<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Reverse Transcriptase Inhibitors

Subtype A
Gene RT
Mutation K238T
Rx >= 1 NNRTI
(+/- NRTI)
IncludeMixtures No
References 23
Patients 52
Isolates 52
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# NRTIs NNRTIsNRTIDRMs NNRTIDRMs OtherMutSubtype
Montes (2004)MB_patSAA01_SAA704AJ577990DDC, AZT, 3TC, D4T, DDI, ABCNVP, EFVK70R, M184V, K219QK103N, K238TE6K, K11T, K20R, V35T, E36A, T39K, K122E, D123N, I142V, S162Y, K173S, D177E, V179I, I202V, Q207A, R211K, F214L, K223Q, L228HA
Seyler (2007)547CS_547 AZT, D4T, 3TC, DDIEFV K103KN, K238TK11T, V35T, T39K, K43E, K102KE, K122E, D123ST, I142V, S162H, K173T, Q174K, D177E, I178L, V179VI, I195L, T200A, Q207A, R211K, V245Q, E248DA
Ndembi (2010)DT1745_05_P11745GQ409602AZT, 3TCNVPM184VG190A, K238TP4H, K11A, A33V, V35K, T39A, K122E, D123N, I135T, I142L, K173L, Q174K, D177E, V179I, T200A, Q207T, R211S, F214LA
Fokam (2011)CIRCB-4899CIRCB-4899JQ796151AZT, 3TCNVPD67DN, M184VK103KN, K238TE6D, K11T, E29EG, V35T, T39K, K43E, S68G, V90I, D121H, K122E, I135T, S162H, K173S, Q174K, D177E, D186DE, G196E, T200A, Q207A, R211S, V245Q, T286A, I293V, E297KA
Sigaloff (2011)HIV104220HIV104220JN132360D4T, 3TCNVPD67N, K70R, M184V, K219QK103N, K238TK20KR, V35T, T39TA, K43R, V60I, T69TN, V90I, I94L, D121H, K122E, D123S, I135T, S162D, E169EA, K173S, Q174K, N175Y, D177E, V179T, T200E, K201KR, E203K, Q207A, R211S, H221HY, L228LH, V245I, D250E, K281R, T286A, E291D, V292I, I293V, P294T, E312NA
Hamers (2012)CP076304187CP076304187JQ480169AZT, 3TCEFVM184VK103KN, K238TE6ED, G18X, K20KR, V35T, T39A, V60I, K122E, D123N, I135T, I142IV, K173T, Q174K, D177E, V179I, T200A, I202IV, Q207A, R211S, F214FL, V245EK, D250E, S251HN, K275KQ, K281KR, T286TA, E291D, V292I, I293V, P294TA
Aghokeng (2013)HJ3121HJ3121JX983026NRTINNRTIM41L, D67DN, V75M, M184V, L210W, T215YK103N, V108VI, K238TS3C, K11A, V35T, T39K, K43KE, E44ED, K122E, D123N, I135T, I142V, E169D, K173A, Q174K, D177E, I178L, Q207A, R211NS, V245Q, A272P, L283I, T286A, E291D, I293V, E297R, E312D, G335D, R356K, M357R, R358S, G359S, E370Q, A371V, I375V, S379C, K390R, E399D, A400T, T403MA
 HJ3393HJ3393JX983031NRTINNRTIM184VK103N, V108I, K238TK11T, V35T, T39K, D76DE, D121H, K122E, D123G, I135T, T165L, K173R, Q174K, D177E, V179I, G196E, Q207A, R211S, F214L, V245Q, A272P, T286A, V292VI, I293V, E297R, E312D, G333E, Q334H, R356K, M357R, R358K, G359S, A360T, K366R, A371V, I375V, A376T, T377L, T386A, K390R, A400TA
Nouhin (2013)U0420125U0420125KF292774NRTINNRTID67E, M184VK103N, K238TE29A, K30S, K32Q, V35R, C38S, T39K, K43E, N57D, T58P, K66R, S68G, T69S, W71G, K122E, D123N, K173A, Q174K, D177E, I178L, V179I, T200A, E204Q, Q207A, R211RSA
