Reverse Transcriptase Inhibitors

HOME Genotype-Rx Genotype-Pheno Genotype-Clinical hivdb program

Reverse Transcriptase Inhibitors

Subtype	A
Gene	RT
Mutation	Y181C
Rx	>= 1 NNRTI (+/- NRTI)
IncludeMixtures	No

References	33
Patients	111
Isolates	116

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr)	Patient	Isolate	Acc#	NRTIs	NNRTIs	NRTIDRMs	NNRTIDRMs	OtherMut	Subtype
Yahi (2001)	NY_M35	M35	AY010501	D4T	NVP	K70N, V75T	V108I, Y181C	K20R, V35T, T39N, K104R, K122E, D123S, I135V, T139A, K173A, Q174K, D177E, Q207A, R211S, H221HY	A
Richard (2004)	RNJCR33	RNJCR33	AY556820	AZT, 3TC	NVP	K70R	Y181C	E6N, K11T, V21I, V35T, K122E, D123S, I135T, K173L, Q174K, D177E, V179I	A
	RNJCR41	RNJCR41	AY556837	AZT, 3TC, D4T, DDI	NVP	M41L, D67N, K70R, V75I	Y181C, G190A	K11T, K20R, V21I, V35T, D123S, E138A, S162A, T165L, K173S, V179I	A
Weber (2005)	F51354	F51354	AY677539	AZT, 3TC, DDC, D4T, DDI	NVP, EFV	D67DN, K70KR, L74LV, T215F	A98G, K103N, Y181C	K11T, K20R, V21I, V35T, T39L, N57NI, T69X, V106I, D123N, I135L, D177E, I178L, V179I, T200A, I202V, Q207A, R211X, V245Q, E248D, A272P, T286A, E291D, V292I, I293V, P294T, E312G	A
	F65588	F65588	AY677546	D4T, 3TC, DDI, DDC	NVP		Y181C	K11T, K20R, V21I, V35T, T39G, D123N, K173S, Q174QK, D177G, V179I, T200A, I202V, Q207A, R211S, H221Y, L228R, V245Q, E248N, A272P, T286A, E291D, I293V, P294T, E312N	A
	F30020	F30020-2	AY714407	3TC, DDI	NVP	K65R	Y181C	E6D, E28A, V35T, V60I, V118I, K122E, D123N, I135T, I159IL, K173S, Q174K, D177E, I178L, V179I, T200A, E204ED, Q207*E, R211K, F214L, V245Q, D250E, A272P, T286A, E291D, I293V, P294A, E312D, V317A	A
	M41984	M41984	AY677598	AZT, 3TC, D4T, DDI	EFV	M41L, D67N, K70R, V75M, M184V, L210W, T215Y, K219E	K103N, V108I, Y181C	V35T, V60I, K122E, D123S, I135T, K173S, Q174K, V179I, T200A, E203K, Q207D, R211K, D218E, H221Y, L228H, V245Q, D250E, A272T, E291D, V292I, I293V	A
	F74928	F74928	AY714434	D4T, DDI, AZT, 3TC	NVP	M184V	Y181C	E6K, T7A, V35T, T39L, V60I, D121H, K122E, I135T, T139R, I142V, K173A, Q174K, D177E, T200A, Q207A, R211S, F214L, D250E, E291D, V292I, I293V, P294T, E312D, S322A	A
		F74928	AY714470	D4T, DDI, AZT, 3TC	NVP	M184V	Y181C	E6K, V35T, T39L, D121H, K122E, I135T, T139R, I142V, K173A, Q174K, D177E, Q207A, R211S, D250E, T286A, E291D, V292I, I293V, P294T, E312D, S322A	A
	F56706	F56706	AY714472	AZT, DDI, 3TC, D4T	NVP	M184V	Y181C	E6K, V35T, T39L, D121H, K122E, I135T, T139R, I142V, K173A, Q174K, D177E, Q207A, R211S, D250E, T286A, E291D, V292I, I293V, P294T, E312D, S322A	A
Baxter (2006)	12-2120	2120-30715	DQ880034	NRTI	NNRTI	M41L, D67N, L74V, M184V, L210W, T215Y, K219R	Y181C, G190A	T39A, E44D, V60I, K101Q, V118I, K122E, D123N, I135T, K173S, Q174K, V179I, T200A, Q207E, H208Y, R211K, H221C, V245Q	A
		2120-40510	DQ880035	NRTI	NNRTI	M41L, D67N, L74V, L210W, T215Y, K219R	V106A, Y181C, G190A	T39A, E44D, V60I, K101Q, V118I, K122E, D123N, I135T, K173S, Q174K, V179I, T200A, Q207E, H208Y, R211K, H221C, V245Q	A
	48-1204	1204-30709	DQ877748	NRTI	NNRTI	M41L, D67N, L74V, M184V, L210W, T215Y, K219N	K103S, Y181C, G190A	P4S, V35T, T39A, E44D, K64R, K101Q, K122E, D123S, T165I, K173S, Q174K, D177E, I178L, V179I, T200A, I202V, E203D, Q207N, H208Y, R211N, W212C, H221Y, L228H, V245T, D250E, A272P, K281R, I293V, P294T, G335D, M357R, G359S, T369A, A371V, I375V, A376V, T377M, T386S, A400T	A
