<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Reverse Transcriptase Inhibitors

Subtype A
Gene RT
Mutation Y188L
Rx >= 1 NNRTI
(+/- NRTI)
IncludeMixtures No
References 18
Patients 44
Isolates 44
 
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# NRTIs NNRTIsNRTIDRMs NNRTIDRMs OtherMutSubtype
Gomez-Carrillo (2004)103396103396AY365678NRTINNRTIT215YY188LV21VI, V35T, D121H, K122E, I135T, D177E, R211K, V245K, K281R, T286A, E291D, V292I, I293V, E297K, A304E, I329L, G335D, R356K, M357K, R358K, G359S, A360T, T377M, K390R, Q394H, E399D, A400TA
Non-B Workgroup (2005)TK5005TK5005a AZT, 3TC, DDC, D4T, ABCNVP, EFVD67N, T69D, K70R, F116FY, M184LV, T215F, K219QY188L, G190AP4PS, E6D, T27S, V35IT, V60I, V118VI, K122E, D123S, I135T, Q151X, K173S, Q174K, D177E, T200A, I202V, Q207A, R211S, L228X, V245K, D250E, A272G, T286A, I293V, P294T, E312NA
 TK5012TK5012c AZT, 3TC, ABC, DDIEFV K101P, Y188LK11T, V21VI, V35T, T39A, D121DN, Y146YC, S162SG, K173A, Q174K, D177E, V179I, I202V, Q207A, R211K, T240TA, V245Q, I257IV, T286A, E291D, I293V, P294T, E312DA
Baxter (2006)48-72277227-30828DQ879040NRTINNRTIM41L, L74IV, M184V, L210W, T215YY188LV35K, T39E, K43R, E44D, S68G, D121H, K122E, I135T, S162C, R172K, K173S, D177E, I178L, T200A, E203K, Q207A, R211K, K223E, L228H, V245E, K277R, T286A, E291D, V292I, I293V, P294T, E297K, A304E, G335D, R356K, M357R, G359S, A360AT, T377V, T386I, K390R, A400TA
Rosen-Zvi (2008)3908p39-3 AZT, DDI, 3TC, D4T, ABC, TDF, FTCNVP, EFVD67N, K70R, L74V, M184V, T215V, K219QY188LK11T, V35T, T39N, D121H, K122E, A158S, K173S, Q174K, D177E, G196E, Q207A, V245Q, A272G, T286A, E291D, I293V, K311R, E312DA
Steegen (2009)BV133BV133-2EU8721413TC, D4TNVPQ151M, M184VY188L, G190AV35T, V60I, T69TN, D121H, K122E, D123DE, F171Y, K173S, Q174K, D177E, I178M, V179I, T200A, Q207A, R211S, F214LA
Germanaud (2010)56765676 AZT, 3TCNVPM184VY188LI5V, K11T, V35T, E36T, T39K, K43E, K102Q, D123N, I142V, S162Y, K173A, D177E, V179I, E194D, I202V, Q207A, R211K, V245QA
Ndembi (2010)13263D_P113263GQ409551ABC, AZT, 3TCNVPM184V, T215FY188LK11T, K20R, V21I, V35T, T39RS, K43KE, K122E, D123N, K173S, D177E, I178L, V179I, T200A, I202V, Q207A, R211KA
Charpentier (2011)3CP001-039 Unknown, D4T, DDIUnknown, EFVM41L, D67N, K70R, M184L, T215Y, K219QY188L, M230LK11T, V35KR, T39D, V106L, L109I, D121H, K122E, D123S, S134SN, A158S, K173S, Q174K, D177E, V179I, G196E, T200A, I202V, Q207A, R211S, F227Y, V245Q, T286TA, A288AS, I293V, P294T, E312D, D324EA
Reynolds (2012)E7105E7105-1JN652186AZT, 3TCNVPM184VY188LE6ED, K11KT, K20R, V21I, V35T, E40D, K49R, I50V, V60I, K122E, D123N, T165TI, K173S, D177E, V179I, T200A, I202V, Q207A, V245E, T286A, I293V, P294TA
Inzaule (2013)182182JQ914053AZT, 3TCNVPM184VY188LV35T, K49R, V60I, K122E, D123S, I135T, K173A, Q174K, V179I, Q207A, R211SA
Theys (2013)4037440374KC221195NRTI, TDFNNRTID67N, K70R, L74V, M184V, T215V, K219QY188LD121H, K122E, A158S, K173S, Q174K, D177E, G196E, Q207AA
