<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Reverse Transcriptase Inhibitors

Subtype A
Gene RT
Mutation V108I
Rx >= 1 NNRTI
(+/- NRTI)
IncludeMixtures No
References 18
Patients 23
Isolates 24
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# NRTIs NNRTIsNRTIDRMs NNRTIDRMs OtherMutSubtype
Yahi (2001)NY_M35M35AY010501D4TNVPK70N, V75TV108I, Y181CK20R, V35T, T39N, K104R, K122E, D123S, I135V, T139A, K173A, Q174K, D177E, Q207A, R211S, H221HYA
Weber (2005)M41984M41984AY677598AZT, 3TC, D4T, DDIEFVM41L, D67N, K70R, V75M, M184V, L210W, T215Y, K219EK103N, V108I, Y181CV35T, V60I, K122E, D123S, I135T, K173S, Q174K, V179I, T200A, E203K, Q207D, R211K, D218E, H221Y, L228H, V245Q, D250E, A272T, E291D, V292I, I293VA
Lwembe (2007)NYU4444MMAR03 AZT, DDINVP, EFVD67N, K70R, T215I, K219QK103N, V108I, G190AV35T, T39A, S48T, V60I, D121H, K122E, I135T, K173L, Q174K, D177E, T200A, Q207A, R211K, F214LA
  44MDEC03 AZT, DDINVP, EFVD67N, K70R, V75M, T215F, K219QK103N, V108I, G190AV35T, T39A, S48T, V60I, D121H, K122E, I135T, K173L, Q174K, D177E, T200A, Q207A, R211K, F214LA
Hawkins (2009)R40ZZR40FJ931279D4T, 3TCNVPM41L, L74V, M184V, L210W, T215YA98G, V108I, Y181CI5V, E28K, K32E, V35T, E36A, T39K, K43E, D86E, V118I, D121H, K122E, I135T, I142V, S162Y, K173T, Q174K, D177E, V179I, T200A, I202V, Q207D, R211K, H221Y, V245Q, T286A, E291D, V292I, I293V, P294T, E312D, I326VA
Steegen (2009)BV145BV145-2EU8721493TC, D4TEFVM184VK103N, V108IV35T, V60I, K102Q, K122E, D123S, I135T, I142V, K173S, Q174K, D177E, I178M, Q207T, R211SA
Moussa (2010)338-0147M1HM117951AZT, 3TCEFV K103N, V108IV35T, T39Q, D121H, K122E, I142V, A158S, K173S, D177E, G196E, T200K, Q207A, R211SA
 2814-CP001245HM117957D4T, 3TCNVPM184VK101E, V108I, F227LV35T, K49R, T69S, K122E, D123S, I135T, T139R, S162H, K173S, D177E, G196E, Q207A, R211S, L228F, V245QA
Towler (2010)1393250-SHM037884D4T, 3TCNVPM184VK103N, V108IV35T, T39L, E44D, V60I, S68G, T69N, V118I, K122E, D123S, I135T, T139TK, K166R, F171Y, K173A, Q174K, D177E, V179I, T200A, Q207E, R211K, F214L, V245E, E248D, D250E, K277R, T286A, E291D, V292I, I293V, P294T, E312DA
Charpentier (2011)179CP0011982 D4T, 3TCNVPK65KR, M184VV108I, Y181CE6D, K11T, V35T, T39N, V60I, K122E, D123S, I135IL, A158T, K173S, D177E, T200A, E203K, Q207D, L228LR, V245Q, A272P, K281R, E291D, V292VI, I293V, I326VA
Fourati (2012)94609749460974JQ395871NRTINNRTI K103N, V108IK11T, V35T, T39K, V106I, K122E, D123N, I142V, E169D, K173S, D177E, I178L, G196K, T200A, I202V, Q207A, R211K, F214L, H221Y, E224D, V241IA
