Reverse Transcriptase Inhibitors

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Reverse Transcriptase Inhibitors

Subtype	A
Gene	RT
Mutation	G190S
Rx	>= 1 NNRTI (+/- NRTI)
IncludeMixtures	No

References	11
Patients	57
Isolates	58

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr)	Patient	Isolate	Acc#	NRTIs	NNRTIs	NRTIDRMs	NNRTIDRMs	OtherMut	Subtype
Non-B Workgroup (2005)	TK1007	TK1007		AZT, 3TC	EFV	D67N, T215F	K101E, G190S	E28G, V35T, T39E, E44D, V118I, K122E, D123N, I135T, I142V, K173L, V179I, T200A, Q207A, R211S, F214L, V245Q, K281R, E291D, I293V, E297K, E312D, S322A, D324E	A
		TK1007a		AZT, 3TC	EFV	D67G, K70R, T215F, K219Q	K101E, G190S	E28G, V35T, T39E, E44D, V118I, K122E, D123N, I135T, I142V, K154KN, F160FS, K173L, V179I, T200A, Q207A, R211S, F214L, V245Q, K281R, E291D, I293V, E297K, E312D, S322A, D324E	A
Rosen-Zvi (2008)	89	08p89-2		TDF, FTC	NVP	M184I	K101KE, G190S	V35I, E36D, T39K, K122E, D123S, K173A, Q174K, D177E, V179I, T200I, Q207A, R211S, V245M, E248D, A272P, T286A, E291D, V292I, I293V, I326V	A
Koyalta (2009)	67	TCHAD-67	FJ688198	D4T, 3TC	NVP	D67N, M184V, T215F	K101E, G190S	K43E, D121H, K122E, D123S, I135T, K173A, Q174K, D177E, V179I, T200A, Q207A, R211S, K238R	A
Steegen (2009)	BV223	BV223-2	EU872150	3TC, D4T, ABC	EFV	M184V	G190S	V35T, K101Q, K122E, D123S, K173S, V179I, Q197H, T200A, Q207A, R211S	A
Hamkar (2010)	14	Ir-HIV-DR-14	GU724817	NRTI	NNRTI	M184V, T215Y	G190S	E6D, V8I, K11R, V35T, K49R, V60I, D121Y, K122E, S134R, I135T, K166R, Q174H, D177E, V179I, Q207A, R211K, V245E, D250E, A272P, L283I, R284K, A288S, E291D, V292I, I293V, G335D	A
	15	Ir-HIV-DR-15	GU724818	NRTI	NNRTI	M184V, T215Y	G190S	E6D, V8I, K11R, V35T, K49R, V60I, A98X, K101S, K103E, V106X, D121Y, K122E, I135K, K166R, Q174H, D177E, V179I, Q207A, R211K, V245E, D250E, A272P, L283I, R284K, A288S, E291D, V292I, I293V, G335D	A
	19	Ir-HIV-DR-19	GU724822	NRTI	NNRTI	M184V, T215Y	G190S	E6S, K11R, V35K, V60I, A98X, K101S, K103E, V106X, D121Y, K122E, I135K, K166R, Q174H, D177E, V179I, Q207A, R211K, V245E, D250E, A272P, L283I, R284K, A288S, E291D, V292I, I293V, G335D	A
	21	Ir-HIV-DR-21	GU724824	NRTI	NNRTI	M184V, T215Y	G190S	E6S, K11R, V35K, V60I, D121Y, K122E, I135T, K166R, Q174H, D177E, V179I, Q207A, R211K, V245E, D250E, A272P, L283I, R284K, A288S, E291D, V292I, I293V, G335D	A
Moussa (2010)	4	23-CP001745	HM117953	D4T, 3TC	EFV	M184V, L210W	K101E, Y181C, G190S	V35T, T39L, T107S, K122E, D123S, K173A, D177G, T200A, Q207E, R211K	A
Dvali (2012)	R037	R037	FJ456898	D4T, 3TC	EFV	K65R	A98AG, G190S	K30Q, K32G, A33C, L34T, V35L, E36N, I37F, T39N, V60I, K122E, D123N, K173L, Q174K, Q207A, R211S	A
	R008	R008	FJ456895	AZT, 3TC	EFV	M184V	K101E, G190S	V35L, E36N, I37F, T39IKM, D121H, K122E, D123S, K173LS, Q174KR, D177E, V179VI, Q207A, R211S	A
