<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Reverse Transcriptase Inhibitors

Subtype A
Gene RT
Mutation K103S
Rx >= 1 NNRTI
(+/- NRTI)
IncludeMixtures No
References 14
Patients 26
Isolates 26
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# NRTIs NNRTIsNRTIDRMs NNRTIDRMs OtherMutSubtype
Baxter (2006)48-12041204-30709DQ877748NRTINNRTIM41L, D67N, L74V, M184V, L210W, T215Y, K219NK103S, Y181C, G190AP4S, V35T, T39A, E44D, K64R, K101Q, K122E, D123S, T165I, K173S, Q174K, D177E, I178L, V179I, T200A, I202V, E203D, Q207N, H208Y, R211N, W212C, H221Y, L228H, V245T, D250E, A272P, K281R, I293V, P294T, G335D, M357R, G359S, T369A, A371V, I375V, A376V, T377M, T386S, A400TA
Deshpande (2009)Pat111236RTFJ530830D4T, 3TCNVPM41L, D67N, V75M, M184V, L210W, T215YK103S, G190AK11E, V35T, E44ED, V60I, V106I, V118VI, D121Y, K122E, D123G, I135T, K173S, Q174K, D177E, V179T, Q197K, T200A, Q207A, R211NS, K223KQ, F227FY, V245E, D250EA
Charpentier (2011)118CP001234 D4T, 3TCNVPM184VK103S, G190A, Y318YFK11T, V35T, T39R, K43E, D121H, Q145C, K173A, Q174K, D177E, G196E, T200K, Q207A, R211RS, V245Q, A272P, T286A, E291D, E297EK, E312D, Q334QHA
Sigaloff (2011)HIV100236HIV100236JN132223TDF, FTCEFVK70E, V75M, M184VK103S, G190AK13N, V35T, K49R, V60I, K122E, D123N, I135T, I142T, K173S, Q174K, T200A, Q207A, R211S, D250E, T286A, E291D, V292I, I293V, P294T, L303WA
 HIV101568HIV101568JN132272D4T, 3TCEFVD67N, K70R, M184V, K219QK101P, K103SV35T, V60I, T69N, K102KR, K104KR, K122E, D123S, I135T, K173S, Q174K, D177E, I178M, V179I, T200A, Q207A, R211S, L228H, V245T, D250E, T286A, E291D, I293V, P294AA
Afonso (2012)ANG45ANG45JN937058NRTINNRTID67N, K70R, M184V, T215F, K219QK103S, G190AV35T, T39R, K46Q, K102Q, K122E, K173T, D177E, T200K, I202V, Q207N, R211K, F214L, V245KA
Inzaule (2013)357357JQ914076AZT, 3TC, ABCNVPM184V, T215YA98AG, K103S, G190AV21I, T27S, V35T, T39A, E40D, V60I, K122E, D123G, I135T, K173S, Q174K, D177E, I178M, T200A, Q207D, R211KA
Theys (2013)4519245192KC221323NRTI, TDFNNRTID67N, M184V, T215F, K219QK103SV60I, K122E, D123S, I135T, R172S, Q174K, V179I, T200A, Q207A, R211S, F214LA
Hassan (2014)RS11000460RS11_460KC568520AZT, 3TCNVPM184VK103S, G190AV35T, V60I, S68G, V90VI, K122E, D123N, E138A, K173L, Q174K, I178L, V179I, Q207A, R211S, V245KLMQ, D250DE, A272P, T286A, E291D, V292I, I293V, K311R, E312DA
Konou (2015)H991H991KT316097NRTINNRTIM41L, M184V, L210W, T215Y, K219RK103S, G190A, P225H, K238TE6Q, K11T, V35T, T39K, K43E, I94L, D121Y, K122E, I142V, K173S, Q174K, D177E, T200A, Q207A, R211K, L228H, V245Q, E248D, D250EA
Brooks (2016)2003A2003AKU900868TDF, 3TCEFVD67G, K70Q, M184VK101P, K103SE6K, K11A, V35T, V60I, K122E, D123S, I135T, E138Q, I142T, K173S, Q174K, D177E, T200A, Q207A, R211SA
