<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Reverse Transcriptase Inhibitors

Subtype A
Gene RT
Mutation E138A
Rx >= 1 NNRTI
(+/- NRTI)
IncludeMixtures No
References 26
Patients 60
Isolates 61
 
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# NRTIs NNRTIsNRTIDRMs NNRTIDRMs OtherMutSubtype
Eshleman (2004)ESH_Pat76ESH850AY425356NoneNVP  K11T, K20R, V21I, V35T, T39K, K122E, D123S, E138A, K173S, D177G, V179I, T200A, I202V, Q207A, R211NS, V245Q, E248DY, T286A, E291D, V292T, I293V, P294T, L295MA
Eshleman (2004) SE850_7dAY428728NoneNVP  K11T, K20R, V21I, V35T, T39K, K122E, D123S, E138A, K173S, D177G, V179I, T200A, I202V, Q207A, R211N, V245Q, E248D, T286A, E291D, V292T, I293V, P294T, L295MA
Richard (2004)RNJCR41RNJCR41AY556837AZT, 3TC, D4T, DDINVPM41L, D67N, K70R, V75IY181C, G190AK11T, K20R, V21I, V35T, D123S, E138A, S162A, T165L, K173S, V179IA
Chantratita (2005)NP159NP159DQ130774NRTINNRTIM41L, D67N, K70R, L210W, T215F, K219QA98GT39K, K43E, V60I, K102R, K122E, D123S, E138A, S162A, K173I, Q174K, I178M, T200A, I202V, Q207A, R211S, V245EA
Non-B Workgroup (2005)UK4280UK4280AY901826AZT, 3TCNVPM184VA98G, K101E, G190AK11T, K20R, V35T, E42K, K122E, D123S, I135T, E138A, K173S, Q174K, D177G, V179I, I202V, Q207D, R211S, F214LA
Weber (2005)M41971M41971AY677568AZT, 3TCNVPM41L, D67N, K70KR, M184V, T215F, K219QY181IE6D, T27S, V35T, T39A, V60I, K122E, D123S, I135T, E138A, I142IV, K173A, Q174K, V179I, Q207A, F214L, D218E, L228LH, V245M, D250DE, A272P, T286A, A288T, I293V, P294TA
von Wyl (2007)765056367EF450017NRTINNRTIM184VG190ET27S, V35T, T39N, K122E, D123G, I135T, E138A, I142V, Q174H, D177E, V179I, Q207E, R211KA
Church (2008)361159H361159HEU380728NoneNVP  P4S, K11R, V35T, D123S, I135T, E138A, K173S, D177E, V179I, Q207A, R211S, V245K, D250E, A272P, K277R, L282C, T286A, I293VA
Sylla (2008)D607D607_C2DQ991656AZT, 3TCNVPM41L, D67N, M184V, L210W, T215YK101E, G190AI5V, E6K, K11T, V35T, E36A, T39K, K43E, E53D, K102Q, K122E, D123S, I135T, E138A, S162D, K173S, V179I, T200A, Q207A, R211K, V245Q, T286A, E291D, I293V, P294T, E312D, I326V, G335D, R356K, M357K, G359S, K366R, T369V, A371V, I375V, A376V, T386A, K390R, A400T, T403M, W410Y, E432D, V435AA
Germanaud (2010)55135513 AZT, 3TCNVP  V21I, V35T, T39A, V60I, D121Y, K122E, E138A, I142V, S162Y, K173S, Q174K, D177E, T200I, Q207A, R211KA
 55785578 AZT, 3TCNVPT215P V35T, E36A, T39K, K43E, V60I, S68G, V106T, K122P, D123N, I135V, E138A, T139A, I142V, S162H, K173S, Q174H, D177E, I178L, V179M, E194Q, T200I, Q207AA
Dvali (2012)R117R117FJ456906AZT, 3TCNVPA62V, M184VK101E, G190SK30Q, K32G, A33C, L34T, V35L, E36N, I37F, T39S, W88C, K122E, D123N, I135T, E138A, K173S, Q174K, Q207A, R211S, F214LA
 R144R144FJ456910AZT, 3TCEFVA62V, M184VA98AG, V179DE, G190SK30Q, K32G, A33C, L34T, V35L, E36N, I37F, T39K, V90I, K122E, D123N, I135T, E138A, K173L, Q174K, Q207A, R211S, V245KA
