<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Reverse Transcriptase Inhibitors

Subtype A
Gene RT
Mutation V108I
Rx >= 1 NNRTI
(+/- NRTI)
IncludeMixtures No
References 22
Patients 61
Isolates 62
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# NRTIs NNRTIsNRTIDRMs NNRTIDRMs OtherMutSubtype
Yahi (2001)NY_M35M35AY010501D4TNVPK70N, V75TV108I, Y181CK20R, V35T, T39N, K104R, K122E, D123S, I135V, T139A, K173A, Q174K, D177E, Q207A, R211S, H221HYA
Weber (2005)M41984M41984AY677598AZT, 3TC, D4T, DDIEFVM41L, D67N, K70R, V75M, M184V, L210W, T215Y, K219EK103N, V108I, Y181CV35T, V60I, K122E, D123S, I135T, K173S, Q174K, V179I, T200A, E203K, Q207D, R211K, D218E, H221Y, L228H, V245Q, D250E, A272T, E291D, V292I, I293VA
Lwembe (2007)NYU4444MMAR03 AZT, DDINVP, EFVD67N, K70R, T215I, K219QK103N, V108I, G190AV35T, T39A, S48T, V60I, D121H, K122E, I135T, K173L, Q174K, D177E, T200A, Q207A, R211K, F214LA
  44MDEC03 AZT, DDINVP, EFVD67N, K70R, V75M, T215F, K219QK103N, V108I, G190AV35T, T39A, S48T, V60I, D121H, K122E, I135T, K173L, Q174K, D177E, T200A, Q207A, R211K, F214LA
Hawkins (2009)R40ZZR40FJ931279D4T, 3TCNVPM41L, L74V, M184V, L210W, T215YA98G, V108I, Y181CI5V, E28K, K32E, V35T, E36A, T39K, K43E, D86E, V118I, D121H, K122E, I135T, I142V, S162Y, K173T, Q174K, D177E, V179I, T200A, I202V, Q207D, R211K, H221Y, V245Q, T286A, E291D, V292I, I293V, P294T, E312D, I326VA
Steegen (2009)BV145BV145-2EU8721493TC, D4TEFVM184VK103N, V108IV35T, V60I, K102Q, K122E, D123S, I135T, I142V, K173S, Q174K, D177E, I178M, Q207T, R211SA
Moussa (2010)338-0147M1HM117951AZT, 3TCEFV K103N, V108IV35T, T39Q, D121H, K122E, I142V, A158S, K173S, D177E, G196E, T200K, Q207A, R211SA
 2814-CP001245HM117957D4T, 3TCNVPM184VK101E, V108I, F227LV35T, K49R, T69S, K122E, D123S, I135T, T139R, S162H, K173S, D177E, G196E, Q207A, R211S, L228F, V245QA
Towler (2010)1393250-SHM037884D4T, 3TCNVPM184VK103N, V108IV35T, T39L, E44D, V60I, S68G, T69N, V118I, K122E, D123S, I135T, T139TK, K166R, F171Y, K173A, Q174K, D177E, V179I, T200A, Q207E, R211K, F214L, V245E, E248D, D250E, K277R, T286A, E291D, V292I, I293V, P294T, E312DA
Charpentier (2011)179CP0011982 D4T, 3TCNVPK65KR, M184VV108I, Y181CE6D, K11T, V35T, T39N, V60I, K122E, D123S, I135IL, A158T, K173S, D177E, T200A, E203K, Q207D, L228LR, V245Q, A272P, K281R, E291D, V292VI, I293V, I326VA
Fourati (2012)94609749460974JQ395871NRTINNRTI K103N, V108IK11T, V35T, T39K, V106I, K122E, D123N, I142V, E169D, K173S, D177E, I178L, G196K, T200A, I202V, Q207A, R211K, F214L, H221Y, E224D, V241IA
Kouri (2012)CU376-10CU376-10JQ585390NRTINNRTID67N, K70R, M184V, T215F, K219EV108I, Y181CV35T, T39K, E40D, T69N, K122E, D123S, I135IT, K173S, Q174K, V179I, G196E, T200A, R206K, Q207A, R211S, L228H, V245Q, E248N, K281KR, T286A, E291D, V292I, I293V, P294T, Q334H, G335DA
Avidor (2013)1612_MN1612_MNKC184212TDF, FTCEFVM184VK103N, V108IK30Q, K32G, A33C, L34T, V35L, E36N, I37F, T39A, E40D, V60I, K102Q, D121H, K122Q, I135T, E138Q, K173A, Q174K, I178L, V179I, Q197L, T200A, Q207A, R211S, F214L, V245KA
