<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Reverse Transcriptase Inhibitors

Subtype A
Gene RT
Mutation Y188L
Rx >= 1 NNRTI
(+/- NRTI)
IncludeMixtures No
References 15
Patients 16
Isolates 16
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# NRTIs NNRTIsNRTIDRMs NNRTIDRMs OtherMutSubtype
Gomez-Carrillo (2004)103396103396AY365678NRTINNRTIT215YY188LV21VI, V35T, D121H, K122E, I135T, D177E, R211K, V245K, K281R, T286A, E291D, V292I, I293V, E297K, A304E, I329L, G335D, R356K, M357K, R358K, G359S, A360T, T377M, K390R, Q394H, E399D, A400TA
Non-B Workgroup (2005)TK5005TK5005a AZT, 3TC, DDC, D4T, ABCNVP, EFVD67N, T69D, K70R, F116FY, M184LV, T215F, K219QY188L, G190AP4PS, E6D, T27S, V35IT, V60I, V118VI, K122E, D123S, I135T, Q151X, K173S, Q174K, D177E, T200A, I202V, Q207A, R211S, L228X, V245K, D250E, A272G, T286A, I293V, P294T, E312NA
 TK5012TK5012c AZT, 3TC, ABC, DDIEFV K101P, Y188LK11T, V21VI, V35T, T39A, D121DN, Y146YC, S162SG, K173A, Q174K, D177E, V179I, I202V, Q207A, R211K, T240TA, V245Q, I257IV, T286A, E291D, I293V, P294T, E312DA
Baxter (2006)48-72277227-30828DQ879040NRTINNRTIM41L, L74IV, M184V, L210W, T215YY188LV35K, T39E, K43R, E44D, S68G, D121H, K122E, I135T, S162C, R172K, K173S, D177E, I178L, T200A, E203K, Q207A, R211K, K223E, L228H, V245E, K277R, T286A, E291D, V292I, I293V, P294T, E297K, A304E, G335D, R356K, M357R, G359S, A360AT, T377V, T386I, K390R, A400TA
Rosen-Zvi (2008)3908p39-3 AZT, DDI, 3TC, D4T, ABC, TDF, FTCNVP, EFVD67N, K70R, L74V, M184V, T215V, K219QY188LK11T, V35T, T39N, D121H, K122E, A158S, K173S, Q174K, D177E, G196E, Q207A, V245Q, A272G, T286A, E291D, I293V, K311R, E312DA
Steegen (2009)BV133BV133-2EU8721413TC, D4TNVPQ151M, M184VY188L, G190AV35T, V60I, T69TN, D121H, K122E, D123DE, F171Y, K173S, Q174K, D177E, I178M, V179I, T200A, Q207A, R211S, F214LA
Germanaud (2010)56765676 AZT, 3TCNVPM184VY188LI5V, K11T, V35T, E36T, T39K, K43E, K102Q, D123N, I142V, S162Y, K173A, D177E, V179I, E194D, I202V, Q207A, R211K, V245QA
Ndembi (2010)13263D_P113263GQ409551ABC, AZT, 3TCNVPM184V, T215FY188LK11T, K20R, V21I, V35T, T39RS, K43KE, K122E, D123N, K173S, D177E, I178L, V179I, T200A, I202V, Q207A, R211KA
Charpentier (2011)3CP001-039 Unknown, D4T, DDIUnknown, EFVM41L, D67N, K70R, M184L, T215Y, K219QY188L, M230LK11T, V35KR, T39D, V106L, L109I, D121H, K122E, D123S, S134SN, A158S, K173S, Q174K, D177E, V179I, G196E, T200A, I202V, Q207A, R211S, F227Y, V245Q, T286TA, A288AS, I293V, P294T, E312D, D324EA
Reynolds (2012)E7105E7105-1JN652186AZT, 3TCNVPM184VY188LE6ED, K11KT, K20R, V21I, V35T, E40D, K49R, I50V, V60I, K122E, D123N, T165TI, K173S, D177E, V179I, T200A, I202V, Q207A, V245E, T286A, I293V, P294TA
Inzaule (2013)182182JQ914053AZT, 3TCNVPM184VY188LV35T, K49R, V60I, K122E, D123S, I135T, K173A, Q174K, V179I, Q207A, R211SA
Theys (2013)4037440374KC221195NRTI, TDFNNRTID67N, K70R, L74V, M184V, T215V, K219QY188LD121H, K122E, A158S, K173S, Q174K, D177E, G196E, Q207AA
Aghokeng (2014)TG-3-129TG-3-129KC350311NRTINNRTIM184V, T215YY188LP1PA, E6K, K11T, V35T, E36A, T39K, K43E, K122E, D123S, S162Y, K173S, D177E, V179I, T200A, Q207A, R211E, V245Q, E248N, I257V, A272P, K277R, K281R, T286A, I293V, P294T, E312D, I326V, G335D, M357K, G359S, T369V, A371V, I375V, A376V, T386A, A400T, T403M, W410YA
Hassan (2014)RS09000841RS09_841KC568498AZT, 3TCNVPM184MVY188LK20R, K32R, V35K, T39A, V60I, D121H, K122E, I135T, I142V, T165I, K173E, Q174K, D177E, V179I, T200A, Q207AT, R211S, V245EK, D250E, T286A, E291D, V292VI, I293V, P294T, E297R, A304E, E312DA
Boillot (2016)VIR32VIR32KT315993D4T, 3TCEFVM41L, D67N, K70R, M184V, T215YA98G, Y188LK11T, V35T, T39A, V60I, V106I, D121Y, K122E, D123G, I135T, I142V, K173S, Q174K, D177E, V179I, G196E, Q207A, R211S, F214L, E224D, D237E, V245EA
Steegen (2016)GFKZB174GFKZB174KU128078TDF, 3TC, FTCNVP, EFVM184VA98G, Y188LP4H, K11T, V35T, K46Q, V106I, K122E, D123N, I135T, I142V, S162C, K173S, V179I, T200A, I202V, Q207A, R211S, F214L, L228H, V245Q, E248D, R284K, T286A, E291D, V292I, I293V, G335D, R356K, M357R, G359T, T369TAA