Kouri (2012)CU376-10CU376-10JQ585390NRTINNRTID67N, K70R, M184V, T215F, K219EV108I, Y181CV35T, T39K, E40D, T69N, K122E, D123S, I135IT, K173S, Q174K, V179I, G196E, T200A, R206K, Q207A, R211S, L228H, V245Q, E248N, K281KR, T286A, E291D, V292I, I293V, P294T, Q334H, G335DA
Avidor (2013)1612_MN1612_MNKC184212TDF, FTCEFVM184VK103N, V108IK30Q, K32G, A33C, L34T, V35L, E36N, I37F, T39A, E40D, V60I, K102Q, D121H, K122Q, I135T, E138Q, K173A, Q174K, I178L, V179I, Q197L, T200A, Q207A, R211S, F214L, V245KA
 1996_FT1996_FTKC184324AZT, 3TCEFVM184VK103N, V108I, P225HV35L, E36N, I37F, T39M, K122E, D123S, A158AS, K173L, Q174K, D177E, T200A, E203D, Q207A, R211S, V245MA
 451451 AZT, 3TCEFVM184VV108IT39L, V60VI, D121H, K122E, D123S, P157Q, A158S, F160I, K166R, E169D, K173A, Q174R, D177E, V189VI, Q207A, R211SA
Inzaule (2013)7373JQ914097AZT, 3TCNVPM184VV108I, Y181II31IL, V35T, T39L, K64KR, D121H, K122E, E138A, I142V, T165TM, K173N, Q174K, D177E, V179I, Q207E, R211KA
Pircher (2013)B1120B1120JX110221D4T, 3TC, AZTNVPM41L, L74LI, M184V, L210LW, T215Y, K219RK103N, V108I, F227LK20KR, V35T, T39N, V60I, T107S, V118I, K122E, D123S, S162C, K173A, Q174K, T200A, Q207A, R211N, H221Y, K223KE, L228LR, V245QR, E248D, D250EA
 B1139B1139JX110239D4T, 3TC, AZTNVPM41ML, D67DN, M184V, T215YV108I, V179EK11T, E28KR, K32E, V35M, S68SG, T107A, D123N, I135IV, I142V, K173S, Q174K, D177E, I178L, G196K, I202V, Q207E, R211K, H221Y, V241I, V245Q, D250E, Q258KA
Sigaloff (2013)MBA064_0MBA064_0JX182023NRTINNRTID67N, K70R, M184V, K219QK103N, V108IP4S, E6D, V35T, V60I, K64R, A98S, T107S, V111I, I135M, S162H, K173S, Q174R, D177E, T200A, E203K, Q207D, H208Y, R211S, F214L, H221Y, V245E, D250E, K277R, T286A, V292I, I293VA
Theys (2013)4757747577KC221378NRTI, TDFNNRTIM41L, D67N, L74I, M184V, L210W, T215Y, K219NV108I, Y181CV118I, D121H, I135T, E138T, I142V, S162C, F171Y, K173S, Q174K, G196D, T200A, Q207A, R211KA
 4947949479KC221428NRTI, TDFNNRTID67N, T69D, K70R, L74IV, M184V, T215F, K219QA98G, V108I, Y181CK49R, V60I, K122E, D123N, I135V, K173S, Q174K, N175Y, D177E, V179I, Q197E, T200A, I202V, Q207A, R211S, L228HA
Wallis (2014)4149841498KM458592NRTINNRTID67GS, K70R, V75VI, M184V, T215F, K219EV108I, Y181CV35T, V60I, T69N, K122E, I132IL, I135T, K173L, Q174K, D177E, I178L, V179I, Q207A, R211SA
Meini (2015)109264109264KM438247D4T, 3TC, DDINVPM184V, T215FK101E, V108I, Y181CK20KR, V21I, V35T, E44ED, K49R, V60I, K122E, D123N, I135K, K173L, Q174K, D177E, I178M, T200A, Q207A, R211S, H221YA
Brooks (2016)2187A2187AKU900890TDF, 3TCNVPK65R, M184VV108I, Y181CK20R, V35T, T39M, V60I, K101Q, K122E, I135T, K173S, Q174K, D177E, I178V, V179I, T200E, Q207A, R211K, F214L, H221YA