	48-1253	1253-30605	DQ877778	NRTI	NNRTI		Y181C	V35T, K49R, I50IV, V60I, K122E, K173L, Q174K, D177E, I178IM, V179I, T200A, Q207A, R211S, D218DE, V245Q, E248D, D250E, A272P, K277R, T286A, E291D, V292I, I293V, Q334HR, G335D, M357K, R358G, G359S, K366R, E370A, A371V, I375V, T377M, A400T	A
	48-3045	3045-30317	DQ877957	NRTI	NNRTI	D67N, L74V, Y115F, M184V, T215F, K219Q	Y181C, G190A	T7A, K11T, K20KR, V35T, T39R, K43E, K101Q, D121H, K122E, D123S, I135T, K173S, Q174K, N175Y, D177E, G196E, Q207A, V245Q, T286A, E291D, K311R, M357K, R358K, G359S, K366R, T369V, E370D, A371V, I375V, A376I, T386I	A
	48-3316	3316-30818	DQ878217	NRTI	NNRTI	A62V, K65R, V75I, F77L, F116Y, Q151M	K101N, K103H, Y181C, G190A	P4K, K11T, V35T, T39E, S68G, V118I, D121Y, K122E, D123S, A158S, R172K, K173S, Q174K, D177E, I195L, G196E, Q207A, R211S, F214L, H221Y, V245Q, T286A, E291D, I293V, E297K, E312D, H315Q, V317A, I326T, Q334D, R356K, M357K, G359S, T362S, K366R, T369V, E370D, A371V, I375V, A376S, K390R, A400T	A
	48-4018	4018-30227	DQ878252	NRTI	NNRTI	D67N, K70R, L74V, Y115F, M184V, K219Q	K103N, Y181C, G190A	K11T, M16V, K20R, V35T, T39N, D121H, K122E, I135T, I142T, T165I, K173A, Q174R, D177E, G196E, T200A, Q207A, F214FL, H221Y, L228LR, V245Q, K277R, T286A, E291D, I293V, G335D, R356K, M357K, G359S, K366R, A371LV, I375V, A376S, V381I, T386I, A400T	A
	48-4153	4153-30326	DQ878387	NRTI	NNRTI	M41L, D67S, K70R, M184MIV, T215F, K219E	Y181C, G190A	P4S, K11T, K20R, V21I, V35T, T39Q, T69N, L109I, K122E, D123N, I135T, N137H, K173S, Q174K, D177E, T200A, I202V, Q207A, R211K, D218E, V245Q, E248D, T286A, E291D, V292I, I293V, P294T, E312G, G335D, M357Q, R358K, G359S, T369TA, A371V, I375V, A376S, K390R	A
	48-5021	5021-30606	DQ878555	NRTI	NNRTI	M41L, T69S_SG, L74I, M184V, T215F	Y181C	E6EK, K20R, V35T, T39A, K122E, I135T, K173L, Q174K, D177E, I178IM, V179I, T200A, Q207A, R211A, V245Q, D250E, A272P, K277R, T286A, E291D, V292I, I293V, P294T, G335D, M357S, G359S, T369A, A371V, I375V, A376V, T377M, T386A, A400T	A
	48-5031	5031-30421	DQ878557	NRTI	NNRTI	D67N, K70R, M184V, T215F, K219E	Y181C, G190A	K20R, T27S, V35T, V60I, T69N, K122Q, I135T, K173A, Q174K, V179I, Q207A, L228H, V245K, D250E, K281R, T286A, E291D, I293V, P294T, E312D, G335D, M357K, G359S, T369V, A371V, I375V, T377M, K390R, A400T	A
Laurent (2006)	CK22-50	03CM2-50	AM279458	D4T, 3TC	NVP	K65R, M184V	Y181C	I5V, K11A, E28K, I31L, K32E, V35T, T39K, S48T, K49R, V60I, D121Y, K122E, I135T, S162C, E169D, K173A, Q174K, G196E, Q207A, R211S, V245Q, D250G, L283I, E291D, I293V, E297A, G335D, R356K, M357R, G359S, T369I, A371V, I375V, K390R, A400T, T403M, E432T	A
Lwembe (2007)	NYU62	62MMAY04		AZT, 3TC	NVP	D67N, K70R, T215I, K219E	Y181C, G190A	V35T, E40D, V60I, K101Q, V106I, K122E, D123G, K173L, Q174K, D177E, V179I, T200A, Q207A, R211S	A
	NYU79	79MJUN04		AZT, 3TC, DDI	NVP, EFV	V75M, M184V	K101E, Y181C, G190A	E28A, V35T, T39A, E40D, T69S, D121H, K122E, I135T, T139I, K173S, Q174K, D177E, I178V, V179I, T200A, Q207A, R211S	A