	R116	R116	FJ456905	AZT, 3TC	NVP	D67DN, M184V	G190S	V35L, E36N, I37F, T39M, V60I, K122E, D123S, I135T, K173L, Q174K, D177E, T200A, Q207AP, R211S, F214L, D237E	A
	R149	R149	FJ456914	D4T, 3TC	NVP	A62V, K65R, M184I	K101E, Y181YC, G190S	K30Q, K32G, A33C, L34T, V35L, E36N, I37F, T39K, V90I, K122E, D123N, A158S, K173L, Q174K, T200A, Q207A, R211S, V245M	A
	R117	R117	FJ456906	AZT, 3TC	NVP	A62V, M184V	K101E, G190S	K30Q, K32G, A33C, L34T, V35L, E36N, I37F, T39S, W88C, K122E, D123N, I135T, E138A, K173S, Q174K, Q207A, R211S, F214L	A
	R053	R053	FJ456900	AZT, 3TC	EFV	M184V, T215HPSY, K219KQ	G190S, M230ML	K30Q, K32G, A33C, L34T, V35L, E36N, I37F, T39R, Q91Q*, V106VI, K122E, D123N, I135T, S162C, K173L, Q174K, D177E, V179I, I202IV, Q207A, R211S, L228LR, V245M	A
	R144	R144	FJ456910	AZT, 3TC	EFV	A62V, M184V	A98AG, V179DE, G190S	K30Q, K32G, A33C, L34T, V35L, E36N, I37F, T39K, V90I, K122E, D123N, I135T, E138A, K173L, Q174K, Q207A, R211S, V245K	A
	R142	R142	FJ456909	AZT, 3TC	EFV	M41L, D67N, K70R, L74LI, V75VL, M184V, L210LW, T215Y, K219E	G190S	V35L, E36N, I37F, T39R, K43E, K49R, K122E, D123S, K173S, Q174K, D177E, V179I, Q197EK, T200TA, I202IV, Q207A, V245M	A
	R012	R012	FJ456896	AZT, 3TC	EFV	M184V	K101DEHQ, G190S	V35L, E36N, I37F, T39M, D121DH, K122KE, D123NS, K173S, Q174K, D177E, Q207A, R211S, F214L	A
Aghokeng (2013)	HJ3264	HJ3264	JX983030	NRTI	NNRTI	A62AV, L74LV, M184V	A98AG, G190S	I2IV, K11T, V35T, T39Q, D121H, K122E, I135T, K173S, Q174K, D177E, V179IT, T200A, Q207A, R211S, F214FL, H221HY, Q222QR, V245Q, E248DN, A272P, K277KR, T286A, E291D, I293V, E312D, G335D, M357K, R358RG, G359S, K366R, A371V, I375V, A376S, T377V, T386I, A400T, T403TM, E413D	A
Avidor (2013)	1966_MT	1966_MT	KC184299	TDF, 3TC	EFV	K65KR, M184V	K101E, Y181C, G190S	K30Q, K32G, A33C, L34T, V35L, E36N, I37F, T39V, V106I, D121H, K122E, D123S, I135T, K173S, Q174K, D177E, T200A, Q207A, R211S, L228LR, V245M	A
	2017_MT	2017_MT	KC184342	D4T, DDI	EFV		G190S	V35L, E36N, I37F, T39M, K122E, D123S, K173L, Q174K, T200I, E203EK, Q207A, R211S, V245M	A
	1991_MT	1991_MT	KC184320	3TC, DDI	EFV		G190S	V35L, E36N, I37F, T39M, K122E, D123S, K173L, Q174K, T200I, E203EK, Q207A, R211S, V245M	A
	1778	1778		TDF, FTC	EFV	L74LI, M184V	G190S	T39Q, S68G, T69N, K122E, D123N, I135T, K173L, Q174K, V179I, Q207A, R211S, V245M	A
	631	631		AZT, 3TC	EFV	M184V	G190S	T39N, D121H, K122E, A158S, K173S, Q174K, D177E, Q207A, R211S, L228F, V245IT	A
	1785	1785		TDF, 3TC	EFV	K65R, T69~, M184MV	K101E, Y181C, G190S	T39E, K122E, D123S, I142T, A158S, K173S, Q174K, Q207A, R211S, L228LR, V245M	A
Theys (2013)	19956	19956	KC219996	NRTI, TDF	NNRTI	D67N, K70R, T215I, K219E	G190S	V60I, K122E, D123S, I135T, E138A, K173S, Q174K, V179I, T200A, Q207E, R211K, F214L	A
