Reverse Transcriptase Inhibitors

HOME Genotype-Rx Genotype-Pheno Genotype-Clinical hivdb program

Reverse Transcriptase Inhibitors

Subtype	A
Gene	RT
Mutation	Y181C
Rx	>= 1 NNRTI (+/- NRTI)
IncludeMixtures	No

References	22
Patients	60
Isolates	64

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr)	Patient	Isolate	Acc#	NRTIs	NNRTIs	NRTIDRMs	NNRTIDRMs	OtherMut	Subtype
Yahi (2001)	NY_M35	M35	AY010501	D4T	NVP	K70N, V75T	V108I, Y181C	K20R, V35T, T39N, K104R, K122E, D123S, I135V, T139A, K173A, Q174K, D177E, Q207A, R211S, H221HY	A
Richard (2004)	RNJCR33	RNJCR33	AY556820	AZT, 3TC	NVP	K70R	Y181C	E6N, K11T, V21I, V35T, K122E, D123S, I135T, K173L, Q174K, D177E, V179I	A
	RNJCR41	RNJCR41	AY556837	AZT, 3TC, D4T, DDI	NVP	M41L, D67N, K70R, V75I	Y181C, G190A	K11T, K20R, V21I, V35T, D123S, E138A, S162A, T165L, K173S, V179I	A
Weber (2005)	F51354	F51354	AY677539	AZT, 3TC, DDC, D4T, DDI	NVP, EFV	D67DN, K70KR, L74LV, T215F	A98G, K103N, Y181C	K11T, K20R, V21I, V35T, T39L, N57NI, T69X, V106I, D123N, I135L, D177E, I178L, V179I, T200A, I202V, Q207A, R211X, V245Q, E248D, A272P, T286A, E291D, V292I, I293V, P294T, E312G	A
	F65588	F65588	AY677546	D4T, 3TC, DDI, DDC	NVP		Y181C	K11T, K20R, V21I, V35T, T39G, D123N, K173S, Q174QK, D177G, V179I, T200A, I202V, Q207A, R211S, H221Y, L228R, V245Q, E248N, A272P, T286A, E291D, I293V, P294T, E312N	A
	F30020	F30020-2	AY714407	3TC, DDI	NVP	K65R	Y181C	E6D, E28A, V35T, V60I, V118I, K122E, D123N, I135T, I159IL, K173S, Q174K, D177E, I178L, V179I, T200A, E204ED, Q207*E, R211K, F214L, V245Q, D250E, A272P, T286A, E291D, I293V, P294A, E312D, V317A	A
	M41984	M41984	AY677598	AZT, 3TC, D4T, DDI	EFV	M41L, D67N, K70R, V75M, M184V, L210W, T215Y, K219E	K103N, V108I, Y181C	V35T, V60I, K122E, D123S, I135T, K173S, Q174K, V179I, T200A, E203K, Q207D, R211K, D218E, H221Y, L228H, V245Q, D250E, A272T, E291D, V292I, I293V	A
	F74928	F74928	AY714434	D4T, DDI, AZT, 3TC	NVP	M184V	Y181C	E6K, T7A, V35T, T39L, V60I, D121H, K122E, I135T, T139R, I142V, K173A, Q174K, D177E, T200A, Q207A, R211S, F214L, D250E, E291D, V292I, I293V, P294T, E312D, S322A	A
		F74928	AY714470	D4T, DDI, AZT, 3TC	NVP	M184V	Y181C	E6K, V35T, T39L, D121H, K122E, I135T, T139R, I142V, K173A, Q174K, D177E, Q207A, R211S, D250E, T286A, E291D, V292I, I293V, P294T, E312D, S322A	A
	F56706	F56706	AY714472	AZT, DDI, 3TC, D4T	NVP	M184V	Y181C	E6K, V35T, T39L, D121H, K122E, I135T, T139R, I142V, K173A, Q174K, D177E, Q207A, R211S, D250E, T286A, E291D, V292I, I293V, P294T, E312D, S322A	A
