<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Reverse Transcriptase Inhibitors

Subtype A
Gene RT
Mutation H221Y
Rx >= 1 NNRTI
(+/- NRTI)
IncludeMixtures No
References 33
Patients 127
Isolates 127
 
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# NRTIs NNRTIsNRTIDRMs NNRTIDRMs OtherMutSubtype
Montes (2004)MB_patKON00_KON723AJ577921AZT, DDI, 3TC, D4T, DDC, ABCNVPM41L, L74V, M184V, T215FY181C, G190AV35T, E36A, T39K, K43E, D121H, K122E, D123S, I142V, S162F, K173S, Q174K, D177E, I178L, V179I, T200A, E203K, Q207D, H208Y, H221Y, K223NA
Non-B Workgroup (2005)UK1436UK1436AY901336DDC, AZT, D4T, 3TCNVPM184VY181VE6D, V21I, V35T, V60I, R83K, K122E, D123S, K173S, Q174K, D177E, I178L, V179I, T200A, Q207E, R211K, H221YA
Weber (2005)F75698F75698AY677500D4T, DDI, ABC, AZT, 3TCNVPY115F, M184V, T215FYY181VK22KN, V35T, K49KR, V60I, R72RK, V90VI, K122E, D123NS, I135T, K173S, Q174K, V179I, Q207E, R211S, H221Y, V245Q, D250E, T286A, E291D, V292I, I293V, E312DG, Q334QHA
 M76115M76115AY677511D4T, DDI, ABC, TDF, AZT, 3TCNVPF116Y, Q151MG190AE6K, V35T, T39A, F87S, K122E, D123S, E169D, Q174K, D177E, V179I, Q207A, R211S, H221Y, V245T, K277R, K281R, L283I, E291D, I293V, P294TA
 F65588F65588AY677546D4T, 3TC, DDI, DDCNVP Y181CK11T, K20R, V21I, V35T, T39G, D123N, K173S, Q174QK, D177G, V179I, T200A, I202V, Q207A, R211S, H221Y, L228R, V245Q, E248N, A272P, T286A, E291D, I293V, P294T, E312NA
 M41984M41984AY677598AZT, 3TC, D4T, DDIEFVM41L, D67N, K70R, V75M, M184V, L210W, T215Y, K219EK103N, V108I, Y181CV35T, V60I, K122E, D123S, I135T, K173S, Q174K, V179I, T200A, E203K, Q207D, R211K, D218E, H221Y, L228H, V245Q, D250E, A272T, E291D, V292I, I293VA
Baxter (2006)48-12041204-30709DQ877748NRTINNRTIM41L, D67N, L74V, M184V, L210W, T215Y, K219NK103S, Y181C, G190AP4S, V35T, T39A, E44D, K64R, K101Q, K122E, D123S, T165I, K173S, Q174K, D177E, I178L, V179I, T200A, I202V, E203D, Q207N, H208Y, R211N, W212C, H221Y, L228H, V245T, D250E, A272P, K281R, I293V, P294T, G335D, M357R, G359S, T369A, A371V, I375V, A376V, T377M, T386S, A400TA
 48-33163316-30818DQ878217NRTINNRTIA62V, K65R, V75I, F77L, F116Y, Q151MK101N, K103H, Y181C, G190AP4K, K11T, V35T, T39E, S68G, V118I, D121Y, K122E, D123S, A158S, R172K, K173S, Q174K, D177E, I195L, G196E, Q207A, R211S, F214L, H221Y, V245Q, T286A, E291D, I293V, E297K, E312D, H315Q, V317A, I326T, Q334D, R356K, M357K, G359S, T362S, K366R, T369V, E370D, A371V, I375V, A376S, K390R, A400TA
 48-40184018-30227DQ878252NRTINNRTID67N, K70R, L74V, Y115F, M184V, K219QK103N, Y181C, G190AK11T, M16V, K20R, V35T, T39N, D121H, K122E, I135T, I142T, T165I, K173A, Q174R, D177E, G196E, T200A, Q207A, F214FL, H221Y, L228LR, V245Q, K277R, T286A, E291D, I293V, G335D, R356K, M357K, G359S, K366R, A371LV, I375V, A376S, V381I, T386I, A400TA
Hawkins (2009)P622ZZP622FJ931131D4T, 3TCNVPM184VY181CK11T, K20R, V35T, R83RK, K122P, D123N, K173I, Q174K, D177E, T200A, Q207N, R211K, F214L, H221Y, L228LR, V245Q, A272P, E291D, V292I, I293V, R307K, D324E, L325IA
 R40ZZR40FJ931279D4T, 3TCNVPM41L, L74V, M184V, L210W, T215YA98G, V108I, Y181CI5V, E28K, K32E, V35T, E36A, T39K, K43E, D86E, V118I, D121H, K122E, I135T, I142V, S162Y, K173T, Q174K, D177E, V179I, T200A, I202V, Q207D, R211K, H221Y, V245Q, T286A, E291D, V292I, I293V, P294T, E312D, I326VA