Pircher (2013)B1113B1113JX110214D4T, 3TC, AZTNVPM41L, D67N, L74V, M184V, L210W, T215Y, K219KNK103N, M230L, K238TI2IV, E6D, K20R, E28K, K32E, V35T, E36ED, T39K, K43E, E44D, K49R, V60I, K64R, V111I, V118I, K122KE, D123DN, K173A, Q174K, Q207A, H208HY, R211RK, V245EA
Rusine (2013)753H753HKC841766AZT, 3TCNVPM184VK103N, K238TK20R, E28A, V35T, T39L, S48T, V60I, K122E, D123S, I135T, K173L, Q174K, D177E, Q207A, R211S, V245E, K281R, T286A, E291D, V292I, I293V, P294T, E297R, E312DA
Sigaloff (2013)JCR017_0JCR017_0JX181984NRTINNRTIM184VK103N, P225H, K238TV35T, T39N, K122E, D123S, I135L, K173A, T200A, Q207A, R211K, V245Q, D250E, A272P, K275R, T286A, E291D, V292I, I293V, P294TA
Van Zyl (2013)O1127347KC423998AZT, 3TCNVPM184VV108I, Y181C, K238TK11T, V35T, V118I, D123N, I135M, K173S, Q174K, D177E, I202V, Q207N, R211G, F214L, L228LR, V245Q, E248D, K259KNA
Acharya (2014)DGP063DGP063KJ185233AZT, 3TCNVPD67N, M184IK103N, K238TV35T, V60I, K122E, D123S, I135T, I142V, S162A, T165I, K173S, Q174K, D177E, V179I, Q197E, T200A, Q207A, R211K, V245K, D250E, T286A, E291D, V292I, I293V, P294TA
Aghokeng (2014)CM-1-057CM-1-057KC350321NRTINNRTID67G, K70R, L74I, M184V, T215F, K219EL100I, K103N, K238TK11T, T27S, E28A, V35T, S48T, K64R, T69N, K122E, D123N, I135T, S162A, K173S, Q174K, V179I, I202V, Q207A, V245Q, E248D, T286A, E291D, I293V, P294A, E312D, S322A, Q334H, G335DA
 CI-1-459CI-1-459KC350390NRTINNRTIM184VK103N, V108VI, P225PH, K238TV35T, E36A, T39K, K43E, N57NH, D121H, K122D, I135T, S162Y, K173L, Q174K, D177E, V179I, Q207A, V245QA
Crawford (2014)SN-062060SN-062060KF781848AZT, 3TCEFVK70E, M184V, K219RK103N, P225H, K238TV60I, D121H, K122E, D123S, I135T, E138G, K173S, Q174K, D177E, T200A, Q207A, R211S, L228R, V245AA
Hassan (2014)RS09000819RS09_819KC568493D4T, 3TCNVPM184VK103N, K238TK11T, V21I, V35T, T39N, V60I, K122E, D123N, N147NK, E169EK, R172RK, K173A, Q174K, D177EK, E194EK, R199RK, T200A, I202V, R206RK, Q207A, R211S, V245Q, E248DN, V261VG, Y271F, A272P, K275Q, R284RK, T286A, E291DN, I293V, P294V, E300EK, E302EK, E305EK, E312DNA
Konou (2015)H991H991KT316097NRTINNRTIM41L, M184V, L210W, T215Y, K219RK103S, G190A, P225H, K238TE6Q, K11T, V35T, T39K, K43E, I94L, D121Y, K122E, I142V, K173S, Q174K, D177E, T200A, Q207A, R211K, L228H, V245Q, E248D, D250EA
 H351H351KT316059NRTINNRTIK70R, M184VA98AG, K103N, K238TP1L, E6D, K11T, K20KR, V35T, E36EA, T39K, K43E, V60I, K64R, D121H, K122E, I135V, I142V, K173A, Q174K, D177E, I178L, V179X, T200A, E203ED, Q207A, R211K, V245QA
Meini (2015)111128111128KM438261DDI, AZT, 3TCNVPM41L, M184V, T215FLK103N, K238TV35K, V60I, K122E, D123S, I135T, D177E, T200A, Q207A, R211K, D237EA
Karade (2016)YCM-151YCM-151KR816077NRTINNRTIM41L, D67DN, M184V, L210L*W, T215Y, K219KNA98AG, K103N, K238TE28EAKT, V35T, T39K, K43E, E44EA, V60I, V90VI, K122E, D123S, I135T, I142V, S162Y, K173A, D177DE, I178IM, T200A, Q207E, H208HY, R211RK, V245QA
