<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Reverse Transcriptase Inhibitors

Subtype A
Gene RT
Mutation H221Y
Rx >= 1 NNRTI
(+/- NRTI)
IncludeMixtures No
References 20
Patients 33
Isolates 33
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# NRTIs NNRTIsNRTIDRMs NNRTIDRMs OtherMutSubtype
Non-B Workgroup (2005)UK1436UK1436AY901336DDC, AZT, D4T, 3TCNVPM184VY181VE6D, V21I, V35T, V60I, R83K, K122E, D123S, K173S, Q174K, D177E, I178L, V179I, T200A, Q207E, R211K, H221YA
Weber (2005)F75698F75698AY677500D4T, DDI, ABC, AZT, 3TCNVPY115F, M184V, T215FYY181VK22KN, V35T, K49KR, V60I, R72RK, V90VI, K122E, D123NS, I135T, K173S, Q174K, V179I, Q207E, R211S, H221Y, V245Q, D250E, T286A, E291D, V292I, I293V, E312DG, Q334QHA
 M76115M76115AY677511D4T, DDI, ABC, TDF, AZT, 3TCNVPF116Y, Q151MG190AE6K, V35T, T39A, F87S, K122E, D123S, E169D, Q174K, D177E, V179I, Q207A, R211S, H221Y, V245T, K277R, K281R, L283I, E291D, I293V, P294TA
 F65588F65588AY677546D4T, 3TC, DDI, DDCNVP Y181CK11T, K20R, V21I, V35T, T39G, D123N, K173S, Q174QK, D177G, V179I, T200A, I202V, Q207A, R211S, H221Y, L228R, V245Q, E248N, A272P, T286A, E291D, I293V, P294T, E312NA
 M41984M41984AY677598AZT, 3TC, D4T, DDIEFVM41L, D67N, K70R, V75M, M184V, L210W, T215Y, K219EK103N, V108I, Y181CV35T, V60I, K122E, D123S, I135T, K173S, Q174K, V179I, T200A, E203K, Q207D, R211K, D218E, H221Y, L228H, V245Q, D250E, A272T, E291D, V292I, I293VA
Baxter (2006)48-12041204-30709DQ877748NRTINNRTIM41L, D67N, L74V, M184V, L210W, T215Y, K219NK103S, Y181C, G190AP4S, V35T, T39A, E44D, K64R, K101Q, K122E, D123S, T165I, K173S, Q174K, D177E, I178L, V179I, T200A, I202V, E203D, Q207N, H208Y, R211N, W212C, H221Y, L228H, V245T, D250E, A272P, K281R, I293V, P294T, G335D, M357R, G359S, T369A, A371V, I375V, A376V, T377M, T386S, A400TA
 48-33163316-30818DQ878217NRTINNRTIA62V, K65R, V75I, F77L, F116Y, Q151MK101N, K103H, Y181C, G190AP4K, K11T, V35T, T39E, S68G, V118I, D121Y, K122E, D123S, A158S, R172K, K173S, Q174K, D177E, I195L, G196E, Q207A, R211S, F214L, H221Y, V245Q, T286A, E291D, I293V, E297K, E312D, H315Q, V317A, I326T, Q334D, R356K, M357K, G359S, T362S, K366R, T369V, E370D, A371V, I375V, A376S, K390R, A400TA
 48-40184018-30227DQ878252NRTINNRTID67N, K70R, L74V, Y115F, M184V, K219QK103N, Y181C, G190AK11T, M16V, K20R, V35T, T39N, D121H, K122E, I135T, I142T, T165I, K173A, Q174R, D177E, G196E, T200A, Q207A, F214FL, H221Y, L228LR, V245Q, K277R, T286A, E291D, I293V, G335D, R356K, M357K, G359S, K366R, A371LV, I375V, A376S, V381I, T386I, A400TA
Hawkins (2009)R40ZZR40FJ931279D4T, 3TCNVPM41L, L74V, M184V, L210W, T215YA98G, V108I, Y181CI5V, E28K, K32E, V35T, E36A, T39K, K43E, D86E, V118I, D121H, K122E, I135T, I142V, S162Y, K173T, Q174K, D177E, V179I, T200A, I202V, Q207D, R211K, H221Y, V245Q, T286A, E291D, V292I, I293V, P294T, E312D, I326VA