Wallis (2009)GP00018022GP00018022 D4T, 3TCEFVM184VK103NK11T, K20R, V35T, T39K, V60VI, S68G, T69TI, K122E, D123N, I135V, S162A, K173S, D177E, V179I, T200TA, I202V, Q207A, R211RS, H221Y, V245Q, E248D, A272P, K277R, R284K, T286TA, E291D, V292I, I293V, P294AA
Ndembi (2010)13929D_P113929GQ409560AZT, 3TCNVPM184V, T215YY181CI31L, V35T, V60I, T69TN, D121H, I142V, D177E, Q207A, R211S, H221YA
Puthanakit (2010)CR1513CR1513 D4T, 3TCNVPM184VY181CV35T, T39Q, E42G, G45R, S68G, K122E, D123S, I135T, A158T, K166R, R172K, K173I, Q174K, D177E, I178M, V179I, G196E, T200A, E203D, Q207A, R211S, H221Y, K238R, V245EA
Aghokeng (2011)SK6031-M18SK6031-M18HQ864323D4T, 3TCNVPK65KR, M184MVK103N, Y181CV35KR, T39TA, V60I, K122E, D123NS, I135IT, I142IT, K173A, Q174K, T200A, Q207A, F214L, H221Y, L228LH, V245Q, E248D, D250E, A272P, K275KQ, V276T, K281R, L283I, E291D, V292VI, I293V, R307K, E312NA
Charpentier (2011)31CP005026 D4T, 3TCNVPK65R, T69~, K70KN, K219RY181C, G190AK11T, V21I, L34I, V35T, T39E, S68SDGN, K82KR, V90VI, K101KQ, D121H, K122E, K173S, D177E, G196E, E204Q, Q207D, F214L, H221Y, V245Q, D250E, S251DG, L283LI, E291ED, I293V, P294T, L295F, E297K, E312DA
 232CP0011420 D4T, 3TCNVPT69TADN, K70KN, L74I, V75S, M184VK103N, Y181IVK11T, K20KR, V35IT, T39TA, E40D, D121H, K122E, D123S, K173S, D177E, I178L, G196E, Q207A, R211S, F214FL, H221Y, V245Q, D256DE, T286A, A288S, E291D, I293V, L295F, E297K, E312D, D324EA
Fokam (2011)CIRCB-7842CIRCB-7842JQ796155AZT, 3TCNVPM41L, M184V, L210W, T215YK101KE, Y181YC, G190AK20R, E28EK, V35T, T39S, E40ED, E44ED, S48T, K49R, K122E, D123N, K173S, Q174K, V179I, T200A, E203D, Q207N, H208HY, R211K, H221Y, V245M, E291D, I293V, P294T, G335DA
 CIRCB-10615CIRCB-10615JQ796175D4T, 3TCNVPM41L, D67N, M184V, L210W, T215Y V35T, E44D, V60I, K64KR, D121H, K122E, I135T, N137NY, Q145QP, S162DN, S163A, Q174K, D177E, Q182Q*, G196E, T200A, E203K, E204D, Q207D, H208Y, R211K, H221Y, D237DA, V245M, A272P, E291D, I293V, E298EG, E308KA
Sigaloff (2011)HIV100887HIV100887JN132253AZT, 3TCEFVM184V, T215YA98G, K101E, V108I, Y181C, G190AK11T, K20R, V21I, V35T, T39S, K122Q, D123N, T165I, K173A, Q174K, D177E, V179I, T200A, Q207A, R211S, H221Y, V245Q, E248D, D250E, E291D, V292I, I293V, P294TA
 HIV102940HIV102940JN132322D4T, 3TCNVP Y181CV21I, V35T, T39E, T69N, K122E, D123N, I142T, K173A, D177E, T200A, Q207E, R211S, F214L, H221Y, K238R, P243A, V245Q, A272P, K281R, E291D, I293V, P294T, L310IA
 HIV102999HIV102999JN132335AZT, 3TCNVPD67N, K70R, M184V, T215YY181VI5IV, K11T, K20R, V35T, K49R, K102KN, K122E, D123S, I135T, S162C, K173S, Q174K, D177E, V179I, T200A, Q207A, R211S, F214L, H221Y, V245K, R284K, E291D, I293V, P294T, R307K, E312DA
Dvali (2012)R017R017FJ456897D4T, 3TCNVP Y181CK30Q, K32G, A33C, L34T, V35L, E36N, I37F, T39K, E40DY, D121H, K122E, I135T, K173LS, Q174K, D177DEG, V179I, Q197E, Q207A, R211S, H221Y, V241VI, V245VMA
Fourati (2012)94609749460974JQ395871NRTINNRTI K103N, V108IK11T, V35T, T39K, V106I, K122E, D123N, I142V, E169D, K173S, D177E, I178L, G196K, T200A, I202V, Q207A, R211K, F214L, H221Y, E224D, V241IA
Avidor (2013)196196 ABCEFVA62V, K65R, V75I, F77FL, Y115YF, F116Y, Q151MK101EQ, K103KN, Y181C, G190AT39TA, K49KR, E53ED, S68K, W88WAGS, V106VI, V111VI, V118I, K122E, D123S, I135IT, K173S, Q174R, D177E, V179I, T200A, Q207A, R211RS, F214L, H221Y, F227FY, V245TA
