<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Reverse Transcriptase Inhibitors

Subtype A
Gene RT
Mutation E138A
Rx >= 1 NRTI
(but no NNRTI)
IncludeMixtures No
References 7
Patients 11
Isolates 11
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# NRTIs NNRTIsNRTIDRMs NNRTIDRMs OtherMutSubtype
Eshleman (2002)145027t145027tAF410243AZTNone  V21I, V35AT, T39A, E40ED, V60I, V90VI, K122E, D123S, I135T, E138A, K173S, Q174K, V179I, T200TA, I202V, Q207A, R211S, V245Q, E248D, A272P, T286A, E291D, V292VI, I293V, P294T, E312DA
 145484o145484oAF410245AZTNone  V35T, E40D, V60I, D121H, K122E, I135T, E138A, I142V, K173A, Q174K, I178M, V179I, T200A, Q207A, R211S, V245K, D250E, T286A, E291D, I293V, P294T, L295M, E312DA
Non-B Workgroup (2005)UK2088UK2088AY901395AZT, 3TCNoneM41L, M184V, L210W, T215Y K11T, K20R, V21I, V35T, T39G, V60I, K122E, D123N, I135T, E138A, I142V, K173S, D177E, V179I, T200A, I202V, Q207AA
 PL5027093684 TDF, AZT, 3TC, DDINoneK65KR V35T, V60I, K122E, D123DN, I135T, E138A, I142V, S162SN, K166KR, K173IL, Q174K, V179VI, Q197E, I202V, Q207A, R211S, F214L, V245M, D250E, A272P, K277R, T286A, E291D, I293V, P294T, L295LM, K311KR, E312DA
Rhee (2005)ASRU023ASRU023 D4T, DDINoneM184V V35T, T39E, K122E, D123S, E138A, K173S, T200A, Q207A, R211KA
Thomson (2009)D9RU_D9FJ009779AZT, 3TCNone  K11T, V35T, E36ED, T39R, S68G, K122E, D123S, E138A, A158S, K173L, Q174K, D177E, I178M, Q207A, R211S, V245M, E248D, A272P, T286A, E291D, V292I, I293V, P294TA
 SP_B_051RU_SP_B_051FJ009809TDF, FTCNoneA62V K11T, E28K, K32E, V35I, E36D, T39K, V90I, K122E, D123S, E138A, A158S, K173L, Q174K, I178M, Q207A, R211S, A272P, K277R, T286A, E291D, V292I, I293V, P294TA
Ndembi (2010)DT3165_05_P13165GQ409612ABC, AZT, 3TCNoneM184V E6D, V35T, T39L, V60I, K122E, D123S, I135T, E138A, I142V, K173S, Q174K, D177E, V179I, T200A, Q207E, R211S, F214LA
Avidor (2013)989_MT989_MTKC184397AZT, 3TCNoneM184V V35L, E36N, I37F, T39N, K122E, D123NS, I135IMT, E138A, Q145Q*, K173L, Q174K, D177DE, T200TI, I202V, Q207ADNT, R211RKNSA
Kolomeets (2014)297297_395KJ870495AZT, 3TCNoneA62V K11T, V35I, E36ED, T39KN, V90VI, K122E, D123S, E138A, K173LS, Q174K, V179VI, T200A, Q207A, R211S, V245VM, E248DA
 280280_552KJ870603AZT, 3TCNoneA62V K11T, V35I, E36D, T39K, K122KE, D123S, E138A, A158S, K173LPS, Q174K, I202IV, Q207A, R211S, V245M, E248DA