Church (2008)	361358A	361358A	EU380729	None	NVP		Y181C	V21I, V35T, K49R, I50V, V60I, K122E, D123S, E169D, K173A, Q174K, D177E, V179I, I202V, Q207A, R211S, V245E, D250E, A272P, K277R, L283I, I293V, K311R, E312N, S322A	A
	362363H	362363H	EU380730	None	NVP		Y181C	K11T, K20R, V21I, V35T, T39R, D123N, S162SC, K173S, D177E, V179I, T200A, I202V, Q207A, R211K, V245E, D250E, T286A, E291D, V292I, I293V, P294T, K311R, E312D	A
	367927-J	367927-J	EU380735	None	NVP		Y181C	K20R, V21I, V35T, T39R, K43E, V60I, I135R, S162A, K173S, Q174K, V179I, Q207A, R211S, V245Q, D250E, S251D, E291D, V292I, I293V, P294T, E312D, D320E, D324E	A
	390900V	390900V	EU380746	None	NVP		Y181C	K11T, V35T, E40D, K43R, T139I, K173S, D177E, V179I, T200A, Q207A, R211S, F214L, V245Q, A272T, E291D, I293V, P294T, E312D, D320E	A
	400177E	400177E	EU380750	None	NVP		K103KN, Y181C	P4S, V21I, K32R, V35T, T39A, E40D, V60I, T107S, K122E, D123N, I142V, K173A, Q174K, D177E, T200A, Q207E, R211K, H221HY, V245E, D250E, T286A, E291D, I293V, E312D, I329V	A
	413282X	413282X	EU380756	None	NVP		Y181C	K11T, K20R, V21I, V35T, T39K, T69S, K122E, D123N, K173S, V179I, I202V, Q207A, V245M, E248N, T286A, E291D, V292I, I293V, P294T, E312D, V317I	A
Gody (2008)	Pt041	Pt041		D4T, 3TC	NVP	M41L, M184V	Y181C, G190A	K49R, V60I, K101D, D121H, K122E, I135T, K173A, Q174K, D177E, I178L, T200A, Q207A, R211S, K238R	A
	Pt047	Pt047		D4T, 3TC	NVP	K65KR	K101E, Y181C, G190A	K11AT, V35L, S68SG, S105SA, D121HY, K122E, I135IV, K173A, Q174K, D177E, G196E, Q207A, R211N, L228LR, V245Q, E248DN, D250DE, K281R, T286A, E291D, I293V	A
Hawkins (2009)	P628	ZZP628	FJ931135	D4T, 3TC	NVP	A62V, M184V	Y181C	E6Q, K11T, V35T, T39K, K43E, D123E, T139K, I142V, A158T, S162H, F171Y, K173S, D177E, I178L, V179I, T200A, Q207A, R211K, V245Q, E248D, T286A, E291D, V292I, I293V, P294T, I326V	A
	P671	ZZP671	FJ931165	D4T, 3TC	NVP	V75VI, M184V	Y181C	E6EK, T7TP, V35T, T39TR, V60I, K102Q, D121H, K122E, I132IL, I135T, T139TR, S162SC, S163ST, K166KN, K173A, D177E, I178L, E204K, Q207E, R211K, D250E, K281R, T286A, E291D, P294T, I326V, I329L	A
	P963	ZZP963	FJ931176	D4T, 3TC	NVP	K65R, Q151M, M184V	K103N, Y181C	E28K, V35T, T39E, S68G, I135T, K173L, Q174K, T200A, Q207A, R211K, F214L, I244V, V245L, A272P, K281KR, T286A, I293V, E297EQ, I326V	A
	R40	ZZR40	FJ931279	D4T, 3TC	NVP	M41L, L74V, M184V, L210W, T215Y	A98G, V108I, Y181C	I5V, E28K, K32E, V35T, E36A, T39K, K43E, D86E, V118I, D121H, K122E, I135T, I142V, S162Y, K173T, Q174K, D177E, V179I, T200A, I202V, Q207D, R211K, H221Y, V245Q, T286A, E291D, V292I, I293V, P294T, E312D, I326V	A
	Q956	ZZQ956	FJ931325	D4T, 3TC	NVP	D67DN, K70KR, M184V	K101E, Y181C	I5V, K11A, E28K, V35T, T39K, D121Y, K122E, I135T, I142T, E169D, K173A, Q174K, G196E, Q207A, R211S, V245Q, T286A, E291D, I293V	A
Rey (2009)	9	9w24		TDF, 3TC	NVP	K65R	Y181C, G190A	T39N, G51GR, K122E, D123G, E169D, K173A, Q174K, D177E, G196E, Q207A, R211S, G213GR, V245Q	A
Steegen (2009)	BV264	BV264-2	EU872142	3TC, D4T	NVP	K65R, V75I, M184V	Y181C, G190A	V35T, V60I, D121H, K122E, I132L, I135T, I142IV, S162C, K173L, Q174K, Q207A, R211S	A
Moussa (2010)	4	23-CP001745	HM117953	D4T, 3TC	EFV	M184V, L210W	K101E, Y181C, G190S	V35T, T39L, T107S, K122E, D123S, K173A, D177G, T200A, Q207E, R211K	A