Fourati (2012)94505259450525JQ396163NRTINNRTI K103KN, V179VEM16MT, V35T, T39K, D121DH, K122E, D123NT, I135V, E138A, S162C, P170PS, K173A, Q174N, D177DE, I178LM, T200A, Q207N, R211KA
 1007076310070763JQ396161NRTINNRTIL74V, M184V V35T, K122E, D123N, I135T, E138A, S162A, K173S, V179I, E204G, Q207A, F214LA
 92105999210599JQ396157NRTINNRTI K103KN, V179VEM16MT, V35T, T39K, D121DH, K122E, I135V, E138A, S162C, K173A, Q174N, D177DE, I178LM, T200A, Q207N, R211KA
Reynolds (2012)A0721A0721-1JN652170AZT, 3TCNVPM184VA98AG, G190A, M230LK11T, G15GR, K20R, V21I, V35T, T39E, K122E, D123N, E138A, Q145C, K173S, Q174K, D177G, V179I, T200A, I202V, Q207A, R211S, L228LR, V245Q, E248D, A272P, T286A, V292I, I293V, P294TA
 H0534H0534-1JN652196AZT, 3TCEFVM184VY181IK11T, V21I, V35T, V60I, K101Q, K122E, D123N, E138A, P157PS, K173L, D177G, V179I, I202V, Q207A, R211K, V245E, D250E, A272P, K277R, T286A, V292I, P294T, L295MA
Inzaule (2013)7373JQ914097AZT, 3TCNVPM184VV108I, Y181II31IL, V35T, T39L, K64KR, D121H, K122E, E138A, I142V, T165TM, K173N, Q174K, D177E, V179I, Q207E, R211KA
Nii-Trebi (2013)KF7KF7AB751480NRTINNRTI  V35T, K43E, K49R, V60I, K102Q, K122E, E138A, Q174E, Q207D, R211K, V245Q, D250E, S251NA
Rusine (2013)717H717HKC841741AZT, 3TCNVP  K20R, V35T, T39N, E44ED, V60I, K122E, D123S, I135T, E138A, I142V, K173S, Q174K, V179I, Q207A, R211RS, F214L, D250E, A272P, T286A, E291D, V292I, I293V, P294T, E312DA
Sigaloff (2013)JCR070_0JCR070_0JX181992NRTINNRTIM184V, K219QG190AE6D, K20R, V35T, E40D, E42K, K43R, K46R, V60I, K122E, D123N, I135T, E138A, K173S, Q174K, D177E, V179I, T200A, I202V, E203K, Q207D, R211K, V245Q, E248D, D250E, T286A, E291D, I293V, P294T, E312DA
 JCR066_0JCR066_0JX181991NRTINNRTI  V35T, E40ED, V60I, D121H, K122E, D123S, I135T, E138A, I142V, S162A, K173S, Q174K, V179I, T200E, I202V, Q207A, R211S, E248D, L283I, T286A, E291D, V292I, I293V, P294T, L295MA
Theys (2013)4082440824KC221210NRTI, TDFNNRTIA62V V90I, K122E, D123N, E138A, K173L, Q174K, Q207A, R211SA
 1995619956KC219996NRTI, TDFNNRTID67N, K70R, T215I, K219EG190SV60I, K122E, D123S, I135T, E138A, K173S, Q174K, V179I, T200A, Q207E, R211K, F214LA
Crawford (2014)SN-031169SN-031169KF781844AZT, 3TCNVPM41L, T69S_XS, V75M, F77FL, M184V, L210W, T215FK101E, V108I, G190AT39E, V60I, K64KR, D86E, W88C, I94IL, A98S, D121Y, K122E, E138A, K173A, Q174K, D177E, V179I, G196E, Q207D, R211K, L228H, V245QA
 SN-042062SN-042062KF7818433TC, D4TEFV  S48E, V60I, E138A, K173L, Q174K, I178M, V179I, G196E, E203Q, Q207D, R211S, V245EA
 SN-042020SN-042020KF781841AZT, 3TCEFVD67N, K70R, M184V, K219QV108IS48ST, K49R, V60I, K101Q, D121H, K122E, D123S, E138A, K166Q, E169D, K173A, Q174K, D177E, I178L, V179I, T200A, Q207A, Y232H, V245QA