Pircher (2013)B1120B1120JX110221D4T, 3TC, AZTNVPM41L, L74LI, M184V, L210LW, T215Y, K219RK103N, V108I, F227LK20KR, V35T, T39N, V60I, T107S, V118I, K122E, D123S, S162C, K173A, Q174K, T200A, Q207A, R211N, H221Y, K223KE, L228LR, V245QR, E248D, D250EA
 B1139B1139JX110239D4T, 3TC, AZTNVPM41ML, D67DN, M184V, T215YV108I, V179EK11T, E28KR, K32E, V35M, S68SG, T107A, D123N, I135IV, I142V, K173S, Q174K, D177E, I178L, G196K, I202V, Q207E, R211K, H221Y, V241I, V245Q, D250E, Q258KA
Sigaloff (2013)MBA064_0MBA064_0JX182023NRTINNRTID67N, K70R, M184V, K219QK103N, V108IP4S, E6D, V35T, V60I, K64R, A98S, T107S, V111I, I135M, S162H, K173S, Q174R, D177E, T200A, E203K, Q207D, H208Y, R211S, F214L, H221Y, V245E, D250E, K277R, T286A, V292I, I293VA
Thiam (2013)MH-018MH-018JN673574NRTINNRTIK70E, M184VK103N, V108IK11T, V35T, T39R, E40K, K43E, V60I, K102H, D121H, K122E, D123S, I135T, I142V, S162F, K173L, Q174K, D177E, V179L, T200A, Q207A, R211K, F214L, H221Y, V245Q, A272P, T286A, E291D, P294T, E312D, I326V, Q334P, G335DA
Van Zyl (2013)O15522995KC423922ABC, 3TCEFVL74V, Y115F, M184VL100LI, K103N, V108VIW88S, V90I, K102Q, K122E, I135T, S162N, S163T, T165I, K173T, Q174K, D177E, V179I, T200A, I202V, Q207A, R211K, H221Y, V241VA, V245E, D250EA
Acharya (2014)DGP124DGP124KJ185294AZT, 3TCNVPL74V, M184V, K219NK103N, V108I, Y181CV35T, V60I, K122E, D123S, I135T, I142V, S162A, T165I, K173S, Q174K, D177E, V179I, Q197E, T200A, Q207A, R211K, H221Y, V245K, D250E, T286A, E291D, V292I, I293V, P294TA
Aghokeng (2014)CI-1-411CI-1-411KC350383NRTINNRTIV75M, M184VY181CI31L, V35T, E36A, T39K, K43E, V90VI, K122E, D123N, I142V, S162H, K173S, Q174K, D177E, I178ILM, V179I, T200A, Q207A, R211K, H221YA
 TG-3-550TG-3-550KC350272NRTINNRTIM184V, T215TNSYA98AG, V108I, Y181CE6K, K11Q, V35T, E36A, T39K, K43E, K122E, D123N, S162D, K173S, D177E, V179I, I202IV, R211K, H221Y, V245Q, E248N, K281R, T286A, E291D, V292I, I293V, P294T, E312DG, I326V, Q334P, G335D, M357R, G359S, K366R, T369V, A371V, I375V, A376V, T386A, K395R, A400T, W410CA
 TG-3-343TG-3-343KC350270NRTINNRTIM184V, N348NIK101E, V108VI, Y181CK11T, E28K, V35T, E36A, T39K, K43E, V90I, D123E, I135IT, I142V, S162H, K173S, Q174K, D177E, V179I, T200A, Q207A, R211K, H221Y, D237E, V245Q, E248D, K281R, E291D, I293V, E297EK, I326V, G335D, R356K, M357R, G359S, T369V, A371V, I375V, A376V, K390R, A400T, W410C, E432DA
 TG-3-659TG-3-659KC350315NRTINNRTIM184VK103N, Y181CM16MT, V35T, V90I, K122E, D123N, I135T, A158S, S162A, S163T, T165I, K173S, Q174K, V179I, T200A, Q207A, F214L, H221Y, V245Q, A272P, V292I, I293V, P294T, L295M, E312D, V317A, I326V, G335D, R356K, M357K, G359S, T369V, A371V, I375V, A376I, T386A, K390R, A400T, T403M, E404D, W410YA
 TG-4-638TG-4-638KC350297NRTINNRTIM41L, M184VY181CK11T, K20R, V35T, T39N, V90I, K122E, D123S, I135T, S162Y, K173S, D177E, V179I, Q207A, F214L, H221Y, V245Q, K281R, T286A, E291D, V292I, I293V, P294T, E312D, I326V, R356K, M357K, G359S, K366R, T369V, A371V, I375V, A376V, A400T, T403M, W410C, E432DA
 TG-2-273TG-2-273KC350196NRTINNRTIV75A, M184VY181IK11T, V35T, T39K, K43E, K73Q, K122E, D123S, I135T, K173A, Q174K, D177E, I178L, V179I, T200A, Q207A, R211K, F214L, H221Y, V245Q, T286A, E291D, I293V, P294T, E312D, I326V, Q334D, G335D, M357K, G359S, K366R, T369V, A371V, I375V, A376V, T386P, A400T, T403M, W410YA