	25	11-CP001021	HM117952	D4T, 3TC	NVP	M184V, T215F	A98G, K101E, Y181C, G190A	E28K, K32E, V35T, T39M, K122E, D123N, I135T, I142V, K173A, Q174K, D177E, I178M, T200A, Q207A, V245K	A
Ndembi (2010)	13929D_P1	13929	GQ409560	AZT, 3TC	NVP	M184V, T215Y	Y181C	I31L, V35T, V60I, T69TN, D121H, I142V, D177E, Q207A, R211S, H221Y	A
	16233D_05_P1	16233	GQ409633	AZT, 3TC	NVP	M184V	Y181C	E6D, K32R, V35T, K49R, V60I, K122E, D123S, I135T, T139R, K173S, Q174K, Q207A, R211K	A
Towler (2010)	11	416275-M	HM037886	D4T, 3TC	NVP	D67DG, M184V	Y181C	I31L, V35T, T39K, K49R, V60I, T69TKN, K122E, I135T, S162N, K173L, Q174K, D177E, V179I, G196E, T200A, I202V, Q207A, R211S, F214L, V245E, D250E, T286A, E291D, I293V, P294T	A
		503727-G	HM037897	D4T, 3TC	NVP	M41ML, D67DG, M184V, T215F	Y181C	I31IL, L34LI, V35T, T39K, K49R, V60I, T69TN, V118VI, K122E, I135T, S162D, S163SR, K173L, Q174K, D177E, V179I, G196E, T200A, I202V, Q207A, R211S, F214L, V245E, D250E, T286A, E291D, I293V, P294T	A
	2	519810-R	HM037891	D4T, 3TC	NVP	K70KR, M184V	Y181C	K20R, V35T, T39N, E40D, K49KR, T69N, I135IT, A158S, K173S, T200A, Q207A, R211K, H221HY, L228LR, V245Q, D250E, S251H, A272P, T286A, E291D, V292I, I293V, P294A, K311R, E312D	A
	3or5	521684-A	HM037892	D4T, 3TC	NVP	M184V	Y181C	K11S, V35I, I47L, S48T, V60I, K122E, D123S, I135T, T139R, K173S, Q174K, V179I, T200A, Q207A, R211T, V245Q, E248D, D250E, K275Q, T286A, E291D, V292VI, I293V, P294T, K311R	A
	4	529392-J	HM037893	D4T, 3TC	NVP	V75VI, M184V	V108VI, Y181C	K20R, V21I, V35T, T39A, E40D, T69N, K122E, D123N, I132IL, I135T, K173S, Q174K, D177E, V179I, T200A, I202V, Q207A, H221HY, V245Q, E248D, K281R, T286A, E291D, I293V, P294T	A
Charpentier (2011)	18	CP 001 2151		D4T, 3TC	NVP	K65KR, M184MV, K219KN	A98AG, K103KN, Y181C	K11ST, V35T, T39N, K102KR, D121H, K122E, D123S, T139TK, K173S, D177DE, G196E, T200A, Q207A, R211S, H221HY, V245Q, K277R, Q278H, K281R, T286A, E291D, I293V, E312DN, G333GE	A
	23	CP 001 2052		D4T, 3TC	NVP	V75I, M184V	Y181C	K11T, P14PT, I31IL, V35T, T39N, V90VI, K104KN, D121H, K122E, D123S, I132L, I135T, S162C, K173S, Q174K, D177E, G196E, T200A, Q207A, R211K, H221HY, V245Q, A272AP, T286A, E291D, I293IV, E297K	A
	30	CP 001 399		D4T, 3TC	NVP	K65R, D67H, T69D, K219EG	K103N, Y181C, G190A	E6D, K11T, K20R, V35T, T39KR, K43E, S68G, V90I, D121H, K122E, I135M, I142V, S162A, K173A, Q174K, D177E, I178L, T200A, E204K, Q207A, R211S, F214L, L228R, V245E, T286A, E291D, V292I, I293V, E297K, A304E, P313T, I329V	A
	31	CP 005 026		D4T, 3TC	NVP	K65R, T69~, K70KN, K219R	Y181C, G190A	K11T, V21I, L34I, V35T, T39E, S68SDGN, K82KR, V90VI, K101KQ, D121H, K122E, K173S, D177E, G196E, E204Q, Q207D, F214L, H221Y, V245Q, D250E, S251DG, L283LI, E291ED, I293V, P294T, L295F, E297K, E312D	A
	33	CP 001 621a		D4T, 3TC	NVP		Y181C, G190GA	E6D, V35T, T39K, K43E, T69N, T107S, K122E, D123S, K173I, Q174K, D177E, I178M, V179I, G196E, T200A, Q207A, R211S, F214FL, L228R, K238KR, V245E, K277R, T286A, E291D, I293V, K311KR, E312N, I326IV	A
	77	CP 001 2322		D4T, 3TC	NVP	M184V	K101KE, V106VA, Y181C	K11AT, V35T, T39D, K64R, D121HY, K122E, K173S, Q174K, D177E, I178M, G196E, T200K, Q207A, R211S, V245Q, A272P, Q278H, T286A, E291D, I293V, P321S, I326L	A
