<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Reverse Transcriptase Inhibitors

Subtype A
Gene RT
Mutation Y181I
Rx >= 1 NNRTI
(+/- NRTI)
IncludeMixtures No
References 14
Patients 16
Isolates 16
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# NRTIs NNRTIsNRTIDRMs NNRTIDRMs OtherMutSubtype
Non-B Workgroup (2005)TK5001TK5001 AZT, D4T, 3TC, TDFNVPM41L, D67N, T69D, K70R, T215F, K219QV108VI, Y181IE6K, K11T, K20R, V35T, T39L, L109I, V118I, K122E, D123N, S162D, K173T, Q174K, N175Y, D177E, V179I, Q197E, I202V, E203K, Q207DY, H208Y, R211K, D218E, L228H, V245Q, E248D, A272P, T286A, E291D, V292I, I293V, V317AA
Weber (2005)M41971M41971AY677568AZT, 3TCNVPM41L, D67N, K70KR, M184V, T215F, K219QY181IE6D, T27S, V35T, T39A, V60I, K122E, D123S, I135T, E138A, I142IV, K173A, Q174K, V179I, Q207A, F214L, D218E, L228LH, V245M, D250DE, A272P, T286A, A288T, I293V, P294TA
Hawkins (2009)R475ZZR475FJ931437D4T, 3TCNVPM184VY181IE6K, K20KR, K32I, V35T, T39K, K43E, T69N, K122E, I135V, T139TKR, I142V, S162AD, T165TI, F171Y, D177E, V179I, T200A, Q207A, R211K, F214L, V245Q, E248D, K281KR, T286A, E291D, I293V, P294T, I326VA
Hamers (2012)CP076304748CP076304748 TDF, FTCNVPM184VY181IV35T, V60I, K122E, D123S, I135T, E138A, K173L, Q174K, I178M, V179I, G196E, Q197K, Q207T, R211S, V245Q, E248D, A272P, T286A, V292I, I293V, P294TA
Reynolds (2012)H0534H0534-1JN652196AZT, 3TCEFVM184VY181IK11T, V21I, V35T, V60I, K101Q, K122E, D123N, E138A, P157PS, K173L, D177G, V179I, I202V, Q207A, R211K, V245E, D250E, A272P, K277R, T286A, V292I, P294T, L295MA
Inzaule (2013)7373JQ914097AZT, 3TCNVPM184VV108I, Y181II31IL, V35T, T39L, K64KR, D121H, K122E, E138A, I142V, T165TM, K173N, Q174K, D177E, V179I, Q207E, R211KA
Nouhin (2013)R0220214R0220214KF292451NRTINNRTIM41L, D67N, L74LV, V75M, M184V, L210W, T215YL100I, K103N, Y181IV35T, T39A, E44D, V111I, V118I, K122E, D123S, I135T, I159L, T165V, K173I, Q174K, D177E, I178M, V179I, T200A, E203D, Q207K, H208Y, R211D, K223KQ, K238RA
Sigaloff (2013)JCR104_0JCR104_0JX182001NRTINNRTIL74V, Y115F, M184VY181IE6D, V35T, T39K, V60I, W88C, K122E, D123G, K173S, Q174K, D177E, V179I, T200A, Q207A, F214L, V245E, D250E, I257L, V261I, T286A, E291D, I293V, K311RA
Acharya (2014)DGP035DGP035KJ185205TDF, 3TCEFVM41L, K70R, M184V, L210W, T215Y, K219EY181IK20R, V35T, E44D, V60I, I94L, A98S, L109I, D121H, K122E, D123S, I135T, S162D, K166R, K173A, Q174K, D177E, V179I, Q197K, T200A, Q207A, R211N, D218E, L228H, V245T, D250E, A272P, R284K, T286A, V292I, I293VA
Aghokeng (2014)TG-2-273TG-2-273KC350196NRTINNRTIV75A, M184VY181IK11T, V35T, T39K, K43E, K73Q, K122E, D123S, I135T, K173A, Q174K, D177E, I178L, V179I, T200A, Q207A, R211K, F214L, H221Y, V245Q, T286A, E291D, I293V, P294T, E312D, I326V, Q334D, G335D, M357K, G359S, K366R, T369V, A371V, I375V, A376V, T386P, A400T, T403M, W410YA
Ndahimana (2016)11181118KU922885TDF, 3TCNVPK65R, Y115F, M184VY181IE40D, K49R, V60I, K122E, D123N, I135M, K173L, Q174K, D177E, V179I, T200A, Q207A, R211S, V245NA
Kekitiinwa (2017)79399_105679399_1056KY238007NRTINNRTIL74V, Y115F, M184VY181IK122E, D123N, I135IT, K173S, D177G, V179I, T200A, I202V, Q207A, R211K, H221YA
 42201_47942201_479KY237858NRTINNRTIL74V, Y115F, M184VY181IV60I, K122E, D123S, I135T, I142IT, S162A, K173L, Q174K, N175Y, V179I, T200A, I202V, Q207E, F214L, H221YA
Kityo (2017)8329383293KY061848NRTINNRTIM41L, D67N, M184V, L210W, T215YY181IK43E, K49KR, V118VI, D121H, K122E, D123DG, S162N, K173S, Q174E, D177E, V179I, G196GE, T200TA, I202V, Q207A, R211RK, H221YA
 8296482964KY061528NRTINNRTID67N, K70R, M184V, T215F, K219QY181IV60I, T69N, K122E, D123N, I135T, T165L, K173A, Q174K, D177E, I178IL, V179I, T200A, I202V, Q207A, R211RS, F214L, L228HA
Svard (2017)1st_581st_58KX775252AZT, 3TCNVPM41L, D67N, V75I, M184V, L210W, T215YY181IV35T, T39M, E44D, V60I, V118I, I132L, I135T, K173Q, Q174K, D177E, I178M, V179I, G196E, T200A, E203K, Q207D, R211N, L228H, V245I, D250EA