DA
Kolomeets (2014)171171_263KJ870385AZT, 3TCEFVA62V K11T, V35I, E36D, T39K, V90I, K122E, D123N, A158AS, S162X, K173LV, Q174K, D177E, T200I, Q207A, R211S, E248DA
 6565_157KJ870301AZT, 3TCNVPA62V, M184VK101E, G190SK11T, V35T, E36A, T39E, V90I, V106VI, K122E, D123N, A158S, K173L, Q174K, T200A, Q207A, R211S, E248DA
 132132_256KJ870379AZT, 3TCNVPA62V, M184VK103NK11T, V35I, E36D, T39K, V90I, K102N, K122E, D123S, T139R, K173L, Q174K, D177E, T200A, I202V, Q207A, R211S, V245M, E248DA
 118118_145KJ870292AZT, 3TCEFVA62V K11T, V35I, E36D, T39K, V90I, K122E, D123S, I135T, S162C, K173L, Q174K, Q207A, R211S, E248DA
 1414_273KJ870394AZT, 3TCEFVA62V, V75I, M184VK103NK11T, I31L, V35I, T39K, V90I, K122E, D123N, S162Y, K173L, Q174K, D177E, T200A, Q207A, H208HD, R211S, E248DA
 399399_565KJ870611NRTINNRTIA62V K11T, V35T, E36D, T39K, E40ED, K43KE, K49R, I50IV, V90I, K122E, D123NS, A158S, K173S, Q174K, Q207A, R211KN, V245M, E248DA
 1414_197KJ870337AZT, 3TCEFVV75I, M184LK103NK11T, T39K, V90I, K122E, D123N, Y183Y*, F214L, E248DA
 282282_434KJ8705213TC, DDIEFVA62V, M184I I2N, S3N, K11T, V35I, E36D, T39K, V90I, K122E, D123S, I135T, A158S, K173L, Q174K, D177E, T200A, Q207A, R211S, V245M, E248DA
 480480_570KJ870613ABC, 3TCEFVA62V, L74I, V75VAIT, Y115F, M184V, K219KDENY181C, G190SK11T, V35IM, E36D, T39K, T58N, V90I, K122E, D123N, A158AS, K173S, Q174K, T200A, Q207A, R211S, Y232H, V245M, E248DA
 222222_315KJ870428AZT, 3TCNVPA62V, M184VA98AG, K101KE, G190AK11T, V35T, T39K, V90I, K122E, D123N, A158S, K173S, Q174K, D177E, I178IV, V179VI, T200A, Q207A, R211S, T215X, V245M, E248DA
 8888_160KJ870304AZT, 3TCEFVD67N, K70R, M184V, K219QK101E, G190SK11T, V35I, E36D, T39K, V90I, V106I, K122E, D123N, A158S, K173S, Q174K, D177E, T200A, Q207A, V245MT, E248DA
 107107_320KJ870433AZT, 3TCEFVA62V I5IV, K11T, V35I, E36D, T39K, V90I, K122E, D123S, A158S, S162C, K173L, Q174K, D177E, Q207A, R211S, V245M, E248DA
 9797_249KJ870374AZT, 3TCEFVA62V, D67N, K219KEK101E, G190SK11T, V35R, E36D, T39K, I50T, V90I, K122E, D123N, S162A, D177E, R211S, V245M, E248DA
Wallis (2014)4151741517KM458599NRTINNRTIK65KR, M184MV, K219KRA98G, Y181CK11T, K20KR, V21VI, L34LI, V35T, T39TA, V60I, S68SN, T69X, V90I, K122E, D123DN, I135T, K166KR, R172RK, K173A, Q174K, D177E, I178LM, T200A, Q207D, R211K, F214L, D218EA
 4108041080KM458604NRTINNRTIM184V, T215YK103NV8VI, V21I, V35T, V60I, V90I, K122E, D123N, I135T, T139R, S162Y, K173L, Q174K, D177E, V179I, T200A, Q207A, R211SA
Meini (2015)109276109276KM438252AZT, 3TCNVPK70R, M184EK103N, F227LV35T, V60I, V90I, V106I, K122E, D123N, I135T, T139R, S162H, K173L, Q174K, I178L, V179I, D185E, T200A, Q207A, R211NA
 111125111125KM438258AZT, 3TCNVP K103NV35T, V60I, K64R, V90I, K122E, D123S, I135T, E138A, S162C, K173S, Q174K, I178L, V179I, T200A, Q207A, R211SA
 109272109272KM438250D4T, 3TC, DDINVPK70R, M184VK103NV35T, T39I, V60I, V90I, D123S, I135T, T139R, S162A, K173S, Q174K, D177E, T200A, Q207A, R211S, D237EA
Saravanan (2015)CTLA65CTLA65KP993668NRTINNRTIM184I, K219QK101N, K103N, Y181C, G190AE28A, V35T, T39N, K43Q, V60I, V90I, D121H, K122E, I135T, S162Y, K173L, Q174K, D177E, V179I, Q207S, R211SA
Brooks (2016)2068A2068AKU900878TDF, 3TCNVPK65R, M184MVY181G, G190AI5IV, K20R, V35T, V60I, S68G, T69S, V90I, K101Q, K122E, D123N, I135T, K173A, Q174R, D177E, V179I, Q207A, R211NS, E224DA
 2052A2052AKU900870TDF, 3TCEFVK65R, K70T, M184IL100I, K103NK11Q, V35T, T39I, K49R, V60I, S68G, V90I, K122E, D123S, I135T, T165I, K173S, Q174K, D177E, T200A, I202V, Q207A, R211SA