 SN-1-179SN-1-179KC350360NRTINNRTIM184V, T215FYY181CFGVE6K, K11T, I31L, V35T, E36A, T39K, K43E, V90VI, K102Q, K122E, D123N, I142V, S162Y, K173L, D177E, V179I, T200A, Q207EK, R211K, H221Y, V245KA
Hassan (2014)RS09000809RS09_809KC568490AZT, 3TCNVPM184V, T215YY181CK11T, I31L, V35K, T39E, K49KR, K122E, D123S, I135T, K173S, Q174K, D177E, V179I, Q207A, R211S, F214L, H221Y, V245E, R284K, E291D, V292I, I293V, P294T, E312DA
 RS11000464RS11_464KC568521AZT, 3TCNVPL74V, M184VK103N, Y181CK11E, V35T, V60I, V90VI, D121H, K122E, D123S, I135T, T165I, K173S, Q174K, G196E, T200A, Q207A, R211S, H221Y, T286V, E291D, I293V, P294TA
 RS11000411RS11_411KC568509AZT, 3TCNVPM41L, D67N, K70R, M184V, T215Y, K219QY181IVP4S, E6D, K11S, V21I, K32I, V35T, T39K, V60I, D123N, V148VG, S162SN, T165TK, K173S, Q174K, D177E, V179I, T200A, I202V, Q207A, R211K, H221Y, P243S, V245K, R284RK, T286A, E291D, V292I, I293VA
Wallis (2014)4151441514KM458601NRTINNRTIK65R, K219RK103N, Y181CK20R, E28A, V35T, K43E, V60I, S68G, T69X, V90I, D121H, K122E, S162A, K173T, Q174K, D177E, I178M, T200A, Q207A, R211S, H221Y, L228RA
 4168741687KM458586NRTINNRTIM184VY181CK20R, V35T, E40D, K49KR, V60I, S68SG, K122E, D123N, I135T, K173L, Q174K, V179I, T200A, Q207A, R211S, F214L, H221YA
Jenabian (2015)DR09DR09KF735820NRTINNRTIM41L, L74I, M184V, T215F, K219NK103N, V108I, F227L, M230LV35T, T39D, E44D, K49R, K122E, D123S, S162C, E169D, P170PL, K173T, Q174K, D177E, I178IM, G196E, T200A, Q207A, R211X, H221Y, L228R, V245Q, E248D, D250E, T286A, E291D, I293V, E297EA, E312D, G335DA
Kaleebu (2015)MSK-0017UGA-MSK-0017-2012 TDF, FTCNVPK70E, Y115YF, M184IVV108I, Y181CK20R, V35T, V60I, V90I, K122E, D123S, I135T, S162A, K173Q, Q174K, D177E, I178L, Q207A, R211S, F214L, H221Y, V245Q, E248N, D250E, S268C, A272P, V276T, T286A, E291D, V292I, E297K, E312DA
 MSK-0038UGA-MSK-0038-2012 TDF, FTCNVPK70E, M184VA98G, V108I, Y181C, G190AK11T, K20R, V21I, V35T, T39R, E40K, K43E, V60I, K101X, K122E, D123N, K173S, Q174K, D177E, I178L, V179I, T200A, I202V, Q207A, H221Y, L228R, V245Q, E248D, D250E, T286A, E291D, I293V, K311KR, E312DA
Meini (2015)109264109264KM438247D4T, 3TC, DDINVPM184V, T215FK101E, V108I, Y181CK20KR, V21I, V35T, E44ED, K49R, V60I, K122E, D123N, I135K, K173L, Q174K, D177E, I178M, T200A, Q207A, R211S, H221YA
Boillot (2016)MAG15MAG15KT315963D4T, 3TCNVPM184VY181CE6K, K11T, I31L, K32I, V35T, T39N, T69N, K122E, D123S, K173A, Q174K, D177E, I202V, Q207A, R211K, H221Y, V245Q, D250EA
Brooks (2016)2044A2044AKU900875TDF, 3TCNVPK70E, Y115F, M184VY181CK11S, K32I, V35T, V60I, K122E, D123N, I135R, K173S, D177G, V179I, T200A, I202V, Q207A, L210LS, R211S, H221Y, L228LRA
 2202A2202AKU900891TDF, 3TCNVPK65R, Y115YFY181CE6D, V35T, T39M, V60I, W88C, K122E, D123S, I135T, K173A, Q174K, D177E, V179I, Q207A, R211S, F214L, H221YA
 2187A2187AKU900890TDF, 3TCNVPK65R, M184VV108I, Y181CK20R, V35T, T39M, V60I, K101Q, K122E, I135T, K173S, Q174K, D177E, I178V, V179I, T200E, Q207A, R211K, F214L, H221YA
Ndahimana Jd Riedel (2016)21402140KT982515NRTINNRTIM41L, D67N, M184V, T215YY181CT39TA, E44D, S48T, K49R, S117A, K122E, D123N, Q145C, K173A, Q174K, D177E, V179I, T200A, I202V, Q207A, H221Y, V245QA
