<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Reverse Transcriptase Inhibitors

Subtype A
Gene RT
Mutation Y181V
Rx >= 1 NNRTI
(+/- NRTI)
IncludeMixtures No
References 11
Patients 20
Isolates 20
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# NRTIs NNRTIsNRTIDRMs NNRTIDRMs OtherMutSubtype
Non-B Workgroup (2005)UK1436UK1436AY901336DDC, AZT, D4T, 3TCNVPM184VY181VE6D, V21I, V35T, V60I, R83K, K122E, D123S, K173S, Q174K, D177E, I178L, V179I, T200A, Q207E, R211K, H221YA
Weber (2005)F75698F75698AY677500D4T, DDI, ABC, AZT, 3TCNVPY115F, M184V, T215FYY181VK22KN, V35T, K49KR, V60I, R72RK, V90VI, K122E, D123NS, I135T, K173S, Q174K, V179I, Q207E, R211S, H221Y, V245Q, D250E, T286A, E291D, V292I, I293V, E312DG, Q334QHA
Hawkins (2009)P625ZZP625FJ931133D4T, 3TCNVPM41ML, M184V, L210LW, T215F, K219K*RWK101E, Y181VE28K, K32K*E, V35T, E36E*, K49KR, V60I, T69TN, V118VI, K122E, D123S, I135T, K173L, Q174K, D177E, V179I, Q207A, R211S, L228LR, V245E, D250E, A272T, T286TP, E291D, I293V, V317VAA
Towler (2010)5or3533249-HHM037894D4T, 3TCNVPM184VY181VK11T, V35T, V60I, K122E, D123N, I135K, K173S, Q174K, D177E, V179I, Q207E, V245Q, D250E, S251D, A272P, L282C, L283IA
Charpentier (2011)CR-43CR-43FJ688249AZT, 3TCNNRTID67G, K70R, M184V, T215I, K219EY181VK11T, V35T, T39L, S48T, V60I, S68G, D121H, K122E, I135T, E169D, K173A, Q174K, D177E, V179I, G196E, I202V, Q207V, H208N, R211S, F214FL, V245E, E291D, I293V, E312YA
Sigaloff (2011)HIV102971HIV102971JN132329AZT, 3TCNVPM184V, L210LWY181VE6D, V35T, T39A, K122E, D123S, I135T, K173L, Q174K, D177E, V179I, Q207E, R211K, V245N, D250E, A272P, K275Q, K277R, T286A, I293V, L295M, E297KA
 HIV102999HIV102999JN132335AZT, 3TCNVPD67N, K70R, M184V, T215YY181VI5IV, K11T, K20R, V35T, K49R, K102KN, K122E, D123S, I135T, S162C, K173S, Q174K, D177E, V179I, T200A, Q207A, R211S, F214L, H221Y, V245K, R284K, E291D, I293V, P294T, R307K, E312DA
Aghokeng (2014)CI-1-348CI-1-348KC350378NRTINNRTIM184V, L210W, T215DY181VV35T, T39N, K49R, S68G, V90I, K122E, D123N, I135T, S162Q, F171Y, R172K, K173A, D177E, I178M, V179I, G196E, T200A, E203EK, E204K, Q207E, R211KA
Ndahimana Jd Riedel (2016)20662066KT982513NRTINNRTI Y181VE44D, K49R, I50V, V60I, T69TN, K122E, D123S, I135T, K173S, Q174K, D177E, V179I, Q207A, R211RK, F214L, V245QA
Chaplin (2017)NJIH0325NJIH0325MF622876NRTINNRTIM184VY181VE6K, K11T, V35T, E36A, T39K, K43E, K49KR, V90I, K122E, D123N, I135IT, I142V, S162H, F171Y, K173X, D177E, V179I, T200A, I202V, Q207A, R211K, V245Q, E248DA
Kityo (2017)8341383413KY061967NRTINNRTIM41L, D67N, K70R, V75M, M184V, T215F, K219QY181VV60I, K122E, D123S, I135T, K173S, Q174K, D177E, V179I, T200A, I202V, Q207A, R211KN, F214L, H221YA
 8359083590KY062144NRTINNRTIM41ML, D67N, K70R, M184V, T215F, K219QY181VG45GR, V60I, T69N, K104KR, D121H, K122E, I135T, K173T, Q174K, D177E, V179I, T200A, Q207A, R211S, D218EA
 8344583445KY061999NRTINNRTIA62V, V75I, F77L, Y115F, F116Y, Q151M, M184V, T215Y, K219KQK101E, Y181V, G190AK43E, S68G, V111VI, K122E, D123S, I167V, K173S, Q174QR, D177E, V179T, I202V, Q207A, R211RKNS, H221YA
 8344383443KY061997NRTINNRTIM41L, M184V, T215FA98G, Y181VK43E, V60I, K122E, D123S, I135T, I142V, K173L, Q174K, D177E, V179I, T200A, Q207E, F214L, L228RA
 8316183161KY061717NRTINNRTIK65R, T69~, K219RY181VV60I, I63L, S68G, K122E, D123N, I135T, P140PT, K173S, Q174K, D177E, V179I, Q207A, R211S, F214FL, H221Y, L228LRA
 8346883468KY062022NRTINNRTIM41L, K70R, L74I, M184V, T215F, K219QK101E, K103KN, Y181V, G190AK64R, T69N, S162D, D177E, I178M, V179I, D192N, T200A, Q207A, R211K, K223KQ, L228RA
Rhee (2017)KE03760KE03760KY364292TDF, 3TCNVPK65R, M184VY181VK20R, V35T, A62P, S68SG, K122E, D123S, I135T, I142V, K173S, Q174K, V179I, T200A, I202IV, Q207A, R211S, H221Y, V245Q, E248DA
 KE07447KE07447KY364332TDF, 3TCNVPK65R, Y115F, M184VY181VV35T, K49R, V60I, K122E, D123S, I135T, Q145C, F171Y, K173A, Q174K, D177E, V179I, T200A, Q207E, V245MA
 KE14128KE14128KY364334TDF, 3TCNVPK65R, M184VK103KN, V108I, Y181VK20R, V35T, T39M, V60I, S68G, D121HY, K122E, I135T, I142V, K173S, Q174K, D177DE, V179I, G196E, T200M, Q207A, R211H, H221HY, V245M, D250EA
 KE14173KE14173KY364341TDF, 3TCNVPK65R, M184VY181VV35T, V60I, S68G, K122E, D123N, I135L, K166R, K173I, Q174K, D177E, I202V, Q207A, R211S, V245Q, E248D, D250EA