Kolomeets (2014)	279	279_551	KJ870602	AZT, 3TC	EFV	A62V, M184V	K101E, E138K, G190S	K11T, V35I, E36D, T39K, K122E, D123N, A158S, S162C, K173S, Q174R, D177E, I178L, T200A, Q207A, R211S, V245Q, E248D	A
	85	85_121	KJ870274	AZT, 3TC	EFV	A62V, M184V	K101E, G190S	K11T, V35I, E36D, T39K, K64R, K122E, D123N, E138A, K173L, Q174K, V189VI, I202IV, Q207A, R211S, E248D	A
	250	250_316	KJ870429	AZT, 3TC	NVP	A62V, M184V	K101KE, G190S	K11T, V35I, T39K, K122E, D123N, A158S, T165TI, K173A, Q174K, G196K, T200A, I202V, Q207A, R211S, E248D	A
	69	69_356	KJ870463	AZT, 3TC	EFV	A62V, M184V	G190S	E6EK, K11T, E28EG, V35I, T39K, K122E, D123N, I135T, K173A, Q174K, D177E, V179I, Q207A, R211S, V245M, E248D	A
	27	27_199	KJ870338	AZT, 3TC	EFV	A62V, M184V	G190S	K11T, V35I, E36D, T39K, K43E, K49R, K122E, D123N, A158S, K166R, K173I, Q174K, D177E, T200A, Q207A, R211S, V245M, E248D	A
	65	65_157	KJ870301	AZT, 3TC	NVP	A62V, M184V	K101E, G190S	K11T, V35T, E36A, T39E, V90I, V106VI, K122E, D123N, A158S, K173L, Q174K, T200A, Q207A, R211S, E248D	A
	39	39_642	KJ870667	3TC, DDI	EFV	A62V, K65R, M184I	K101E, Y181C, G190S, P225H	K11T, V35I, E36D, T39K, K122E, D123N, A158S, K173LS, Q174R, D177E, G196E, T200A, Q207A, R211S, E248D	A
	422	422_576	KJ870618	D4T, 3TC	EFV	A62V, M184V	G190S	K11T, V35T, E36D, T39K, K101Q, K122E, D123S, I135T, T165I, K173A, Q174K, Q207A, R211S, E248D	A
	116	116_143	KJ870291	AZT, 3TC	EFV	A62V, M184V	G190S	K11T, V35IT, E36D, T39K, K49KR, K101KQ, V106VI, K122E, D123N, K173I, Q174K, Q207A, R211S, E248D	A
	114	114_141	KJ870290	AZT, 3TC	EFV	A62V, M184V	G190S	K11T, V35I, E36D, T39K, K49KR, K101KQ, K122E, D123N, A158S, K166R, K173L, Q174K, T200A, E204ED, Q207A, R211S, V245M, E248D	A
	345	345_524	KJ870583	ABC, 3TC	EFV	A62V, L74V, M184V	K101E, G190S	K11T, V35T, T39E, K122E, D123N, E138A, S162SN, K173L, Q174K, Q207A, R211K, E248D	A
	179	179_322	KJ870435	AZT, 3TC	EFV	A62V, M184V, T215TS	K101E, G190S	K11T, V35I, E36D, K122E, D123N, E138A, K173L, Q174K, Q207A, R211S, E248D	A
	495	495_155	KJ870300	AZT, 3TC	EFV	M41L, A62V, M184V, L210LW, T215F	K101E, G190S	K11T, V35T, E36D, T39K, K49R, V90VI, K122E, D123S, S162C, K173T, Q174K, D177E, Q207A, R211S, E248D	A
	160	160_189	KJ870330	3TC, DDI	EFV	A62V, K65R, V75I	Y181C, G190S, P225H	K11T, V35I, E36D, T39N, K103R, K122E, D123N, A158S, Q174K, D177E, T200A, Q207A, R211S, V245M, E248D	A
	414	414_633	KJ870659	AZT, 3TC	EFV	D67DN, K70KR, M184V, T215TNSY, K219KQ	K101E, G190S	E6K, K11T, V35T, E36D, T39N, V106I, K122E, D123S, S162C, K173L, Q174K, D177E, G196E, Q197QKR, T200A, Q207A, R211S, V245M, E248D	A
