<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Reverse Transcriptase Inhibitors

Subtype A
Gene RT
Mutation K238R
Rx >= 1 NNRTI
(+/- NRTI)
IncludeMixtures No
References 14
Patients 21
Isolates 21
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# NRTIs NNRTIsNRTIDRMs NNRTIDRMs OtherMutSubtype
Montes (2004)MB_patSAN01_SANC718AJ577992D4T, AZT, 3TC, ABCEFVM41L, D67N, L74V, L210W, T215Y, K219RG190EE6D, K11P, K20R, V35I, T39N, E44D, V118I, K122E, D123N, I135V, P157A, K173M, Q174K, D177E, V179N, G196E, E203K, Q207S, H208Y, R211N, K223E, H235I, K238R, V245K, P247Q, E248KA
Nyombi (2008)TMS305TMS305EU251857NoneNVP  K11T, K20R, V21I, V35T, T39G, V60I, K122E, D123N, K173S, V179I, I202V, Q207A, R211S, K238R, V245Q, E248D, T286A, K287R, E291D, V292I, I293V, P294T, E312N, A327V, G335D, M357K, G359S, T369A, A371V, I375V, A376TA
Puthanakit (2010)CR1513CR1513 D4T, 3TCNVPM184VY181CV35T, T39Q, E42G, G45R, S68G, K122E, D123S, I135T, A158T, K166R, R172K, K173I, Q174K, D177E, I178M, V179I, G196E, T200A, E203D, Q207A, R211S, H221Y, K238R, V245EA
Bunupuradah (2011)079-010-027079-010-027 D4T, 3TCNVPA62V, K65N, D67N, K70T, V75M, K219RV106AK20R, A33V, V35R, E36D, T39K, K43E, K49R, S68R, T69N, V90I, I94L, K101A, V118I, K122E, D123S, S162D, K173T, Q174K, D177E, I178M, V179I, T200A, I202V, E203D, Q207A, R211K, F214L, E224EG, K238R, Q242K, V245E, K249RA
Charpentier (2011)121CP001724 D4T, 3TCNVPA62V, V75I, F116Y, Q151M, M184VA98G, Y181CI31L, V35T, T39R, K43E, S68SG, N81ND, D121H, K122E, I135IT, I142V, K173A, Q174K, D177E, G196GE, T200A, Q207A, R211S, K238R, V245E, A272P, K281R, E291D, I293V, E312N, D324EA
Sigaloff (2011)HIV101943HIV101943JN132289D4T, 3TCNVPD67N, F116Y, Q151M, M184V, T215FK101E, G190AE28K, K32Q, V35T, T39L, V118I, K122E, D123S, A158S, K173S, Q174K, N175Y, V179I, T200A, K201R, Q207D, K238R, V245Q, A272P, T286A, E291D, V292I, I293V, P294TA
 HIV102940HIV102940JN132322D4T, 3TCNVP Y181CV21I, V35T, T39E, T69N, K122E, D123N, I142T, K173A, D177E, T200A, Q207E, R211S, F214L, H221Y, K238R, P243A, V245Q, A272P, K281R, E291D, I293V, P294T, L310IA
Afonso (2012)ANG81ANG81JN937093NRTINNRTI  I5V, E6D, V35T, T39K, K122E, D123G, A158S, S163T, K173A, D177E, Q207A, R211S, K238R, V245Q, E248DA
Nouhin (2013)R0220214R0220214KF292451NRTINNRTIM41L, D67N, L74LV, V75M, M184V, L210W, T215YL100I, K103N, Y181IV35T, T39A, E44D, V111I, V118I, K122E, D123S, I135T, I159L, T165V, K173I, Q174K, D177E, I178M, V179I, T200A, E203D, Q207K, H208Y, R211D, K223KQ, K238RA