 SN-072012SN-072012KF781840AZT, 3TCNVPM184V K122E, I135T, E138A, K173S, Q174K, D177E, I178V, V179X, T200A, I202V, Q207D, R211S, F214L, V245EA
Hassan (2014)RS11000385RS11_385KC568505AZT, 3TCEFVM184VK103NV35T, T39L, V60I, K102Q, K122E, I135T, E138A, K173S, Q174K, V179I, T200A, Q207A, R211S, Y232H, V245E, E248D, D250E, T286A, E291D, I293V, P294T, V317AA
 RS11000460RS11_460KC568520AZT, 3TCNVPM184VK103S, G190AV35T, V60I, S68G, V90VI, K122E, D123N, E138A, K173L, Q174K, I178L, V179I, Q207A, R211S, V245KLMQ, D250DE, A272P, T286A, E291D, V292I, I293V, K311R, E312DA
 RS11000495RS11_495KC568525AZT, 3TCEFV, NVPK65R, M184VK103NK11T, K20R, V21I, V35T, T39N, V60I, K122E, D123N, T131TP, E138A, K173S, D177E, T200K, I202V, Q207E, R211K, V245Q, E248D, S251Q, A272P, K275R, K277R, T286A, E291D, V292I, E312DA
Kolomeets (2014)8585_121KJ870274AZT, 3TCEFVA62V, M184VK101E, G190SK11T, V35I, E36D, T39K, K64R, K122E, D123N, E138A, K173L, Q174K, V189VI, I202IV, Q207A, R211S, E248DA
 431431_657KJ8706773TC, DDIEFVA62V T7TA, K11T, V35IT, E36D, T39EK, I50V, V60VI, K122E, D123S, E138A, A158S, K173L, Q174K, D186DAE, Q207A, R211S, Y232YS, E248DA
 345345_524KJ870583ABC, 3TCEFVA62V, L74V, M184VK101E, G190SK11T, V35T, T39E, K122E, D123N, E138A, S162SN, K173L, Q174K, Q207A, R211K, E248DA
 179179_322KJ870435AZT, 3TCEFVA62V, M184V, T215TSK101E, G190SK11T, V35I, E36D, K122E, D123N, E138A, K173L, Q174K, Q207A, R211S, E248DA
 2323_268KJ870389AZT, 3TCEFVA62V, M184V K11T, E36D, T39N, K102KR, K122E, D123N, E138A, A158AS, K173L, Q174K, T200I, Q207A, R211S, V245M, E248DA
 274274_443KJ870528AZT, 3TCEFVA62V, M184VK101E, G190SK11T, V35T, E36D, T39K, K122E, D123N, E138A, K166R, Q174K, Q207A, R211SA
 411411_600KJ870632AZT, 3TCNVPA62V, M184VK101E, G190SK11T, V35I, E36D, T39K, K122E, D123N, E138A, A158S, S162SN, K173L, Q174K, D177E, I178V, I202V, Q207A, R211S, E248DA
Meini (2015)111125111125KM438258AZT, 3TCNVP K103NV35T, V60I, K64R, V90I, K122E, D123S, I135T, E138A, S162C, K173S, Q174K, I178L, V179I, T200A, Q207A, R211SA
Ndahimana Jd Riedel (2016)20292029KT982523NRTINNRTIV75M, L210W, T215YA98G, K103NK20R, V35K, T39E, K49KR, V60I, K122E, D123S, I135L, E138A, K173L, Q174K, T200A, Q207A, R211N, A272P, K275KNRS, T286A, A288AS, E291D, V292I, I293V, P294T, K311R, G335D, M357K, G359S, T369A, A371V, I375A, A376T, T377M, T386A, A400TA
Ndahimana (2016)14301430KU922856TDF, 3TCNVP G190AS48T, K49R, K122E, D123N, E138A, S162C, K173S, Q174K, D177DE, V179T, T200A, R206RK, Q207AD, R211K, V245QA
Kekitiinwa (2017)42192_87542192_875KY237849NRTINNRTI  V60I, K122E, D123N, I135T, E138A, K173S, Q174K, D177EG, I178IV, V179I, T200E, I202V, Q207A, R211SA
 42197_65242197_652KY237854NRTINNRTI K103N, Y188LK43E, G45GR, K49R, K64R, K122E, D123N, E138A, K173S, V179I, I202V, Q207AA
 65772_66465772_664KY237922NRTINNRTIM184VK103N, Y188LV60I, K122E, D123NS, E138A, K173S, Q174K, D177E, V179I, T200A, I202V, Q207A, R211S, F214LA
