<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Reverse Transcriptase Inhibitors

Subtype A
Gene RT
Mutation G190S
Rx >= 1 NNRTI
(+/- NRTI)
IncludeMixtures No
References 11
Patients 57
Isolates 58
 
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# NRTIs NNRTIsNRTIDRMs NNRTIDRMs OtherMutSubtype
Non-B Workgroup (2005)TK1007TK1007 AZT, 3TCEFVD67N, T215FK101E, G190SE28G, V35T, T39E, E44D, V118I, K122E, D123N, I135T, I142V, K173L, V179I, T200A, Q207A, R211S, F214L, V245Q, K281R, E291D, I293V, E297K, E312D, S322A, D324EA
  TK1007a AZT, 3TCEFVD67G, K70R, T215F, K219QK101E, G190SE28G, V35T, T39E, E44D, V118I, K122E, D123N, I135T, I142V, K154KN, F160FS, K173L, V179I, T200A, Q207A, R211S, F214L, V245Q, K281R, E291D, I293V, E297K, E312D, S322A, D324EA
Rosen-Zvi (2008)8908p89-2 TDF, FTCNVPM184IK101KE, G190SV35I, E36D, T39K, K122E, D123S, K173A, Q174K, D177E, V179I, T200I, Q207A, R211S, V245M, E248D, A272P, T286A, E291D, V292I, I293V, I326VA
Koyalta (2009)67TCHAD-67FJ688198D4T, 3TCNVPD67N, M184V, T215FK101E, G190SK43E, D121H, K122E, D123S, I135T, K173A, Q174K, D177E, V179I, T200A, Q207A, R211S, K238RA
Steegen (2009)BV223BV223-2EU8721503TC, D4T, ABCEFVM184VG190SV35T, K101Q, K122E, D123S, K173S, V179I, Q197H, T200A, Q207A, R211SA
Hamkar (2010)14Ir-HIV-DR-14GU724817NRTINNRTIM184V, T215YG190SE6D, V8I, K11R, V35T, K49R, V60I, D121Y, K122E, S134R, I135T, K166R, Q174H, D177E, V179I, Q207A, R211K, V245E, D250E, A272P, L283I, R284K, A288S, E291D, V292I, I293V, G335DA
 15Ir-HIV-DR-15GU724818NRTINNRTIM184V, T215YG190SE6D, V8I, K11R, V35T, K49R, V60I, A98X, K101S, K103E, V106X, D121Y, K122E, I135K, K166R, Q174H, D177E, V179I, Q207A, R211K, V245E, D250E, A272P, L283I, R284K, A288S, E291D, V292I, I293V, G335DA
 19Ir-HIV-DR-19GU724822NRTINNRTIM184V, T215YG190SE6S, K11R, V35K, V60I, A98X, K101S, K103E, V106X, D121Y, K122E, I135K, K166R, Q174H, D177E, V179I, Q207A, R211K, V245E, D250E, A272P, L283I, R284K, A288S, E291D, V292I, I293V, G335DA
 21Ir-HIV-DR-21GU724824NRTINNRTIM184V, T215YG190SE6S, K11R, V35K, V60I, D121Y, K122E, I135T, K166R, Q174H, D177E, V179I, Q207A, R211K, V245E, D250E, A272P, L283I, R284K, A288S, E291D, V292I, I293V, G335DA
Moussa (2010)423-CP001745HM117953D4T, 3TCEFVM184V, L210WK101E, Y181C, G190SV35T, T39L, T107S, K122E, D123S, K173A, D177G, T200A, Q207E, R211KA
Dvali (2012)R037R037FJ456898D4T, 3TCEFVK65RA98AG, G190SK30Q, K32G, A33C, L34T, V35L, E36N, I37F, T39N, V60I, K122E, D123N, K173L, Q174K, Q207A, R211SA
 R008R008FJ456895AZT, 3TCEFVM184VK101E, G190SV35L, E36N, I37F, T39IKM, D121H, K122E, D123S, K173LS, Q174KR, D177E, V179VI, Q207A, R211SA
