<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Reverse Transcriptase Inhibitors

Subtype A
Gene RT
Mutation K101Q
Rx >= 1 NNRTI
(+/- NRTI)
IncludeMixtures No
References 21
Patients 43
Isolates 46
 
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# NRTIs NNRTIsNRTIDRMs NNRTIDRMs OtherMutSubtype
Eshleman (2004)ESH_Pat88ESH421AY435267NoneNVP  K11T, K20R, V21I, V35T, T39R, V60I, K101Q, D110DH, D123N, K173A, D177G, V179I, T200A, I202V, Q207A, R211S, V245Q, E248N, D250E, A272V, R284K, E291D, V292I, I293V, P294T, E312DA
Weber (2005)95F527295F5272AY677605AZT, 3TCNVP G190GAE6N, V21I, V35I, K101Q, K122E, D123S, I135T, S162C, K173S, Q174K, D177E, V179I, T200A, Q207A, R211S, V245E, D250E, T286A, E291D, V292VI, I293V, P294T, E312D, S322SAA
Baxter (2006)12-21202120-30715DQ880034NRTINNRTIM41L, D67N, L74V, M184V, L210W, T215Y, K219RY181C, G190AT39A, E44D, V60I, K101Q, V118I, K122E, D123N, I135T, K173S, Q174K, V179I, T200A, Q207E, H208Y, R211K, H221C, V245QA
  2120-40510DQ880035NRTINNRTIM41L, D67N, L74V, L210W, T215Y, K219RV106A, Y181C, G190AT39A, E44D, V60I, K101Q, V118I, K122E, D123N, I135T, K173S, Q174K, V179I, T200A, Q207E, H208Y, R211K, H221C, V245QA
 48-12041204-30709DQ877748NRTINNRTIM41L, D67N, L74V, M184V, L210W, T215Y, K219NK103S, Y181C, G190AP4S, V35T, T39A, E44D, K64R, K101Q, K122E, D123S, T165I, K173S, Q174K, D177E, I178L, V179I, T200A, I202V, E203D, Q207N, H208Y, R211N, W212C, H221Y, L228H, V245T, D250E, A272P, K281R, I293V, P294T, G335D, M357R, G359S, T369A, A371V, I375V, A376V, T377M, T386S, A400TA
 48-30453045-30317DQ877957NRTINNRTID67N, L74V, Y115F, M184V, T215F, K219QY181C, G190AT7A, K11T, K20KR, V35T, T39R, K43E, K101Q, D121H, K122E, D123S, I135T, K173S, Q174K, N175Y, D177E, G196E, Q207A, V245Q, T286A, E291D, K311R, M357K, R358K, G359S, K366R, T369V, E370D, A371V, I375V, A376I, T386IA
Lwembe (2007)NYU3333FMAR03 AZT, 3TC, DDIEFVD67N, K70RK103NK11Q, V35T, V60I, K101Q, D121H, K122E, I135T, T139M, S162N, K173S, Q174K, D177E, V179I, T200A, Q207A, R211SA
  33FFEB04 AZT, 3TC, DDIEFVD67N, K70R, K219QK103NK11Q, V35T, V60I, K101Q, D121H, K122E, I135T, S162N, K173S, Q174K, D177E, V179I, T200A, Q207A, R211S, D218EA
 NYU6262MMAR03 AZT, 3TCNVPD67N, K70R, T215F, K219EG190AV35T, E40D, V60I, K101Q, V106I, K122E, D123G, K173S, Q174K, D177E, I178M, V179I, T200A, Q207A, R211SA
  62MMAY04 AZT, 3TCNVPD67N, K70R, T215I, K219EY181C, G190AV35T, E40D, V60I, K101Q, V106I, K122E, D123G, K173L, Q174K, D177E, V179I, T200A, Q207A, R211SA
Steegen (2009)BV223BV223-2EU8721503TC, D4T, ABCEFVM184VG190SV35T, K101Q, K122E, D123S, K173S, V179I, Q197H, T200A, Q207A, R211SA
Dau (2010)07520A07520AGU581851NRTINNRTIM41L, D67G, T69G, K70R, V75M, M184V, T215F, K219QY188LK20R, V35T, T39Q, V60I, K101Q, V106I, V118I, K122E, D123S, I135T, I142V, S162D, K173A, Q174K, D177E, I178M, V179M, G196E, T200A, E204K, Q207E, R211K, F214L, V245Q, E248D, D250E, A272P, T286A, V292I, I293V, P294T, Q334E, G335DH, R356K, M357R, G359T, A371V, I375IV, A376SA
 08793B08793BGU581948NRTINNRTIM41L, D67G, T69G, K70R, V75M, M184V, T215F, K219QY188LK20R, V35T, T39Q, V60I, K101Q, V106I, V118I, K122E, D123S, I135T, I142V, S162D, K173A, Q174K, D177E, I178M, V179M, G196E, T200A, E204K, Q207E, R211K, F214L, I244IV, V245Q, E248D, D250E, S268SC, A272P, K275KR, T286A, V292I, I293V, P294T, Q334E, G335D, K350KR, R356K, M357R, G359T, A371V, I375IMV, A376SA
