<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Reverse Transcriptase Inhibitors

Subtype A
Gene RT
Mutation V179T
Rx >= 1 NNRTI
(+/- NRTI)
IncludeMixtures No
References 15
Patients 34
Isolates 34
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# NRTIs NNRTIsNRTIDRMs NNRTIDRMs OtherMutSubtype
Eshleman (2004)ESH_Pat55ESH485AY435281NoneNVP  E6N, V35T, K49KR, V60I, K64R, K122E, D123G, I135T, I142V, K173AS, Q174K, D177E, V179T, T200A, Q207E, R211S, V245K, D250E, V276I, K277KR, T286A, K287KR, E291D, I293V, P294AT, E312DA
Eshleman (2004)ESH_Pat169ESH672AY435337NoneNVP K103KNRS, Y181YC, Y188YC, G190GAE6EK, K11KT, K20R, V35T, K49KR, K122KE, D123DEKN, K126KR, T165TI, K173S, D177E, V179T, Q207A, V245Q, E248N, A272P, K277R, Q278H, T286A, I293V, E312DA
Deshpande (2009)Pat111236RTFJ530830D4T, 3TCNVPM41L, D67N, V75M, M184V, L210W, T215YK103S, G190AK11E, V35T, E44ED, V60I, V106I, V118VI, D121Y, K122E, D123G, I135T, K173S, Q174K, D177E, V179T, Q197K, T200A, Q207A, R211NS, K223KQ, F227FY, V245E, D250EA
Ndembi (2010)13305D_P113305GQ409552ABC, AZT, 3TCNVPM184VK103N, G190AE6K, K11T, G15R, L26M, V35T, T39M, V60I, K122E, D123S, I135T, T165I, K173L, Q174K, D177E, V179T, T200I, I202V, Q207E, F214LA
 DT2794_05_P12794GQ409609AZT, 3TC, TDFNVPM41L, D67N, K70R, M184V, T215Y E6D, V35T, V60I, K64R, K122E, D123S, I135T, K173A, Q174K, D177E, V179T, T200A, E203K, Q207E, R211KA
Sigaloff (2011)HIV101802HIV101802JN132279AZT, 3TCNVPM184VK103NE6D, V8I, V35T, V60I, K122E, D123S, I135T, I142V, S162N, T165L, Q174R, D177E, I178L, V179T, T200A, Q207E, R211S, F214L, V245E, D250E, T286A, E291D, I293VA
 HIV103095HIV103095JN132338AZT, 3TCEFVM41L, M184V, T215FK103N, Y188LK11T, K20R, V21I, V35T, K173S, D177E, V179T, T200A, I202V, Q207A, R211S, V245Q, E248D, K281R, T286A, E291D, I293V, P294TA
 HIV104220HIV104220JN132360D4T, 3TCNVPD67N, K70R, M184V, K219QK103N, K238TK20KR, V35T, T39TA, K43R, V60I, T69TN, V90I, I94L, D121H, K122E, D123S, I135T, S162D, E169EA, K173S, Q174K, N175Y, D177E, V179T, T200E, K201KR, E203K, Q207A, R211S, H221HY, L228LH, V245I, D250E, K281R, T286A, E291D, V292I, I293V, P294T, E312NA
Hamers (2012)CP076305774CP076305774JQ480253TDF, FTCEFVK65R, M184VG190EE6S, K20R, V21I, V35T, T39K, K43N, V60I, K122E, D123S, I135T, K173L, Q174K, D177E, V179T, Q197K, T200A, Q207A, R211S, V245Q, D250E, S251SR, A272P, E291D, I293V, E297T, L310IA
Inzaule (2013)227227JQ914068AZT, 3TCNVP  K11T, K20R, V21I, V35T, T39E, V106I, D123N, T139A, K173S, D177G, V179T, T200A, I202V, Q207A, R211NA
Pircher (2013)B1128B1128JX110229D4T, 3TC, AZTNVPD67DG, M184V, T215YK101E, G190AE6D, K11T, E28K, V35T, T39N, D86DE, D123N, K166R, D177E, I178F, V179T, T200A, Q207A, R211KA
Crawford (2014)SN-082031SN-082031KF781842TDF, 3TCNVP E138KE40D, V60I, K122E, D123N, I142V, K173S, Q174K, D177E, V179T, T200A, I202V, Q207T, R211N, V245QA
Hassan (2014)RS09000807RS09_807KC568489D4T, 3TCEFV  K20R, V21I, V35T, T39R, K43KE, G45GE, K122E, D123GS, I142IT, K166R, K173A, Q174R, D177E, I178L, V179T, T200TA, Q207A, R211K, F214L, D250E, A272P, K277R, T286A, A288AT, E291D, V292I, I293V, E312D, V317AA
Meini (2015)109273109273KM438240AZT, 3TC, DDIEFVM41L, L74V, M184V, T215YL100I, K103NE28A, K32Q, V35T, T39A, V60I, S68SG, D123E, I135T, K173A, Q174K, D177E, I178IM, V179T, T200A, Q207A, R211SA
Ndahimana (2016)14301430KU922856TDF, 3TCNVP G190AS48T, K49R, K122E, D123N, E138A, S162C, K173S, Q174K, D177DE, V179T, T200A, R206RK, Q207AD, R211K, V245QA
