<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Reverse Transcriptase Inhibitors

Subtype A
Gene RT
Mutation H221Y
Rx >= 1 NNRTI
(+/- NRTI)
IncludeMixtures No
References 14
Patients 22
Isolates 22
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# NRTIs NNRTIsNRTIDRMs NNRTIDRMs OtherMutSubtype
Non-B Workgroup (2005)UK1436UK1436AY901336DDC, AZT, D4T, 3TCNVPM184VY181VE6D, V21I, V35T, V60I, R83K, K122E, D123S, K173S, Q174K, D177E, I178L, V179I, T200A, Q207E, R211K, H221YA
Weber (2005)F75698F75698AY677500D4T, DDI, ABC, AZT, 3TCNVPY115F, M184V, T215FYY181VK22KN, V35T, K49KR, V60I, R72RK, V90VI, K122E, D123NS, I135T, K173S, Q174K, V179I, Q207E, R211S, H221Y, V245Q, D250E, T286A, E291D, V292I, I293V, E312DG, Q334QHA
 M76115M76115AY677511D4T, DDI, ABC, TDF, AZT, 3TCNVPF116Y, Q151MG190AE6K, V35T, T39A, F87S, K122E, D123S, E169D, Q174K, D177E, V179I, Q207A, R211S, H221Y, V245T, K277R, K281R, L283I, E291D, I293V, P294TA
 F65588F65588AY677546D4T, 3TC, DDI, DDCNVP Y181CK11T, K20R, V21I, V35T, T39G, D123N, K173S, Q174QK, D177G, V179I, T200A, I202V, Q207A, R211S, H221Y, L228R, V245Q, E248N, A272P, T286A, E291D, I293V, P294T, E312NA
 M41984M41984AY677598AZT, 3TC, D4T, DDIEFVM41L, D67N, K70R, V75M, M184V, L210W, T215Y, K219EK103N, V108I, Y181CV35T, V60I, K122E, D123S, I135T, K173S, Q174K, V179I, T200A, E203K, Q207D, R211K, D218E, H221Y, L228H, V245Q, D250E, A272T, E291D, V292I, I293VA
Baxter (2006)48-12041204-30709DQ877748NRTINNRTIM41L, D67N, L74V, M184V, L210W, T215Y, K219NK103S, Y181C, G190AP4S, V35T, T39A, E44D, K64R, K101Q, K122E, D123S, T165I, K173S, Q174K, D177E, I178L, V179I, T200A, I202V, E203D, Q207N, H208Y, R211N, W212C, H221Y, L228H, V245T, D250E, A272P, K281R, I293V, P294T, G335D, M357R, G359S, T369A, A371V, I375V, A376V, T377M, T386SA
 48-33163316-30818DQ878217NRTINNRTIA62V, K65R, V75I, F77L, F116Y, Q151MK101N, K103H, Y181C, G190AP4K, K11T, V35T, T39E, S68G, V118I, D121Y, K122E, D123S, A158S, R172K, K173S, Q174K, D177E, I195L, G196E, Q207A, R211S, F214L, H221Y, V245Q, T286A, E291D, I293V, E297K, E312D, H315Q, V317A, I326T, Q334D, R356K, M357K, G359S, T362S, K366R, T369V, E370D, A371V, I375V, A376S, K390RA
 48-40184018-30227DQ878252NRTINNRTID67N, K70R, L74V, Y115F, M184V, K219QK103N, Y181C, G190AK11T, M16V, K20R, V35T, T39N, D121H, K122E, I135T, I142T, T165I, K173A, Q174R, D177E, G196E, T200A, Q207A, F214FL, H221Y, L228LR, V245Q, K277R, T286A, E291D, I293V, G335D, R356K, M357K, G359S, K366R, A371LV, I375V, A376S, V381I, T386IA
Hawkins (2009)R40ZZR40FJ931279D4T, 3TCNVPM41L, L74V, M184V, L210W, T215YA98G, V108I, Y181CI5V, E28K, K32E, V35T, E36A, T39K, K43E, D86E, V118I, D121H, K122E, I135T, I142V, S162Y, K173T, Q174K, D177E, V179I, T200A, I202V, Q207D, R211K, H221Y, V245Q, T286A, E291D, V292I, I293V, P294T, E312D, I326VA
Wallis (2009)GP00018022GP00018022 D4T, 3TCEFVM184VK103NK11T, K20R, V35T, T39K, V60VI, S68G, T69TI, K122E, D123N, I135V, S162A, K173S, D177E, V179I, T200TA, I202V, Q207A, R211RS, H221Y, V245Q, E248D, A272P, K277R, R284K, T286TA, E291D, V292I, I293V, P294AA
