<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Reverse Transcriptase Inhibitors

Subtype A
Gene RT
Mutation Y181C
Rx >= 1 NNRTI
(+/- NRTI)
IncludeMixtures No
References 16
Patients 53
Isolates 57
 
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# NRTIs NNRTIsNRTIDRMs NNRTIDRMs OtherMutSubtype
Yahi (2001)NY_M35M35AY010501D4TNVPK70N, V75TV108I, Y181CK20R, V35T, T39N, K104R, K122E, D123S, I135V, T139A, K173A, Q174K, D177E, Q207A, R211S, H221HYA
Richard (2004)RNJCR33RNJCR33AY556820AZT, 3TCNVPK70RY181CE6N, K11T, V21I, V35T, K122E, D123S, I135T, K173L, Q174K, D177E, V179IA
 RNJCR41RNJCR41AY556837AZT, 3TC, D4T, DDINVPM41L, D67N, K70R, V75IY181C, G190AK11T, K20R, V21I, V35T, D123S, E138A, S162A, T165L, K173S, V179IA
Weber (2005)F51354F51354AY677539AZT, 3TC, DDC, D4T, DDINVP, EFVD67DN, K70KR, L74LV, T215FA98G, K103N, Y181CK11T, K20R, V21I, V35T, T39L, N57NI, T69X, V106I, D123N, I135L, D177E, I178L, V179I, T200A, I202V, Q207A, R211X, V245Q, E248D, A272P, T286A, E291D, V292I, I293V, P294T, E312GA
 F65588F65588AY677546D4T, 3TC, DDI, DDCNVP Y181CK11T, K20R, V21I, V35T, T39G, D123N, K173S, Q174QK, D177G, V179I, T200A, I202V, Q207A, R211S, H221Y, L228R, V245Q, E248N, A272P, T286A, E291D, I293V, P294T, E312NA
 F30020F30020-2AY7144073TC, DDINVPK65RY181CE6D, E28A, V35T, V60I, V118I, K122E, D123N, I135T, I159IL, K173S, Q174K, D177E, I178L, V179I, T200A, E204ED, Q207*E, R211K, F214L, V245Q, D250E, A272P, T286A, E291D, I293V, P294A, E312D, V317AA
 M41984M41984AY677598AZT, 3TC, D4T, DDIEFVM41L, D67N, K70R, V75M, M184V, L210W, T215Y, K219EK103N, V108I, Y181CV35T, V60I, K122E, D123S, I135T, K173S, Q174K, V179I, T200A, E203K, Q207D, R211K, D218E, H221Y, L228H, V245Q, D250E, A272T, E291D, V292I, I293VA
 F74928F74928AY714434D4T, DDI, AZT, 3TCNVPM184VY181CE6K, T7A, V35T, T39L, V60I, D121H, K122E, I135T, T139R, I142V, K173A, Q174K, D177E, T200A, Q207A, R211S, F214L, D250E, E291D, V292I, I293V, P294T, E312D, S322AA
  F74928AY714470D4T, DDI, AZT, 3TCNVPM184VY181CE6K, V35T, T39L, D121H, K122E, I135T, T139R, I142V, K173A, Q174K, D177E, Q207A, R211S, D250E, T286A, E291D, V292I, I293V, P294T, E312D, S322AA
 F56706F56706AY714472AZT, DDI, 3TC, D4TNVPM184VY181CE6K, V35T, T39L, D121H, K122E, I135T, T139R, I142V, K173A, Q174K, D177E, Q207A, R211S, D250E, T286A, E291D, V292I, I293V, P294T, E312D, S322AA
Baxter (2006)12-21202120-30715DQ880034NRTINNRTIM41L, D67N, L74V, M184V, L210W, T215Y, K219RY181C, G190AT39A, E44D, V60I, K101Q, V118I, K122E, D123N, I135T, K173S, Q174K, V179I, T200A, Q207E, H208Y, R211K, H221C, V245QA