Ndahimana Jd Riedel (2016)21592159KT982532NRTINNRTIM41L, M184V, T215FK103S, G190AV35T, V60I, K122E, K173L, Q174K, D177E, V179I, I195L, T200A, I202V, Q207A, R211N, T240K, V245T, E248D, T286A, E291D, V292I, I293V, P294T, E312D, V317A, G335D, M357Q, G359A, T369A, A371V, I375V, T377R, A400TA
Kekitiinwa (2017)42213_77442213_774KY237867NRTINNRTIL74V, Y115F, M184VK101P, K103SV106I, K122E, D123N, I135T, K173S, D177E, V179T, D192N, T200A, Q207A, R211S, F214LA
Kityo (2017)8304383043KY061602NRTINNRTIM41L, D67DN, M184V, L210W, T215YK103S, G190AV60I, K122E, D123N, I135T, K173S, Q174K, D177E, V179I, T200A, I202IV, E203D, Q207A, R211NA
 8353883538KY062092NRTINNRTID67N, K70R, M184V, K219QA98G, K103S, K238TV60I, K122E, D123NS, I135T, K173S, Q174K, D177E, V179I, Q207A, R211S, F214L, L228HA
 6608466084KY061437NRTINNRTID67N, K70R, M184V, T215FV, K219EK103S, G190AV60I, T69N, L109LI, K122E, D123S, I135T, F171Y, K173A, Q174K, D177E, V179IT, T200A, I202V, Q207D, R211KA
 8349783497KY062051NRTINNRTIK70KE, M184V, T215TIK101P, K103S, V108VI, G190A, P236PLK122E, D123N, K173S, Q174K, D177E, V179I, D192DN, T200A, I202V, Q207A, R211S, L228INA
 8346783467KY062021NRTINNRTIM41L, M184V, L210W, T215YK103S, G190AK43KN, V60I, K122E, D123S, I135T, K166R, F171Y, K173I, Q174K, V179I, G196GE, T200A, Q207A, R211K, L228LHA
 8354983549KY062103NRTINNRTIK70N, L74I, M184VK103S, G190A, P236PL, K238TK43E, K122E, D123N, K173S, D177E, V179T, Q197QK, T200A, Q207A, R211S, F214L, L228LRA
 8341783417KY061971NRTINNRTID67N, K70R, L74LI, M184V, T215FV, K219EK103S, G190AS48ST, T69N, K122E, S162T, K173S, Q174K, D177E, V179I, T200A, I202V, Q207A, R211SA
 8356783567KY062121NRTINNRTIM184VK103S, G190A, P225HV60I, K122E, D123DG, K173AT, Q174K, D177DE, T200A, Q207E, R211S, F214LA
 8313583135KY061692NRTINNRTIM41L, D67N, V75M, F77L, M184V, L210W, T215Y, K219NK103S, G190A, K238TE44D, V118I, K122E, D123N, K173S, Q174K, D177E, V179T, T200A, I202V, Q207A, R211K, E224G, L228LHA
 8303083030KY061590NRTINNRTID67N, K70R, M184V, T215F, K219EK103S, G190AV60I, T69N, K102Q, V118I, K122E, D123S, S162A, K173S, V179I, Q207A, R211S, F214LA
 8349183491KY062045NRTINNRTIK65R, Y115F, M184V, K219EL100I, K103SV60I, S68G, K122E, D123S, I135T, I142V, K173S, Q174K, T200A, I202V, Q207G, R211KA
Svard (2017)2nd_50082nd_5008KX7752843TC, D4T, ABC, DDINVP K103SV35T, V60I, K122E, D123S, E138Q, K173A, Q174K, V179I, T200A, Q207A, R211S, D237E, V245Q, D250EA
 2nd_50162nd_5016KX7752863TC, D4T, TDF, FTCEFVD67N, T69D, K70R, M184V, L210W, T215Y, K219EK103S, G190AK20R, V35T, E44D, V60I, V118I, K122E, K173S, Q174K, N175Y, D177E, V179X, T200S, K201R, I202V, Q207A, R211N, K223Q, V245Q, E248D, D250E, I257LA