Ndembi (2010)13929D_P113929GQ409560AZT, 3TCNVPM184V, T215YY181CI31L, V35T, V60I, T69TN, D121H, I142V, D177E, Q207A, R211S, H221YA
Charpentier (2011)31CP 005 026 D4T, 3TCNVPK65R, T69~, K70KN, K219RY181C, G190AK11T, V21I, L34I, V35T, T39E, S68SDGN, K82KR, V90VI, K101KQ, D121H, K122E, K173S, D177E, G196E, E204Q, Q207D, F214L, H221Y, V245Q, D250E, S251DG, L283LI, E291ED, I293V, P294T, L295F, E297K, E312DA
 232CP 001 1420 D4T, 3TCNVPT69TADN, K70KN, L74I, V75S, M184VK103N, Y181IVK11T, K20KR, V35IT, T39TA, E40D, D121H, K122E, D123S, K173S, D177E, I178L, G196E, Q207A, R211S, F214FL, H221Y, V245Q, D256DE, T286A, A288S, E291D, I293V, L295F, E297K, E312D, D324EA
Fokam (2011)CIRCB-7842CIRCB-7842JQ796155AZT, 3TCNVPM41L, M184V, L210W, T215YK101KE, Y181YC, G190AK20R, E28EK, V35T, T39S, E40ED, E44ED, S48T, K49R, K122E, D123N, K173S, Q174K, V179I, T200A, E203D, Q207N, H208HY, R211K, H221Y, V245M, E291D, I293V, P294T, G335DA
 CIRCB-10615CIRCB-10615JQ796175D4T, 3TCNVPM41L, D67N, M184V, L210W, T215Y V35T, E44D, V60I, K64KR, D121H, K122E, I135T, N137NY, Q145QP, S162DN, S163A, Q174K, D177E, Q182Q*, G196E, T200A, E203K, E204D, Q207D, H208Y, R211K, H221Y, D237DA, V245M, A272P, E291D, I293V, E298EG, E308KA
Dvali (2012)R017R017FJ456897D4T, 3TCNVP Y181CK30Q, K32G, A33C, L34T, V35L, E36N, I37F, T39K, E40DY, D121H, K122E, I135T, K173LS, Q174K, D177DEG, V179I, Q197E, Q207A, R211S, H221Y, V241VI, V245VMA
Fourati (2012)94609749460974JQ395871NRTINNRTI K103N, V108IK11T, V35T, T39K, V106I, K122E, D123N, I142V, E169D, K173S, D177E, I178L, G196K, T200A, I202V, Q207A, R211K, F214L, H221Y, E224D, V241IA
Avidor (2013)196196 ABCEFVA62V, K65R, V75I, F77FL, Y115YF, F116Y, Q151MK101EQ, K103KN, Y181C, G190AT39TA, K49KR, E53ED, S68K, W88WAGS, V106VI, V111VI, V118I, K122E, D123S, I135IT, K173S, Q174R, D177E, V179I, T200A, Q207A, R211RS, F214L, H221Y, F227FY, V245TA
Pircher (2013)B1120B1120JX110221D4T, 3TC, AZTNVPM41L, L74LI, M184V, L210LW, T215Y, K219RK103N, V108I, F227LK20KR, V35T, T39N, V60I, T107S, V118I, K122E, D123S, S162C, K173A, Q174K, T200A, Q207A, R211N, H221Y, K223KE, L228LR, V245QR, E248D, D250EA
 B1139B1139JX110239D4T, 3TC, AZTNVPM41ML, D67DN, M184V, T215YV108I, V179EK11T, E28KR, K32E, V35M, S68SG, T107A, D123N, I135IV, I142V, K173S, Q174K, D177E, I178L, G196K, I202V, Q207E, R211K, H221Y, V241I, V245Q, D250E, Q258KA
Sigaloff (2013)MBA064_0MBA064_0JX182023NRTINNRTID67N, K70R, M184V, K219QK103N, V108IP4S, E6D, V35T, V60I, K64R, A98S, T107S, V111I, I135M, S162H, K173S, Q174R, D177E, T200A, E203K, Q207D, H208Y, R211S, F214L, H221Y, V245E, D250E, K277R, T286A, V292I, I293VA
Van Zyl (2013)15522995KC423922ABC, 3TCEFVL74V, Y115F, M184VL100LI, K103N, V108VIW88S, V90I, K102Q, K122E, I135T, S162N, S163T, T165I, K173T, Q174K, D177E, V179I, T200A, I202V, Q207A, R211K, H221Y, V241VA, V245E, D250EA