<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Reverse Transcriptase Inhibitors

Subtype A
Gene RT
Mutation K101E
Rx >= 1 NNRTI
(+/- NRTI)
IncludeMixtures No
References 20
Patients 49
Isolates 51
 
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# NRTIs NNRTIsNRTIDRMs NNRTIDRMs OtherMutSubtype
Richard (2004)RNJCR36RNJCR36AY556814D4T, DDI, AZT, 3TCNVPD67N, M184VK101E, G190AV35T, V60I, D121H, K122E, D123S, I135T, K166R, K173S, Q174R, D177E, I178L, V179I, T200AA
Non-B Workgroup (2005)UK4280UK4280AY901826AZT, 3TCNVPM184VA98G, K101E, G190AK11T, K20R, V35T, E42K, K122E, D123S, I135T, E138A, K173S, Q174K, D177G, V179I, I202V, Q207D, R211S, F214LA
 TK1007TK1007 AZT, 3TCEFVD67N, T215FK101E, G190SE28G, V35T, T39E, E44D, V118I, K122E, D123N, I135T, I142V, K173L, V179I, T200A, Q207A, R211S, F214L, V245Q, K281R, E291D, I293V, E297K, E312D, S322A, D324EA
  TK1007a AZT, 3TCEFVD67G, K70R, T215F, K219QK101E, G190SE28G, V35T, T39E, E44D, V118I, K122E, D123N, I135T, I142V, K154KN, F160FS, K173L, V179I, T200A, Q207A, R211S, F214L, V245Q, K281R, E291D, I293V, E297K, E312D, S322A, D324EA
Weber (2005)F54577F54577AY677508AZT, DDI, 3TCNVPD67N, K70R, M184V, T215V, K219QK101E, G190AV35T, T39A, E40D, V60I, D121H, K122E, D123G, I135T, K173S, Q174K, D177E, V179I, G196E, T200A, Q207A, R211N, V245Q, K281R, T286A, E291D, V292I, I293V, P294T, E312SA
 M55405M55405AY6775643TC, D4TNVPM184VK101E, G190AP4S, K11T, K20R, V21I, V35T, T39K, S68G, V90I, A98S, K122E, D123N, T165I, K166R, K173S, D177E, V179I, T200A, I202V, Q207A, R211K, V245Q, E248D, T286A, E291D, V292I, I293V, E297EA, E312DYA
Baxter (2006)48-80538053-30818DQ879078NRTINNRTIA62AV, D67N, T69D, V75I, Y115F, F116Y, Q151M, M184V, K219QK101E, G190GSP4H, K11T, K32KR, A33IV, V35T, T39A, V60I, V118VI, K122E, D123N, K173S, Q174K, D177E, V179I, Q207A, R211S, F214FL, V245Q, I293V, P294T, G335D, M357K, R358K, G359S, K366R, A371V, I375V, T377Q, A400LA
Lwembe (2007)NYU7979MFEB04 AZT, 3TCNVPV75M, M184VK101E, G190AE28A, V35T, T39A, E40D, T69S, R83G, D121H, K122E, I135T, K173S, Q174K, D177E, I178V, V179I, T200A, Q207A, R211SA
  79MJUN04 AZT, 3TC, DDINVP, EFVV75M, M184VK101E, Y181C, G190AE28A, V35T, T39A, E40D, T69S, D121H, K122E, I135T, T139I, K173S, Q174K, D177E, I178V, V179I, T200A, Q207A, R211SA
Gody (2008)Pt047Pt047 D4T, 3TCNVPK65KRK101E, Y181C, G190AK11AT, V35L, S68SG, S105SA, D121HY, K122E, I135IV, K173A, Q174K, D177E, G196E, Q207A, R211N, L228LR, V245Q, E248DN, D250DE, K281R, T286A, E291D, I293VA