  2120-40510DQ880035NRTINNRTIM41L, D67N, L74V, L210W, T215Y, K219RV106A, Y181C, G190AT39A, E44D, V60I, K101Q, V118I, K122E, D123N, I135T, K173S, Q174K, V179I, T200A, Q207E, H208Y, R211K, H221C, V245QA
 48-12041204-30709DQ877748NRTINNRTIM41L, D67N, L74V, M184V, L210W, T215Y, K219NK103S, Y181C, G190AP4S, V35T, T39A, E44D, K64R, K101Q, K122E, D123S, T165I, K173S, Q174K, D177E, I178L, V179I, T200A, I202V, E203D, Q207N, H208Y, R211N, W212C, H221Y, L228H, V245T, D250E, A272P, K281R, I293V, P294T, G335D, M357R, G359S, T369A, A371V, I375V, A376V, T377M, T386SA
 48-12531253-30605DQ877778NRTINNRTI Y181CV35T, K49R, I50IV, V60I, K122E, K173L, Q174K, D177E, I178IM, V179I, T200A, Q207A, R211S, D218DE, V245Q, E248D, D250E, A272P, K277R, T286A, E291D, V292I, I293V, Q334HR, G335D, M357K, R358G, G359S, K366R, E370A, A371V, I375V, T377MA
 48-30453045-30317DQ877957NRTINNRTID67N, L74V, Y115F, M184V, T215F, K219QY181C, G190AT7A, K11T, K20KR, V35T, T39R, K43E, K101Q, D121H, K122E, D123S, I135T, K173S, Q174K, N175Y, D177E, G196E, Q207A, V245Q, T286A, E291D, K311R, M357K, R358K, G359S, K366R, T369V, E370D, A371V, I375V, A376I, T386IA
 48-33163316-30818DQ878217NRTINNRTIA62V, K65R, V75I, F77L, F116Y, Q151MK101N, K103H, Y181C, G190AP4K, K11T, V35T, T39E, S68G, V118I, D121Y, K122E, D123S, A158S, R172K, K173S, Q174K, D177E, I195L, G196E, Q207A, R211S, F214L, H221Y, V245Q, T286A, E291D, I293V, E297K, E312D, H315Q, V317A, I326T, Q334D, R356K, M357K, G359S, T362S, K366R, T369V, E370D, A371V, I375V, A376S, K390RA
 48-40184018-30227DQ878252NRTINNRTID67N, K70R, L74V, Y115F, M184V, K219QK103N, Y181C, G190AK11T, M16V, K20R, V35T, T39N, D121H, K122E, I135T, I142T, T165I, K173A, Q174R, D177E, G196E, T200A, Q207A, F214FL, H221Y, L228LR, V245Q, K277R, T286A, E291D, I293V, G335D, R356K, M357K, G359S, K366R, A371LV, I375V, A376S, V381I, T386IA
 48-41534153-30326DQ878387NRTINNRTIM41L, D67S, K70R, M184MIV, T215F, K219EY181C, G190AP4S, K11T, K20R, V21I, V35T, T39Q, T69N, L109I, K122E, D123N, I135T, N137H, K173S, Q174K, D177E, T200A, I202V, Q207A, R211K, D218E, V245Q, E248D, T286A, E291D, V292I, I293V, P294T, E312G, G335D, M357Q, R358K, G359S, T369TA, A371V, I375V, A376S, K390RA
 48-50215021-30606DQ878555NRTINNRTIM41L, T69S_SG, L74I, M184V, T215FY181CE6EK, K20R, V35T, T39A, K122E, I135T, K173L, Q174K, D177E, I178IM, V179I, T200A, Q207A, R211A, V245Q, D250E, A272P, K277R, T286A, E291D, V292I, I293V, P294T, G335D, M357S, G359S, T369A, A371V, I375V, A376V, T377M, T386AA
 48-50315031-30421DQ878557NRTINNRTID67N, K70R, M184V, T215F, K219EY181C, G190AK20R, T27S, V35T, V60I, T69N, K122Q, I135T, K173A, Q174K, V179I, Q207A, L228H, V245K, D250E, K281R, T286A, E291D, I293V, P294T, E312D, G335D, M357K, G359S, T369V, A371V, I375V, T377M, K390RA