 R116R116FJ456905AZT, 3TCNVPD67DN, M184VG190SV35L, E36N, I37F, T39M, V60I, K122E, D123S, I135T, K173L, Q174K, D177E, T200A, Q207AP, R211S, F214L, D237EA
 R149R149FJ456914D4T, 3TCNVPA62V, K65R, M184IK101E, Y181YC, G190SK30Q, K32G, A33C, L34T, V35L, E36N, I37F, T39K, V90I, K122E, D123N, A158S, K173L, Q174K, T200A, Q207A, R211S, V245MA
 R117R117FJ456906AZT, 3TCNVPA62V, M184VK101E, G190SK30Q, K32G, A33C, L34T, V35L, E36N, I37F, T39S, W88C, K122E, D123N, I135T, E138A, K173S, Q174K, Q207A, R211S, F214LA
 R053R053FJ456900AZT, 3TCEFVM184V, T215HPSY, K219KQG190S, M230MLK30Q, K32G, A33C, L34T, V35L, E36N, I37F, T39R, Q91Q*, V106VI, K122E, D123N, I135T, S162C, K173L, Q174K, D177E, V179I, I202IV, Q207A, R211S, L228LR, V245MA
 R144R144FJ456910AZT, 3TCEFVA62V, M184VA98AG, V179DE, G190SK30Q, K32G, A33C, L34T, V35L, E36N, I37F, T39K, V90I, K122E, D123N, I135T, E138A, K173L, Q174K, Q207A, R211S, V245KA
 R142R142FJ456909AZT, 3TCEFVM41L, D67N, K70R, L74LI, V75VL, M184V, L210LW, T215Y, K219EG190SV35L, E36N, I37F, T39R, K43E, K49R, K122E, D123S, K173S, Q174K, D177E, V179I, Q197EK, T200TA, I202IV, Q207A, V245MA
 R012R012FJ456896AZT, 3TCEFVM184VK101DEHQ, G190SV35L, E36N, I37F, T39M, D121DH, K122KE, D123NS, K173S, Q174K, D177E, Q207A, R211S, F214LA
Aghokeng (2013)HJ3264HJ3264JX983030NRTINNRTIA62AV, L74LV, M184VA98AG, G190SI2IV, K11T, V35T, T39Q, D121H, K122E, I135T, K173S, Q174K, D177E, V179IT, T200A, Q207A, R211S, F214FL, H221HY, Q222QR, V245Q, E248DN, A272P, K277KR, T286A, E291D, I293V, E312D, G335D, M357K, R358RG, G359S, K366R, A371V, I375V, A376S, T377V, T386I, A400T, T403TM, E413DA
Avidor (2013)1966_MT1966_MTKC184299TDF, 3TCEFVK65KR, M184VK101E, Y181C, G190SK30Q, K32G, A33C, L34T, V35L, E36N, I37F, T39V, V106I, D121H, K122E, D123S, I135T, K173S, Q174K, D177E, T200A, Q207A, R211S, L228LR, V245MA
 2017_MT2017_MTKC184342D4T, DDIEFV G190SV35L, E36N, I37F, T39M, K122E, D123S, K173L, Q174K, T200I, E203EK, Q207A, R211S, V245MA
 1991_MT1991_MTKC1843203TC, DDIEFV G190SV35L, E36N, I37F, T39M, K122E, D123S, K173L, Q174K, T200I, E203EK, Q207A, R211S, V245MA
 17781778 TDF, FTCEFVL74LI, M184VG190ST39Q, S68G, T69N, K122E, D123N, I135T, K173L, Q174K, V179I, Q207A, R211S, V245MA
 631631 AZT, 3TCEFVM184VG190ST39N, D121H, K122E, A158S, K173S, Q174K, D177E, Q207A, R211S, L228F, V245ITA
 17851785 TDF, 3TCEFVK65R, T69~, M184MVK101E, Y181C, G190ST39E, K122E, D123S, I142T, A158S, K173S, Q174K, Q207A, R211S, L228LR, V245MA