Sylla (2008)D607D607_C2DQ991656AZT, 3TCNVPM41L, D67N, M184V, L210W, T215YK101E, G190AI5V, E6K, K11T, V35T, E36A, T39K, K43E, E53D, K102Q, K122E, D123S, I135T, E138A, S162D, K173S, V179I, T200A, Q207A, R211K, V245Q, T286A, E291D, I293V, P294T, E312D, I326V, G335D, R356K, M357K, G359S, K366R, T369V, A371V, I375V, A376V, T386A, K390R, A400T, T403M, W410Y, E432D, V435AA
 A1424A1424_C1EF525664D4T, 3TCNVPM184VK101E, G190AK32E, V35T, E36A, T39K, K43E, K122E, D123S, I135R, I142V, S162Y, K173T, Q174K, D177E, V179I, Q197E, Q207A, R211K, V245Q, A272P, T286A, E291D, V292I, I293V, E312D, I326V, G335D, M357K, G359S, K366R, T369V, A371V, I375V, A376V, T386A, K388R, A400T, T403M, W410Y, E432D, V435IA
Deshpande (2009)Pat21810RTFJ530723D4T, 3TCNVP K101E, G190AK11T, V35T, E42K, V60I, T69TN, D121H, K122E, D123DGNS, K173S, Q174K, D177E, V179I, Q197K, T200E, Q207DE, R211S, V245Q, D250EA
Hawkins (2009)Q956ZZQ956FJ931325D4T, 3TCNVPD67DN, K70KR, M184VK101E, Y181CI5V, K11A, E28K, V35T, T39K, D121Y, K122E, I135T, I142T, E169D, K173A, Q174K, G196E, Q207A, R211S, V245Q, T286A, E291D, I293VA
Koyalta (2009)67TCHAD-67FJ688198D4T, 3TCNVPD67N, M184V, T215FK101E, G190SK43E, D121H, K122E, D123S, I135T, K173A, Q174K, D177E, V179I, T200A, Q207A, R211S, K238RA
Moussa (2010)423-CP001745HM117953D4T, 3TCEFVM184V, L210WK101E, Y181C, G190SV35T, T39L, T107S, K122E, D123S, K173A, D177G, T200A, Q207E, R211KA
 2511-CP001021HM117952D4T, 3TCNVPM184V, T215FA98G, K101E, Y181C, G190AE28K, K32E, V35T, T39M, K122E, D123N, I135T, I142V, K173A, Q174K, D177E, I178M, T200A, Q207A, V245KA
 2814-CP001245HM117957D4T, 3TCNVPM184VK101E, V108I, F227LV35T, K49R, T69S, K122E, D123S, I135T, T139R, S162H, K173S, D177E, G196E, Q207A, R211S, L228F, V245QA
Charpentier (2011)11CP 001 554 D4T, 3TCNVPM184V, T215FK101E, Y181YC, G190AE6D, K11T, V35T, T39K, K43E, K49KR, S68SG, D121Y, K122E, D123G, I135IT, I142V, A158AS, K173A, Q174R, D177E, V179I, Q207DN, R211K, L228LR, K238KR, V245EK, K249KN, A272P, K281R, L283I, T286A, E291A, V292T, I293V, P294T, L295LM, V317A, I326VA
 219CP 001 004 D4T, 3TCNVPM41L, D67DN, L74LI, M184V, L210LW, T215FYA98G, K101E, G190AG45GR, L109I, V118VI, D121H, K122E, D123S, I142IT, S162D, E169EK, K173AT, Q174K, D177E, V179I, G196GS, I202IV, E203EK, Q207ADE, H208HY, R211RKNS, H221HYA
Dvali (2012)R008R008FJ456895AZT, 3TCEFVM184VK101E, G190SV35L, E36N, I37F, T39IKM, D121H, K122E, D123S, K173LS, Q174KR, D177E, V179VI, Q207A, R211SA
 R149R149FJ456914D4T, 3TCNVPA62V, K65R, M184IK101E, Y181YC, G190SK30Q, K32G, A33C, L34T, V35L, E36N, I37F, T39K, V90I, K122E, D123N, A158S, K173L, Q174K, T200A, Q207A, R211S, V245MA