Wallis (2009)GP00018022GP00018022 D4T, 3TCEFVM184VK103NK11T, K20R, V35T, T39K, V60VI, S68G, T69TI, K122E, D123N, I135V, S162A, K173S, D177E, V179I, T200TA, I202V, Q207A, R211RS, H221Y, V245Q, E248D, A272P, K277R, R284K, T286TA, E291D, V292I, I293V, P294AA
Ndembi (2010)13929D_P113929GQ409560AZT, 3TCNVPM184V, T215YY181CI31L, V35T, V60I, T69TN, D121H, I142V, D177E, Q207A, R211S, H221YA
Charpentier (2011)31CP005026 D4T, 3TCNVPK65R, T69~, K70KN, K219RY181C, G190AK11T, V21I, L34I, V35T, T39E, S68SDGN, K82KR, V90VI, K101KQ, D121H, K122E, K173S, D177E, G196E, E204Q, Q207D, F214L, H221Y, V245Q, D250E, S251DG, L283LI, E291ED, I293V, P294T, L295F, E297K, E312DA
 232CP0011420 D4T, 3TCNVPT69TADN, K70KN, L74I, V75S, M184VK103N, Y181IVK11T, K20KR, V35IT, T39TA, E40D, D121H, K122E, D123S, K173S, D177E, I178L, G196E, Q207A, R211S, F214FL, H221Y, V245Q, D256DE, T286A, A288S, E291D, I293V, L295F, E297K, E312D, D324EA
Fokam (2011)CIRCB-7842CIRCB-7842JQ796155AZT, 3TCNVPM41L, M184V, L210W, T215YK101KE, Y181YC, G190AK20R, E28EK, V35T, T39S, E40ED, E44ED, S48T, K49R, K122E, D123N, K173S, Q174K, V179I, T200A, E203D, Q207N, H208HY, R211K, H221Y, V245M, E291D, I293V, P294T, G335DA
 CIRCB-10615CIRCB-10615JQ796175D4T, 3TCNVPM41L, D67N, M184V, L210W, T215Y V35T, E44D, V60I, K64KR, D121H, K122E, I135T, N137NY, Q145QP, S162DN, S163A, Q174K, D177E, Q182Q*, G196E, T200A, E203K, E204D, Q207D, H208Y, R211K, H221Y, D237DA, V245M, A272P, E291D, I293V, E298EG, E308KA
Dvali (2012)R017R017FJ456897D4T, 3TCNVP Y181CK30Q, K32G, A33C, L34T, V35L, E36N, I37F, T39K, E40DY, D121H, K122E, I135T, K173LS, Q174K, D177DEG, V179I, Q197E, Q207A, R211S, H221Y, V241VI, V245VMA
Fourati (2012)94609749460974JQ395871NRTINNRTI K103N, V108IK11T, V35T, T39K, V106I, K122E, D123N, I142V, E169D, K173S, D177E, I178L, G196K, T200A, I202V, Q207A, R211K, F214L, H221Y, E224D, V241IA
Avidor (2013)196196 ABCEFVA62V, K65R, V75I, F77FL, Y115YF, F116Y, Q151MK101EQ, K103KN, Y181C, G190AT39TA, K49KR, E53ED, S68K, W88WAGS, V106VI, V111VI, V118I, K122E, D123S, I135IT, K173S, Q174R, D177E, V179I, T200A, Q207A, R211RS, F214L, H221Y, F227FY, V245TA
Pircher (2013)B1120B1120JX110221D4T, 3TC, AZTNVPM41L, L74LI, M184V, L210LW, T215Y, K219RK103N, V108I, F227LK20KR, V35T, T39N, V60I, T107S, V118I, K122E, D123S, S162C, K173A, Q174K, T200A, Q207A, R211N, H221Y, K223KE, L228LR, V245QR, E248D, D250EA
 B1139B1139JX110239D4T, 3TC, AZTNVPM41ML, D67DN, M184V, T215YV108I, V179EK11T, E28KR, K32E, V35M, S68SG, T107A, D123N, I135IV, I142V, K173S, Q174K, D177E, I178L, G196K, I202V, Q207E, R211K, H221Y, V241I, V245Q, D250E, Q258KA
