<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Reverse Transcriptase Inhibitors

Subtype A
Gene RT
Mutation P225H
Rx >= 1 NNRTI
(+/- NRTI)
IncludeMixtures No
References 19
Patients 51
Isolates 52
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# NRTIs NNRTIsNRTIDRMs NNRTIDRMs OtherMutSubtype
Zhong (2007)D000805CN_008EF199556NRTINVPM41L, T215YK103N, P225HL34I, V35T, T39K, K43E, V90I, K122E, D123S, I178M, K238R, V245E, V254A, N255DA
Steegen (2009)BV114BV114-2EU8721373TC, D4T, AZTEFV K103N, P225HV35T, W88C, D121H, R125RK, I135T, I142V, D177E, I178L, T200A, E204K, Q207E, R211QA
 BV147BV147-1EU8785483TC, D4TEFVM184V, T215FK103N, P225HI31L, V35T, T39N, D121Y, K122E, D123E, I142V, S162C, D177E, I178L, Q207E, R211KA
Charpentier (2011)CR-27CR-27FJ688233AZT, 3TCNNRTIM184VK103N, P225H, K238KTK11E, T27S, V35T, T39R, K43E, S68G, D121Y, K122E, D123G, I135T, K173A, Q174K, D177E, G196E, T200A, Q207A, R211S, V245Q, D250E, A272P, T286TA, E291D, I293V, E312DA
Avidor (2013)1996_FT1996_FTKC184324AZT, 3TCEFVM184VK103N, V108I, P225HV35L, E36N, I37F, T39M, K122E, D123S, A158AS, K173L, Q174K, D177E, T200A, E203D, Q207A, R211S, V245MA
 1978_MT1978_MTKC184309AZT, 3TCEFVA62V, M184VK103N, P225HK30Q, K32G, A33C, L34T, V35L, E36N, I37F, T39K, K122E, D123N, A158S, K173L, Q174K, D177E, Q207A, R211S, L228LH, V245MA
Nouhin (2013)S1124162S1124162KF292606NRTINNRTIK65KN, V75M, F77L, F116FY, Q151M, M184VK103N, V108VI, P225HV35T, T39N, S68SG, V90I, A98S, K102KR, K122E, D123S, A158T, S162A, T165L, K173R, Q174K, N175Y, D177E, T200K, K201I, Q207V, R211N, F214L, L228R, K238RA
 T0526166T0526166KF292635NRTINNRTIA62V, V75I, F77L, F116Y, Q151M, M184VK103N, V106A, P225HK20R, V21I, V35T, T39E, V111IM, K122E, D123S, S163I, K166R, K173T, Q174R, D177E, G196E, T200A, I202V, Q207A, R211SA
Pircher (2013)B1147B1147JX110245D4T, 3TC, AZTNVPM184VK103N, P225HI5V, K11T, K20R, V35T, T39N, E40D, V60I, K102Q, D121H, K122E, D123S, I135L, K173A, Q174K, D177E, G196E, Q207A, R211K, V245K, E248D, D250EA
Sigaloff (2013)MBA054_0MBA054_0JX182020NRTINNRTIM184VK103N, P225HE6D, V35T, E40D, V60I, V118I, K122E, D123S, I135T, T165L, K173A, Q174N, D177E, T200TA, Q207A, R211S, F214L, V245E, D250E, A272P, K277R, K281R, T286A, E291D, I293VA
 JCR083_0JCR083_0JX181996NRTINNRTID67N, T69D, K70R, M184V, T215F, K219QK103N, P225HE6D, K20R, E28A, V35T, V60I, W88C, I94L, K101Q, V118I, K122E, D123S, I135T, E169D, K173A, Q174K, D177E, I178L, E194D, G196E, T200A, Q207E, F214L, V245K, D250E, K277R, E291D, V292I, I293V, P294TA
 JCR017_0JCR017_0JX181984NRTINNRTIM184VK103N, P225H, K238TV35T, T39N, K122E, D123S, I135L, K173A, T200A, Q207A, R211K, V245Q, D250E, A272P, K275R, T286A, E291D, V292I, I293V, P294TA
Theys (2013)4365143651KC221286TDF, FTCEFVM184IVK103N, P225HE53D, V60I, V90I, D121H, K122E, D123S, I135T, S162H, K173L, Q174R, D177E, I178L, V179I, T200A, Q207D, R211KA
 37843784KC219302NRTI, TDFNNRTIM184VK103N, P225HK43E, W88WC, V90VI, A98AS, K102KR, K122E, D123S, S162H, K173S, D177E, V179I, T200A, I202V, Q207A, R211TA
 4064140641KC221204NRTI, TDFNNRTI K103N, Y188C, P225HV90I, D121H, K122E, I135V, A158S, K173A, Q174K, D177E, V179VI, T200A, Q207A, R211KA