Baxter (2006)	12-2120	2120-30715	DQ880034	NRTI	NNRTI	M41L, D67N, L74V, M184V, L210W, T215Y, K219R	Y181C, G190A	T39A, E44D, V60I, K101Q, V118I, K122E, D123N, I135T, K173S, Q174K, V179I, T200A, Q207E, H208Y, R211K, H221C, V245Q	A
		2120-40510	DQ880035	NRTI	NNRTI	M41L, D67N, L74V, L210W, T215Y, K219R	V106A, Y181C, G190A	T39A, E44D, V60I, K101Q, V118I, K122E, D123N, I135T, K173S, Q174K, V179I, T200A, Q207E, H208Y, R211K, H221C, V245Q	A
	48-1204	1204-30709	DQ877748	NRTI	NNRTI	M41L, D67N, L74V, M184V, L210W, T215Y, K219N	K103S, Y181C, G190A	P4S, V35T, T39A, E44D, K64R, K101Q, K122E, D123S, T165I, K173S, Q174K, D177E, I178L, V179I, T200A, I202V, E203D, Q207N, H208Y, R211N, W212C, H221Y, L228H, V245T, D250E, A272P, K281R, I293V, P294T, G335D, M357R, G359S, T369A, A371V, I375V, A376V, T377M, T386S	A
	48-1253	1253-30605	DQ877778	NRTI	NNRTI		Y181C	V35T, K49R, I50IV, V60I, K122E, K173L, Q174K, D177E, I178IM, V179I, T200A, Q207A, R211S, D218DE, V245Q, E248D, D250E, A272P, K277R, T286A, E291D, V292I, I293V, Q334HR, G335D, M357K, R358G, G359S, K366R, E370A, A371V, I375V, T377M	A
	48-3045	3045-30317	DQ877957	NRTI	NNRTI	D67N, L74V, Y115F, M184V, T215F, K219Q	Y181C, G190A	T7A, K11T, K20KR, V35T, T39R, K43E, K101Q, D121H, K122E, D123S, I135T, K173S, Q174K, N175Y, D177E, G196E, Q207A, V245Q, T286A, E291D, K311R, M357K, R358K, G359S, K366R, T369V, E370D, A371V, I375V, A376I, T386I	A
	48-3316	3316-30818	DQ878217	NRTI	NNRTI	A62V, K65R, V75I, F77L, F116Y, Q151M	K101N, K103H, Y181C, G190A	P4K, K11T, V35T, T39E, S68G, V118I, D121Y, K122E, D123S, A158S, R172K, K173S, Q174K, D177E, I195L, G196E, Q207A, R211S, F214L, H221Y, V245Q, T286A, E291D, I293V, E297K, E312D, H315Q, V317A, I326T, Q334D, R356K, M357K, G359S, T362S, K366R, T369V, E370D, A371V, I375V, A376S, K390R	A
	48-4018	4018-30227	DQ878252	NRTI	NNRTI	D67N, K70R, L74V, Y115F, M184V, K219Q	K103N, Y181C, G190A	K11T, M16V, K20R, V35T, T39N, D121H, K122E, I135T, I142T, T165I, K173A, Q174R, D177E, G196E, T200A, Q207A, F214FL, H221Y, L228LR, V245Q, K277R, T286A, E291D, I293V, G335D, R356K, M357K, G359S, K366R, A371LV, I375V, A376S, V381I, T386I	A
	48-4153	4153-30326	DQ878387	NRTI	NNRTI	M41L, D67S, K70R, M184MIV, T215F, K219E	Y181C, G190A	P4S, K11T, K20R, V21I, V35T, T39Q, T69N, L109I, K122E, D123N, I135T, N137H, K173S, Q174K, D177E, T200A, I202V, Q207A, R211K, D218E, V245Q, E248D, T286A, E291D, V292I, I293V, P294T, E312G, G335D, M357Q, R358K, G359S, T369TA, A371V, I375V, A376S, K390R	A
	48-5021	5021-30606	DQ878555	NRTI	NNRTI	M41L, T69S_SG, L74I, M184V, T215F	Y181C	E6EK, K20R, V35T, T39A, K122E, I135T, K173L, Q174K, D177E, I178IM, V179I, T200A, Q207A, R211A, V245Q, D250E, A272P, K277R, T286A, E291D, V292I, I293V, P294T, G335D, M357S, G359S, T369A, A371V, I375V, A376V, T377M, T386A	A