	121	CP 001 724		D4T, 3TC	NVP	A62V, V75I, F116Y, Q151M, M184V	A98G, Y181C	I31L, V35T, T39R, K43E, S68SG, N81ND, D121H, K122E, I135IT, I142V, K173A, Q174K, D177E, G196GE, T200A, Q207A, R211S, K238R, V245E, A272P, K281R, E291D, I293V, E312N, D324E	A
	148	CP 001 621b		D4T, 3TC	NVP		Y181C, G190A	E6D, V35T, T39K, K43E, T69N, T107S, K122E, D123S, K173I, Q174K, D177E, I178M, V179I, G196E, T200A, Q207A, R211S, F214FL, L228R, K238KR, V245E, K277R, T286A, E291D, I293V, K311KR, E312N, I326IV	A
	179	CP 001 1982		D4T, 3TC	NVP	K65KR, M184V	V108I, Y181C	E6D, K11T, V35T, T39N, V60I, K122E, D123S, I135IL, A158T, K173S, D177E, T200A, E203K, Q207D, L228LR, V245Q, A272P, K281R, E291D, V292VI, I293V, I326V	A
Dvali (2012)	R017	R017	FJ456897	D4T, 3TC	NVP		Y181C	K30Q, K32G, A33C, L34T, V35L, E36N, I37F, T39K, E40DY, D121H, K122E, I135T, K173LS, Q174K, D177DEG, V179I, Q197E, Q207A, R211S, H221Y, V241VI, V245VM	A
	R004	R004	FJ376434	AZT, 3TC	NVP	M184V	Y181C	V35L, E36N, I37F, T39M, K49KR, K102KQ, K122A, D123S, I135IT, K173S, Q174K, D177E, Q207A, R211S, F214FL, L228LR, V245M	A
Kouri (2012)	CU376-10	CU376-10	JQ585390	NRTI	NNRTI	D67N, K70R, M184V, T215F, K219E	V108I, Y181C	V35T, T39K, E40D, T69N, K122E, D123S, I135IT, K173S, Q174K, V179I, G196E, T200A, R206K, Q207A, R211S, L228H, V245Q, E248N, K281KR, T286A, E291D, V292I, I293V, P294T, Q334H, G335D	A
Reynolds (2012)	K0808	K0808-1	JN652204	D4T, 3TC	NVP	M184V	V108VI, Y181C	I31IL, V35T, E40D, K49R, V60I, K122E, D123S, I135T, K173S, Q174K, D177E, V179I, T200A, Q207A, R211S, V245K, D250E, K281R, T286A, E291D, I293V, P294T	A
Aghokeng (2013)	HJ3169	HJ3169	JX983028	NRTI	NNRTI	D67DN, T69D, K70KR, M184V, T215F	Y181C, G190A	K11T, V35T, T39K, K43E, Y56YS, N57NI, K122E, D123S, E169D, K173A, Q174K, D177E, E194Q, G196E, Q197K, T200A, Q207A, R211S, F214L, V245Q, E248D, T286A, E291D, I293V, E312N, G335D, N348T, M357K, R358K, G359S, K366R, E370N, A371V, I375V, K390R, A400T, T403M, E404D	A
Avidor (2013)	1966_MT	1966_MT	KC184299	TDF, 3TC	EFV	K65KR, M184V	K101E, Y181C, G190S	K30Q, K32G, A33C, L34T, V35L, E36N, I37F, T39V, V106I, D121H, K122E, D123S, I135T, K173S, Q174K, D177E, T200A, Q207A, R211S, L228LR, V245M	A
	1785	1785		TDF, 3TC	EFV	K65R, T69~, M184MV	K101E, Y181C, G190S	T39E, K122E, D123S, I142T, A158S, K173S, Q174K, Q207A, R211S, L228LR, V245M	A
	196	196		ABC	EFV	A62V, K65R, V75I, F77FL, Y115YF, F116Y, Q151M	K101EQ, K103KN, Y181C, G190A	T39TA, K49KR, E53ED, S68K, W88WAGS, V106VI, V111VI, V118I, K122E, D123S, I135IT, K173S, Q174R, D177E, V179I, T200A, Q207A, R211RS, F214L, H221Y, F227FY, V245T	A
Inzaule (2013)	200	200	JQ914070	AZT, 3TC	NVP	M184V	Y181C	V35T, K43R, V60I, D121H, K122E, D123E, I135T, T139R, K173L, Q174K, D177E, I178V, Q207A, R211S	A
Pircher (2013)	B1108	B1108	JX110210	D4T, 3TC, AZT	NVP	D67N, K70R, V75A, F77L, Q151M, M184V, T215I, K219Q	V179E, Y181C, G190A	V35T, T39N, K46KQ, V60I, K73L, K101R, K103R, V111I, K122E, D123S, I135T, I142V, K173A, T200A, Q207E, R211K, F214L, D218E, L228H, V245Q	A
Rawizza (2013)	LM3929	LM3929	KF241482	NRTI	NNRTI	D67N, K70R, M184V, T215F, K219E	V108VI, Y181C	P4S, T27S, V35T, T39K, K43A, T69TN, V90I, K102Q, V111I, D123E, I142V, S162Y, K173S, D177DE, V179I, T200A, Q207A, R211K, P243PS, V245T, E248D, T286A, E291D, I293V, P294PT	A
