<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Reverse Transcriptase Inhibitors

Subtype A
Gene RT
Mutation M230L
Rx >= 1 NNRTI
(+/- NRTI)
IncludeMixtures No
References 18
Patients 29
Isolates 29
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# NRTIs NNRTIsNRTIDRMs NNRTIDRMs OtherMutSubtype
Non-B Workgroup (2005)PL5052194398 3TC, D4TNVPM184V, T215FK103N, M230LT7A, E28K, K32KE, V35T, T39DEKN, V118VI, D121H, I135T, I142V, S162C, K173A, Q174KR, D177E, G196D, T200A, Q207A, R211K, V245K, T286A, E291D, V292I, I293V, P294T, E297K, A304E, E312DA
Charpentier (2011)3CP001-039 Unknown, D4T, DDIUnknown, EFVM41L, D67N, K70R, M184L, T215Y, K219QY188L, M230LK11T, V35KR, T39D, V106L, L109I, D121H, K122E, D123S, S134SN, A158S, K173S, Q174K, D177E, V179I, G196E, T200A, I202V, Q207A, R211S, F227Y, V245Q, T286TA, A288AS, I293V, P294T, E312D, D324EA
Fokam (2011)CIRCB-7759CIRCB-7759JQ796153AZT, 3TCEFVM184V, T215FYK103N, M230LK11A, V35T, T39M, D121H, K122E, K173A, Q174K, D177E, G196E, Q207A, R211S, V245Q, E248N, A272P, T286A, E291D, I293VA
Hamers (2012)CP076304354CP076304354JQ480173AZT, 3TCEFVM184VK103N, P225H, M230LV35M, T39K, E40D, I50V, K122E, D123S, I178M, T200A, Q207E, R211K, V245K, V261I, A272P, K275Q, K281R, T286A, E291D, V292I, I293V, P294T, E297K, A304EA
 CP076304915CP076304915JQ480247AZT, 3TCNVPM184VV106A, M230LE6D, K20R, V35T, V60I, T69N, K122E, D123N, I135T, K173S, Q174R, D177E, I178L, I202V, Q207K, R211S, F214L, V245E, D250E, K277R, T286A, E291D, V292I, I293VA
 CP076305017CP076305017JQ480252AZT, 3TCEFVM184VA98G, K103N, M230LK11T, K20R, V21I, V35T, T39L, V60I, K122E, D123S, K173L, Q174K, V179I, T200K, I202IV, Q207A, R211S, V245E, E248D, D250E, E291D, I293V, P294TA
Reynolds (2012)A0721A0721-1JN652170AZT, 3TCNVPM184VA98AG, G190A, M230LK11T, G15GR, K20R, V21I, V35T, T39E, K122E, D123N, E138A, Q145C, K173S, Q174K, D177G, V179I, T200A, I202V, Q207A, R211S, L228LR, V245Q, E248D, A272P, T286A, V292I, I293V, P294TA
 F0293F0293-1JN652188D4T, 3TCNVPM184V, T215FG190A, M230LV35T, V60I, K122E, D123NS, K173A, Q174K, D177E, V179I, T200A, Q207AD, R211K, V245Q, D250E, A272S, T286A, E291D, V292I, I293VA
Pircher (2013)B1113B1113JX110214D4T, 3TC, AZTNVPM41L, D67N, L74V, M184V, L210W, T215Y, K219KNK103N, M230L, K238TI2IV, E6D, K20R, E28K, K32E, V35T, E36ED, T39K, K43E, E44D, K49R, V60I, K64R, V111I, V118I, K122KE, D123DN, K173A, Q174K, Q207A, H208HY, R211RK, V245EA
Sigaloff (2013)MBA079_0MBA079_0JX182024NRTINNRTIM41L, T69D, M184V, T215YK103N, V108I, M230LV35T, K43E, E44A, V60I, V111I, V118I, K122E, D123S, K173L, Q174K, D177E, V189I, T200A, R206K, Q207A, L210S, R211S, T216M, L228R, V245E, A272P, K275Q, K277R, T286A, E291D, I293V, P294T, E297KA
Acharya (2014)DGP150DGP150KJ185320TDF, 3TCNVPD67N, T69D, K70R, M184V, T215Y, K219NK103N, V108I, M230LK11E, V35T, V60I, V118I, D121H, K122E, D123S, I135T, K173L, Q174K, D177E, V179I, Q197E, T200A, E203D, Q207A, L210S, R211S, V245Q, D250E, T286A, E291D, I293VA
Aghokeng (2014)TG-2-450TG-2-450KC350166NRTINNRTIM184VK103N, M230LP4H, I5V, V35T, T39L, D121H, K122E, I135T, S162C, E169D, K173S, I178IL, I202V, Q207A, R211S, L228LR, V245Q, T286A, E291D, V292I, I293V, E297K, E312N, G335D, R356K, M357K, R358G, G359S, K366R, E370A, A371V, I375V, A376S, T377Q, K390R, T403M, E413ED, E432D, V435MA