Laurent (2006)CK22-5003CM2-50AM279458D4T, 3TCNVPK65R, M184VY181CI5V, K11A, E28K, I31L, K32E, V35T, T39K, S48T, K49R, V60I, D121Y, K122E, I135T, S162C, E169D, K173A, Q174K, G196E, Q207A, R211S, V245Q, D250G, L283I, E291D, I293V, E297A, G335D, R356K, M357R, G359S, T369I, A371V, I375V, K390R, A400T, T403M, E432TA
Lwembe (2007)NYU6262MMAY04 AZT, 3TCNVPD67N, K70R, T215I, K219EY181C, G190AV35T, E40D, V60I, K101Q, V106I, K122E, D123G, K173L, Q174K, D177E, V179I, T200A, Q207A, R211SA
 NYU7979MJUN04 AZT, 3TC, DDINVP, EFVV75M, M184VK101E, Y181C, G190AE28A, V35T, T39A, E40D, T69S, D121H, K122E, I135T, T139I, K173S, Q174K, D177E, I178V, V179I, T200A, Q207A, R211SA
Church (2008)361358A361358AEU380729NoneNVP Y181CV21I, V35T, K49R, I50V, V60I, K122E, D123S, E169D, K173A, Q174K, D177E, V179I, I202V, Q207A, R211S, V245E, D250E, A272P, K277R, L283I, I293V, K311R, E312N, S322AA
 362363H362363HEU380730NoneNVP Y181CK11T, K20R, V21I, V35T, T39R, D123N, S162SC, K173S, D177E, V179I, T200A, I202V, Q207A, R211K, V245E, D250E, T286A, E291D, V292I, I293V, P294T, K311R, E312DA
 367927-J367927-JEU380735NoneNVP Y181CK20R, V21I, V35T, T39R, K43E, V60I, I135R, S162A, K173S, Q174K, V179I, Q207A, R211S, V245Q, D250E, S251D, E291D, V292I, I293V, P294T, E312D, D320E, D324EA
 390900V390900VEU380746NoneNVP Y181CK11T, V35T, E40D, K43R, T139I, K173S, D177E, V179I, T200A, Q207A, R211S, F214L, V245Q, A272T, E291D, I293V, P294T, E312D, D320EA
 400177E400177EEU380750NoneNVP K103KN, Y181CP4S, V21I, K32R, V35T, T39A, E40D, V60I, T107S, K122E, D123N, I142V, K173A, Q174K, D177E, T200A, Q207E, R211K, H221HY, V245E, D250E, T286A, E291D, I293V, E312D, I329VA
 413282X413282XEU380756NoneNVP Y181CK11T, K20R, V21I, V35T, T39K, T69S, K122E, D123N, K173S, V179I, I202V, Q207A, V245M, E248N, T286A, E291D, V292I, I293V, P294T, E312D, V317IA
Gody (2008)Pt041Pt041 D4T, 3TCNVPM41L, M184VY181C, G190AK49R, V60I, K101D, D121H, K122E, I135T, K173A, Q174K, D177E, I178L, T200A, Q207A, R211S, K238RA
 Pt047Pt047 D4T, 3TCNVPK65KRK101E, Y181C, G190AK11AT, V35L, S68SG, S105SA, D121HY, K122E, I135IV, K173A, Q174K, D177E, G196E, Q207A, R211N, L228LR, V245Q, E248DN, D250DE, K281R, T286A, E291D, I293VA
Hawkins (2009)P628ZZP628FJ931135D4T, 3TCNVPA62V, M184VY181CE6Q, K11T, V35T, T39K, K43E, D123E, T139K, I142V, A158T, S162H, F171Y, K173S, D177E, I178L, V179I, T200A, Q207A, R211K, V245Q, E248D, T286A, E291D, V292I, I293V, P294T, I326VA