 R117R117FJ456906AZT, 3TCNVPA62V, M184VK101E, G190SK30Q, K32G, A33C, L34T, V35L, E36N, I37F, T39S, W88C, K122E, D123N, I135T, E138A, K173S, Q174K, Q207A, R211S, F214LA
Avidor (2013)1966_MT1966_MTKC184299TDF, 3TCEFVK65KR, M184VK101E, Y181C, G190SK30Q, K32G, A33C, L34T, V35L, E36N, I37F, T39V, V106I, D121H, K122E, D123S, I135T, K173S, Q174K, D177E, T200A, Q207A, R211S, L228LR, V245MA
 17851785 TDF, 3TCEFVK65R, T69~, M184MVK101E, Y181C, G190ST39E, K122E, D123S, I142T, A158S, K173S, Q174K, Q207A, R211S, L228LR, V245MA
Inzaule (2013)7979JQ914094AZT, 3TCNVPM184VK101E, G190AE6T, E28A, V35T, V60I, D121F, K122E, D177E, I178M, E203Q, Q207E, R211KA
Pircher (2013)B1128B1128JX110229D4T, 3TC, AZTNVPD67DG, M184V, T215YK101E, G190AE6D, K11T, E28K, V35T, T39N, D86DE, D123N, K166R, D177E, I178F, V179T, T200A, Q207A, R211KA
Sigaloff (2013)JCR120_0JCR120_0JX182008NRTINNRTIM184V, T215FK101E, G190AK20R, V21I, E28K, V35T, T39S, V60I, K122E, D123N, I135T, Q145V, K173A, D177E, V179I, T200A, I202V, Q207AT, R211K, V245Q, E248D, A272P, T286A, E291D, P294T, E297KA
 MBA005_0MBA005_0JX182012NRTINNRTIM41L, D67N, V75M, M184V, T215YK101E, K103N, G190AK20R, T27S, E28A, V35T, E44ED, V60I, K122E, D123S, I135T, I142Q, K173S, Q174K, D192N, T200A, E203K, Q207D, R211K, V245T, D250E, A272P, T286A, E291D, V292I, I293VA
 JFP103_0JFP103_0JX182011NRTINNRTIM41L, D67N, K70R, L74I, M184V, L210W, T215F, K219QA98G, K101E, G190AK20R, E28K, K32Q, V35T, T39E, T69N, I94L, K103R, K122E, D123N, S162SN, K173S, Q174K, D177E, T200A, Q207A, R211N, D218E, V245Q, E248D, D250E, S251D, R284K, T286A, E291D, V292I, I293V, P294T, E312NA
Thiam (2013)3713-HALD3713-HALDJN673567NRTINNRTIM184VK101E, G190AE6A, V35T, E36A, T39K, K43E, V106I, D121H, K122E, K173S, D177E, V179I, T200A, Q207A, R211RK, V245Q, A272P, T286A, E291D, V292I, I293V, P294T, E312D, I326V, G335DA
Hassan (2014)RS11000426RS11_426KC568513D4T, 3TC, AZTNVP K101E, G190AE28K, K32Q, V35T, K49R, V60I, K122E, D123N, I135T, S162C, K173S, Q174K, D177G, V179I, T200A, E203EQ, Q207A, R211S, D237DN, V245T, D250E, A272P, T286A, E291D, V292I, I293V, P294TA
Kolomeets (2014)279279_551KJ870602AZT, 3TCEFVA62V, M184VK101E, E138K, G190SK11T, V35I, E36D, T39K, K122E, D123N, A158S, S162C, K173S, Q174R, D177E, I178L, T200A, Q207A, R211S, V245Q, E248DA
 8585_121KJ870274AZT, 3TCEFVA62V, M184VK101E, G190SK11T, V35I, E36D, T39K, K64R, K122E, D123N, E138A, K173L, Q174K, V189VI, I202IV, Q207A, R211S, E248DA
 126126_172KJ870314AZT, 3TCNVPA62V, M184VK101E, G190GASTK11T, V35I, E36D, T39K, K82R, V106VI, K122E, D123N, A158S, K173L, Q174K, D177E, T200E, Q207A, R211S, V245K, E248DA
