<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Reverse Transcriptase Inhibitors

Subtype A
Gene RT
Mutation F227L
Rx >= 1 NNRTI
(+/- NRTI)
IncludeMixtures No
References 10
Patients 22
Isolates 22
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# NRTIs NNRTIsNRTIDRMs NNRTIDRMs OtherMutSubtype
Moussa (2010)2814-CP001245HM117957D4T, 3TCNVPM184VK101E, V108I, F227LV35T, K49R, T69S, K122E, D123S, I135T, T139R, S162H, K173S, D177E, G196E, Q207A, R211S, L228F, V245QA
Pircher (2013)B1120B1120JX110221D4T, 3TC, AZTNVPM41L, L74LI, M184V, L210LW, T215Y, K219RK103N, V108I, F227LK20KR, V35T, T39N, V60I, T107S, V118I, K122E, D123S, S162C, K173A, Q174K, T200A, Q207A, R211N, H221Y, K223KE, L228LR, V245QR, E248D, D250EA
Sigaloff (2013)JCR079_0JCR079_0JX181995NRTINNRTIV75M, M184VV106A, F227LV35T, T39K, S48T, K122E, I135V, R172RS, K173PT, T200A, Q207A, R211K, V245Q, D250E, S251D, A272P, K277R, T286A, E291D, V292I, I293V, P294TA
Jenabian (2015)DR09DR09KF735820NRTINNRTIM41L, L74I, M184V, T215F, K219NK103N, V108I, F227L, M230LV35T, T39D, E44D, K49R, K122E, D123S, S162C, E169D, P170PL, K173T, Q174K, D177E, I178IM, G196E, T200A, Q207A, R211RKNS, H221Y, L228R, V245Q, E248D, D250E, T286A, E291D, I293V, E297EA, E312D, G335DA
Meini (2015)109276109276KM438252AZT, 3TCNVPK70R, M184EK103N, F227LV35T, V60I, V90I, V106I, K122E, D123N, I135T, T139R, S162H, K173L, Q174K, I178L, V179I, D185E, T200A, Q207A, R211NA
Ndahimana (2016)875875KU922837TDF, 3TCNVPK65RV106A, F227LV60I, K122E, D123N, I135T, I142V, K173S, Q174K, D177E, Q207A, R211KA
Chaplin (2017)NJIH0130NJIH0130MF622681NRTINNRTIA62V, K65R, M184VV106A, F227LE6N, K11T, K20R, V35T, S68G, K122E, D123N, I142V, S162Y, S163ST, K173S, Q174X, D177E, V179I, T200A, I202V, Q207G, R211K, P243T, V245QA
 NJIH0129NJIH0129MF622680NRTINNRTIK65R, M184MVV106A, F227LE6N, K11T, V35T, S68SG, K122E, D123N, I142V, S162Y, E169EK, K173S, Q174X, D177E, V179I, G196GE, T200TA, I202V, Q207X, R211K, P243T, V245Q, D250E, Y271F, V276I, Q278H, T286A, E291D, V292I, I293V, G335DA
Kityo (2017)8359783597KY062150NRTINNRTIM41L, D67N, V75M, M184V, L210W, T215YV106A, F227LK43KQ, V60I, K104R, V118I, K122E, D123S, I135T, K173S, D177E, V179I, G196GE, T200A, I202V, Q207A, R211RKA
 8351283512KY062066NRTINNRTIM41L, D67N, K70R, V75M, M184V, L210W, T215YK101E, V106A, F227LK43E, V60I, A98S, L109I, V111I, V118I, K122E, D123N, E138A, K173S, V179VI, V189VM, T200A, I202V, Q207A, H208Y, R211K, H221YA
 8318083180KY061736NRTINNRTID67N, K70R, M184V, T215F, K219QV106A, F227LK43R, A98AS, L109LI, V118I, K122E, D123S, I135T, K166R, K173A, Q174K, D177E, V179I, I202V, Q207A, R211S, F214LA
 8355683556KY062110NRTINNRTIM41L, D67N, K70R, V75M, M184V, T215F, K219QV106A, F227LV60I, I94L, K101Q, L109I, K122E, D123S, I135T, K173S, Q174K, V179I, G196GE, T200A, I202V, Q207A, R211K, H221YA
 8356383563KY062117NRTINNRTID67N, K70R, M184V, T215F, K219EG190A, F227LT69N, A98S, L109I, K122E, D123N, I142V, K173S, D177E, V179T, T200A, I202V, Q207A, R211N, D218E, L228HA
 8301783017KY061578NRTINNRTIM41L, D67N, K70R, V75M, M184V, L210W, T215Y, K219EV106A, F227LK43E, K73M, L109I, K122E, D123N, K173S, D177E, V179I, T200A, I202V, Q207A, R211S, L228HA
 8318783187KY061743NRTINNRTIA62V, K70N, V75T, M184VV106A, F227LK102KQ, L109I, V118I, K122E, D123N, E138A, K173S, Q174K, N175Y, V179I, G196E, Q197E, T200A, I202V, Q207DN, R211K, D218DE, H221HY, L228RA
 8355083550KY062104NRTINNRTIL74LI, M184V, K219RA98AG, K103N, P225H, F227LV60I, V90VI, K122E, D123S, I135T, S162Y, K173A, Q174K, D177E, V179VI, T200A, Q207A, R211S, L228LQA
 8326083260KY061815NRTINNRTIK65R, D67N, M184IVK103N, V108I, F227LK43Q, K46M, V60I, T69N, W88C, V90I, K102Y, D121H, K122E, I135T, I142IV, S162Y, K173S, Q174K, T200A, E203K, Q207A, R211N, K223EA
 8317583175KY061731NRTINNRTIM41L, M184V, T215YV106A, F227LV60I, K122E, D123N, I135T, K173A, Q174K, D177E, V179I, T200A, I202V, Q207A, R211SA
 8294182941KY061505NRTINNRTID67N, T69D, M184V, L210W, T215YK103N, V106A, F227LT58S, V60I, K102R, L109I, K122E, D123N, I135T, I142V, S162N, K173S, Q174K, D177E, I178M, G196GE, T200A, E203V, Q207DE, H208HY, R211K, H221HYA
 8314683146KY061702NRTINNRTIM184VK103KN, V106A, F227LK122E, D123N, I135V, K173S, Q174K, D177E, V179I, T200A, I202V, Q207A, R211S, F214LA
Rhee (2017)222229222229KY373203TDF, FTCEFV V106A, F227LK20R, V35T, S48ST, K49R, V60I, V118VIM, D121DH, K122E, D123NS, I135T, E138EA, K173S, Q174K, D177E, I202V, Q207A, R211S, F214L, V245Q, E248DA
Svard (2017)1st_711st_71KX775255AZT, 3TCEFVM41L, V75M, M184V, T215YA98G, K101E, G190A, F227LP4H, K11A, E28K, K32E, V35T, V60I, K103R, D121H, K122E, D123S, I135T, K173S, Q174K, D177E, T200A, Q207A, R211H, D250EA