Kityo (2017)8341883418KY061972NRTINNRTIM41L, D67N, V75M, M184V, L210W, T215Y, K219NV106A, G190A, K238TE44ED, V60I, L109LI, V118I, K122E, D123N, I135T, E138A, S162SN, K173A, Q174K, V179I, I202V, Q207A, R211NSA
 8351283512KY062066NRTINNRTIM41L, D67N, K70R, V75M, M184V, L210W, T215YK101E, V106A, F227LK43E, V60I, A98S, L109I, V111I, V118I, K122E, D123N, E138A, K173S, V179VI, V189VM, T200A, I202V, Q207A, H208Y, R211K, H221YA
 8354883548KY062102NRTINNRTIL74I, M184VA98G, G190E, P236PLV60I, K122E, D123S, I135T, E138A, K173S, Q174K, I178L, T200TA, Q207E, R211S, F214L, L228HA
 8330883308KY061863NRTINNRTID67N, K70R, M184V, K219QK103N, K238TV60I, K122E, D123S, I135T, E138A, K173L, Q174K, V179I, T200TA, R211S, F214LA
 8318783187KY061743NRTINNRTIA62V, K70N, V75T, M184VV106A, F227LK102KQ, L109I, V118I, K122E, D123N, E138A, K173S, Q174K, N175Y, V179I, G196E, Q197E, T200A, I202V, Q207DN, R211K, D218DE, H221HY, L228RA
 8326283262KY061817NRTINNRTIM41L, M184V, L210W, T215Y, K219RK101E, G190AE44ED, V60I, V118VI, D123E, I135T, E138A, I142V, S162A, T165L, K173S, Q174K, D177E, V179I, T200A, E203D, Q207E, R211K, L228HA
 8309983099KY061656NRTINNRTIM41L, M184V, T215FK101E, Y188L, G190AV60I, K122E, D123S, I135T, E138A, I142V, K173S, Q174K, D177E, I178M, V179I, T200A, Q207A, R211K, D237EA
 6604866048KY061415NRTINNRTIM41L, L74LI, V75M, M184V, L210W, T215YV106AK43N, K64R, K82KR, V90I, A98S, V118I, K122E, D123S, E138A, S162H, K166KQ, K173IL, Q174QK, V179I, G196E, Q207A, R211K, Y232HA
 8344083440KY061994NRTINNRTIM41L, M184V, L210W, T215YY188LE44D, V118I, K122E, D123S, I135T, E138A, T165I, K173S, G196E, T200A, I202V, Q207A, R211NA
 8295182951KY061515NRTINNRTI K103NK43KE, V60I, K102Q, K122E, D123N, E138A, T165I, K173S, Q174K, N175H, V179I, T200A, I202V, Q207A, R211KA
 8307883078KY061636NRTINNRTID67N, K70R, M184V, K219QY188LV60I, K64R, T69N, K122E, D123S, I135T, E138A, K173T, Q174K, V179I, T200A, I202V, Q207K, R211S, F214L, K238RA
 8364883648KY062155NRTINNRTIM41L, D67N, M184V, L210W, T215YA98G, K101E, G190AK43E, E53D, V118I, K122E, D123N, E138A, K173S, D177G, V179I, T200A, I202V, Q207A, R211KA
 8289782897KY061462NRTINNRTID67N, K70R, M184V, T215F, K219QK101E, G190AV60I, V118VI, K122E, D123DN, I135T, E138A, K173LS, Q174K, V179I, T200E, I202V, E203Q, Q207D, R211K, F214LA
 8351583515KY062069NRTINNRTI K101E, G190A, P236PLV60I, P119PS, K122E, D123S, E138A, K173L, Q174K, V179I, Q207A, R211S, F214FLA
 6605566055KY061420NRTINNRTIM41L, V75I, M184V, T215YK103NE53D, V60I, W88C, K101A, K122E, D123NS, I132L, I135T, E138A, S162H, K173L, Q174K, V179VI, G196GE, T200A, Q207A, R211SA
 6603966039KY061408NRTINNRTIK70N, L74V, M184VL100I, K103N, P225HV60I, D121H, K122E, I135T, E138A, S162C, K173S, Q174K, V179IL, G196E, T200A, Q207A, R211KA