<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Reverse Transcriptase Inhibitors

Subtype A
Gene RT
Mutation V106I
Rx >= 1 NNRTI
(+/- NRTI)
IncludeMixtures No
References 26
Patients 42
Isolates 44
 
Show mutation frequency as:
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# NRTIs NNRTIsNRTIDRMs NNRTIDRMs OtherMutSubtype
Holguin (2003)SP_LP22SP_LP22AF455663NRTINNRTIM184V A33H, L34S, V35T, E36D, T69N, V106I, K122E, D123S, I135T, I142V, S162Y, K173S, D177E, V179I, Q207A, R211K, K220RA
Richard (2004)RNJCR58RNJCR58AY556819AZT, 3TC, ABCEFVM184VY188HK11T, V21I, V35T, V106I, K122E, D123S, I135L, I142V, K173S, Q174K, D177E, I178L, V179I, T200AA
Weber (2005)M74228M74228AY677510D4T, DDI, AZT, 3TCNVP G190AV35K, T39D, V60I, T69S, V106I, D121H, K122E, I135T, K173S, Q174A, D177E, V179I, G196K, T200A, Q207E, V245I, D250E, A272P, K281R, L283I, T286A, E291D, V292I, I293V, E312S, D324EA
 F51354F51354AY677539AZT, 3TC, DDC, D4T, DDINVP, EFVD67DN, K70KR, L74LV, T215FA98G, K103N, Y181CK11T, K20R, V21I, V35T, T39L, N57NI, T69X, V106I, D123N, I135L, D177E, I178L, V179I, T200A, I202V, Q207A, R211X, V245Q, E248D, A272P, T286A, E291D, V292I, I293V, P294T, E312GA
Lwembe (2007)NYU6262MMAR03 AZT, 3TCNVPD67N, K70R, T215F, K219EG190AV35T, E40D, V60I, K101Q, V106I, K122E, D123G, K173S, Q174K, D177E, I178M, V179I, T200A, Q207A, R211SA
  62MMAY04 AZT, 3TCNVPD67N, K70R, T215I, K219EY181C, G190AV35T, E40D, V60I, K101Q, V106I, K122E, D123G, K173L, Q174K, D177E, V179I, T200A, Q207A, R211SA
Deshpande (2009)Pat111236RTFJ530830D4T, 3TCNVPM41L, D67N, V75M, M184V, L210W, T215YK103S, G190AK11E, V35T, E44ED, V60I, V106I, V118VI, D121Y, K122E, D123G, I135T, K173S, Q174K, D177E, V179T, Q197K, T200A, Q207A, R211NS, K223KQ, F227FY, V245E, D250EA
Dau (2010)07520A07520AGU581851NRTINNRTIM41L, D67G, T69G, K70R, V75M, M184V, T215F, K219QY188LK20R, V35T, T39Q, V60I, K101Q, V106I, V118I, K122E, D123S, I135T, I142V, S162D, K173A, Q174K, D177E, I178M, V179M, G196E, T200A, E204K, Q207E, R211K, F214L, V245Q, E248D, D250E, A272P, T286A, V292I, I293V, P294T, Q334E, G335DH, R356K, M357R, G359T, A371V, I375IV, A376SA
 08793B08793BGU581948NRTINNRTIM41L, D67G, T69G, K70R, V75M, M184V, T215F, K219QY188LK20R, V35T, T39Q, V60I, K101Q, V106I, V118I, K122E, D123S, I135T, I142V, S162D, K173A, Q174K, D177E, I178M, V179M, G196E, T200A, E204K, Q207E, R211K, F214L, I244IV, V245Q, E248D, D250E, S268SC, A272P, K275KR, T286A, V292I, I293V, P294T, Q334E, G335D, K350KR, R356K, M357R, G359T, A371V, I375IMV, A376SA
Charpentier (2011)CR-49CR-49FJ688255AZT, 3TCNNRTIA62V, K70N, V75I, F77L, Y115F, F116Y, Q151M, M184VK101E, Y188LK11T, E28K, K32E, V35T, T58N, S68G, V106I, D121DY, K122E, D123G, I135T, S162C, T165I, E169K, K173A, Q174K, D177E, V179I, G196E, T200A, I202V, Q207A, R211ST, F214L, V245Q, D250E, I293V, P294T, E297K, K311KRA
 CR-55CR-55FJ688261AZT, 3TCNNRTI  K11T, V35T, S48T, V106I, K122E, D123N, I135IT, I142IV, K173K*IL, V179I, T200A, E204ED, Q207A, R211S, F214L, V245VELQ, A272P, I293V, P294T, E312D, I326IV, Q334QHA
Afonso (2012)ANG74ANG74JN937086NRTINNRTI  V35T, T39N, E40D, K49R, V60I, V90I, V106I, K122E, D123G, E138A, S162D, K173A, Q174K, V179I, Q207D, R211K, V245QA