 P671ZZP671FJ931165D4T, 3TCNVPV75VI, M184VY181CE6EK, T7TP, V35T, T39TR, V60I, K102Q, D121H, K122E, I132IL, I135T, T139TR, S162SC, S163ST, K166KN, K173A, D177E, I178L, E204K, Q207E, R211K, D250E, K281R, T286A, E291D, P294T, I326V, I329LA
 P963ZZP963FJ931176D4T, 3TCNVPK65R, Q151M, M184VK103N, Y181CE28K, V35T, T39E, S68G, I135T, K173L, Q174K, T200A, Q207A, R211K, F214L, I244V, V245L, A272P, K281KR, T286A, I293V, E297EQ, I326VA
 R40ZZR40FJ931279D4T, 3TCNVPM41L, L74V, M184V, L210W, T215YA98G, V108I, Y181CI5V, E28K, K32E, V35T, E36A, T39K, K43E, D86E, V118I, D121H, K122E, I135T, I142V, S162Y, K173T, Q174K, D177E, V179I, T200A, I202V, Q207D, R211K, H221Y, V245Q, T286A, E291D, V292I, I293V, P294T, E312D, I326VA
 Q956ZZQ956FJ931325D4T, 3TCNVPD67DN, K70KR, M184VK101E, Y181CI5V, K11A, E28K, V35T, T39K, D121Y, K122E, I135T, I142T, E169D, K173A, Q174K, G196E, Q207A, R211S, V245Q, T286A, E291D, I293VA
Rey (2009)99w24 TDF, 3TCNVPK65RY181C, G190AT39N, G51GR, K122E, D123G, E169D, K173A, Q174K, D177E, G196E, Q207A, R211S, G213GR, V245QA
Steegen (2009)BV264BV264-2EU8721423TC, D4TNVPK65R, V75I, M184VY181C, G190AV35T, V60I, D121H, K122E, I132L, I135T, I142IV, S162C, K173L, Q174K, Q207A, R211SA
Moussa (2010)423-CP001745HM117953D4T, 3TCEFVM184V, L210WK101E, Y181C, G190SV35T, T39L, T107S, K122E, D123S, K173A, D177G, T200A, Q207E, R211KA
 2511-CP001021HM117952D4T, 3TCNVPM184V, T215FA98G, K101E, Y181C, G190AE28K, K32E, V35T, T39M, K122E, D123N, I135T, I142V, K173A, Q174K, D177E, I178M, T200A, Q207A, V245KA
Ndembi (2010)13929D_P113929GQ409560AZT, 3TCNVPM184V, T215YY181CI31L, V35T, V60I, T69TN, D121H, I142V, D177E, Q207A, R211S, H221YA
 16233D_05_P116233GQ409633AZT, 3TCNVPM184VY181CE6D, K32R, V35T, K49R, V60I, K122E, D123S, I135T, T139R, K173S, Q174K, Q207A, R211KA
Towler (2010)11416275-MHM037886D4T, 3TCNVPD67DG, M184VY181CI31L, V35T, T39K, K49R, V60I, T69TKN, K122E, I135T, S162N, K173L, Q174K, D177E, V179I, G196E, T200A, I202V, Q207A, R211S, F214L, V245E, D250E, T286A, E291D, I293V, P294TA
  503727-GHM037897D4T, 3TCNVPM41ML, D67DG, M184V, T215FY181CI31IL, L34LI, V35T, T39K, K49R, V60I, T69TN, V118VI, K122E, I135T, S162D, S163SR, K173L, Q174K, D177E, V179I, G196E, T200A, I202V, Q207A, R211S, F214L, V245E, D250E, T286A, E291D, I293V, P294TA
 2519810-RHM037891D4T, 3TCNVPK70KR, M184VY181CK20R, V35T, T39N, E40D, K49KR, T69N, I135IT, A158S, K173S, T200A, Q207A, R211K, H221HY, L228LR, V245Q, D250E, S251H, A272P, T286A, E291D, V292I, I293V, P294A, K311R, E312DA
 3or5521684-AHM037892D4T, 3TCNVPM184VY181CK11S, V35I, I47L, S48T, V60I, K122E, D123S, I135T, T139R, K173S, Q174K, V179I, T200A, Q207A, R211T, V245Q, E248D, D250E, K275Q, T286A, E291D, V292VI, I293V, P294T, K311RA