Thiam (2013)619-HPD619-HPDJQ855853NRTINNRTIL74V, M184VK103N, P225HV35T, K102Y, K122E, I135T, I142V, S162Y, K173S, Q174K, D177E, V179I, Q207A, R211K, V245QA
Acharya (2014)DGP098DGP098KJ185268AZT, 3TCEFVM41L, M184V, T215YK103N, P225HV35T, V60I, K122E, D123S, I135T, I142V, S162A, T165I, K173S, Q174K, D177E, V179I, Q197E, T200A, Q207A, R211K, V245K, D250E, T286A, E291D, V292I, I293V, P294TA
Aghokeng (2014)CI-1-57-CI-1-57-KC350128NRTINNRTIM184VK103N, P225HP1S, V35T, T39K, K43E, S68G, T69TI, V90VI, K102Q, D123E, T139TK, S162H, K173S, D177E, T200A, Q207A, R211K, V245Q, E248NA
 CI-1-430CI-1-430KC350385NRTINNRTID67N, K70R, M184V, T215TI, K219EQK103N, P225HV35T, T39K, K43E, K102HQ, K122E, D123DN, I142V, S162SY, K173S, Q174K, D177E, I178IM, V179I, T200A, Q207A, R211K, L228LHA
Crawford (2014)SN-062060SN-062060KF781848AZT, 3TCEFVK70E, M184V, K219RK103N, P225H, K238TV60I, D121H, K122E, D123S, I135T, E138G, K173S, Q174K, D177E, T200A, Q207A, R211S, L228R, V245AA
Kolomeets (2014)421421_666KJ870683AZT, 3TCEFVA62V, M184VK103N, P225H, K238KTK11T, V35I, E36D, T39K, K122E, D123N, A158S, I167IF, K173L, Q174K, D177E, T200A, Q207A, R211S, I244V, V245M, E248DA
 102102_286KJ870404AZT, 3TCEFVA62V, M184VK103N, P225HK11T, K20KR, V35I, T39E, K122E, D123N, I135T, A158S, K173L, Q174K, D177E, T200A, Q207A, R211S, E248DA
 3939_642KJ8706673TC, DDIEFVA62V, K65R, M184IK101E, Y181C, G190S, P225HK11T, V35I, E36D, T39K, K122E, D123N, A158S, K173LS, Q174R, D177E, G196E, T200A, Q207A, R211S, E248DA
 3232_267KJ870388AZT, 3TCEFVA62V, M184VK103N, P225HK11T, V35I, E36D, T39Q, D123N, I135T, N147NH, A158S, K173A, Q174K, D177E, T200A, Q207A, R211S, E248DA
 160160_189KJ8703303TC, DDIEFVA62V, K65R, V75IY181C, G190S, P225HK11T, V35I, E36D, T39N, K103R, K122E, D123N, A158S, Q174K, D177E, T200A, Q207A, R211S, V245M, E248DA
 3232_324KJ870437AZT, 3TCEFVA62V, M184VA98AG, K103N, P225HK11T, V35IM, E36D, T39Q, D123N, I135IT, A158S, K173ALSV, Q174K, D177DE, V179VI, T200A, Q207A, R211S, H221HY, E248DA
Wallis (2014)4128141281KM458600NRTINNRTIM184VG190A, P225HV35T, T39A, E40D, K122E, D123N, I135T, I142V, K173A, Q174K, D177E, V179I, T200A, Q207A, R211S, F214LA
 4123541235KM458480NRTINNRTIM184VK103N, V108VI, P225HV35T, T39K, K122E, D123S, I135IT, A158S, K173S, Q174K, D177E, T200A, Q207A, R211HA
Jenabian (2015)DR05DR05KF735816NRTINNRTIM184VK103N, P225HK20R, V35T, T39K, K43Q, S68G, D121H, K122E, I135T, E169D, K173A, Q174K, D177E, G196E, T200A, Q207A, V245Q, T286A, E291ED, I293IV, E297EK, E312D, G335DA
Ndahimana Jd Riedel (2016)21412141KT982504NRTINNRTIM41L, D67N, K70R, V75M, M184V, T215F, K219QP225H, K238TT39A, E40D, V60I, K64R, V118I, K122E, I135T, K173S, Q174K, D177E, T200TA, Q207A, F214L, L228H, E233D, V245EA
 21322132KT982503NRTINNRTID67N, K70R, M184MV, T215TAIV, K219KEK103N, V108I, P225HT39A, V60I, K64KR, T69N, D121H, K122E, D123S, I135T, K173LQ, Q174QK, D177DE, I178IM, T200AE, Q207XA
Steegen (2016)GFKZB161GFKZB161KU128052TDF, 3TC, FTCEFVA62AV, K70E, L74LI, M184V, K219RK103N, P225HE6K, K20KR, K22KR, V35T, A98S, K122E, I135T, I142V, K173S, V189I, T200TA, I202V, Q207KNRS, R211K, L228R, D237DE, V245Q, E248D, A272P, V276I, L283I, T286A, E291D, I293V, P294T, E297KR, E312D, I326V, G335D, R356K, M357K, G359S, A371V, I375V, A376V, T386A, E399ED, A400TA