 12041204KU922893TDF, 3TCNVPA62V, K65R, M184VK103N, Y181CT39TA, E44ED, K122E, D123S, I135T, K173S, Q174K, D177E, V179T, T200A, Q207D, R211K, L228LR, P243T, V245EA
 13181318KU922852ABC, 3TCNVPM184MVK103NK43R, K122E, D123N, I135T, I142IV, K173S, D177E, I178IL, V179T, T200A, Q207A, R211S, F214L, V245QA
Kekitiinwa (2017)28165_30228165_302KY237802NRTINNRTIY115F, M184V, T215F L12I, V21I, V35T, T39E, K43R, D123S, K173A, Q174K, D177E, V179T, T200A, I202V, Q207A, R211K, F214L, V245Q, E248D, A272P, T286A, E291D, I293V, P294E, E302EDA
 65797_110565797_1105KY237941NRTINNRTIL74V, Y115YF, M184VK103N, Y188CV60I, D121H, K122E, I135T, S162C, K173A, Q174K, D177E, V179T, G196E, Q207A, R211NA
 65761_46165761_461KY237919NRTINNRTIL74V, Y115F, M184VK101E, G190ST69NS, K122E, E138G, K173S, D177E, V179T, T200K, Q207A, R211NSA
 42200_102342200_1023KY237857NRTINNRTIM184VK103N, Y188LK102KN, S105T, L109LI, K122E, D123N, I135IT, K173L, Q174K, D177EG, V179T, T200A, I202V, Q207A, R211KA
 42213_77442213_774KY237867NRTINNRTIL74V, Y115F, M184VK101P, K103SV106I, K122E, D123N, I135T, K173S, D177E, V179T, D192N, T200A, Q207A, R211S, F214LA
 79397_112379397_1123KY238005NRTINNRTIL74V, Y115F, M184VL100I, K103NV60I, K66R, V118I, K122E, D123N, I135T, K173S, Q174K, D177E, I178IM, V179T, Q207A, R211S, H221YA
 35354_47735354_477KY237833NRTINNRTID67DN, K70KEGR, V75VM, M184MV, K219KQK101H, V106M, G190GAV35T, V60I, K122E, D123N, I135T, K173S, Q174K, D177E, V179T, T200A, I202IV, Q207K, R211N, F214L, V245M, D250E, A272P, T286A, E291ED, I293V, P294TA
Kityo (2017)8291182911KY061475NRTINNRTIK65R, Y115F, M184VK101KE, K103KN, Y181C, G190GAS48T, V60VI, D121H, K122E, I142V, K173S, Q174K, D177E, I178L, V179T, T200A, Q207AA
 8346183461KY062015NRTINNRTIK70KR, M184V, T215TSA98G, G190AT69TS, K122E, D123NS, I135IT, S162SCNY, K173S, Q174K, D177E, V179T, T200A, Q207DA
 8297982979KY061542NRTINNRTIK65R, Y115F, M184VK103N, V106AV60I, S68SDGN, D121H, K122E, I135IT, I142V, Q174K, D177E, I178L, V179T, V189I, T200A, Q207E, R211S, F214L, Q222QLA
 8356383563KY062117NRTINNRTID67N, K70R, M184V, T215F, K219EG190A, F227LT69N, A98S, L109I, K122E, D123N, I142V, K173S, D177E, V179T, T200A, I202V, Q207A, R211N, D218E, L228HA
 8305583055KY061614NRTINNRTIK70KR, M184V, T215FK103N, G190A, K238TK49R, V60I, K122E, D123S, I135T, K173T, Q174K, D177E, I178M, V179T, T200A, Q207E, R211K, F214LA
 8354983549KY062103NRTINNRTIK70N, L74I, M184VK103S, G190A, P236PL, K238TK43E, K122E, D123N, K173S, D177E, V179T, Q197QK, T200A, Q207A, R211S, F214L, L228LRA
 8342083420KY061974NRTINNRTIM41L, V75M, F77L, M184V, L210W, T215YK103N, K238KNS48T, V60I, V118I, K122E, D123N, I135T, T139I, K173L, Q174R, D177E, V179T, T200A, Q207E, R211K, L228RA
 8344583445KY061999NRTINNRTIA62V, V75I, F77L, Y115F, F116Y, Q151M, M184V, T215Y, K219KQK101E, Y181V, G190AK43E, S68G, V111VI, K122E, D123S, I167V, K173S, Q174QR, D177E, V179T, I202V, Q207A, R211RKNS, H221YA
 8313583135KY061692NRTINNRTIM41L, D67N, V75M, F77L, M184V, L210W, T215Y, K219NK103S, G190A, K238TE44D, V118I, K122E, D123N, K173S, Q174K, D177E, V179T, T200A, I202V, Q207A, R211K, E224G, L228LHA
Svard (2017)2nd_50232nd_5023KX775291AZT, 3TC, TDF, FTCEFVM184VK103N, Y188FV35T, K49R, V60I, K122E, D123S, I135T, T165L, K173S, Q174K, D177E, V179T, T200A, Q207A, R211K, V245K, E248D, D250EA