	424	424_578	KJ870620	ABC, 3TC	EFV	A62V, L74IV, Y115F, M184V	K101H, V179D, G190S	K11T, V35I, E36D, T39HN, V90VI, K122E, D123N, K173L, Q174K, D177E, I178L, Q207A, R211S, E248D	A
	326	326_462	KJ870541	AZT, 3TC	EFV	A62V, M184V	K101E, G190S	K11T, V35I, E36D, T39K, R72RK, V106I, K122E, D123N, A158S, K173A, Q174K, D177E, Q207A, R211S, V245M, E248D	A
	141	141_309	KJ870423	AZT, 3TC	EFV	A62V, M184V, T215TFIS	K101H, G190S	K11T, V35T, V118VI, K122E, D123N, A158S, K166R, K173I, Q174K, D177DE, T200TA, Q207A, R211S, V245M, E248D	A
	103	103_287	KJ870405	D4T, 3TC	EFV	M41ML, D67N, K70KR, M184V, L210LW, K219KQ	K101DEHQ, G190S	K11T, V35T, E36D, T39N, E42X, V118VI, K122E, D123N, K173L, V179VI, Q207A, R211NS, T215X, V245M, E248D	A
	347	347_527	KJ870585	3TC, DDI	EFV	A62V, L74V, M184IV	G190S	K11T, V35T, T39N, K104I, S105T, K122E, D123N, A158S, K173L, Q174K, Q207A, R211S, E248D	A
	494	494_154	KJ870299	AZT, 3TC	EFV	A62V, M184V	K101E, G190S	K11T, E28EK, K32KE, V35I, T39K, T84TI, K122E, D123N, K173L, Q174K, D177E, T200A, E203ED, Q207A, R211S, E248D, S251SI	A
	428	428_582	KJ870623	AZT, 3TC	EFV	A62V, M184V	G190S	K11T, V35T, E36D, T39K, V60I, K122E, A158S, K173S, Q174K, D177E, T200A, Q207A, R211S, E248D	A
	480	480_570	KJ870613	ABC, 3TC	EFV	A62V, L74I, V75VAIT, Y115F, M184V, K219KDEN	Y181C, G190S	K11T, V35IM, E36D, T39K, T58N, V90I, K122E, D123N, A158AS, K173S, Q174K, T200A, Q207A, R211S, Y232H, V245M, E248D	A
	284	284_438	KJ870524	ABC, 3TC	EFV	A62V, L74LV, M184V	G190S	K11T, V35I, E36D, K122E, D123N, A158S, K173L, Q174K, T200A, Q207A, R211S, V245M, E248D	A
	133	133_258	KJ870381	D4T, 3TC	EFV	A62V, M184MV	K103KN, G190S	K11T, V35I, E36D, T39K, K101KQ, D121H, K122E, A158S, K173V, Q174K, D177E, I178IL, T200A, Q207A, R211S, V245M, E248D	A
	254	254_162	KJ870306	AZT, 3TC	EFV	A62V, M184V	G190S	K11T, V35I, I37L, T39K, K49KR, L100F, L120I, K122E, D123N, A158AS, K173L, Q174K, Q207A, R211S, E248D	A
	88	88_160	KJ870304	AZT, 3TC	EFV	D67N, K70R, M184V, K219Q	K101E, G190S	K11T, V35I, E36D, T39K, V90I, V106I, K122E, D123N, A158S, K173S, Q174K, D177E, T200A, Q207A, V245MT, E248D	A
	274	274_443	KJ870528	AZT, 3TC	EFV	A62V, M184V	K101E, G190S	K11T, V35T, E36D, T39K, K122E, D123N, E138A, K166R, Q174K, Q207A, R211S	A
	97	97_249	KJ870374	AZT, 3TC	EFV	A62V, D67N, K219KE	K101E, G190S	K11T, V35R, E36D, T39K, I50T, V90I, K122E, D123N, S162A, D177E, R211S, V245M, E248D	A
	411	411_600	KJ870632	AZT, 3TC	NVP	A62V, M184V	K101E, G190S	K11T, V35I, E36D, T39K, K122E, D123N, E138A, A158S, S162SN, K173L, Q174K, D177E, I178V, I202V, Q207A, R211S, E248D	A
	119	119_146	KJ870293	AZT, 3TC	EFV	A62V, D67N, K70R	K101E, G190S	K11T, V35I, E36D, T39K, K46Q, K122E, D123N, S163T, K173S, Q174K, D177E, V179VI, D186H, F214L, E248D	A

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