Ndahimana (2016)12891289KU922889TDF, 3TCNVPA62V, K65R, M184VL100I, Y181C, G190AT39TA, K101R, V111I, K122E, D123S, I135T, I142V, T165I, K173S, D177E, V179I, T200A, Q207A, R211S, H221Y, V245QA
 12751275KU922850TDF, 3TCNVPK70KE, L74LI, M184VY181CT39K, K49A, V60I, F77S, K122E, D123N, I135T, I142K, K173S, Q174K, V179I, T200A, Q207A, R211S, H221Y, V245TA
 14411441KU922875TDF, 3TCNVPD67N, K70E, M184VY181YFIN, G190GAT39A, E40D, E44D, K122E, D123S, I142V, S162AT, K173S, D177E, V179I, I195L, T200A, Q207A, R211S, H221YA
 937937KU922898TDF, 3TCNVPK70E, M184VY181CT39S, E40Q, K43N, V60I, V90VI, K122E, D123NS, T139R, K166R, K173S, Q174N, D177E, I178M, V179I, T200A, I202V, Q207A, R211K, H221Y, V245EA
 15241524KU922860TDF, 3TCNVPK65R, K70KE, M184VA98AG, K103KN, V108VI, Y181CT39L, I50V, V60I, S68SN, K122E, D123S, I135T, I142V, K173S, Q174K, V179I, G196E, Q207A, R211S, F214L, H221Y, V245QA
Kekitiinwa (2017)65562_72265562_722KY237897NRTINNRTIL74V, Y115F, M184VY181CV60I, K66KR, T69TN, K82R, K122KE, D123KN, K173A, D177E, V179I, T200TA, I202V, Q207A, R211N, H221YA
 65806_79465806_794KY237947NRTINNRTIM41ML, L74V, Y115FY181CV60I, K122E, D123S, I135T, T139TI, K166KR, E169ED, K173AV, Q174KR, D177EG, V179I, G196GE, T200A, I202V, Q207D, H221YA
 79399_105679399_1056KY238007NRTINNRTIL74V, Y115F, M184VY181IK122E, D123N, I135IT, K173S, D177G, V179I, T200A, I202V, Q207A, R211K, H221YA
 65773_80065773_800KY237923NRTINNRTIL74V, M184V, K219KNA98G, Y181CK173A, Q174K, D177E, V179I, I202V, Q207A, R211K, H221YA
 79260_112579260_1125KY237951NRTINNRTIM184VY181CV60I, K122E, D123S, I135T, T139R, S162A, K173S, Q174K, D177E, I178L, V179I, T200A, Q207A, R211S, H221YA
 42201_47942201_479KY237858NRTINNRTIL74V, Y115F, M184VY181IV60I, K122E, D123S, I135T, I142IT, S162A, K173L, Q174K, N175Y, V179I, T200A, I202V, Q207E, F214L, H221YA
 79397_112379397_1123KY238005NRTINNRTIL74V, Y115F, M184VL100I, K103NV60I, K66R, V118I, K122E, D123N, I135T, K173S, Q174K, D177E, I178IM, V179T, Q207A, R211S, H221YA
 42203_112942203_1129KY237860NRTINNRTIM41ML, L74V, Y115F, M184VY181CK46Q, S48ST, K49KR, V60I, V118VI, K122E, D123S, I135T, I142IT, S162Y, K173IL, Q174K, V179I, T200TA, Q207E, R211S, F214L, H221Y, L228VA
 42206_120042206_1200KY237863NRTINNRTIL74V, Y115F, M184VK103KN, V108I, Y181C, G190A, F227FLT69S, K101KR, V118I, K122T, I135T, I142L, T165TI, K173S, Q174K, D177E, I178IV, T200A, Q207A, R211S, F214L, K219T, H221YA
 65807_66565807_665KY237948NRTINNRTIL74V, Y115F, M184V, L210LWV108I, Y181CV60I, K65KE, K101KR, K122E, D123S, K173S, D177E, I178L, E204K, Q207A, R211S, H221YA
 65527_87365527_873KY237887NRTINNRTIL74V, Y115F, M184VK103N, M230LI50V, V60I, K122E, D123N, K166KR, E169D, K173S, Q174R, D177E, I178IM, V179I, G196E, T200A, Q207A, R211K, H221Y, P225RA
 65800_83265800_832KY237943NRTINNRTIL74V, Y115F, M184VY181CK46KM, V60VI, K101KR, I142V, D177DE, I178IM, G196E, T200A, Q207A, R211K, H221YA
 42210_60742210_607KY237864NRTINNRTIL74V, Y115F, M184VY181CV60I, K122E, D123N, I135T, I142V, K173S, Q174K, D177E, V179I, I202V, Q207E, H221Y, L228RA
 65791_107465791_1074KY237936NRTINNRTID67N, K70R, M184V, T215TI, K219Q S48E, V60I, D123NS, T165I, E169EK, K173S, Q174K, D177E, V179I, T200A, I202V, Q207A, F214L, H221YA