	48-5031	5031-30421	DQ878557	NRTI	NNRTI	D67N, K70R, M184V, T215F, K219E	Y181C, G190A	K20R, T27S, V35T, V60I, T69N, K122Q, I135T, K173A, Q174K, V179I, Q207A, L228H, V245K, D250E, K281R, T286A, E291D, I293V, P294T, E312D, G335D, M357K, G359S, T369V, A371V, I375V, T377M, K390R	A
Laurent (2006)	CK22-50	03CM2-50	AM279458	D4T, 3TC	NVP	K65R, M184V	Y181C	I5V, K11A, E28K, I31L, K32E, V35T, T39K, S48T, K49R, V60I, D121Y, K122E, I135T, S162C, E169D, K173A, Q174K, G196E, Q207A, R211S, V245Q, D250G, L283I, E291D, I293V, E297A, G335D, R356K, M357R, G359S, T369I, A371V, I375V, K390R, A400T, T403M, E432T	A
Lwembe (2007)	NYU62	62MMAY04		AZT, 3TC	NVP	D67N, K70R, T215I, K219E	Y181C, G190A	V35T, E40D, V60I, K101Q, V106I, K122E, D123G, K173L, Q174K, D177E, V179I, T200A, Q207A, R211S	A
	NYU79	79MJUN04		AZT, 3TC, DDI	NVP, EFV	V75M, M184V	K101E, Y181C, G190A	E28A, V35T, T39A, E40D, T69S, D121H, K122E, I135T, T139I, K173S, Q174K, D177E, I178V, V179I, T200A, Q207A, R211S	A
Church (2008)	361358A	361358A	EU380729	None	NVP		Y181C	V21I, V35T, K49R, I50V, V60I, K122E, D123S, E169D, K173A, Q174K, D177E, V179I, I202V, Q207A, R211S, V245E, D250E, A272P, K277R, L283I, I293V, K311R, E312N, S322A	A
	362363H	362363H	EU380730	None	NVP		Y181C	K11T, K20R, V21I, V35T, T39R, D123N, S162SC, K173S, D177E, V179I, T200A, I202V, Q207A, R211K, V245E, D250E, T286A, E291D, V292I, I293V, P294T, K311R, E312D	A
	367927-J	367927-J	EU380735	None	NVP		Y181C	K20R, V21I, V35T, T39R, K43E, V60I, I135R, S162A, K173S, Q174K, V179I, Q207A, R211S, V245Q, D250E, S251D, E291D, V292I, I293V, P294T, E312D, D320E, D324E	A
	390900V	390900V	EU380746	None	NVP		Y181C	K11T, V35T, E40D, K43R, T139I, K173S, D177E, V179I, T200A, Q207A, R211S, F214L, V245Q, A272T, E291D, I293V, P294T, E312D, D320E	A
	400177E	400177E	EU380750	None	NVP		K103KN, Y181C	P4S, V21I, K32R, V35T, T39A, E40D, V60I, T107S, K122E, D123N, I142V, K173A, Q174K, D177E, T200A, Q207E, R211K, H221HY, V245E, D250E, T286A, E291D, I293V, E312D, I329V	A
	413282X	413282X	EU380756	None	NVP		Y181C	K11T, K20R, V21I, V35T, T39K, T69S, K122E, D123N, K173S, V179I, I202V, Q207A, V245M, E248N, T286A, E291D, V292I, I293V, P294T, E312D, V317I	A
Gody (2008)	Pt041	Pt041		D4T, 3TC	NVP	M41L, M184V	Y181C, G190A	K49R, V60I, K101D, D121H, K122E, I135T, K173A, Q174K, D177E, I178L, T200A, Q207A, R211S, K238R	A
	Pt047	Pt047		D4T, 3TC	NVP	K65KR	K101E, Y181C, G190A	K11AT, V35L, S68SG, S105SA, D121HY, K122E, I135IV, K173A, Q174K, D177E, G196E, Q207A, R211N, L228LR, V245Q, E248DN, D250DE, K281R, T286A, E291D, I293V	A