 1996_FT1996_FTKC184324AZT, 3TCEFVM184VK103N, V108I, P225HV35L, E36N, I37F, T39M, K122E, D123S, A158AS, K173L, Q174K, D177E, T200A, E203D, Q207A, R211S, V245MA
 451451 AZT, 3TCEFVM184VV108IT39L, V60VI, D121H, K122E, D123S, P157Q, A158S, F160I, K166R, E169D, K173A, Q174R, D177E, V189VI, Q207A, R211SA
Inzaule (2013)7373JQ914097AZT, 3TCNVPM184VV108I, Y181II31IL, V35T, T39L, K64KR, D121H, K122E, E138A, I142V, T165TM, K173N, Q174K, D177E, V179I, Q207E, R211KA
Pircher (2013)B1120B1120JX110221D4T, 3TC, AZTNVPM41L, L74LI, M184V, L210LW, T215Y, K219RK103N, V108I, F227LK20KR, V35T, T39N, V60I, T107S, V118I, K122E, D123S, S162C, K173A, Q174K, T200A, Q207A, R211N, H221Y, K223KE, L228LR, V245QR, E248D, D250EA
 B1139B1139JX110239D4T, 3TC, AZTNVPM41ML, D67DN, M184V, T215YV108I, V179EK11T, E28KR, K32E, V35M, S68SG, T107A, D123N, I135IV, I142V, K173S, Q174K, D177E, I178L, G196K, I202V, Q207E, R211K, H221Y, V241I, V245Q, D250E, Q258KA
Sigaloff (2013)MBA064_0MBA064_0JX182023NRTINNRTID67N, K70R, M184V, K219QK103N, V108IP4S, E6D, V35T, V60I, K64R, A98S, T107S, V111I, I135M, S162H, K173S, Q174R, D177E, T200A, E203K, Q207D, H208Y, R211S, F214L, H221Y, V245E, D250E, K277R, T286A, V292I, I293VA
Theys (2013)4757747577KC221378NRTI, TDFNNRTIM41L, D67N, L74I, M184V, L210W, T215Y, K219NV108I, Y181CV118I, D121H, I135T, E138T, I142V, S162C, F171Y, K173S, Q174K, G196D, T200A, Q207A, R211KA
 4947949479KC221428NRTI, TDFNNRTID67N, T69D, K70R, L74IV, M184V, T215F, K219QA98G, V108I, Y181CK49R, V60I, K122E, D123N, I135V, K173S, Q174K, N175Y, D177E, V179I, Q197E, T200A, I202V, Q207A, R211S, L228HA
Wallis (2014)4149841498KM458592NRTINNRTID67GS, K70R, V75VI, M184V, T215F, K219EV108I, Y181CV35T, V60I, T69N, K122E, I132IL, I135T, K173L, Q174K, D177E, I178L, V179I, Q207A, R211SA
Meini (2015)109264109264KM438247D4T, 3TC, DDINVPM184V, T215FK101E, V108I, Y181CK20KR, V21I, V35T, E44ED, K49R, V60I, K122E, D123N, I135K, K173L, Q174K, D177E, I178M, T200A, Q207A, R211S, H221YA
Saravanan (2015)CTLA301CTLA301KP993904NRTINNRTIK65R, M184V, K219EK103N, V108IV35T, E53D, V60I, K64R, S68K, V106I, D121H, K122E, D123E, S163T, T165I, K173A, Q174K, D177E, Q197E, T200A, Q207D, R211K, L228FA
Brooks (2016)2187A2187AKU900890TDF, 3TCNVPK65R, M184VV108I, Y181CK20R, V35T, T39M, V60I, K101Q, K122E, I135T, K173S, Q174K, D177E, I178V, V179I, T200E, Q207A, R211K, F214L, H221YA
Ndahimana Jd Riedel (2016)21322132KT982503NRTINNRTID67N, K70R, M184MV, T215TAIV, K219KEK103N, V108I, P225HT39A, V60I, K64KR, T69N, D121H, K122E, D123S, I135T, K173LQ, Q174QK, D177DE, I178IM, T200AE, Q207XA
Kekitiinwa (2017)42165_23942165_239KY237848NRTINNRTIM184VK103N, V108IV60I, D121H, K122E, I135T, K173LS, Q174K, D177E, V179I, S191SF, T200A, E203D, Q207A, R211SA
 65528_116465528_1164KY237888NRTINNRTIK65R, K70T, V75I, Y115F, F116Y, M184VV108IM41MI, V60I, S68G, T69I, K102R, K122E, D123N, K173S, D177G, I202V, Q207A, R211S, L228LHA
 79369_23979369_239KY237988NRTINNRTIM184VK103N, V108IV60I, V90VI, D121H, K122E, I135T, K173S, Q174K, D177E, V179I, T200A, E203D, Q207A, R211S, L228RA