Aghokeng (2014)TG-3-129TG-3-129KC350311NRTINNRTIM184V, T215YY188LP1PA, E6K, K11T, V35T, E36A, T39K, K43E, K122E, D123S, S162Y, K173S, D177E, V179I, T200A, Q207A, R211E, V245Q, E248N, I257V, A272P, K277R, K281R, T286A, I293V, P294T, E312D, I326V, G335D, M357K, G359S, T369V, A371V, I375V, A376V, T386A, A400T, T403M, W410YA
Hassan (2014)RS09000841RS09_841KC568498AZT, 3TCNVPM184MVY188LK20R, K32R, V35K, T39A, V60I, D121H, K122E, I135T, I142V, T165I, K173E, Q174K, D177E, V179I, T200A, Q207AT, R211S, V245EK, D250E, T286A, E291D, V292VI, I293V, P294T, E297R, A304E, E312DA
Boillot (2016)VIR32VIR32KT315993D4T, 3TCEFVM41L, D67N, K70R, M184V, T215YA98G, Y188LK11T, V35T, T39A, V60I, V106I, D121Y, K122E, D123G, I135T, I142V, K173S, Q174K, D177E, V179I, G196E, Q207A, R211S, F214L, E224D, D237E, V245EA
Ndahimana Jd Riedel (2016)20402040KT982527NRTINNRTIM184VA98AG, Y188LV35T, K43KR, V106I, K122E, I135T, K173L, D177E, V179I, I195K, G196E, I202V, Q207D, F214FL, V245Q, D250E, A272P, V276I, K277R, E291D, I293V, G335E, R356K, M357K, G359S, T369A, I375IM, A376T, T377M, S379C, T386I, A400TA
Steegen (2016)GFKZB174GFKZB174KU128078TDF, 3TC, FTCNVP, EFVM184VA98G, Y188LP4H, K11T, V35T, K46Q, V106I, K122E, D123N, I135T, I142V, S162C, K173S, V179I, T200A, I202V, Q207A, R211S, F214L, L228H, V245Q, E248D, R284K, T286A, E291D, V292I, I293V, G335D, R356K, M357R, G359T, T369TAA
Kekitiinwa (2017)35359_94935359_949KY237834NRTINNRTIV75MY188LV21I, V35T, T39S, V60I, K122E, D123NS, I135T, F171Y, K173S, Q174K, T200A, Q207A, R211S, E248Q, D250E, A272P, K275R, V276I, Q278H, T286A, E291D, V292I, I293V, P294TA
 42197_65242197_652KY237854NRTINNRTI K103N, Y188LK43E, G45GR, K49R, K64R, K122E, D123N, E138A, K173S, V179I, I202V, Q207AA
 28699_97728699_977KY237829NRTINNRTIM41L, D67H, K70R, M184V, T215F, K219EA98G, Y188LK20R, V35T, V60I, T69N, L109V, K122E, K173S, Q174K, D177E, V179I, G196E, I202V, Q207A, R211S, F214L, D218E, L228H, V245Q, E248D, D250E, A272P, T286A, A288T, E291D, V292I, I293VA
 42200_102342200_1023KY237857NRTINNRTIM184VK103N, Y188LK102KN, S105T, L109LI, K122E, D123N, I135IT, K173L, Q174K, D177EG, V179T, T200A, I202V, Q207A, R211KA
 65517_94765517_947KY237883NRTINNRTIK65KR, L74LV, Y115YF, M184VY188L, G190GA, K238KTV60I, S68SG, V106VI, K122E, D123N, I135T, K173S, Q174K, D177E, I178IM, V179I, T200A, I202V, Q207E, L228LRA
 65772_66465772_664KY237922NRTINNRTIM184VK103N, Y188LV60I, K122E, D123NS, E138A, K173S, Q174K, D177E, V179I, T200A, I202V, Q207A, R211S, F214LA
 65519_72665519_726KY237884NRTINNRTI K103N, Y188L, F227FCK43KE, K102N, K122E, D123N, T139TA, K173A, Q174K, D177E, V179VI, T200TA, I202V, Q207A, R211RS, E233EKA
Kityo (2017)8348283482KY062036NRTINNRTIM41L, D67DN, K70R, L74LI, V75M, M184V, T215F, K219QK101E, Y188LK49E, V60I, T69N, K122E, D123S, I135T, I142K, S162Y, K173S, Q174K, D177E, I178IF, V179I, T200I, Q207A, R211S, F214FL, K223KQ, E224D, L228LH, K238RA