Sigaloff (2013)	JCR109_0	JCR109_0	JX182002	NRTI	NNRTI	D67N, K70R, M184V, T215I, K219E	A98G, Y181C	E6S, V35T, V60I, D121Y, K122E, I135IT, K173T, Q174K, D177E, V179I, G190X, I202V, Q207A, R211S, F214L, L228H, V245E, E248D, D250E, I293V, P294T	A
	MBA046_0	MBA046_0	JX182017	NRTI	NNRTI	M184V	A98G, K103N, Y181C	E6D, V21I, E28EK, V35T, T39A, E40D, V60I, K122E, D123N, I135T, S162A, K173S, Q174K, D177E, V179I, T200A, I202V, Q207E, R211S, V245E, D250E, S251H, K281R, T286A, E291D, V292I, I293V, P294T, K311R	A
Theys (2013)	47577	47577	KC221378	NRTI, TDF	NNRTI	M41L, D67N, L74I, M184V, L210W, T215Y, K219N	V108I, Y181C	V118I, D121H, I135T, E138T, I142V, S162C, F171Y, K173S, Q174K, G196D, T200A, Q207A, R211K	A
	49479	49479	KC221428	NRTI, TDF	NNRTI	D67N, T69D, K70R, L74IV, M184V, T215F, K219Q	A98G, V108I, Y181C	K49R, V60I, K122E, D123N, I135V, K173S, Q174K, N175Y, D177E, V179I, Q197E, T200A, I202V, Q207A, R211S, L228H	A
	40530	40530	KC221199	NRTI, TDF	NNRTI	D67N, K70R, M184MI, T215DE, K219Q	K103H, Y181C, G190A	K43KR, T69TN, V90I, K101Q, K122E, D123N, S134R, A158S, T165TI, R172K, K173S, Q174K, D177E, I178M, T200A, Q207A, R211S	A
Thiam (2013)	2666-HALD	2666-HALD	JN673686	NRTI	NNRTI	M184V	Y181C	E6Q, K11T, V35T, E36A, T39K, K43E, D86E, D121H, K122E, I135T, I142V, S162F, M164*, T165Q, K173S, T200A, Q207A, V245E, K281R, T286A, E291D, V292I, I293V, P294T, L295M, K311R, Y319YH, S322T	A
Hassan (2014)	RS09000809	RS09_809	KC568490	AZT, 3TC	NVP	M184V, T215Y	Y181C	K11T, I31L, V35K, T39E, K49KR, K122E, D123S, I135T, K173S, Q174K, D177E, V179I, Q207A, R211S, F214L, H221Y, V245E, R284K, E291D, V292I, I293V, P294T, E312D	A
	RS11000442	RS11_442	KC568516	AZT, 3TC	NVP	M184V	Y181C	I5V, V35T, V60I, D121Y, K122E, D123E, I135T, K173S, Q174K, D177E, V179I, G196E, T200V, Q207A, K238R, V245T, D250E, A272P, E291D, V292I, I293V, E312D, V317G	A
	RS11000437	RS11_437	KC568514	D4T, 3TC, AZT	NVP	M184V	Y181C	K11T, V21I, V35T, T39Q, V60I, K122E, D123S, I135V, T165M, K173S, Q174T, D177E, V179I, T200A, I202V, Q207A, R211K, V245Q, E248D, T286A, E291D, V292I, I293V, E312D	A
	RS11000464	RS11_464	KC568521	AZT, 3TC	NVP	L74V, M184V	K103N, Y181C	K11E, V35T, V60I, V90VI, D121H, K122E, D123S, I135T, T165I, K173S, Q174K, G196E, T200A, Q207A, R211S, H221Y, T286V, E291D, I293V, P294T	A
Kolomeets (2014)	39	39_642	KJ870667	3TC, DDI	EFV	A62V, K65R, M184I	K101E, Y181C, G190S, P225H	K11T, V35I, E36D, T39K, K122E, D123N, A158S, K173LS, Q174R, D177E, G196E, T200A, Q207A, R211S, E248D	A
	148	148_132	KJ870282	AZT, 3TC	NVP	A62V, D67DN, K70KR, V75VM, M184V, T215TI, K219KE	Y181C	K11T, V35I, E36D, T39K, K122E, D123N, K173L, Q174K, D177E, T200TI, I202V, Q207A, R211S, L228R, E248D	A
	150	150_135	KJ870284	AZT, 3TC	NNRTI	A62V, M184V	Y181C	K11T, V35T, E36D, T39K, K49R, K82R, K122E, D123S, I135T, A158S, S162HN, K173L, Q174K, D177E, Q207A, R211S, V245T, E248D	A
	160	160_189	KJ870330	3TC, DDI	EFV	A62V, K65R, V75I	Y181C, G190S, P225H	K11T, V35I, E36D, T39N, K103R, K122E, D123N, A158S, Q174K, D177E, T200A, Q207A, R211S, V245M, E248D	A