Ndahimana Jd Riedel (2016)21412141KT982504NRTINNRTIM41L, D67N, K70R, V75M, M184V, T215F, K219QP225H, K238TT39A, E40D, V60I, K64R, V118I, K122E, I135T, K173S, Q174K, D177E, T200TA, Q207A, F214L, L228H, E233D, V245EA
 20342034KT982524NRTINNRTID67N, K70R, T215Y, K219EK101N, K103N, K238TK11T, E28A, V35T, A98S, K122E, D123N, I135T, S162A, K173S, D177E, V179I, T200A, I202V, Q207A, R211S, V245M, D250E, Q278H, E291D, I293V, P294T, E312D, M357K, R358K, G359S, A360T, K366R, T369TI, E370D, A371V, I375V, A376S, T377M, K390R, E399D, A400TA
Kekitiinwa (2017)65792_44265792_442KY237937NRTINNRTIL74V, Y115F, M184VK103N, P225H, K238TK122E, D123G, E138G, Q145C, K173L, Q174K, D177E, T200E, I202V, Q207A, R211SA
 41449_30441449_304KY237846NRTINNRTIL74V, M184VK103N, K238TV21VI, V35T, T39Q, K122E, D123N, K173S, D177E, V179I, V189I, Q197K, T200A, I202V, Q207A, L228LI, V245Q, E248D, T286A, V292I, I293V, P294TA
 79390_30479390_304KY238003NRTINNRTIL74V, Y115F, M184V, K219KEK103N, Y181YC, K238TK122E, D123N, K173S, D177E, V179IT, V189I, Q197K, T200A, I202V, Q207A, L228LIA
Kityo (2017)8355583555KY062109NRTINNRTIM184VK103N, P225H, K238TV60I, D121H, K122E, I135T, K173I, Q174K, V179I, I202V, Q207A, R211SA
 8341883418KY061972NRTINNRTIM41L, D67N, V75M, M184V, L210W, T215Y, K219NV106A, G190A, K238TE44ED, V60I, L109LI, V118I, K122E, D123N, I135T, E138A, S162SN, K173A, Q174K, V179I, I202V, Q207A, R211NSA
 8353883538KY062092NRTINNRTID67N, K70R, M184V, K219QA98G, K103S, K238TV60I, K122E, D123NS, I135T, K173S, Q174K, D177E, V179I, Q207A, R211S, F214L, L228HA
 8300683006KY061568NRTINNRTIM41L, D67N, K70KR, M184V, L210W, T215Y, K219KNA98G, K103N, K238TV60I, K101Q, K122E, D123N, I142V, K173LS, Q174K, D177E, V179I, T200A, I202V, Q207AA
 8330883308KY061863NRTINNRTID67N, K70R, M184V, K219QK103N, K238TV60I, K122E, D123S, I135T, E138A, K173L, Q174K, V179I, T200TA, R211S, F214LA
 8342983429KY061983NRTINNRTIM41L, D67N, M184V, L210W, T215YA98G, K103N, K238TE44D, I94L, K122KE, I135IT, K173S, D177E, V179I, T200A, I202V, Q207ADA
 8304683046KY061605NRTINNRTIM184V, T215YK103N, P225H, K238TA98S, K101Q, K122E, D123DN, K173L, Q174K, N175Y, T200A, Q207AA
 8346683466KY062020NRTINNRTIM41L, D67N, M184V, L210W, T215YA98AG, K103KN, G190GA, K238TE44D, V111VIM, D121H, K122E, D123S, I135IT, K173S, Q174K, D177E, I178FL, T200E, Q207A, R211NA
 8300783007KY061569NRTINNRTIM41L, A62AV, V75L, M184V, T215FA98G, K103N, V108I, K238TL109LI, K122E, D123S, I142V, I167IV, K173L, Q174K, D177E, V179I, V189VI, I202V, Q207A, R211SA
 8328683286KY061841NRTINNRTID67N, K70R, M184V, T215Y, K219EQK103N, P225H, K238TV60I, H96HL, A98S, K122E, D123S, I135T, K173A, Q174K, D177E, V179I, T200A, Q207A, R211SA