Dvali (2012)R072R072FJ456901AZT, 3TCEFVM184VK103N, V108VIV35L, E36N, I37F, T39K, V106I, K122E, D123S, I135T, A158S, K173L, Q174K, D177E, Q207A, R211S, V245MTA
Fourati (2012)94609749460974JQ395871NRTINNRTI K103N, V108IK11T, V35T, T39K, V106I, K122E, D123N, I142V, E169D, K173S, D177E, I178L, G196K, T200A, I202V, Q207A, R211K, F214L, H221Y, E224D, V241IA
Avidor (2013)1966_MT1966_MTKC184299TDF, 3TCEFVK65KR, M184VK101E, Y181C, G190SK30Q, K32G, A33C, L34T, V35L, E36N, I37F, T39V, V106I, D121H, K122E, D123S, I135T, K173S, Q174K, D177E, T200A, Q207A, R211S, L228LR, V245MA
Inzaule (2013)227227JQ914068AZT, 3TCNVP  K11T, K20R, V21I, V35T, T39E, V106I, D123N, T139A, K173S, D177G, V179T, T200A, I202V, Q207A, R211NA
  227JQ914091AZT, 3TCNVP  K11T, K20R, V21I, V35T, T39E, V106I, D123N, K173S, D177G, V179IT, T200A, I202V, Q207A, R211NA
Nii-Trebi (2013)KF113KF113AB751463NRTINNRTI  E6K, K11T, V35T, V106I, K122E, D123G, I135T, I142V, A158S, S162Y, K173S, D177E, V179I, Q207AT, F214L, V245QA
Nouhin (2013)T0820238T0820238KF292673NRTINNRTIA62AV, M184V, T215YA98G, Y181CK32X, L34X, V35T, T39N, K49R, V106I, K122E, D123N, I132L, S162C, S163ST, K173V, Q174K, D177E, I178IV, V179I, T200A, I202V, Q207E, L210LS, H221Y, L228HA
Thiam (2013)3713-HALD3713-HALDJN673567NRTINNRTIM184VK101E, G190AE6A, V35T, E36A, T39K, K43E, V106I, D121H, K122E, K173S, D177E, V179I, T200A, Q207A, R211RK, V245Q, A272P, T286A, E291D, V292I, I293V, P294T, E312D, I326V, G335DA
Acharya (2014)DGP196DGP196KJ185366TDF, 3TCNVPK65R, K219QK103N, Y181CK11E, V35T, V60I, T69X, V106I, D121H, K122E, D123S, I135T, K173L, Q174K, D177E, V179I, Q197E, T200A, E203D, Q207A, R211S, V245Q, D250E, T286A, E291D, I293VA
 DGP164DGP164KJ185334TDF, 3TCEFVM41L, D67N, T69D, K70R, M184V, T215F, K219QY188LV35T, V60I, V106I, K122E, D123S, I135T, I142V, S162A, T165I, K173S, Q174K, D177E, V179I, Q197E, T200A, Q207A, R211K, V245K, D250E, T286A, E291D, V292I, I293V, P294TA
Aghokeng (2014)TG-3-626TG-3-626KC350319NRTINNRTIV75I, M184V, T215F, N348IK103NV35T, T39A, V90VI, V106I, K122E, D123S, I132L, I135T, S162Y, K173S, V179I, Q207A, R211K, F214L, V245Q, K281R, T286A, E291D, V292I, I293V, P294T, E312D, I326V, G335D, R356K, M357K, G359S, K366R, T369V, A371V, I375V, A376V, A400T, T403R, W410CA
Kolomeets (2014)470470_612KJ870643NRTINNRTIL74V, M184VK101E, Y181C, G190SE6K, V35T, V106I, K122E, D123S, I135T, S162Y, K173L, Q174K, D177E, V179I, T200A, Q207A, R211S, V245M, E248DA
 414414_633KJ870659AZT, 3TCEFVD67DN, K70KR, M184V, T215TNSY, K219KQK101E, G190SE6K, K11T, V35T, E36D, T39N, V106I, K122E, D123S, S162C, K173L, Q174K, D177E, G196E, Q197QKR, T200A, Q207A, R211S, V245M, E248DA
 326326_462KJ870541AZT, 3TCEFVA62V, M184VK101E, G190SK11T, V35I, E36D, T39K, R72RK, V106I, K122E, D123N, A158S, K173A, Q174K, D177E, Q207A, R211S, V245M, E248DA
 8888_160KJ870304AZT, 3TCEFVD67N, K70R, M184V, K219QK101E, G190SK11T, V35I, E36D, T39K, V90I, V106I, K122E, D123N, A158S, K173S, Q174K, D177E, T200A, Q207A, V245MT, E248DA