Sigaloff (2013)MBA064_0MBA064_0JX182023NRTINNRTID67N, K70R, M184V, K219QK103N, V108IP4S, E6D, V35T, V60I, K64R, A98S, T107S, V111I, I135M, S162H, K173S, Q174R, D177E, T200A, E203K, Q207D, H208Y, R211S, F214L, H221Y, V245E, D250E, K277R, T286A, V292I, I293VA
Van Zyl (2013)O15522995KC423922ABC, 3TCEFVL74V, Y115F, M184VL100LI, K103N, V108VIW88S, V90I, K102Q, K122E, I135T, S162N, S163T, T165I, K173T, Q174K, D177E, V179I, T200A, I202V, Q207A, R211K, H221Y, V241VA, V245E, D250EA
Aghokeng (2014)TG-3-659TG-3-659KC350315NRTINNRTIM184VK103N, Y181CM16MT, V35T, V90I, K122E, D123N, I135T, A158S, S162A, S163T, T165I, K173S, Q174K, V179I, T200A, Q207A, F214L, H221Y, V245Q, A272P, V292I, I293V, P294T, L295M, E312D, V317A, I326V, G335D, R356K, M357K, G359S, T369V, A371V, I375V, A376I, T386A, K390R, A400T, T403M, E404D, W410YA
 TG-4-638TG-4-638KC350297NRTINNRTIM41L, M184VY181CK11T, K20R, V35T, T39N, V90I, K122E, D123S, I135T, S162Y, K173S, D177E, V179I, Q207A, F214L, H221Y, V245Q, K281R, T286A, E291D, V292I, I293V, P294T, E312D, I326V, R356K, M357K, G359S, K366R, T369V, A371V, I375V, A376V, A400T, T403M, W410C, E432DA
Hassan (2014)RS09000809RS09_809KC568490AZT, 3TCNVPM184V, T215YY181CK11T, I31L, V35K, T39E, K49KR, K122E, D123S, I135T, K173S, Q174K, D177E, V179I, Q207A, R211S, F214L, H221Y, V245E, R284K, E291D, V292I, I293V, P294T, E312DA
 RS11000464RS11_464KC568521AZT, 3TCNVPL74V, M184VK103N, Y181CK11E, V35T, V60I, V90VI, D121H, K122E, D123S, I135T, T165I, K173S, Q174K, G196E, T200A, Q207A, R211S, H221Y, T286V, E291D, I293V, P294TA
Wallis (2014)4168741687KM458586NRTINNRTIM184VY181CK20R, V35T, E40D, K49KR, V60I, S68SG, K122E, D123N, I135T, K173L, Q174K, V179I, T200A, Q207A, R211S, F214L, H221YA
Meini (2015)109264109264KM438247D4T, 3TC, DDINVPM184V, T215FK101E, V108I, Y181CK20KR, V21I, V35T, E44ED, K49R, V60I, K122E, D123N, I135K, K173L, Q174K, D177E, I178M, T200A, Q207A, R211S, H221YA
Brooks (2016)2202A2202AKU900891TDF, 3TCNVPK65R, Y115YFY181CE6D, V35T, T39M, V60I, W88C, K122E, D123S, I135T, K173A, Q174K, D177E, V179I, Q207A, R211S, F214L, H221YA
 2187A2187AKU900890TDF, 3TCNVPK65R, M184VV108I, Y181CK20R, V35T, T39M, V60I, K101Q, K122E, I135T, K173S, Q174K, D177E, I178V, V179I, T200E, Q207A, R211K, F214L, H221YA
Ndahimana (2016)12891289KU922889TDF, 3TCNVPA62V, K65R, M184VL100I, Y181C, G190AT39TA, K101R, V111I, K122E, D123S, I135T, I142V, T165I, K173S, D177E, V179I, T200A, Q207A, R211S, H221Y, V245QA
 14411441KU922875TDF, 3TCNVPD67N, K70E, M184VY181YFIN, G190GAT39A, E40D, E44D, K122E, D123S, I142V, S162AT, K173S, D177E, V179I, I195L, T200A, Q207A, R211S, H221YA
 15241524KU922860TDF, 3TCNVPK65R, K70KE, M184VA98AG, K103KN, V108VI, Y181CT39L, I50V, V60I, S68SN, K122E, D123S, I135T, I142V, K173S, Q174K, V179I, G196E, Q207A, R211S, F214L, H221Y, V245QA