	480	480_570	KJ870613	ABC, 3TC	EFV	A62V, L74I, V75VAIT, Y115F, M184V, K219KDEN	Y181C, G190S	K11T, V35IM, E36D, T39K, T58N, V90I, K122E, D123N, A158AS, K173S, Q174K, T200A, Q207A, R211S, Y232H, V245M, E248D	A
Wallis (2014)	41501	41501	KM458609	NRTI	NNRTI	A62V, M184V, K219KR	Y181C, M230ML	E6K, K11T, I31L, V35T, K66X, V118VI, D121H, K122E, I135T, K173S, D177E, V179I, T200A, Q207A, R211S, F214L	A
	41517	41517	KM458599	NRTI	NNRTI	K65KR, M184MV, K219KR	A98G, Y181C	K11T, K20KR, V21VI, L34LI, V35T, T39TA, V60I, S68SN, T69X, V90I, K122E, D123DN, I135T, K166KR, R172RK, K173A, Q174K, D177E, I178LM, T200A, Q207D, R211K, F214L, D218E	A
	41145	41145	KM458616	NRTI	NNRTI	D67N, K70KR, M184V, T215TFIS, K219KDEN	K101E, Y181C, G190A	V35T, T39M, V60I, D121Y, K122E, D123DEG, I135T, K173S, Q174K, D177E, I178LV, V179RS, G196E, Q207E, R211K, L228LH	A
	41687	41687	KM458586	NRTI	NNRTI	M184V	Y181C	K20R, V35T, E40D, K49KR, V60I, S68SG, K122E, D123N, I135T, K173L, Q174K, V179I, T200A, Q207A, R211S, F214L, H221Y	A
	41256	41256	KM458603	NRTI	NNRTI	D67G, V75I, M184V, T215Y	Y181C	K11T, K20R, V21I, V35T, V60I, S68G, K101KR, K122E, D123N, I132L, A158S, E169EAD, K173A, Q174K, D177E, V179I, Q207A, R211K	A
	41498	41498	KM458592	NRTI	NNRTI	D67GS, K70R, V75VI, M184V, T215F, K219E	V108I, Y181C	V35T, V60I, T69N, K122E, I132IL, I135T, K173L, Q174K, D177E, I178L, V179I, Q207A, R211S	A
Meini (2015)	111121	111121	KM438254	D4T, 3TC	NVP	M184V, T215F	Y181C, G190A	V35T, T39L, K49R, V60I, S68G, K122E, D123N, I135T, S162D, K173L, Q174K, D177E, I178M, V179I, Q207A, R211S, F214L	A
	111124	111124	KM438257	AZT, 3TC	NVP	M41ML, K70R, M184V, T215TI, K219Q	K103N, Y181C	E28K, K32KE, V35T, T39L, V60I, T69N, K122E, D123G, I135T, K173S, Q174K, V179I, T200TA, I202V, Q207A, R211S, F214L, L228R	A
	111129	111129	KM438262	AZT, 3TC	NVP	M41L, M184V, T215FY	V108VI, Y181C	V35T, T39Q, V60I, K122E, D123S, I135T, T139R, S162C, K173S, Q174K, I178M, V179I, Q207A, R211S, L228R	A
	109256	109256	KM438242	AZT, 3TC, DDI, D4T	NVP, EFV	M41L, D67N, K70R, M184V, L210W, T215Y, K219E	Y181C, G190A	V35T, T39A, E40D, V60I, T69N, K122E, D123S, K173S, Q174K, V179I, T200A, Q207A, R211S, E233EQ, V245Q	A
	109264	109264	KM438247	D4T, 3TC, DDI	NVP	M184V, T215F	K101E, V108I, Y181C	K20KR, V21I, V35T, E44ED, K49R, V60I, K122E, D123N, I135K, K173L, Q174K, D177E, I178M, T200A, Q207A, R211S, H221Y	A
Brooks (2016)	2009A	2009A		TDF, 3TC	NVP, EFV	K65R, M184V	A98G, V179F, Y181C, G190A	K20R, V35T, K43KR, V60I, K103R, D121Y, K122E, I135T, K173A, Q174K, D177E, T200A, Q207RS, R211NS	A
	2047A	2047A		TDF, 3TC	NVP	K65R, M184I	Y181C, M230L	V35T, V60I, T69S, D121H, K122E, I135T, K173A, Q174K, D177E, I178M, V179I, Q197E, T200A, E204D, Q207A, R211K	A
	2156A	2156A		TDF, 3TC	NVP	K65R, Y115F, M184V	K103N, Y181C	K20KR, K32R, V35T, V60I, K122E, D123S, I135T, T139A, K173A, Q174K, D177E, V179I, T200E, Q207A, R211K, F214L	A
	2202A	2202A		TDF, 3TC	NVP	K65R, Y115YF	Y181C	E6D, V35T, T39M, V60I, W88C, K122E, D123S, I135T, K173A, Q174K, D177E, V179I, Q207A, R211S, F214L, H221Y	A
	2187A	2187A		TDF, 3TC	NVP	K65R, M184V	V108I, Y181C	K20R, V35T, T39M, V60I, K101Q, K122E, I135T, K173S, Q174K, D177E, I178V, V179I, T200E, Q207A, R211K, F214L, H221Y	A
