<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Reverse Transcriptase Inhibitors

Subtype A
Gene RT
Mutation L100I
Rx >= 1 NNRTI
(+/- NRTI)
IncludeMixtures No
References 14
Patients 23
Isolates 24
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# NRTIs NNRTIsNRTIDRMs NNRTIDRMs OtherMutSubtype
Non-B Workgroup (2005)TK5008TK5008 D4T, 3TC, DDIEFVT215YL100I, K103KNK11T, V35T, E40D, I50V, V118I, K122E, D123S, T165L, K173S, D177E, V179I, T200A, Q207D, R211K, F214L, V245Q, A272T, K277R, T286A, E291D, I293V, P294T, E312N, Q332P, G335DA
Lwembe (2007)NYU3030FJAN04DQ679544AZT, 3TC, DDIEFVD67G, K70R, V75E, F77L, K219QL100I, K103NK20R, V35T, V60I, D76I, K122E, D123S, I135T, K173L, Q174K, D177E, T200A, Q207A, R211SA
  30FAPR04DQ679543AZT, 3TC, DDIEFVD67G, K70R, K219QL100I, K103NV35T, V60I, K122E, D123S, I135T, E138Q, K173L, Q174K, D177E, T200A, Q207A, R211SA
Dau (2010)11741A11741AGU582052NRTINNRTID67DG, T69DN, K70R, V75VIM, M184MV, T215TI, K219QL100I, K103NE6D, V8VI, K20R, V35T, T39A, V60I, K122E, D123S, I135T, K173S, Q174K, D177EG, V179I, T200A, Q207A, R211S, F214L, D218E, L228HR, V245Q, E248D, D250E, T286A, E291D, I293V, P294T, E297K, G335D, M357R, G359S, A371V, I375V, A376V, T377M, T386A, A400TA
Nouhin (2013)R0220214R0220214KF292451NRTINNRTIM41L, D67N, L74LV, V75M, M184V, L210W, T215YL100I, K103N, Y181IV35T, T39A, E44D, V111I, V118I, K122E, D123S, I135T, I159L, T165V, K173I, Q174K, D177E, I178M, V179I, T200A, E203D, Q207K, H208Y, R211D, K223KQ, K238RA
Theys (2013)4378643786KC221290NRTI, TDFNNRTIM41L, D67N, L74V, M184V, L210W, T215F, K219EL100I, K103NV60I, K66R, K122E, D123S, K173A, D177E, I178M, V179I, T200A, E204Q, Q207A, R211K, D218E, L228HRA
 52485248KC219402NRTI, TDFNNRTID67DG, K70KR, M184IV, K219HL100I, K103NV60I, T69N, K122E, D123S, I135T, S162H, K173S, Q174K, D177E, I178L, V179L, Q207A, R211N, L228RA
Van Zyl (2013)O7211935KC423520AZT, D4T, 3TC, TDFNVP, EFVL74V, M184VL100I, K103NK20R, V35T, T39G, K49R, D121H, K122E, I135T, T139S, E169D, K173S, Q174K, D177E, T200A, E203ED, Q207DEKN, R211K, F214LA
Aghokeng (2014)CM-1-057CM-1-057KC350321NRTINNRTID67G, K70R, L74I, M184V, T215F, K219EL100I, K103N, K238TK11T, T27S, E28A, V35T, S48T, K64R, T69N, K122E, D123N, I135T, S162A, K173S, Q174K, V179I, I202V, Q207A, V245Q, E248D, T286A, E291D, I293V, P294A, E312D, S322A, Q334H, G335DA
Meini (2015)109273109273KM438240AZT, 3TC, DDIEFVM41L, L74V, M184V, T215YL100I, K103NE28A, K32Q, V35T, T39A, V60I, S68SG, D123E, I135T, K173A, Q174K, D177E, I178IM, V179T, T200A, Q207A, R211SA