 09757A09757AGU581982NRTINNRTIM41L, D67G, T69DG, K70R, V75M, M184MV, T215FV, K219QY188LK20R, V35T, T39Q, V60I, K101Q, V106VI, V118I, K122E, D123S, I135T, I142V, S162SDGN, K173A, Q174K, D177E, I178M, V179VM, G196E, T200AE, I202IV, E204K, Q207E, R211K, F214L, I244IV, V245Q, E248D, D250E, A272P, K275KR, L282LV, T286A, V292I, I293V, P294T, Q334E, G335D, K350KR, R356K, M357R, G359T, A371V, I375V, A376SA
Charpentier (2011)117CP001201 D4T, 3TCEFVM184VK103NK11T, V35T, T39N, V60I, T69S, K101Q, D121H, K122E, D123S, I135T, I142V, K173S, Q174K, D177E, I178L, G196E, T200E, Q207A, V245Q, E248D, S251I, A272P, T286A, I293V, E297K, E312DA
Reynolds (2012)H0534H0534-1JN652196AZT, 3TCEFVM184VY181IK11T, V21I, V35T, V60I, K101Q, K122E, D123N, E138A, P157PS, K173L, D177G, V179I, I202V, Q207A, R211K, V245E, D250E, A272P, K277R, T286A, V292I, P294T, L295MA
Aghokeng (2013)HJ3146HJ3146JX983027NRTINNRTIM41L, D67N, M184V, L210W, T215YK103NP4K, K11A, D17N, E28A, V35T, I94L, K101Q, V111I, D121H, K122E, I135T, S162C, E169A, K173A, Q174K, D177E, G196E, T200A, Q207A, H208Y, R211D, V245Q, E248D, T286A, A288S, E291D, E297K, I329V, G335D, N348T, M357R, R358K, G359S, A371L, I375V, T377Q, S379C, T403M, E404DA
Nouhin (2013)S1117398S1117398KF292594NRTINNRTIK65R, D67E, V75M, M184V, K219RY181C, G190AV35T, E36R, T39A, E40D, K46Q, K64T, K66D, S68N, K101Q, K103R, K122E, I132L, S162C, K173I, Q174R, D177E, T200A, Q207A, R211SA
Sigaloff (2013)JCR083_0JCR083_0JX181996NRTINNRTID67N, T69D, K70R, M184V, T215F, K219QK103N, P225HE6D, K20R, E28A, V35T, V60I, W88C, I94L, K101Q, V118I, K122E, D123S, I135T, E169D, K173A, Q174K, D177E, I178L, E194D, G196E, T200A, Q207E, F214L, V245K, D250E, K277R, E291D, V292I, I293V, P294TA
Theys (2013)4053040530KC221199NRTI, TDFNNRTID67N, K70R, M184MI, T215DE, K219QK103H, Y181C, G190AK43KR, T69TN, V90I, K101Q, K122E, D123N, S134R, A158S, T165TI, R172K, K173S, Q174K, D177E, I178M, T200A, Q207A, R211SA
 4017740177KC221187NRTI, TDFNNRTID67N, K70R, K219QK103N, K238KTV60I, K101Q, D121H, K122E, I135T, K173S, Q174K, D177E, V179I, Q207A, R211S, F214LA
Aghokeng (2014)SN-1-106SN-1-106KC350204NRTINNRTIM184VG190AV35T, T39TA, K43E, K49R, I50V, E53D, V60I, K64R, K101Q, K122E, D123S, I135T, K173L, Q174K, D177E, E203K, Q207A, R211SA
Crawford (2014)SN-042020SN-042020KF781841AZT, 3TCEFVD67N, K70R, M184V, K219QV108IS48ST, K49R, V60I, K101Q, D121H, K122E, D123S, E138A, K166Q, E169D, K173A, Q174K, D177E, I178L, V179I, T200A, Q207A, Y232H, V245QA
Hassan (2014)RS11000510RS11_510KC568529AZT, 3TCNVPM184VG190AK20R, V21I, I31L, V35T, E36D, T39R, K43E, K101Q, K102R, D121H, K122E, T165I, K173A, D177E, V179I, T200E, I202V, Q207A, R211K, L228R, K275Q, T286A, E291D, V292I, I293V, P294T, E312DA
Kolomeets (2014)422422_576KJ870618D4T, 3TCEFVA62V, M184VG190SK11T, V35T, E36D, T39K, K101Q, K122E, D123S, I135T, T165I, K173A, Q174K, Q207A, R211S, E248DA
 263263_112KJ870270AZT, 3TCNVPA62V, M184V, T215YK103NK11T, V35L, E36D, K49R, K101Q, K122E, D123S, I135T, E138G, A158S, K173S, Q174K, T200A, Q207A, R211S, V245T, E248DA
Saravanan (2015)CTLA31CTLA31KP993634NRTINNRTID67N, V75I, F77L, Y115F, F116Y, Q151M, M184V, T215FV179F, Y181C, G190AT27S, V35T, T39K, K101Q, V111I, K122E, D123N, I142V, T165I, I178L, T200A, E204EK, L205F, Q207E, H208Y, R211KA