Theys (2013)1995619956KC219996NRTI, TDFNNRTID67N, K70R, T215I, K219EG190SV60I, K122E, D123S, I135T, E138A, K173S, Q174K, V179I, T200A, Q207E, R211K, F214LA
Kolomeets (2014)279279_551KJ870602AZT, 3TCEFVA62V, M184VK101E, E138K, G190SK11T, V35I, E36D, T39K, K122E, D123N, A158S, S162C, K173S, Q174R, D177E, I178L, T200A, Q207A, R211S, V245Q, E248DA
 8585_121KJ870274AZT, 3TCEFVA62V, M184VK101E, G190SK11T, V35I, E36D, T39K, K64R, K122E, D123N, E138A, K173L, Q174K, V189VI, I202IV, Q207A, R211S, E248DA
 250250_316KJ870429AZT, 3TCNVPA62V, M184VK101KE, G190SK11T, V35I, T39K, K122E, D123N, A158S, T165TI, K173A, Q174K, G196K, T200A, I202V, Q207A, R211S, E248DA
 6969_356KJ870463AZT, 3TCEFVA62V, M184VG190SE6EK, K11T, E28EG, V35I, T39K, K122E, D123N, I135T, K173A, Q174K, D177E, V179I, Q207A, R211S, V245M, E248DA
 2727_199KJ870338AZT, 3TCEFVA62V, M184VG190SK11T, V35I, E36D, T39K, K43E, K49R, K122E, D123N, A158S, K166R, K173I, Q174K, D177E, T200A, Q207A, R211S, V245M, E248DA
 6565_157KJ870301AZT, 3TCNVPA62V, M184VK101E, G190SK11T, V35T, E36A, T39E, V90I, V106VI, K122E, D123N, A158S, K173L, Q174K, T200A, Q207A, R211S, E248DA
 3939_642KJ8706673TC, DDIEFVA62V, K65R, M184IK101E, Y181C, G190S, P225HK11T, V35I, E36D, T39K, K122E, D123N, A158S, K173LS, Q174R, D177E, G196E, T200A, Q207A, R211S, E248DA
 422422_576KJ870618D4T, 3TCEFVA62V, M184VG190SK11T, V35T, E36D, T39K, K101Q, K122E, D123S, I135T, T165I, K173A, Q174K, Q207A, R211S, E248DA
 116116_143KJ870291AZT, 3TCEFVA62V, M184VG190SK11T, V35IT, E36D, T39K, K49KR, K101KQ, V106VI, K122E, D123N, K173I, Q174K, Q207A, R211S, E248DA
 114114_141KJ870290AZT, 3TCEFVA62V, M184VG190SK11T, V35I, E36D, T39K, K49KR, K101KQ, K122E, D123N, A158S, K166R, K173L, Q174K, T200A, E204ED, Q207A, R211S, V245M, E248DA
 345345_524KJ870583ABC, 3TCEFVA62V, L74V, M184VK101E, G190SK11T, V35T, T39E, K122E, D123N, E138A, S162SN, K173L, Q174K, Q207A, R211K, E248DA
 179179_322KJ870435AZT, 3TCEFVA62V, M184V, T215TSK101E, G190SK11T, V35I, E36D, K122E, D123N, E138A, K173L, Q174K, Q207A, R211S, E248DA
 495495_155KJ870300AZT, 3TCEFVM41L, A62V, M184V, L210LW, T215FK101E, G190SK11T, V35T, E36D, T39K, K49R, V90VI, K122E, D123S, S162C, K173T, Q174K, D177E, Q207A, R211S, E248DA
 160160_189KJ8703303TC, DDIEFVA62V, K65R, V75IY181C, G190S, P225HK11T, V35I, E36D, T39N, K103R, K122E, D123N, A158S, Q174K, D177E, T200A, Q207A, R211S, V245M, E248DA
 414414_633KJ870659AZT, 3TCEFVD67DN, K70KR, M184V, T215TNSY, K219KQK101E, G190SE6K, K11T, V35T, E36D, T39N, V106I, K122E, D123S, S162C, K173L, Q174K, D177E, G196E, Q197QKR, T200A, Q207A, R211S, V245M, E248DA