	2181A	2181A		TDF, 3TC	NVP	M41L, K65KR, L74V, M184V	K101E, Y181C, G190A	E6EK, E28A, V35T, T39E, V60I, T69S, D121H, K122E, I135T, I142V, K173S, Q174K, D177E, V179I, T200A, Q207A, R211S	A
Inzaule (2016)	1.0212	1.0212	HM164114	AZT, 3TC	NVP		Y181C	V35T, E40D, V60I, K122E, D123S, I135T, S162H, K173S, Q174K, D177E, V179I, G196E, Q207A, R211S, K238R, V245E, D250E, K281KR, T286A, E291D, V292I, I293V, E312N	A
Ndahimana (2016)	837	837	KU922867	TDF, 3TC	NVP	M184V, K219KE	A98G, Y181C	T39R, V60I, D123N, K173A, D177E, V179I, T200E, I202V, Q207A, R211K, V245Q	A
	1289	1289	KU922889	TDF, 3TC	NVP	A62V, K65R, M184V	L100I, Y181C, G190A	T39TA, K101R, V111I, K122E, D123S, I135T, I142V, T165I, K173S, D177E, V179I, T200A, Q207A, R211S, H221Y, V245Q	A
	1173	1173	KU922873	TDF, 3TC	NVP	K65KR, K70KE, M184V, K219KE	Y181C	E40D, K49R, V60I, S68SG, K122E, D123NS, I135T, S162A, K173S, Q174K, I178L, V179I, T200K, Q207A, R211S, F214L, H221HY, L228LR, V245Q	A
	868	868	KU922899	TDF, 3TC	NVP	K65R, K70R	K103N, Y181C	T39A, E40D, V60I, K122E, D123S, I135T, S162A, K173S, Q174K, D177E, Q207A, R211S, F214L, V245Q	A
	1506	1506	KU922881	TDF, 3TC	NVP	A62V, K65R, M184V	Y181C	T39A, K122E, D123S, I135T, T139KR, I142V, K173S, Q174K, D177E, V179I, T200A, E204Q, Q207E, R211K, F214L, L228Q	A
	957	957	KU922849	TDF, 3TC	NVP	K65R, M184I	Y181C	K49R, V60I, V90I, K101KR, K122E, D123N, I135T, I142V, W153R, S162A, K173A, Q174K, D177E, V179I, I195L, T200A, I202IV, Q207A, R211S, V245Q	A
	1445	1445	KU922876	TDF, 3TC	NVP	K65R, M184V, K219E	K101E, Y181C, G190A	T39A, K43R, V60I, S68G, I135T, T165I, K173A, Q174K, N175H, D177E, T200A, I202V, Q207A, R211K, V241I	A
	1346	1346	KU922869	TDF, 3TC	NVP	K65KR, K70KEGR, M184V	K101KE, Y181C, G190A	V60I, D121H, K122E, D123S, I135T, I142V, K173A, D177E, T200A, Q207E, R211K, V245E	A
	1520	1520	KU922863	TDF, 3TC	NVP	A62V, K65R, V75I, M184V	Y181C, G190A	T39A, E40D, K46Q, T58S, S68N, K122E, D123N, I135T, I142V, S162SN, K173S, D177E, I178IM, V179I, T200A, I202V, Q207A, F214L, V245Q	A
	1234	1234	KU922844	TDF, 3TC	NVP	K65R, Y115F, M184V	A98AG, Y181C	T39KN, V60I, K122E, D123G, I135T, S162A, K173S, Q174K, D177E, V179I, T200AE, Q207A, R211S, H221HY, V245Q	A
	930	930	KU922900	TDF, 3TC	NVP	M184V	Y181C	S48T, T69S, K122E, D123S, I135T, I142V, K173S, D177E, V179I, Q207A, R211S, D218DE, L228LR, V245Q	A
	1204	1204	KU922893	TDF, 3TC	NVP	A62V, K65R, M184V	K103N, Y181C	T39TA, E44ED, K122E, D123S, I135T, K173S, Q174K, D177E, V179T, T200A, Q207D, R211K, L228LR, P243T, V245E	A
	1251	1251	KU922843	TDF, 3TC	NVP	K70E, M184V	A98AG, Y181C	V60I, K101KR, D121H, K122E, I135T, K173S, Q174K, D177E, V179I, T200A, Q207A, R211K, L228R, V245Q	A
	1180	1180	KU922872	TDF, 3TC	EFV	K65R	K103N, Y181C	E44D, K104KR, V118I, K122KE, D123N, I135T, T165I, K173S, D177E, I178M, V179I, Q207A, R211S, F214L, V245Q	A
	1524	1524	KU922860	TDF, 3TC	NVP	K65R, K70KE, M184V	A98AG, K103KN, V108VI, Y181C	T39L, I50V, V60I, S68SN, K122E, D123S, I135T, I142V, K173S, Q174K, V179I, G196E, Q207A, R211S, F214L, H221Y, V245Q	A
	961	961	KU922848	TDF, 3TC	NVP	K65R, M184V	K101KE, Y181C, G190A	T39M, I47L, V60I, S68SN, V90VI, K122E, K173S, Q174K, V179I, Q197E, T200A, E204D, Q207A, R211S	A

Reverse Transcriptase Inhibitors

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