Nerrienet (2014)U0519246U0519246JN675839NRTINNRTIA62V, K65R, V75I, F77L, Q151MA98G, Y181C, G190AV21I, V35T, S68G, D76DN, V90I, V106I, K122E, D123N, I142V, R172K, K173A, Q174K, D177E, I178L, Q207A, R211S, F214LA
Meini (2015)109276109276KM438252AZT, 3TCNVPK70R, M184EK103N, F227LV35T, V60I, V90I, V106I, K122E, D123N, I135T, T139R, S162H, K173L, Q174K, I178L, V179I, D185E, T200A, Q207A, R211NA
Saravanan (2015)CTLA301CTLA301KP993904NRTINNRTIK65R, M184V, K219EK103N, V108IV35T, E53D, V60I, K64R, S68K, V106I, D121H, K122E, D123E, S163T, T165I, K173A, Q174K, D177E, Q197E, T200A, Q207D, R211K, L228FA
Boillot (2016)VIR32VIR32KT315993D4T, 3TCEFVM41L, D67N, K70R, M184V, T215YA98G, Y188LK11T, V35T, T39A, V60I, V106I, D121Y, K122E, D123G, I135T, I142V, K173S, Q174K, D177E, V179I, G196E, Q207A, R211S, F214L, E224D, D237E, V245EA
Ndahimana Jd Riedel (2016)20402040KT982527NRTINNRTIM184VA98AG, Y188LV35T, K43KR, V106I, K122E, I135T, K173L, D177E, V179I, I195K, G196E, I202V, Q207D, F214FL, V245Q, D250E, A272P, V276I, K277R, E291D, I293V, G335E, R356K, M357K, G359S, T369A, I375IM, A376T, T377M, S379C, T386I, A400TA
 21372137KT982522NRTINNRTI  K49R, V106I, K122E, D123DEG, I135T, T139TA, E169A, K173S, Q174K, D177E, I178L, T200A, Q207A, R211S, F214L, V245QA
Steegen (2016)GFKZB174GFKZB174KU128078TDF, 3TC, FTCNVP, EFVM184VA98G, Y188LP4H, K11T, V35T, K46Q, V106I, K122E, D123N, I135T, I142V, S162C, K173S, V179I, T200A, I202V, Q207A, R211S, F214L, L228H, V245Q, E248D, R284K, T286A, E291D, V292I, I293V, G335D, R356K, M357R, G359T, T369TAA
Kekitiinwa (2017)79387_29879387_298KY238001NRTINNRTIK65R, Y115F, M184VY181C, G190AV106I, K122E, D123N, T139K, T165I, K173S, Q174K, D177E, I178IM, V179I, T200A, I202V, Q207A, R211NA
 42213_77442213_774KY237867NRTINNRTIL74V, Y115F, M184VK101P, K103SV106I, K122E, D123N, I135T, K173S, D177E, V179T, D192N, T200A, Q207A, R211S, F214LA
Kityo (2017)6606566065KY061427NRTINNRTIA62V, K65R, Y115F, M184VY181YC, Y188LV60I, V106I, K122E, D123N, I135T, K173L, Q174K, D177E, V189VI, I195L, G196E, R206K, Q207D, R211KA
 8359383593KY062147NRTINNRTIK70~, M184VY188LK49R, V60I, V106I, K122E, D123N, I135T, K173L, Q174K, I178M, V179I, Q207A, R211S, E224EDA
 8327783277KY061832NRTINNRTID67G, K70R, M184V, K219QY181CK43E, V60I, S68G, V106I, K122E, D123S, I135T, T139TR, I142V, K173S, Q174K, D177E, V179I, T200TA, Q207A, R211S, F214L, H221YA
 6605066050KY061417NRTINNRTIM41L, M184V, L210LW, T215YY188LV106I, K122E, D123N, K173A, Q197QR, T200E, Q207A, R211KA
 8345983459KY062013NRTINNRTIM41L, L74V, M184V, L210W, T215F, K219WG190S, M230LT69N, V106I, V118I, K122E, D123N, I142IV, K173A, Q174K, D177E, V179I, T200A, I202V, Q207D, H208HY, R211K, L228HA
 8297282972KY061535NRTINNRTIM41L, M184V, L210LW, T215YA98G, K101E, Y188LV60I, V106I, K122E, D123N, I135T, S162H, K173S, Q174K, D177E, V179I, T200A, E203ED, Q207D, H208HYA
 8291482914KY061478NRTINNRTIK65R, M184V, K219KAETA98AG, K103N, V108I, L234IV60I, K64R, S68K, V106I, T107S, K122E, D123S, I135IM, K173S, Q174K, V179I, V189VI, T200A, I202V, Q207A, R211S, F214FL, D218DE, H221HYA
 8306483064KY061623NRTINNRTIK70R, M184VA98AG, Y188LV60I, T69S, V106I, D121H, K122E, D123S, I135T, I142V, K173A, Q174K, D177E, V179I, T200A, Q207A, R211S, F214FLA