 424424_578KJ870620ABC, 3TCEFVA62V, L74IV, Y115F, M184VK101H, V179D, G190SK11T, V35I, E36D, T39HN, V90VI, K122E, D123N, K173L, Q174K, D177E, I178L, Q207A, R211S, E248DA
 326326_462KJ870541AZT, 3TCEFVA62V, M184VK101E, G190SK11T, V35I, E36D, T39K, R72RK, V106I, K122E, D123N, A158S, K173A, Q174K, D177E, Q207A, R211S, V245M, E248DA
 141141_309KJ870423AZT, 3TCEFVA62V, M184V, T215TFISK101H, G190SK11T, V35T, V118VI, K122E, D123N, A158S, K166R, K173I, Q174K, D177DE, T200TA, Q207A, R211S, V245M, E248DA
 103103_287KJ870405D4T, 3TCEFVM41ML, D67N, K70KR, M184V, L210LW, K219KQK101DEHQ, G190SK11T, V35T, E36D, T39N, E42X, V118VI, K122E, D123N, K173L, V179VI, Q207A, R211NS, T215X, V245M, E248DA
 347347_527KJ8705853TC, DDIEFVA62V, L74V, M184IVG190SK11T, V35T, T39N, K104I, S105T, K122E, D123N, A158S, K173L, Q174K, Q207A, R211S, E248DA
 494494_154KJ870299AZT, 3TCEFVA62V, M184VK101E, G190SK11T, E28EK, K32KE, V35I, T39K, T84TI, K122E, D123N, K173L, Q174K, D177E, T200A, E203ED, Q207A, R211S, E248D, S251SIA
 428428_582KJ870623AZT, 3TCEFVA62V, M184VG190SK11T, V35T, E36D, T39K, V60I, K122E, A158S, K173S, Q174K, D177E, T200A, Q207A, R211S, E248DA
 480480_570KJ870613ABC, 3TCEFVA62V, L74I, V75VAIT, Y115F, M184V, K219KDENY181C, G190SK11T, V35IM, E36D, T39K, T58N, V90I, K122E, D123N, A158AS, K173S, Q174K, T200A, Q207A, R211S, Y232H, V245M, E248DA
 284284_438KJ870524ABC, 3TCEFVA62V, L74LV, M184VG190SK11T, V35I, E36D, K122E, D123N, A158S, K173L, Q174K, T200A, Q207A, R211S, V245M, E248DA
 133133_258KJ870381D4T, 3TCEFVA62V, M184MVK103KN, G190SK11T, V35I, E36D, T39K, K101KQ, D121H, K122E, A158S, K173V, Q174K, D177E, I178IL, T200A, Q207A, R211S, V245M, E248DA
 254254_162KJ870306AZT, 3TCEFVA62V, M184VG190SK11T, V35I, I37L, T39K, K49KR, L100F, L120I, K122E, D123N, A158AS, K173L, Q174K, Q207A, R211S, E248DA
 8888_160KJ870304AZT, 3TCEFVD67N, K70R, M184V, K219QK101E, G190SK11T, V35I, E36D, T39K, V90I, V106I, K122E, D123N, A158S, K173S, Q174K, D177E, T200A, Q207A, V245MT, E248DA
 274274_443KJ870528AZT, 3TCEFVA62V, M184VK101E, G190SK11T, V35T, E36D, T39K, K122E, D123N, E138A, K166R, Q174K, Q207A, R211SA
 9797_249KJ870374AZT, 3TCEFVA62V, D67N, K219KEK101E, G190SK11T, V35R, E36D, T39K, I50T, V90I, K122E, D123N, S162A, D177E, R211S, V245M, E248DA
 411411_600KJ870632AZT, 3TCNVPA62V, M184VK101E, G190SK11T, V35I, E36D, T39K, K122E, D123N, E138A, A158S, S162SN, K173L, Q174K, D177E, I178V, I202V, Q207A, R211S, E248DA
 119119_146KJ870293AZT, 3TCEFVA62V, D67N, K70RK101E, G190SK11T, V35I, E36D, T39K, K46Q, K122E, D123N, S163T, K173S, Q174K, D177E, V179VI, D186H, F214L, E248DA