 65750_43165750_431KY237912NRTINNRTIL74LIV, M184VK103N, V108I, P225PH, F227FLK43E, K122E, D123N, I135T, I142V, K173S, D177E, V179I, T200K, I202V, Q207A, R211S, H221HYA
 42206_120042206_1200KY237863NRTINNRTIL74V, Y115F, M184VK103KN, V108I, Y181C, G190A, F227FLT69S, K101KR, V118I, K122T, I135T, I142L, T165TI, K173S, Q174K, D177E, I178IV, T200A, Q207A, R211S, F214L, K219T, H221YA
 65807_66565807_665KY237948NRTINNRTIL74V, Y115F, M184V, L210LWV108I, Y181CV60I, K65KE, K101KR, K122E, D123S, K173S, D177E, I178L, E204K, Q207A, R211S, H221YA
Kityo (2017)8351783517KY062071NRTINNRTIM41L, D67N, V75M, M184V, L210W, T215Y, K219KNV108I, Y181CE44D, V60I, T107S, V118I, K122E, D123S, I135T, I142V, K173S, Q174K, D177E, V179I, T200A, Q207A, R211NS, D218E, H221YA
 8301383013KY061574NRTINNRTID67N, V75M, M184V, L210W, T215Y, K219KNV108I, Y181CK43N, V60I, V118I, K122E, D123N, I135T, S162Y, K166R, K173L, Q174K, D177E, V179I, Q207A, R211NS, K223Q, L228HA
 8325583255KY061810NRTINNRTIL74I, M184VA98G, K103N, V108I, P225HV60I, L109I, K122E, D123S, K173S, Q174K, D177E, V179I, I202V, Q207AA
 8325283252KY061807NRTINNRTIK65R, K70KEGR, M184VK101KE, V108I, Y181C, F227FLK122E, D123N, I135T, K173S, D177E, V179I, V189VI, I202V, Q207A, R211K, H221Y, L228LRA
 8300783007KY061569NRTINNRTIM41L, A62AV, V75L, M184V, T215FA98G, K103N, V108I, K238TL109LI, K122E, D123S, I142V, I167IV, K173L, Q174K, D177E, V179I, V189VI, I202V, Q207A, R211SA
 8315283152KY061708NRTINNRTIK70Q, M184VK103N, V108I, L234IV60I, R78RI, K102H, D121Y, K122E, D123G, T128I, I135T, K166KR, K173A, D177E, V179I, V189VI, T200A, I202V, Q207A, R211K, H221YA
 8304783047KY061606NRTINNRTIM41L, D67N, K70R, M184V, L210W, T215F, K219EA98G, K101E, V108I, Y181C, G190AE44D, K49R, V60I, I94L, L109I, K122E, I135T, S162D, K173S, D177E, V179I, T200A, E203K, Q207D, R211K, D218EA
 8329683296KY061851NRTINNRTIM184V, L210LW, T215FV108I, Y181CG93GR, K122E, D123S, I135T, K173S, Q174K, D177E, V179I, T200A, I202V, Q207A, R211NS, F214L, H221YA
 6608366083KY061436NRTINNRTIM41L, V75M, M184V, L210W, T215YA98G, K103N, V108IV60I, T69TA, I94L, K122E, I135T, K173S, D177E, V179I, V189I, T200A, I202V, E203K, Q207D, R211K, K219KT, H221YA
 8342383423KY061977NRTINNRTIK70KR, M184V, T215F, K219QK101H, V108I, G190AK43KE, V60I, T69N, V118I, D121H, K122E, I135T, T165I, K173AS, Q174K, D177E, T200A, E203EDKN, Q207E, F214L, L228RA
 8298382983KY061546NRTINNRTID67DN, M184V, L210LW, T215YV108I, Y181CV60I, L109I, K122E, I135T, S163SC, K173IT, Q174KR, D177E, V179I, Q207A, R211S, D218EA
 8326083260KY061815NRTINNRTIK65R, D67N, M184IVK103N, V108I, F227LK43Q, K46M, V60I, T69N, W88C, V90I, K102Y, D121H, K122E, I135T, I142IV, S162Y, K173S, Q174K, T200A, E203K, Q207A, R211N, K223EA
 8340183401KY061955NRTINNRTIM41L, D67N, T69DN, K70KR, V75I, M184V, L210W, T215YV108I, Y181CFISE44ED, K49KR, K122E, D123N, T165I, K173S, D177E, V179VI, G196GE, T200A, I202V, E203KQ, Q207D, R211K, H221YA