 U0602211U0602211KF292782NRTINNRTIK65R, D67N, Q151M, K219EK101E, V179E, Y181C, G190AE28A, L34I, V35T, T39K, K43E, S68G, K103KR, G112A, K122E, D123N, I135T, I142IT, A158AS, S162CW, M164I, R172RK, Q174S, D177E, I178L, T200I, Q207A, F214L, K238RA
Hassan (2014)RS11000442RS11_442KC568516AZT, 3TCNVPM184VY181CI5V, V35T, V60I, D121Y, K122E, D123E, I135T, K173S, Q174K, D177E, V179I, G196E, T200V, Q207A, K238R, V245T, D250E, A272P, E291D, V292I, I293V, E312D, V317GA
 RS11000492RS11_492KC568524AZT, 3TCNVPM184VK103KN, Y318YFV35T, E40D, K49R, V60I, D121H, K122E, R125*K, T131TP, I135T, K173S, Q174K, D177E, V179I, I202V, Q207A, K238R, V245E, T286TA, E291D, I293V, E312NA
Khairunisa (2014)DT3DT3KM212875AZT, 3TCEFVD67N, T69D, M184V, L210W, T215YM230LI2V, E6D, V21I, V35T, T39E, E44D, V111I, V118I, D121H, K122E, K173I, Q174K, D177E, I178V, D192N, G196E, Q207E, H208Y, R211K, W212C, H221C, K238R, V245KA
Inzaule (2016)1.02121.0212HM164114AZT, 3TCNVP Y181CV35T, E40D, V60I, K122E, D123S, I135T, S162H, K173S, Q174K, D177E, V179I, G196E, Q207A, R211S, K238R, V245E, D250E, K281KR, T286A, E291D, V292I, I293V, E312NA
Kityo (2017)8348283482KY062036NRTINNRTIM41L, D67DN, K70R, L74LI, V75M, M184V, T215F, K219QK101E, Y188LK49E, V60I, T69N, K122E, D123S, I135T, I142K, S162Y, K173S, Q174K, D177E, I178IF, V179I, T200I, Q207A, R211S, F214FL, K223KQ, E224D, L228LH, K238RA
 8351683516KY062070NRTINNRTID67N, K70R, M184V, T215V, K219QK103N, P225HG45GE, T69TN, V118I, K122E, D123N, T165L, K173S, Q174K, N175NY, D177E, G196E, T200A, Q207A, F214L, K238RA
 8307883078KY061636NRTINNRTID67N, K70R, M184V, K219QY188LV60I, K64R, T69N, K122E, D123S, I135T, E138A, K173T, Q174K, V179I, T200A, I202V, Q207K, R211S, F214L, K238RA
Rhee (2017)221006221006KY373204TDF, FTCNVPM184VK101E, G190AE6D, V35T, K49R, V60I, K122E, D123S, I135T, E138G, E169D, K173A, Q174K, D177E, I178L, T200A, Q207A, R211S, K238R, V245EA
 1185311853KY358945TDF, 3TCEFVA62V, K65R, V75I, Q151M, M184VV179F, Y181C, G190AV21I, I31L, V35T, T39K, S68G, K101Q, V111I, K122E, D123N, S162A, T165I, K173I, Q174K, D177E, Q182H, Q207A, R211S, F214L, K238RA
Svard (2017)1st_551st_55KX775249AZT, 3TCEFVM41L, D67N, V75I, M184V, L210W, T215Y, K219NV108I, Y181C, G190AV35T, K43E, E44A, V60I, K102Q, K122E, D123N, I132L, K173A, Q174K, D177E, V179I, V189I, Q207A, R211N, H221Y, K238R, V245M, D250EA
 2nd_20152nd_2015KX7752703TC, D4T, TDF, FTCNVPD67N, K70R, M184V, T215F, K219EA98G, Y181C, G190AK20R, V35T, T39N, E40D, V60I, K122E, D123N, K173S, Q174K, V179I, T200A, I202V, Q207D, R211K, K238R, P243T, V245E, D250E, S251HA