Kityo (2017)8351783517KY062071NRTINNRTIM41L, D67N, V75M, M184V, L210W, T215Y, K219KNV108I, Y181CE44D, V60I, T107S, V118I, K122E, D123S, I135T, I142V, K173S, Q174K, D177E, V179I, T200A, Q207A, R211NS, D218E, H221YA
 8351283512KY062066NRTINNRTIM41L, D67N, K70R, V75M, M184V, L210W, T215YK101E, V106A, F227LK43E, V60I, A98S, L109I, V111I, V118I, K122E, D123N, E138A, K173S, V179VI, V189VM, T200A, I202V, Q207A, H208Y, R211K, H221YA
 8350083500KY062054NRTINNRTIK65R, K70T, M184VY181CV60I, S68G, I135T, K173S, D177E, V179I, T200V, I202V, Q207A, R211K, H221Y, P225PLA
 6608666086KY061438NRTINNRTID67DN, K70KR, M184V, T215FYA98AG, Y181CFGVV60VI, K122E, D123NS, I135T, I142IV, K173AS, Q174QK, V179I, I202V, Q207A, R211K, H221Y, D237VA
 8330183301KY061856NRTINNRTIM41L, M184V, L210W, T215YY181CK49R, V60I, V111I, K122E, I135T, T139R, K173S, Q174K, D177E, V179I, E203EDKN, Q207E, R211K, H221YA
 8355683556KY062110NRTINNRTIM41L, D67N, K70R, V75M, M184V, T215F, K219QV106A, F227LV60I, I94L, K101Q, L109I, K122E, D123S, I135T, K173S, Q174K, V179I, G196GE, T200A, I202V, Q207A, R211K, H221YA
 8325283252KY061807NRTINNRTIK65R, K70KEGR, M184VK101KE, V108I, Y181C, F227FLK122E, D123N, I135T, K173S, D177E, V179I, V189VI, I202V, Q207A, R211K, H221Y, L228LRA
 8329383293KY061848NRTINNRTIM41L, D67N, M184V, L210W, T215YY181IK43E, K49KR, V118VI, D121H, K122E, D123DG, S162N, K173S, Q174E, D177E, V179I, G196GE, T200TA, I202V, Q207A, R211RK, H221YA
 8345883458KY062012NRTINNRTIM41ML, M184V, T215TFISA98G, Y181CK43E, K49R, I135T, I142V, K173S, D177E, V179I, T200K, I202V, Q207A, F214L, H221YA
 6606266062KY061425NRTINNRTIK65R, K70T, M184VY181C, K238KTV60I, S68G, Y115YHPS, I135T, K173S, D177E, V179I, T200V, I202V, Q207A, R211K, H221YA
 8345783457KY062011NRTINNRTIM184VY181CK49R, P52PL, Y56YF, V60VI, T69TS, K104KE, P119PL, K122E, D123N, I135R, K173S, D177E, V179I, T200A, I202V, Q207A, R211S, F214L, H221Y, M230MR, Y232YDA
 8306383063KY061622NRTINNRTIM41L, M184V, L210W, T215Y, K219NY181CE44D, N57NHKQ, D121H, K122E, D123S, I135T, I142V, K173S, Q174K, I178L, V179I, E203K, Q207D, H208HY, R211K, H221YA
 8315283152KY061708NRTINNRTIK70Q, M184VK103N, V108I, L234IV60I, R78RI, K102H, D121Y, K122E, D123G, T128I, I135T, K166KR, K173A, D177E, V179I, V189VI, T200A, I202V, Q207A, R211K, H221YA
 8300083000KY061562NRTINNRTIM41L, M184V, T215YY181CV60I, D121H, K122E, D123S, I135T, E169A, K173A, Q174K, N175NY, I178M, V179I, Q197E, T200A, Q207A, R211NS, H221YA
 8307983079KY061637NRTINNRTIA62V, K65R, M184V, K219EY181C, G190SE44D, S68K, K102N, V111I, K122E, D123N, K166R, K173S, D177E, V179IT, T200A, I202V, Q207A, R211S, H221YA
 8294682946KY061510NRTINNRTIM41L, A62V, D67N, M184V, T215YV179D, G190AE44D, K102KR, K103R, V111I, K122E, D123N, D177N, I178M, T200A, E203D, Q207ADNT, H208Y, R211KN, H221YA
 8297882978KY061541NRTINNRTIK70E, M184VA98G, Y181CV60I, D123S, I135T, K173A, Q174K, D177E, V179I, T200A, Q207D, R211RKNS, F214L, H221Y, L228RA
 8341383413KY061967NRTINNRTIM41L, D67N, K70R, V75M, M184V, T215F, K219QY181VV60I, K122E, D123S, I135T, K173S, Q174K, D177E, V179I, T200A, I202V, Q207A, R211KN, F214L, H221YA
 8356083560KY062114NRTINNRTIK70R, M184V, K219KQV108VI, Y181CK49R, V60I, T69TS, K122E, D123S, I135T, K173S, Q174K, D177E, V179I, T200A, Q207A, R211S, F214L, H221YA