 8312583125KY061682NRTINNRTIM41L, D67G, K70R, L74I, V75I, M184V, T215F, K219QA98G, K101KE, K103N, V108I, Y181C, G190AV60I, S68G, K122E, D123S, I132L, I135T, E138T, I142V, S162H, K173S, Q174K, N175Y, I178IM, V179I, V189VI, G196E, T200A, K201R, Q207A, R211S, F214L, K223Q, L228HA
 6603766037KY061407NRTINNRTIM184VV108I, Y181CK49R, K122E, D123S, I135T, I142V, F171Y, D177E, I178M, Q207E, R211K, F214L, H221YA
 6604066040KY061409NRTINNRTIK70E, M184VV108I, Y181CV60I, K102Q, K122E, I135T, K173L, Q174K, D177E, I178L, V179I, T200A, Q207A, R211K, H221YA
 8328383283KY061838NRTINNRTIM41ML, D67DN, K70KR, M184V, L210LW, T215YK101KE, V108I, Y181YC, G190GAV60I, K122E, D123N, I135T, K166R, K173S, Q174R, D177E, Q207E, R211KA
 8293482934KY061498NRTINNRTID67N, K70R, M184V, T215F, K219QV108I, Y181CK49R, K64R, K101KR, K122E, D123N, I135T, S162D, E169K, K173A, Q174K, V179I, T200A, Q207A, R211S, F214L, H221YA
 8294982949KY061513NRTINNRTIM41L, M184V, L210LW, T215FV108I, Y181CK43E, I50V, K122E, D123N, I135T, K173A, Q174K, D177E, V179I, I202V, Q207A, R211K, H221YA
 8313683136KY061693NRTINNRTIM41L, A62V, M184V, L210W, T215FYK103N, V108IK49R, T69S, V118VI, K122E, D123N, I135T, K173S, D177G, T200A, I202V, Q207K, R211NS, L228RA
 6606466064KY061426NRTINNRTIM41L, D67G, T69D, L74I, M184V, L210W, T215YV108I, Y181CE44ED, K49R, V60I, A98S, V118I, K122E, D123NS, I135T, S162D, K173S, Q174K, D177E, I178IM, V179I, T200E, I202V, E203EK, Q207A, R211N, H221YA
 8290382903KY061468NRTINNRTIM41L, D67N, V75M, M184V, L210W, T215YK101DN, V108I, Y181C, G190A, K238TE44D, K49R, V60I, K166R, D177E, V179IT, E203KQ, Q207D, R211K, H221YA
 8303583035KY061594NRTINNRTID67N, K70R, M184V, T215FY, K219EV108I, Y181C, G190AK43E, T69TN, L109I, K122E, D123N, I135R, K173A, D177E, V179I, T200K, I202V, Q207A, R211S, L228HA
 2845128451KY061383NRTINNRTID67DN, K70KR, V75VIM, M184V, L210LW, T215YV108I, Y181CK20R, V21I, V35T, E40D, K43R, K46R, S48P, K49G, V60I, K64R, F77S, I94IL, K101KQ, K122E, D123S, I135T, K173S, Q174K, D177E, V179I, T200A, Q207E, R211RK, F214FL, H221Y, V245E, D250E, S251H, T286A, E291D, V292I, I293VA
 8318283182KY061738NRTINNRTID67N, K70R, M184V, T215F, K219EV108I, Y181CV60I, T69N, L109I, D123N, I135T, S162Y, E169ED, K173A, Q174K, D177E, V179I, G196GE, I202V, Q207A, R211K, L228HA
 8290682906KY061471NRTINNRTIM41L, V75I, M184V, L210LW, T215FYV108I, Y181CV60I, K101R, L109I, K122E, D123N, I132L, K173S, D177EG, V179I, T200A, I202V, Q207A, R211K, H221YA
 6584065840KY061393NRTINNRTIL74V, M184V, K219QK103N, V108IV60I, S68SG, K102KEGR, K122E, D123N, I135IT, A158S, R172RK, K173S, Q174K, D177E, T200A, I202V, Q207A, R211S, F214L, H221Y, L228IVA
 8291482914KY061478NRTINNRTIK65R, M184V, K219KAETA98AG, K103N, V108I, L234IV60I, K64R, S68K, V106I, T107S, K122E, D123S, I135IM, K173S, Q174K, V179I, V189VI, T200A, I202V, Q207A, R211S, F214FL, D218DE, H221HYA
 8303683036KY061595NRTINNRTID67N, K70R, M184V, T215F, K219QK103N, V108IK102Q, I135T, S162SC, K173A, Q174K, D177E, T200A, I202V, Q207A, R211N, H221HYA
 8324883248KY061803NRTINNRTIM184VV108I, Y181CK49R, K122E, D123S, I135V, K173S, D177G, V179I, T200A, I202V, Q207A, R211S, H221YA