 2077A2077AKU900871TDF, 3TCEFVK65R, M184IK103N, M230L, L234IK11H, V35T, V60I, S68G, V90I, K122E, D123G, I135T, K173L, Q174K, D177E, V179I, G196E, T200TA, I202V, Q207A, R211SA
Lam (2016)2101202421012024KR867967TDF, FTCNVP V106AI5V, V35T, E36D, V60I, V90I, D121H, K122E, I135T, I142V, S162HY, K173S, Q174K, D177E, V179I, I202V, Q207A, R211K, F214FL, V245Q, D250E, A272P, T286A, E291D, V292I, I293V, I326V, G335DA
Ndahimana (2016)15361536KU922864TDF, 3TCNVPM184VG190AV60I, V90I, D121H, K122E, I135T, K173S, Q174K, D177E, V179I, T200A, I202V, Q207A, R211S, V245EA
 957957KU922849TDF, 3TCNVPK65R, M184IY181CK49R, V60I, V90I, K101KR, K122E, D123N, I135T, I142V, W153R, S162A, K173A, Q174K, D177E, V179I, I195L, T200A, I202IV, Q207A, R211S, V245QA
Kekitiinwa (2017)65493_52065493_520KY237878NRTINNRTIM41L, D67DN, K70KR, M184V, L210W, T215F, K219KE V60VI, V90I, K101KQ, K122E, I142V, S162Y, K173L, Q174K, D177E, V179I, T200E, E203K, Q207D, R211NSA
 28266_30528266_305KY237822NRTINNRTIM41L, M184MV, T215F P14A, D17M, P19R, K20R, V21I, V35T, V60I, V90I, K122E, D123S, I135T, S162H, K173AT, Q174K, D177E, V179I, Q207E, R211K, D250E, A272T, T286A, V292I, I293VA
 65795_53165795_531KY237940NRTINNRTIL74V, M184V, K219KEK103N, Y181CV90I, K122E, D123N, K173S, D177E, V179I, T200A, I202V, Q207A, R211SA
 79269_72779269_727KY237956NRTINNRTIM184V V60I, V90I, K122E, D123N, I135T, S162Y, K173A, Q174K, V179I, Q207A, R211S, F214FLA
Kityo (2017)8295582955KY061519NRTINNRTIM41ML, D67N, T69DN, K70R, L74LI, M184IV, T215F, K219QA98G, K103KN, V108VI, Y181C, G190GAK43R, V60I, V90I, D121H, K122E, D123S, I135T, S162Y, K173S, Q174K, D177E, V179I, T200A, Q207A, R211N, D218EA
 8302783027KY061587NRTINNRTIM41L, M184V, L210LW, T215YY181CK49R, V60I, V90I, K122E, D123S, I135T, T139R, D177E, I178M, T200TS, Q207A, R211K, L228LRA
 8356583565KY062119NRTINNRTIK65R, V75L, Y115F, M184MVK103N, G190AV60I, V90I, K122E, D123S, I135V, S162A, K173S, V179I, Q207A, R211SA
 8316383163KY061719NRTINNRTIM184IK103N, M230LK43E, K49R, T69N, V90I, K102N, S117SL, K122E, D123N, K173S, D177E, V179I, T200A, I202V, Q207A, R211K, L228LRA
 8354783547KY062101NRTINNRTIK70Q, M184IY188L, P225H, P236PLW88WS, V90I, L109LI, K122E, D123S, K173S, Q174K, D177E, I178M, V179I, T200A, I202IV, Q207A, R211RS, H221YA
 8326083260KY061815NRTINNRTIK65R, D67N, M184IVK103N, V108I, F227LK43Q, K46M, V60I, T69N, W88C, V90I, K102Y, D121H, K122E, I135T, I142IV, S162Y, K173S, Q174K, T200A, E203K, Q207A, R211N, K223EA
 6604866048KY061415NRTINNRTIM41L, L74LI, V75M, M184V, L210W, T215YV106AK43N, K64R, K82KR, V90I, A98S, V118I, K122E, D123S, E138A, S162H, K166KQ, K173IL, Q174QK, V179I, G196E, Q207A, R211K, Y232HA
 8348683486KY062040NRTINNRTIM184V, T215FY181CK49R, V60I, V90I, K122E, D123S, I135T, T139R, S162A, K173T, Q174K, V179I, T200I, Q207D, R211KA
 8344883448KY062002NRTINNRTIM41L, D67N, K70R, V75M, M184V, L210W, T215F, K219QK101E, G190AV60I, V90I, I94L, K122E, D123N, I135T, S162Y, K173A, Q174K, D177E, I178M, V179I, T200A, Q207S, R211NA
 8341983419KY061973NRTINNRTID67DG, T69DN, K70R, V75I, M184V, T215TI, K219QY181C, P236PLK46Q, V60I, V90I, K122E, D123G, I132L, P133PL, T139M, I142V, S162SN, K173S, D177E, V179I, T200A, I202IV, Q207A, L228LH, G231G*LVA
 8295482954KY061518NRTINNRTIM184V, T215FK103NE44D, K49R, V60I, V90I, K122E, D123N, I135T, E138G, I142V, S162AD, T165L, E169D, K173A, Q174K, D177E, G196E, T200A, I202V, Q207A, R211S, F214LA
 8320283202KY061758NRTINNRTIM41L, D67N, M184V, L210W, T215YK103NS48E, P52PL, V60I, T69TS, V90I, V111I, K122E, D123N, I135T, T139K, K166Q, K173A, Q174K, D177E, V179I, T200A, Q207A, H208HY, R211RKA