 CTLA71CTLA71KP993674NRTINNRTIM41L, D67N, M184V, L210W, T215FK103N, G190AE28A, V35T, E44A, K101Q, K122E, I135T, I142V, S163T, K173S, Q174K, D177E, T200A, Q207A, R211S, L228FA
Brooks (2016)2068A2068AKU900878TDF, 3TCNVPK65R, M184MVY181G, G190AI5IV, K20R, V35T, V60I, S68G, T69S, V90I, K101Q, K122E, D123N, I135T, K173A, Q174R, D177E, V179I, Q207A, R211NS, E224DA
 2187A2187AKU900890TDF, 3TCNVPK65R, M184VV108I, Y181CK20R, V35T, T39M, V60I, K101Q, K122E, I135T, K173S, Q174K, D177E, I178V, V179I, T200E, Q207A, R211K, F214L, H221YA
Ndahimana (2016)12501250KU922845TDF, 3TCEFVK219RY181C, G190ST39A, E40D, K65T, K101Q, K122E, D123S, I135T, K173S, D177E, V179S, T200TK, Q207A, R211S, F214L, P243S, V245EA
Kekitiinwa (2017)42194_69542194_695KY237851NRTINNRTIL74V, Y115F, M184VV106M, G190A, F227LK49R, V60I, K101Q, K122E, D123S, I135T, E138A, S162C, K173S, Q174R, V179IL, T200A, Q207EA
 83623_114383623_1143KY238033NRTINNRTIM41L, D67DN, M184V, T215F K49R, V60I, K101Q, S117A, D123N, I135T, E138R, T165I, K173S, Q174K, D177E, I178L, V179I, T200A, I202V, Q207A, R211SA
Kityo (2017)8349683496KY062050NRTINNRTIM184V, T215FK103NS48T, K101Q, V118VI, K122E, D123N, I135T, E138EQ, I142V, K173S, Q174K, D177E, T200A, I202V, Q207K, R211S, F214MA
 8300683006KY061568NRTINNRTIM41L, D67N, K70KR, M184V, L210W, T215Y, K219KNA98G, K103N, K238TV60I, K101Q, K122E, D123N, I142V, K173LS, Q174K, D177E, V179I, T200A, I202V, Q207AA
 8355683556KY062110NRTINNRTIM41L, D67N, K70R, V75M, M184V, T215F, K219QV106A, F227LV60I, I94L, K101Q, L109I, K122E, D123S, I135T, K173S, Q174K, V179I, G196GE, T200A, I202V, Q207A, R211K, H221YA
 8304683046KY061605NRTINNRTIM184V, T215YK103N, P225H, K238TA98S, K101Q, K122E, D123DN, K173L, Q174K, N175Y, T200A, Q207AA
 8313183131KY061688NRTINNRTID67S, K70R, M184V, T215F, K219EY181C, G190AK43E, K49R, V60I, T69N, K101Q, K122E, D123S, K173S, Q174K, G196GE, T200A, Q207A, R211SA
 8318883188KY061744NRTINNRTIM41L, D67N, K70R, L74LI, V75VIM, M184V, T215F, K219QG190AV60I, K101Q, K122E, D123S, I135T, K173S, Q174K, D177E, V179I, V189I, T200K, I202V, Q207A, R211SA
 8329083290KY061845NRTINNRTID67N, K70R, M184V, T215TI, K219QK103N, K238TV60I, K101Q, K122E, D123S, I135T, S162A, K173I, Q174K, N175NY, D177E, T200TA, Q207AT, R211KA
 8350683506KY062060NRTINNRTIM184VK103NK101Q, K122E, D123N, T139K, I142V, K166R, K173S, D177E, V179I, T200A, I202V, Q207A, R211S, F214LA
 8293182931KY061495NRTINNRTIM41ML, D67N, K70R, L74I, M184V, T215F, K219QK103N, P225HK43E, T69N, K101Q, K122E, D123S, K173L, Q174K, D177E, T200AS, I202V, Q207A, L228IV, K238KRA
 8300483004KY061566NRTINNRTIM41L, D67N, V75M, M184V, L210W, T215YG190AK43KQ, E44ED, V60I, K101Q, K102Q, V118VI, K122E, D123S, I135T, E138Q, I142V, K173A, Q174K, D177E, V179I, G196E, T200A, Q207A, R211NA
 8296982969KY061532NRTINNRTIM41L, A62V, V75L, F77L, M184V, L210W, T215YG190AK101Q, D123N, T139KR, S162SDGN, K173S, Q174K, D177E, V179I, T200A, Q207E, R211S, F214FLA
 8298782987KY061550NRTINNRTIM184V, T215YA98G, K103NV60I, K101Q, K122E, D123N, I135T, I142K, K173AS, Q174K, D177E, V179I, T200A, Q207E, D218EA
 8329783297KY061852NRTINNRTIK70R, M184V, K219KQK103NV60I, K101Q, K102KR, K122E, D123N, I135T, K173S, Q174K, T200L, Q207A, R211SA