<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Reverse Transcriptase Inhibitors

Subtype A
Gene RT
Mutation K101P
Rx >= 1 NNRTI
(+/- NRTI)
IncludeMixtures No
References 14
Patients 25
Isolates 25
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# NRTIs NNRTIsNRTIDRMs NNRTIDRMs OtherMutSubtype
Non-B Workgroup (2005)TK5012TK5012c AZT, 3TC, ABC, DDIEFV K101P, Y188LK11T, V21VI, V35T, T39A, D121DN, Y146YC, S162SG, K173A, Q174K, D177E, V179I, I202V, Q207A, R211K, T240TA, V245Q, I257IV, T286A, E291D, I293V, P294T, E312DA
Baxter (2006)48-50105010-30820DQ878543NRTINNRTIM41L, D67N, K70R, L210W, T215Y, K219EK101P, G190AV35IT, T39TA, V60I, K66KR, V118I, I135T, K173A, Q174K, D177E, V179I, Q207A, R211S, L228H, V245S, D250E, T286A, E291D, V292I, I293V, P294T, E312D, G335D, M357K, G359S, T369A, A371V, I375V, A376AV, T377M, E399D, A400TA
von Wyl (2007)1531461783EF449799NRTINNRTIM184VK101PV35T, V60I, D121H, K122E, D123S, I135T, K173S, Q174K, D177E, V179L, T200A, Q207A, R211SA
Hawkins (2009)R160ZZR160FJ931350D4T, 3TCNVPF77FL, M184V, T215TNSYK101P, Y181YCV35T, E36A, T39K, K43E, K122E, D123S, I135T, T139R, I142V, S162A, K173S, Q174K, D177E, V179I, T200A, Q207A, R211T, V245Q, S251H, A272G, T286A, E291D, V292I, I293V, P294T, E312D, I326VA
Charpentier (2011)CR-13CR-13FJ688219AZT, 3TCNNRTIM41L, D67N, K70R, M184V, T215F, K219QK101P, Y188LK11T, K20R, E28K, K32E, V35T, T39N, V60I, T69N, K122E, D123N, Q174K, N175NY, D177EG, G196E, Q197E, Q207E, H208Y, D218E, L228H, V245Q, T286A, E291D, I293V, E312DA
Fokam (2011)CIRCB-10552CIRCB-10552JQ796173D4T, 3TCEFVM184VK101P, K103NSI5V, K11A, K20R, E28K, K32E, V35T, T39K, V111VG, D121Y, K122E, D123G, I135T, S162SC, E169D, K173A, Q174K, D177E, D192DN, G196E, Q207A, R211RS, V245Q, D250E, S251C, T286A, E291D, I293V, E312D, V317VA, D324EA
Sigaloff (2011)HIV101568HIV101568JN132272D4T, 3TCEFVD67N, K70R, M184V, K219QK101P, K103SV35T, V60I, T69N, K102KR, K104KR, K122E, D123S, I135T, K173S, Q174K, D177E, I178M, V179I, T200A, Q207A, R211S, L228H, V245T, D250E, T286A, E291D, I293V, P294AA
Thiam (2013)467-HPD467-HPDJN673569NRTINNRTIM184VK101PE6K, K11T, V35T, E36A, T39K, K43E, D121H, K122E, D123S, I135T, I142V, S162Y, T165A, R172K, K173S, D177E, V179I, Q207A, V245E, T286A, E291D, V292I, I293V, P294T, L295M, E312D, P321T, I326V, G335DA
Saravanan (2015)CTLA60CTLA60KP993663NRTINNRTIM184V, T215YK101P, K103NE28K, K32Q, V35T, K122E, D123S, K173S, Q174K, D177E, V179I, T200A, Q207A, R211S, K223EA
Brooks (2016)2003A2003AKU900868TDF, 3TCEFVD67G, K70Q, M184VK101P, K103SE6K, K11A, V35T, V60I, K122E, D123S, I135T, E138Q, I142T, K173S, Q174K, D177E, T200A, Q207A, R211SA