 8309083090KY061648NRTINNRTID67DN, K70KR, M184V, T215TNSY, K219KQK103N, P225H, K238TK49KR, V60VI, K122E, D123S, I135IT, D177E, I178M, T200A, Q207AA
 8305583055KY061614NRTINNRTIK70KR, M184V, T215FK103N, G190A, K238TK49R, V60I, K122E, D123S, I135T, K173T, Q174K, D177E, I178M, V179T, T200A, Q207E, R211K, F214LA
 8320583205KY061761NRTINNRTIM41L, M184V, T215FK103N, V108VI, K238TV60I, K122E, D123N, I135T, I142V, K173L, Q174K, D177E, I178IF, V179VI, T200A, Q207A, R211SA
 8293982939KY061503NRTINNRTIM41L, D67N, M184V, L210W, T215YK101E, V108VI, G190A, K238TE44D, V118I, K122E, D123N, K173S, Q174K, D177E, I178F, V179I, V189I, T200K, Q207A, R211NA
 8294082940KY061504NRTINNRTID67G, K70R, M184V, K219QK103N, K238TS48T, V60I, S68G, K122E, I135T, K173S, Q174K, D177E, V179I, T200A, I202V, Q207A, R211S, H221YA
 8360083600KY062153NRTINNRTIM41L, D67N, K70R, M184V, T215F, K219QK103N, K238TV60I, T69TN, R72RK, R78RK, I94L, K122E, I135T, S163T, E169EK, K173S, Q174K, D177E, I178L, E194EK, I202IV, E203EK, Q207K, R211S, D218DEA
 8329083290KY061845NRTINNRTID67N, K70R, M184V, T215TI, K219QK103N, K238TV60I, K101Q, K122E, D123S, I135T, S162A, K173I, Q174K, N175NY, D177E, T200TA, Q207AT, R211KA
 8354983549KY062103NRTINNRTIK70N, L74I, M184VK103S, G190A, P236PL, K238TK43E, K122E, D123N, K173S, D177E, V179T, Q197QK, T200A, Q207A, R211S, F214L, L228LRA
 8325683256KY061811NRTINNRTIM41L, D67N, K70EG, M184MIT, K219RK103N, K238TV60I, K122E, I135T, E138Q, K173S, Q174K, D177E, T200A, I202V, Q207A, H208L, R211RK, F214L, L228LRA
 8313883138KY061695NRTINNRTID67N, K70R, M184V, T215F, K219QA98G, G190A, K238TK43Q, V60VI, T69N, K122E, D123S, K173S, Q174K, V179I, Q207A, F214L, L228HA
 8313583135KY061692NRTINNRTIM41L, D67N, V75M, F77L, M184V, L210W, T215Y, K219NK103S, G190A, K238TE44D, V118I, K122E, D123N, K173S, Q174K, D177E, V179T, T200A, I202V, Q207A, R211K, E224G, L228LHA
 8290382903KY061468NRTINNRTIM41L, D67N, V75M, M184V, L210W, T215YK101DN, V108I, Y181C, G190A, K238TE44D, K49R, V60I, K166R, D177E, V179IT, E203KQ, Q207D, R211K, H221YA
Svard (2017)1st_1081st_108KX7752263TC, D4TNVPM41L, D67N, K70R, L74I, M184V, T215F, K219QA98G, K103N, V108I, K238TE28A, V35T, K43KR, V60I, K122E, D123S, I135T, S162A, K173S, Q174K, D177E, V179VI, T200A, Q207A, R211S, V245T, E248D, K249KQA
 1st_361st_36KX7752413TC, D4TNVPM41L, D67N, L74V, M184V, L210W, T215YK101P, G190A, K238TK11T, V35T, T39A, K43E, V60I, V118I, L120LI, D121H, K122E, I135V, D177E, V179I, T200A, E203K, L205F, Q207D, H208Y, R211K, H221Y, E224K, V245E, D250EA
 1st_681st_68KX775254NRTINNRTIM184V, T215YK103N, K238TK11T, K20R, V21I, V35T, T39K, E40X, K43E, K122E, D123S, I135T, K173L, Q174K, D177E, V179I, T200A, I202V, Q207A, R211N, V245Q, E248DA