 8331083310KY061865NRTINNRTIK65R, M184VK103N, Y188LK46Q, V60I, S68G, K122E, D123N, I135L, T139TA, I142IV, K173S, D177E, V179I, T200TA, I202V, Q207A, R211KA
 6606566065KY061427NRTINNRTIA62V, K65R, Y115F, M184VY181YC, Y188LV60I, V106I, K122E, D123N, I135T, K173L, Q174K, D177E, V189VI, I195L, G196E, R206K, Q207D, R211KA
 8291382913KY061477NRTINNRTIK70KR, M184VY188LS48T, K49KR, V60I, V106L, K122E, D123N, I135T, T139K, K173L, Q174K, D177E, V179I, T200A, Q207A, R211S, F214LA
 8292582925KY061489NRTINNRTIM41ML, M184V, T215FA98G, Y188L, P236PLK43E, V60I, S68SG, V106VI, K122E, D123N, I135T, I142V, K173S, D177E, V179I, T200A, I202V, Q207A, R211RKNS, D218EA
 8316883168KY061724NRTINNRTIM184V, T215TFISY188LV118X, K122E, D123N, P133PL, K173S, D177E, V179I, T200A, I202V, Q207AA
 8359383593KY062147NRTINNRTIK70~, M184VY188LK49R, V60I, V106I, K122E, D123N, I135T, K173L, Q174K, I178M, V179I, Q207A, R211S, E224EDA
 8354783547KY062101NRTINNRTIK70Q, M184IY188L, P225H, P236PLW88WS, V90I, L109LI, K122E, D123S, K173S, Q174K, D177E, I178M, V179I, T200A, I202IV, Q207A, R211RS, H221YA
 8346583465KY062019NRTINNRTIM41L, M184V, L210W, T215YK103N, Y188LV60I, L109I, D121Y, K122E, D123E, I142V, D177E, V179T, T200A, I202V, Q207A, R211RKA
 8309983099KY061656NRTINNRTIM41L, M184V, T215FK101E, Y188L, G190AV60I, K122E, D123S, I135T, E138A, I142V, K173S, Q174K, D177E, I178M, V179I, T200A, Q207A, R211K, D237EA
 6605066050KY061417NRTINNRTIM41L, M184V, L210LW, T215YY188LV106I, K122E, D123N, K173A, Q197QR, T200E, Q207A, R211KA
 8344083440KY061994NRTINNRTIM41L, M184V, L210W, T215YY188LE44D, V118I, K122E, D123S, I135T, E138A, T165I, K173S, G196E, T200A, I202V, Q207A, R211NA
 8317783177KY061733NRTINNRTIM41ML, M184V, L210LW, T215YY188LV60I, K122E, K173S, Q174K, D177E, V179I, V189I, I202V, Q207A, R211KA
 8307883078KY061636NRTINNRTID67N, K70R, M184V, K219QY188LV60I, K64R, T69N, K122E, D123S, I135T, E138A, K173T, Q174K, V179I, T200A, I202V, Q207K, R211S, F214L, K238RA
 8294282942KY061506NRTINNRTIM184VY188LK49R, V60I, K122E, D123S, I135T, I159V, K173A, Q174K, D177E, Q207A, R211SA
 8352683526KY062080NRTINNRTID67N, K70R, M184V, T215F, K219EY188LK49R, V60I, K64R, T69N, A98S, I135T, K173A, D177E, V179I, T200A, Q207A, R211RK, E224D, L228HA
 8302383023KY061583NRTINNRTIM41L, M184V, T215YY188LK122E, D123N, K173S, D177E, V179I, T200A, I202V, Q207A, R211S, F214LA
 8297282972KY061535NRTINNRTIM41L, M184V, L210LW, T215YA98G, K101E, Y188LV60I, V106I, K122E, D123N, I135T, S162H, K173S, Q174K, D177E, V179I, T200A, E203ED, Q207D, H208HYA
 6565265652KY061392NRTINNRTIM41L, L74LI, M184V, T215Y, K219KQY188LG45GR, V60I, V118VI, K122E, D123S, I135T, S162SN, K173A, Q174R, V179I, T200A, Q207S, R211SA
 8306483064KY061623NRTINNRTIK70R, M184VA98AG, Y188LV60I, T69S, V106I, D121H, K122E, D123S, I135T, I142V, K173A, Q174K, D177E, V179I, T200A, Q207A, R211S, F214FLA