Karade (2017)SK_IF_16-202SK_IF_16-202KY787065NRTINNRTID67N, K70R, L74I, M184V, T215F, K219QA98G, K101P, G190AV35T, V60I, I94L, D121H, K122E, I135T, K173T, Q174K, D177E, V179I, Q197K, T200E, E203A, Q207A, R211S, V245K, D250EA
Kekitiinwa (2017)65789_75565789_755KY237934NRTINNRTIL74V, Y115F, M184VK101P, G190AK49R, V60I, K122E, I135T, T139TA, K173S, Q174K, D177E, V179I, V189I, Q207A, L210LS, R211SA
 42198_90842198_908KY237855NRTINNRTIL74V, Y115F, M184VK101P, G190AT69N, K122KE, D123N, Q145C, K173S, P176Q, D177E, V179I, T200A, I202V, Q207A, L210LS, R211KA
 79366_25079366_250KY237987NRTINNRTIL74V, Y115F, M184VK101P, K103NK102KR, K122E, D123N, K173S, Q174K, D177E, V179I, T200A, Q207A, L210LV, R211KA
 42213_77442213_774KY237867NRTINNRTIL74V, Y115F, M184VK101P, K103SV106I, K122E, D123N, I135T, K173S, D177E, V179T, D192N, T200A, Q207A, R211S, F214LA
 79358_25079358_250KY237985NRTINNRTIL74V, Y115F, M184VK101P, K103NK102KR, L109LI, K122E, D123N, K173S, Q174K, D177E, V179I, T200A, Q207A, L210LV, R211KA
Kityo (2017)8301983019KY061579NRTINNRTIM41ML, T69~, M184V, T215YK101P, G190AK43KQ, E44D, V60I, S68G, D121H, K122E, D123S, K173L, Q174K, D177E, V179I, T200A, I202IV, Q207A, R211RKNSA
 6604166041KY061410NRTINNRTID67DG, K70KE, M184VK101P, K103NI50V, S105AT, K122KE, D123N, I142L, A158S, K173S, D177E, V179IT, T200EK, I202V, Q207A, R211SA
 8349783497KY062051NRTINNRTIK70KE, M184V, T215TIK101P, K103S, V108VI, G190A, P236PLK122E, D123N, K173S, Q174K, D177E, V179I, D192DN, T200A, I202V, Q207A, R211S, L228INA
 8313983139KY061696NRTINNRTIM184V, L210W, T215YA98G, K101P, G190AE44D, K122E, D123S, I135T, K173S, Q174KR, D177E, V179I, T200A, E203ED, Q207A, R211S, F214LA
 6608966089KY061441NRTINNRTIM184V, L210W, T215YK101P, G190AV60I, D121H, K122E, I135T, I142V, K173S, Q174K, D177E, V179I, Q207A, R211SA
Svard (2017)1st_281st_28KX775233AZT, 3TCNVPD67N, K70R, M184V, T215F, K219QA98G, K101P, K103NK11T, K20R, V21I, T27S, V35T, T39R, K43E, K122E, D123S, S162A, K173S, Q174K, D177G, I202V, Q207A, V245Q, E248D, D250EA
 1st_30161st_3016KX7752353TC, D4TNVPM41L, D67N, V75M, M184V, L210W, T215YK101P, K103NV35T, E44D, V60I, K122E, I135T, E138Q, K173A, Q174K, D177E, V179I, T200A, E203K, Q207D, H208Y, R211K, V245M, D250EA
 1st_361st_36KX7752413TC, D4TNVPM41L, D67N, L74V, M184V, L210W, T215YK101P, G190A, K238TK11T, V35T, T39A, K43E, V60I, V118I, L120LI, D121H, K122E, I135V, D177E, V179I, T200A, E203K, L205F, Q207D, H208Y, R211K, H221Y, E224K, V245E, D250EA
 1st_471st_47KX775247AZT, 3TCNVPK65R, M184VK101P, G190AK20R, V35T, E36D, T39K, K43E, V60I, S68G, K122E, D123N, K173S, Q174K, D177E, V179I, T200A, Q207A, R211S, V245M, D250EA