Kekitiinwa (2017)79403_93379403_933KY238010NRTINNRTIL74V, Y115F, M184VK103KN, V179VDE, P225HV60I, K122E, D123S, S134SN, I135T, E138G, T139TM, S162A, K173S, Q174K, I178IL, T200A, Q207A, R211S, F214L, L228CA
 79382_29779382_297KY237996NRTINNRTIM184MVK103N, P225HV60I, A98S, K122E, D123S, I135T, K173S, V189VI, T200A, Q207A, R211S, F214LA
 65792_44265792_442KY237937NRTINNRTIL74V, Y115F, M184VK103N, P225H, K238TK122E, D123G, E138G, Q145C, K173L, Q174K, D177E, T200E, I202V, Q207A, R211SA
 79389_22279389_222KY238002NRTINNRTI K103N, P225HV60I, K122E, D123N, Q145C, K173S, Q174K, D177E, V179I, T200A, I202V, Q207A, R211SA
 65801_47065801_470KY237944NRTINNRTIL74V, Y115F, M184VL100I, K103N, P225HS48T, K49R, V60I, T69N, K122E, D123NS, P170PS, K173S, V179IT, T200A, R206RK, Q207A, R211SA
Kityo (2017)8355583555KY062109NRTINNRTIM184VK103N, P225H, K238TV60I, D121H, K122E, I135T, K173I, Q174K, V179I, I202V, Q207A, R211SA
 8318983189KY061745NRTINNRTID67N, K70R, M184V, T215I, K219QA98AG, K101PQ, K103NS, P225HV60I, T69N, K173L, V179I, I202V, Q207A, R211KA
 8345583455KY062009NRTINNRTIA62V, D67E, M184V, L210W, T215FA98G, K103N, P225HT69S, I94L, K122E, D123S, S162A, K173A, D177E, E194D, G196K, T200A, Q207AD, R211K, L228HA
 8325583255KY061810NRTINNRTIL74I, M184VA98G, K103N, V108I, P225HV60I, L109I, K122E, D123S, K173S, Q174K, D177E, V179I, I202V, Q207AA
 8304683046KY061605NRTINNRTIM184V, T215YK103N, P225H, K238TA98S, K101Q, K122E, D123DN, K173L, Q174K, N175Y, T200A, Q207AA
 8328683286KY061841NRTINNRTID67N, K70R, M184V, T215Y, K219EQK103N, P225H, K238TV60I, H96HL, A98S, K122E, D123S, I135T, K173A, Q174K, D177E, V179I, T200A, Q207A, R211SA
 8355083550KY062104NRTINNRTIL74LI, M184V, K219RA98AG, K103N, P225H, F227LV60I, V90VI, K122E, D123S, I135T, S162Y, K173A, Q174K, D177E, V179VI, T200A, Q207A, R211S, L228LQA
 8360183601KY062154NRTINNRTIM41ML, D67N, V75M, M184V, L210W, T215YK103N, P225HE44D, V60I, D121H, K122E, S162Y, K173S, Q174K, D177E, G196S, Q207A, R211N, L228NA
 8351683516KY062070NRTINNRTID67N, K70R, M184V, T215V, K219QK103N, P225HG45GE, T69TN, V118I, K122E, D123N, T165L, K173S, Q174K, N175NY, D177E, G196E, T200A, Q207A, F214L, K238RA
 8354783547KY062101NRTINNRTIK70Q, M184IY188L, P225H, P236PLW88WS, V90I, L109LI, K122E, D123S, K173S, Q174K, D177E, I178M, V179I, T200A, I202IV, Q207A, R211RS, H221YA
 8308283082KY061640NRTINNRTIM184MVK103N, G190GA, P225HS48T, V60I, K101KQ, K122E, D123N, I135IT, K173L, Q174K, D177E, Q207A, R211SA
 8293182931KY061495NRTINNRTIM41ML, D67N, K70R, L74I, M184V, T215F, K219QK103N, P225HK43E, T69N, K101Q, K122E, D123S, K173L, Q174K, D177E, T200AS, I202V, Q207A, L228IV, K238KRA
 8356783567KY062121NRTINNRTIM184VK103S, G190A, P225HV60I, K122E, D123DG, K173AT, Q174K, D177DE, T200A, Q207E, R211S, F214LA
 8326983269KY061824NRTINNRTID67N, K70R, M184V, K219QK103N, P225HV60I, T69N, A98S, D121H, K122E, D123S, K173S, Q174K, D177E, Q197E, T200A, Q207A, K238QA
 6603966039KY061408NRTINNRTIK70N, L74V, M184VL100I, K103N, P225HV60I, D121H, K122E, I135T, E138A, S162C, K173S, Q174K, V179IL, G196E, T200A, Q207A, R211KA