 8329683296KY061851NRTINNRTIM184V, L210LW, T215FV108I, Y181CG93GR, K122E, D123S, I135T, K173S, Q174K, D177E, V179I, T200A, I202V, Q207A, R211NS, F214L, H221YA
 6608366083KY061436NRTINNRTIM41L, V75M, M184V, L210W, T215YA98G, K103N, V108IV60I, T69TA, I94L, K122E, I135T, K173S, D177E, V179I, V189I, T200A, I202V, E203K, Q207D, R211K, K219KT, H221YA
 8327783277KY061832NRTINNRTID67G, K70R, M184V, K219QY181CK43E, V60I, S68G, V106I, K122E, D123S, I135T, T139TR, I142V, K173S, Q174K, D177E, V179I, T200TA, Q207A, R211S, F214L, H221YA
 8294082940KY061504NRTINNRTID67G, K70R, M184V, K219QK103N, K238TS48T, V60I, S68G, K122E, I135T, K173S, Q174K, D177E, V179I, T200A, I202V, Q207A, R211S, H221YA
 8327983279KY061834NRTINNRTIM41L, M184V, L210W, T215YK103NE44D, V60I, S68SG, A98S, K122E, D123N, I135T, K173L, D177E, G196E, I202V, Q207A, H221YA
 8354783547KY062101NRTINNRTIK70Q, M184IY188L, P225H, P236PLW88WS, V90I, L109LI, K122E, D123S, K173S, Q174K, D177E, I178M, V179I, T200A, I202IV, Q207A, R211RS, H221YA
 8340183401KY061955NRTINNRTIM41L, D67N, T69DN, K70KR, V75I, M184V, L210W, T215YV108I, Y181CFISE44ED, K49KR, K122E, D123N, T165I, K173S, D177E, V179VI, G196GE, T200A, I202V, E203KQ, Q207D, R211K, H221YA
 8293282932KY061496NRTINNRTIK65R, Y115F, M184VY181CK43E, D121H, K122E, K173S, P176PS, D177E, V179I, G196GE, T200A, I202V, Q207A, H221YA
 8325883258KY061813NRTINNRTIM41L, D67DN, V75I, M184V, L210W, T215YY181CE44D, K122E, D123N, I132L, I135T, K173S, Q174K, D177E, I178IL, V179I, G196GE, T200A, I202V, Q207A, R211S, D218E, H221YA
 8304883048KY061607NRTINNRTIM41L, D67N, K70R, M184V, T215Y, K219EQK103N, Y181CV60I, K122E, I135T, K173L, Q174K, D177E, V179I, T200A, I202IV, Q207A, R211S, H221Y, L228HRA
 8307283072KY061630NRTINNRTIK65R, M184VV106M, Y181C, G190A, P236PLS68SN, D121H, K122E, D123S, K173A, Q174K, D177E, I178L, V179I, Q207D, R211K, H221YA
 8291282912KY061476NRTINNRTIM41ML, D67N, K70R, M184V, T215F, K219QK101E, Y181C, G190AK49R, V60I, T69TN, I94L, K122E, D123N, I135T, K173S, Q174K, D177E, V179I, T200A, Q207A, R211S, F214L, H221YA
 6604066040KY061409NRTINNRTIK70E, M184VV108I, Y181CV60I, K102Q, K122E, I135T, K173L, Q174K, D177E, I178L, V179I, T200A, Q207A, R211K, H221YA
 8293482934KY061498NRTINNRTID67N, K70R, M184V, T215F, K219QV108I, Y181CK49R, K64R, K101KR, K122E, D123N, I135T, S162D, E169K, K173A, Q174K, V179I, T200A, Q207A, R211S, F214L, H221YA
 8344183441KY061995NRTINNRTIK65R, D67N, K70Q, L74LI, V75I, F116FY, M184V, K219QY181CT58A, S68N, V111I, V118VI, K122E, D123N, M164L, K173V, Q174K, D177E, V179I, T200A, I202V, Q207A, R211S, H221YA
 8294982949KY061513NRTINNRTIM41L, M184V, L210LW, T215FV108I, Y181CK43E, I50V, K122E, D123N, I135T, K173A, Q174K, D177E, V179I, I202V, Q207A, R211K, H221YA
 8344583445KY061999NRTINNRTIA62V, V75I, F77L, Y115F, F116Y, Q151M, M184V, T215Y, K219KQK101E, Y181V, G190AK43E, S68G, V111VI, K122E, D123S, I167V, K173S, Q174QR, D177E, V179T, I202V, Q207A, R211RKNS, H221YA
 8339583395KY061949NRTINNRTIM41ML, D67N, K70R, V75VM, M184V, T215TFIS, K219EY181CK49R, V60I, I135T, K173AS, D177E, V179I, G196GDE, I202V, Q207A, H221YA
 8348083480KY062034NRTINNRTID67N, K70R, L74LI, M184V, T215F, K219QY181CG45GR, L92M, K122E, D123S, I135T, S162A, T165L, K173S, D177E, V179I, T200A, I202V, Q207A, R211RS, H221YA