Hawkins (2009)	P628	ZZP628	FJ931135	D4T, 3TC	NVP	A62V, M184V	Y181C	E6Q, K11T, V35T, T39K, K43E, D123E, T139K, I142V, A158T, S162H, F171Y, K173S, D177E, I178L, V179I, T200A, Q207A, R211K, V245Q, E248D, T286A, E291D, V292I, I293V, P294T, I326V	A
	P671	ZZP671	FJ931165	D4T, 3TC	NVP	V75VI, M184V	Y181C	E6EK, T7TP, V35T, T39TR, V60I, K102Q, D121H, K122E, I132IL, I135T, T139TR, S162SC, S163ST, K166KN, K173A, D177E, I178L, E204K, Q207E, R211K, D250E, K281R, T286A, E291D, P294T, I326V, I329L	A
	P963	ZZP963	FJ931176	D4T, 3TC	NVP	K65R, Q151M, M184V	K103N, Y181C	E28K, V35T, T39E, S68G, I135T, K173L, Q174K, T200A, Q207A, R211K, F214L, I244V, V245L, A272P, K281KR, T286A, I293V, E297EQ, I326V	A
	R40	ZZR40	FJ931279	D4T, 3TC	NVP	M41L, L74V, M184V, L210W, T215Y	A98G, V108I, Y181C	I5V, E28K, K32E, V35T, E36A, T39K, K43E, D86E, V118I, D121H, K122E, I135T, I142V, S162Y, K173T, Q174K, D177E, V179I, T200A, I202V, Q207D, R211K, H221Y, V245Q, T286A, E291D, V292I, I293V, P294T, E312D, I326V	A
	Q956	ZZQ956	FJ931325	D4T, 3TC	NVP	D67DN, K70KR, M184V	K101E, Y181C	I5V, K11A, E28K, V35T, T39K, D121Y, K122E, I135T, I142T, E169D, K173A, Q174K, G196E, Q207A, R211S, V245Q, T286A, E291D, I293V	A
Rey (2009)	9	9w24		TDF, 3TC	NVP	K65R	Y181C, G190A	T39N, G51GR, K122E, D123G, E169D, K173A, Q174K, D177E, G196E, Q207A, R211S, G213GR, V245Q	A
Steegen (2009)	BV264	BV264-2	EU872142	3TC, D4T	NVP	K65R, V75I, M184V	Y181C, G190A	V35T, V60I, D121H, K122E, I132L, I135T, I142IV, S162C, K173L, Q174K, Q207A, R211S	A
Moussa (2010)	4	23-CP001745	HM117953	D4T, 3TC	EFV	M184V, L210W	K101E, Y181C, G190S	V35T, T39L, T107S, K122E, D123S, K173A, D177G, T200A, Q207E, R211K	A
	25	11-CP001021	HM117952	D4T, 3TC	NVP	M184V, T215F	A98G, K101E, Y181C, G190A	E28K, K32E, V35T, T39M, K122E, D123N, I135T, I142V, K173A, Q174K, D177E, I178M, T200A, Q207A, V245K	A
Ndembi (2010)	13929D_P1	13929	GQ409560	AZT, 3TC	NVP	M184V, T215Y	Y181C	I31L, V35T, V60I, T69TN, D121H, I142V, D177E, Q207A, R211S, H221Y	A
	16233D_05_P1	16233	GQ409633	AZT, 3TC	NVP	M184V	Y181C	E6D, K32R, V35T, K49R, V60I, K122E, D123S, I135T, T139R, K173S, Q174K, Q207A, R211K	A
Towler (2010)	11	416275-M	HM037886	D4T, 3TC	NVP	D67DG, M184V	Y181C	I31L, V35T, T39K, K49R, V60I, T69TKN, K122E, I135T, S162N, K173L, Q174K, D177E, V179I, G196E, T200A, I202V, Q207A, R211S, F214L, V245E, D250E, T286A, E291D, I293V, P294T	A
		503727-G	HM037897	D4T, 3TC	NVP	M41ML, D67DG, M184V, T215F	Y181C	I31IL, L34LI, V35T, T39K, K49R, V60I, T69TN, V118VI, K122E, I135T, S162D, S163SR, K173L, Q174K, D177E, V179I, G196E, T200A, I202V, Q207A, R211S, F214L, V245E, D250E, T286A, E291D, I293V, P294T	A