 167167_202KJ870340AZT, 3TCEFVA62V, M184VK101E, Y181YCFK11T, G18W, Q23P, E29G, V35I, T39K, K122E, D123S, I167F, K173N, Q174K, R211S, E248DA
 6565_157KJ870301AZT, 3TCNVPA62V, M184VK101E, G190SK11T, V35T, E36A, T39E, V90I, V106VI, K122E, D123N, A158S, K173L, Q174K, T200A, Q207A, R211S, E248DA
 3939_642KJ8706673TC, DDIEFVA62V, K65R, M184IK101E, Y181C, G190S, P225HK11T, V35I, E36D, T39K, K122E, D123N, A158S, K173LS, Q174R, D177E, G196E, T200A, Q207A, R211S, E248DA
 271271_377KJ870482AZT, 3TCNVPM184VK101E, Y181YC, G190AK11T, E28K, V35T, E36D, T39K, A98AS, K122E, D123S, K173S, Q174K, D177E, Q207A, R211S, E248DA
 345345_524KJ870583ABC, 3TCEFVA62V, L74V, M184VK101E, G190SK11T, V35T, T39E, K122E, D123N, E138A, S162SN, K173L, Q174K, Q207A, R211K, E248DA
 179179_322KJ870435AZT, 3TCEFVA62V, M184V, T215TSK101E, G190SK11T, V35I, E36D, K122E, D123N, E138A, K173L, Q174K, Q207A, R211S, E248DA
 495495_155KJ870300AZT, 3TCEFVM41L, A62V, M184V, L210LW, T215FK101E, G190SK11T, V35T, E36D, T39K, K49R, V90VI, K122E, D123S, S162C, K173T, Q174K, D177E, Q207A, R211S, E248DA
 482482_614KJ870644AZT, 3TCEFVA62V, M184VK101E, E138EKP9PS, K11T, V35I, E36D, T39K, K49R, E53EG, D123N, S162SN, E169D, K173S, Q174K, D177EA
 414414_633KJ870659AZT, 3TCEFVD67DN, K70KR, M184V, T215TNSY, K219KQK101E, G190SE6K, K11T, V35T, E36D, T39N, V106I, K122E, D123S, S162C, K173L, Q174K, D177E, G196E, Q197QKR, T200A, Q207A, R211S, V245M, E248DA
 326326_462KJ870541AZT, 3TCEFVA62V, M184VK101E, G190SK11T, V35I, E36D, T39K, R72RK, V106I, K122E, D123N, A158S, K173A, Q174K, D177E, Q207A, R211S, V245M, E248DA
 494494_154KJ870299AZT, 3TCEFVA62V, M184VK101E, G190SK11T, E28EK, K32KE, V35I, T39K, T84TI, K122E, D123N, K173L, Q174K, D177E, T200A, E203ED, Q207A, R211S, E248D, S251SIA
 8888_160KJ870304AZT, 3TCEFVD67N, K70R, M184V, K219QK101E, G190SK11T, V35I, E36D, T39K, V90I, V106I, K122E, D123N, A158S, K173S, Q174K, D177E, T200A, Q207A, V245MT, E248DA
 274274_443KJ870528AZT, 3TCEFVA62V, M184VK101E, G190SK11T, V35T, E36D, T39K, K122E, D123N, E138A, K166R, Q174K, Q207A, R211SA
 9797_249KJ870374AZT, 3TCEFVA62V, D67N, K219KEK101E, G190SK11T, V35R, E36D, T39K, I50T, V90I, K122E, D123N, S162A, D177E, R211S, V245M, E248DA
 411411_600KJ870632AZT, 3TCNVPA62V, M184VK101E, G190SK11T, V35I, E36D, T39K, K122E, D123N, E138A, A158S, S162SN, K173L, Q174K, D177E, I178V, I202V, Q207A, R211S, E248DA
 119119_146KJ870293AZT, 3TCEFVA62V, D67N, K70RK101E, G190SK11T, V35I, E36D, T39K, K46Q, K122E, D123N, S163T, K173S, Q174K, D177E, V179VI, D186H, F214L, E248DA