 4529392-JHM037893D4T, 3TCNVPV75VI, M184VV108VI, Y181CK20R, V21I, V35T, T39A, E40D, T69N, K122E, D123N, I132IL, I135T, K173S, Q174K, D177E, V179I, T200A, I202V, Q207A, H221HY, V245Q, E248D, K281R, T286A, E291D, I293V, P294TA
Charpentier (2011)18CP 001 2151 D4T, 3TCNVPK65KR, M184MV, K219KNA98AG, K103KN, Y181CK11ST, V35T, T39N, K102KR, D121H, K122E, D123S, T139TK, K173S, D177DE, G196E, T200A, Q207A, R211S, H221HY, V245Q, K277R, Q278H, K281R, T286A, E291D, I293V, E312DN, G333GEA
 23CP 001 2052 D4T, 3TCNVPV75I, M184VY181CK11T, P14PT, I31IL, V35T, T39N, V90VI, K104KN, D121H, K122E, D123S, I132L, I135T, S162C, K173S, Q174K, D177E, G196E, T200A, Q207A, R211K, H221HY, V245Q, A272AP, T286A, E291D, I293IV, E297KA
 30CP 001 399 D4T, 3TCNVPK65R, D67H, T69D, K219EGK103N, Y181C, G190AE6D, K11T, K20R, V35T, T39KR, K43E, S68G, V90I, D121H, K122E, I135M, I142V, S162A, K173A, Q174K, D177E, I178L, T200A, E204K, Q207A, R211S, F214L, L228R, V245E, T286A, E291D, V292I, I293V, E297K, A304E, P313T, I329VA
 31CP 005 026 D4T, 3TCNVPK65R, T69~, K70KN, K219RY181C, G190AK11T, V21I, L34I, V35T, T39E, S68SDGN, K82KR, V90VI, K101KQ, D121H, K122E, K173S, D177E, G196E, E204Q, Q207D, F214L, H221Y, V245Q, D250E, S251DG, L283LI, E291ED, I293V, P294T, L295F, E297K, E312DA
 33CP 001 621a D4T, 3TCNVP Y181C, G190GAE6D, V35T, T39K, K43E, T69N, T107S, K122E, D123S, K173I, Q174K, D177E, I178M, V179I, G196E, T200A, Q207A, R211S, F214FL, L228R, K238KR, V245E, K277R, T286A, E291D, I293V, K311KR, E312N, I326IVA
 77CP 001 2322 D4T, 3TCNVPM184VK101KE, V106VA, Y181CK11AT, V35T, T39D, K64R, D121HY, K122E, K173S, Q174K, D177E, I178M, G196E, T200K, Q207A, R211S, V245Q, A272P, Q278H, T286A, E291D, I293V, P321S, I326LA
 121CP 001 724 D4T, 3TCNVPA62V, V75I, F116Y, Q151M, M184VA98G, Y181CI31L, V35T, T39R, K43E, S68SG, N81ND, D121H, K122E, I135IT, I142V, K173A, Q174K, D177E, G196GE, T200A, Q207A, R211S, K238R, V245E, A272P, K281R, E291D, I293V, E312N, D324EA
 148CP 001 621b D4T, 3TCNVP Y181C, G190AE6D, V35T, T39K, K43E, T69N, T107S, K122E, D123S, K173I, Q174K, D177E, I178M, V179I, G196E, T200A, Q207A, R211S, F214FL, L228R, K238KR, V245E, K277R, T286A, E291D, I293V, K311KR, E312N, I326IVA
 179CP 001 1982 D4T, 3TCNVPK65KR, M184VV108I, Y181CE6D, K11T, V35T, T39N, V60I, K122E, D123S, I135IL, A158T, K173S, D177E, T200A, E203K, Q207D, L228LR, V245Q, A272P, K281R, E291D, V292VI, I293V, I326VA
Reynolds (2012)K0808K0808-1JN652204D4T, 3TCNVPM184VV108VI, Y181CI31IL, V35T, E40D, K49R, V60I, K122E, D123S, I135T, K173S, Q174K, D177E, V179I, T200A, Q207A, R211S, V245K, D250E, K281R, T286A, E291D, I293V, P294TA