 109266109266KM438248D4T, DDIEFVM41L, D67N, K70R, T215FL100I, K103NL34I, V35T, T39TA, K49R, V60I, V90VI, A98S, V118I, T139K, K173LS, V179I, T200A, Q207A, R211S, V245KA
Brooks (2016)2052A2052AKU900870TDF, 3TCEFVK65R, K70T, M184IL100I, K103NK11Q, V35T, T39I, K49R, V60I, S68G, V90I, K122E, D123S, I135T, T165I, K173S, Q174K, D177E, T200A, I202V, Q207A, R211SA
Ndahimana (2016)12891289KU922889TDF, 3TCNVPA62V, K65R, M184VL100I, Y181C, G190AT39TA, K101R, V111I, K122E, D123S, I135T, I142V, T165I, K173S, D177E, V179I, T200A, Q207A, R211S, H221Y, V245QA
Kekitiinwa (2017)65485_89765485_897KY237871NRTINNRTIK70KMR, V75M, Y115F, M184VL100I, K103NI63IV, S68C, T69I, K102KR, K122E, D123N, A158S, K173S, D177EG, V179I, G196K, T200EQ, I202V, Q207A, R211SA
 79397_112379397_1123KY238005NRTINNRTIL74V, Y115F, M184VL100I, K103NV60I, K66R, V118I, K122E, D123N, I135T, K173S, Q174K, D177E, I178IM, V179T, Q207A, R211S, H221YA
 65534_59665534_596KY237891NRTINNRTIL74V, Y115F, M184V, K219NA98G, L100I, K103NV90I, K122E, I135T, Q174K, D177E, I178L, T200A, Q207E, R211KA
 66075_80566075_805KY237950NRTINNRTIL74V, Y115F, M184V, L210LW, K219DNL100I, K103NI50V, V60I, T69TA, V118VI, K122E, D123N, I142T, K173S, Q174K, D177E, I178L, V179IT, T200A, I202V, Q207A, R211KNA
 65801_47065801_470KY237944NRTINNRTIL74V, Y115F, M184VL100I, K103N, P225HS48T, K49R, V60I, T69N, K122E, D123NS, P170PS, K173S, V179IT, T200A, R206RK, Q207A, R211SA
Kityo (2017)8318183181KY061737NRTINNRTIM41L, D67DG, T69DN, K70R, M184V, T215F, K219QL100I, K103NK122E, D123N, I135V, S162SN, K173S, D177E, V179I, T200A, I202V, Q207A, H221HY, E224ED, L228HRA
 8349183491KY062045NRTINNRTIK65R, Y115F, M184V, K219EL100I, K103SV60I, S68G, K122E, D123S, I135T, I142V, K173S, Q174K, T200A, I202V, Q207G, R211KA
 6603966039KY061408NRTINNRTIK70N, L74V, M184VL100I, K103N, P225HV60I, D121H, K122E, I135T, E138A, S162C, K173S, Q174K, V179IL, G196E, T200A, Q207A, R211KA
Rhee (2017)KE10265KE10265KY364288TDF, 3TCEFVK65KR, D67DG, K70KE, M184MIVL100I, K103NP4H, V35T, T39TA, V60I, S68SG, D121Y, K122E, I135T, K173S, Q174K, V179I, T200A, Q207A, R211K, V245I, D250EA
 KE04635KE04635KY364315TDF, 3TCNVPK65R, M184IL100I, K103NV35T, V60I, S68G, T69N, K102R, K122E, D123N, I135T, K173T, Q174K, D177E, I178L, Q207A, R211S, V245E, D250EA
Svard (2017)1st_651st_65KX7752533TC, D4TNVPA62V, T69S_QS, M184V, L210W, T215FL100I, K101E, G190AT7A, K20R, V35T, K49R, S68N, K122E, D123N, I135T, E138G, K173S, Q174R, D177E, I178M, V179I, T200A, Q207E, R211K, L228H, V245Q, E248DA