 8343683436KY061990NRTINNRTID67T, K70R, M184V, T215F, K219EA98AG, Y181CK64R, T69N, V118I, K122E, D123S, I135T, M164MI, K166Q, K173S, Q174K, N175NY, D177E, I178L, V179VI, T200A, I202IV, Q207A, R211S, F214L, H221YA
 6606466064KY061426NRTINNRTIM41L, D67G, T69D, L74I, M184V, L210W, T215YV108I, Y181CE44ED, K49R, V60I, A98S, V118I, K122E, D123NS, I135T, S162D, K173S, Q174K, D177E, I178IM, V179I, T200E, I202V, E203EK, Q207A, R211N, H221YA
 8316183161KY061717NRTINNRTIK65R, T69~, K219RY181VV60I, I63L, S68G, K122E, D123N, I135T, P140PT, K173S, Q174K, D177E, V179I, Q207A, R211S, F214FL, H221Y, L228LRA
 8290382903KY061468NRTINNRTIM41L, D67N, V75M, M184V, L210W, T215YK101DN, V108I, Y181C, G190A, K238TE44D, K49R, V60I, K166R, D177E, V179IT, E203KQ, Q207D, R211K, H221YA
 8315083150KY061706NRTINNRTIM41L, D67DN, M184V, L210L*W, T215FY181CK122E, D123N, I135AMTV, K173A, Q174K, V179I, Q207A, R211N, H221YA
 2845128451KY061383NRTINNRTID67DN, K70KR, V75VIM, M184V, L210LW, T215YV108I, Y181CK20R, V21I, V35T, E40D, K43R, K46R, S48P, K49G, V60I, K64R, F77S, I94IL, K101KQ, K122E, D123S, I135T, K173S, Q174K, D177E, V179I, T200A, Q207E, R211RK, F214FL, H221Y, V245E, D250E, S251H, T286A, E291D, V292I, I293VA
 8290682906KY061471NRTINNRTIM41L, V75I, M184V, L210LW, T215FYV108I, Y181CV60I, K101R, L109I, K122E, D123N, I132L, K173S, D177EG, V179I, T200A, I202V, Q207A, R211K, H221YA
 6608766087KY061439NRTINNRTIM41L, M184V, L210LW, T215YA98G, Y181CE44ED, S48ST, K49R, V60I, K122E, D123S, I135T, K166R, K173I, Q174K, D177E, V179I, T200A, I202V, Q207D, R211K, H221YA
 8302283022KY061582NRTINNRTIM41L, V75M, F77L, M184V, L210W, T215YA98G, Y181CE44D, K49R, K122E, D123S, I135T, K173A, Q174K, D177E, I178L, V179I, T200A, E203K, Q207D, R211S, H221Y, L228HA
 6606866068KY061429NRTINNRTID67N, K70R, V75I, M184V, T215Y, K219QG190A, F227FLV60I, K122E, D123S, I132L, I142V, K173S, Q174R, D177E, V179I, I202V, Q207S, R211S, H221YA
 6584065840KY061393NRTINNRTIL74V, M184V, K219QK103N, V108IV60I, S68SG, K102KEGR, K122E, D123N, I135IT, A158S, R172RK, K173S, Q174K, D177E, T200A, I202V, Q207A, R211S, F214L, H221Y, L228IVA
 8358883588KY062142NRTINNRTIM41L, D67N, K70R, V75M, M184V, L210W, T215F, K219EY181CV60I, D121DH, K122E, I135T, I142L, I167V, K173S, Q174K, G196D, T200A, I202V, Q207A, R211N, H221Y, L228HA
 8324883248KY061803NRTINNRTIM184VV108I, Y181CK49R, K122E, D123S, I135V, K173S, D177G, V179I, T200A, I202V, Q207A, R211S, H221YA
Rhee (2017)AP09-075KAN303816 TDF, 3TCEFVK65R, K70T, M184VV108I, Y181CV35T, T39K, V60I, S68G, T107S, K122E, D123N, I135T, I142V, K173T, Q174K, G196E, Q207N, R211K, F214L, H221Y, V245QA
 KE03760KE03760KY364292TDF, 3TCNVPK65R, M184VY181VK20R, V35T, A62P, S68SG, K122E, D123S, I135T, I142V, K173S, Q174K, V179I, T200A, I202IV, Q207A, R211S, H221Y, V245Q, E248DA
 KE07483KE07483KY364304TDF, 3TCEFVD67G, K70E, M184VG190EV35T, K122E, E138A, K173S, Q174K, D177E, I178L, V179S, T200A, I202V, Q207D, R211K, H221Y, L228K, V245E, D250EA
 KE14492KE14492KY364313TDF, 3TCNVPK65R, Y115F, M184VY181CK20R, V35T, T39K, K43E, V60I, A98S, K102Q, D121Y, K122E, K166R, F171Y, K173L, Q174K, V179I, T200A, Q207A, R211S, H221Y, V245Q, D250EA
 1129011290KY358991TDF, 3TCNVP Y181CV35T, T39E, N81NT, K82KR, D86DA, A98AP, K122E, D123S, I135R, K173R, Q174K, G196GV, Q207A, R211S, H221Y, V245KA