Khairunisa (2014)DT3DT3KM212875AZT, 3TCEFVD67N, T69D, M184V, L210W, T215YM230LI2V, E6D, V21I, V35T, T39E, E44D, V111I, V118I, D121H, K122E, K173I, Q174K, D177E, I178V, D192N, G196E, Q207E, H208Y, R211K, W212C, H221C, K238R, V245KA
Jenabian (2015)DR09DR09KF735820NRTINNRTIM41L, L74I, M184V, T215F, K219NK103N, V108I, F227L, M230LV35T, T39D, E44D, K49R, K122E, D123S, S162C, E169D, P170PL, K173T, Q174K, D177E, I178IM, G196E, T200A, Q207A, R211RKNS, H221Y, L228R, V245Q, E248D, D250E, T286A, E291D, I293V, E297EA, E312D, G335DA
Kaleebu (2015)MSK-0075UGA-MSK-0075-2012 TDF, 3TCNVPK65R, M184IK101KE, Y181C, G190GA, M230LV35T, K49KR, V60I, V90I, K122E, D123N, I135T, T139S, K173A, Q174K, D177E, I178IV, Q207AD, R211RS, V245K, D250E, A272P, K277R, L282C, T286A, K311KRA
Brooks (2016)2047A2047AKU900876TDF, 3TCNVPK65R, M184IY181C, M230LV35T, V60I, T69S, D121H, K122E, I135T, K173A, Q174K, D177E, I178M, V179I, Q197E, T200A, E204D, Q207A, R211KA
 2077A2077AKU900871TDF, 3TCEFVK65R, M184IK103N, M230L, L234IK11H, V35T, V60I, S68G, V90I, K122E, D123G, I135T, K173L, Q174K, D177E, V179I, G196E, T200TA, I202V, Q207A, R211SA
Lam (2016)2001202420012024KR867846D4T, 3TCEFVT69TADN, M184VK103N, V108VI, F227FL, M230LV35T, V60I, K122E, D123N, I135T, I142V, K173L, Q174K, D177E, V179I, T200A, Q207A, R211K, V245Q, A272P, T286A, E291D, V292I, I293V, A327V, G335DA
Steegen (2016)GFGPB157GFGPB157KU128367TDF, 3TC, FTCEFVK70E, M184VK103N, M230LE6D, K11T, K20R, V35T, T39N, V60I, D121Y, K122E, D123G, I135T, I142V, K173A, Q174K, D177E, I178L, T200TA, Q207A, R211S, P225R, L228R, V245Q, K281R, L283I, V292I, I293V, E297R, E312T, V317VA, G335D, Y342F, M357K, R358G, G359S, K366R, T369A, A371V, I375V, A376T, S379C, T386AA
Kekitiinwa (2017)42214_61142214_611KY237868NRTINNRTIL74V, Y115F, M184VK103N, Y188C, M230LK43KE, V60I, T69N, K122E, D123N, S163I, K166R, K173S, D177E, V179I, G196E, T200A, I202V, Q207A, R211RSA
 65527_87365527_873KY237887NRTINNRTIL74V, Y115F, M184VK103N, M230LI50V, V60I, K122E, D123N, K166KR, E169D, K173S, Q174R, D177E, I178IM, V179I, G196E, T200A, Q207A, R211K, H221Y, P225RA
Kityo (2017)6608866088KY061440NRTINNRTID67DE, K70R, M184V, T215F, K219QY181C, M230LK46Q, T69N, K122E, K173S, Q174K, D177E, V179I, G196E, Q197R, T200A, Q207A, L228RA
 8316383163KY061719NRTINNRTIM184IK103N, M230LK43E, K49R, T69N, V90I, K102N, S117SL, K122E, D123N, K173S, D177E, V179I, T200A, I202V, Q207A, R211K, L228LRA
 8341483414KY061968NRTINNRTIM184VK103N, Y181YC, M230LV60I, K122E, I135T, K173S, Q174K, T200A, Q207N, R211SA
 8345983459KY062013NRTINNRTIM41L, L74V, M184V, L210W, T215F, K219WG190S, M230LT69N, V106I, V118I, K122E, D123N, I142IV, K173A, Q174K, D177E, V179I, T200A, I202V, Q207D, H208HY, R211K, L228HA
 8359883598KY062151NRTINNRTIL74LI, M184V, T215F, K219QA98AG, K103N, V108VI, M230LK49R, V60I, V111VM, V118C, K122E, D123S, I142IV, K173S, D177E, V179I, T200A, I202V, Q207A, R211K, L228HA
 8317183171KY061727NRTINNRTIT69D, K70R, M184V, T215F, K219QY181C, M230LK43KE, G45GR, V60I, G93GR, K122E, D123S, I135T, S162SN, K173A, D177G, T200A, I202V, Q207A, R211RS, L228RA
 8347083470KY062024NRTINNRTID67G, M184V, L210W, T215Y, K219DG190A, M230LK43E, E44D, V60I, S68G, V111I, K122E, D123S, I135T, S162A, K173S, Q174K, V179I, I180V, T200A, Q207A, R211SA
Rhee (2017)1064110641KY358800TDF, 3TCEFVK65R, M184IK103N, Y181C, M230LV35T, T39K, V60I, S68G, K122E, D123S, I135L, Q145S, Y146H, N147K, R172K, K173T, Q174K, D177E, Q207A, R211S, V245E, D250R, S251QA