	2	519810-R	HM037891	D4T, 3TC	NVP	K70KR, M184V	Y181C	K20R, V35T, T39N, E40D, K49KR, T69N, I135IT, A158S, K173S, T200A, Q207A, R211K, H221HY, L228LR, V245Q, D250E, S251H, A272P, T286A, E291D, V292I, I293V, P294A, K311R, E312D	A
	3or5	521684-A	HM037892	D4T, 3TC	NVP	M184V	Y181C	K11S, V35I, I47L, S48T, V60I, K122E, D123S, I135T, T139R, K173S, Q174K, V179I, T200A, Q207A, R211T, V245Q, E248D, D250E, K275Q, T286A, E291D, V292VI, I293V, P294T, K311R	A
	4	529392-J	HM037893	D4T, 3TC	NVP	V75VI, M184V	V108VI, Y181C	K20R, V21I, V35T, T39A, E40D, T69N, K122E, D123N, I132IL, I135T, K173S, Q174K, D177E, V179I, T200A, I202V, Q207A, H221HY, V245Q, E248D, K281R, T286A, E291D, I293V, P294T	A
Charpentier (2011)	18	CP 001 2151		D4T, 3TC	NVP	K65KR, M184MV, K219KN	A98AG, K103KN, Y181C	K11ST, V35T, T39N, K102KR, D121H, K122E, D123S, T139TK, K173S, D177DE, G196E, T200A, Q207A, R211S, H221HY, V245Q, K277R, Q278H, K281R, T286A, E291D, I293V, E312DN, G333GE	A
	23	CP 001 2052		D4T, 3TC	NVP	V75I, M184V	Y181C	K11T, P14PT, I31IL, V35T, T39N, V90VI, K104KN, D121H, K122E, D123S, I132L, I135T, S162C, K173S, Q174K, D177E, G196E, T200A, Q207A, R211K, H221HY, V245Q, A272AP, T286A, E291D, I293IV, E297K	A
	30	CP 001 399		D4T, 3TC	NVP	K65R, D67H, T69D, K219EG	K103N, Y181C, G190A	E6D, K11T, K20R, V35T, T39KR, K43E, S68G, V90I, D121H, K122E, I135M, I142V, S162A, K173A, Q174K, D177E, I178L, T200A, E204K, Q207A, R211S, F214L, L228R, V245E, T286A, E291D, V292I, I293V, E297K, A304E, P313T, I329V	A
	31	CP 005 026		D4T, 3TC	NVP	K65R, T69~, K70KN, K219R	Y181C, G190A	K11T, V21I, L34I, V35T, T39E, S68SDGN, K82KR, V90VI, K101KQ, D121H, K122E, K173S, D177E, G196E, E204Q, Q207D, F214L, H221Y, V245Q, D250E, S251DG, L283LI, E291ED, I293V, P294T, L295F, E297K, E312D	A
	33	CP 001 621a		D4T, 3TC	NVP		Y181C, G190GA	E6D, V35T, T39K, K43E, T69N, T107S, K122E, D123S, K173I, Q174K, D177E, I178M, V179I, G196E, T200A, Q207A, R211S, F214FL, L228R, K238KR, V245E, K277R, T286A, E291D, I293V, K311KR, E312N, I326IV	A
	77	CP 001 2322		D4T, 3TC	NVP	M184V	K101KE, V106VA, Y181C	K11AT, V35T, T39D, K64R, D121HY, K122E, K173S, Q174K, D177E, I178M, G196E, T200K, Q207A, R211S, V245Q, A272P, Q278H, T286A, E291D, I293V, P321S, I326L	A
	121	CP 001 724		D4T, 3TC	NVP	A62V, V75I, F116Y, Q151M, M184V	A98G, Y181C	I31L, V35T, T39R, K43E, S68SG, N81ND, D121H, K122E, I135IT, I142V, K173A, Q174K, D177E, G196GE, T200A, Q207A, R211S, K238R, V245E, A272P, K281R, E291D, I293V, E312N, D324E	A
	148	CP 001 621b		D4T, 3TC	NVP		Y181C, G190A	E6D, V35T, T39K, K43E, T69N, T107S, K122E, D123S, K173I, Q174K, D177E, I178M, V179I, G196E, T200A, Q207A, R211S, F214FL, L228R, K238KR, V245E, K277R, T286A, E291D, I293V, K311KR, E312N, I326IV	A
	179	CP 001 1982		D4T, 3TC	NVP	K65KR, M184V	V108I, Y181C	E6D, K11T, V35T, T39N, V60I, K122E, D123S, I135IL, A158T, K173S, D177E, T200A, E203K, Q207D, L228LR, V245Q, A272P, K281R, E291D, V292VI, I293V, I326V	A
Kouri (2012)	CU376-10	CU376-10	JQ585390	NRTI	NNRTI	D67N, K70R, M184V, T215F, K219E	V108I, Y181C	V35T, T39K, E40D, T69N, K122E, D123S, I135IT, K173S, Q174K, V179I, G196E, T200A, R206K, Q207A, R211S, L228H, V245Q, E248N, K281KR, T286A, E291D, V292I, I293V, P294T, Q334H, G335D	A
Reynolds (2012)	K0808	K0808-1	JN652204	D4T, 3TC	NVP	M184V	V108VI, Y181C	I31IL, V35T, E40D, K49R, V60I, K122E, D123S, I135T, K173S, Q174K, D177E, V179I, T200A, Q207A, R211S, V245K, D250E, K281R, T286A, E291D, I293V, P294T	A
Aghokeng (2013)	HJ3169	HJ3169	JX983028	NRTI	NNRTI	D67DN, T69D, K70KR, M184V, T215F	Y181C, G190A	K11T, V35T, T39K, K43E, Y56YS, N57NI, K122E, D123S, E169D, K173A, Q174K, D177E, E194Q, G196E, Q197K, T200A, Q207A, R211S, F214L, V245Q, E248D, T286A, E291D, I293V, E312N, G335D, N348T, M357K, R358K, G359S, K366R, E370N, A371V, I375V, K390R, A400T, T403M, E404D	A
Pircher (2013)	B1108	B1108	JX110210	D4T, 3TC, AZT	NVP	D67N, K70R, V75A, F77L, Q151M, M184V, T215I, K219Q	V179E, Y181C, G190A	V35T, T39N, K46KQ, V60I, K73L, K101R, K103R, V111I, K122E, D123S, I135T, I142V, K173A, T200A, Q207E, R211K, F214L, D218E, L228H, V245Q	A
Rawizza (2013)	LM3929	LM3929	KF241482	NRTI	NNRTI	D67N, K70R, M184V, T215F, K219E	V108VI, Y181C	P4S, T27S, V35T, T39K, K43A, T69TN, V90I, K102Q, V111I, D123E, I142V, S162Y, K173S, D177DE, V179I, T200A, Q207A, R211K, P243PS, V245T, E248D, T286A, E291D, I293V, P294PT	A
Sigaloff (2013)	JCR109_0	JCR109_0	JX182002	NRTI	NNRTI	D67N, K70R, M184V, T215I, K219E	A98G, Y181C	E6S, V35T, V60I, D121Y, K122E, I135IT, K173T, Q174K, D177E, V179I, G190X, I202V, Q207A, R211S, F214L, L228H, V245E, E248D, D250E, I293V, P294T	A
	MBA046_0	MBA046_0	JX182017	NRTI	NNRTI	M184V	A98G, K103N, Y181C	E6D, V21I, E28EK, V35T, T39A, E40D, V60I, K122E, D123N, I135T, S162A, K173S, Q174K, D177E, V179I, T200A, I202V, Q207E, R211S, V245E, D250E, S251H, K281R, T286A, E291D, V292I, I293V, P294T, K311R	A
Thiam (2013)	2666-HALD	2666-HALD	JN673686	NRTI	NNRTI	M184V	Y181C	E6Q, K11T, V35T, E36A, T39K, K43E, D86E, D121H, K122E, I135T, I142V, S162F, M164*, T165Q, K173S, T200A, Q207A, V245E, K281R, T286A, E291D, V292I, I293V, P294T, L295M, K311R, Y319YH, S322T	A

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