<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Reverse Transcriptase Inhibitors

Subtype A
Gene RT
Mutation L100I
Rx >= 1 NNRTI
(+/- NRTI)
IncludeMixtures No
References 10
Patients 11
Isolates 12
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# NRTIs NNRTIsNRTIDRMs NNRTIDRMs OtherMutSubtype
Richard (2004)RNJCR46RNJCR46AY556836AZT, 3TC, D4T, ABCEFVK70N, L74V, M184VL100I, K103NK11T, K20R, V21I, L34S, V35T, T39N, R78T, G93R, K122E, D123S, T165I, K173S, D177E, V179I, T200A, I202VA
Non-B Workgroup (2005)TK5008TK5008 D4T, 3TC, DDIEFVT215YL100I, K103KNK11T, V35T, E40D, I50V, V118I, K122E, D123S, T165L, K173S, D177E, V179I, T200A, Q207D, R211K, F214L, V245Q, A272T, K277R, T286A, E291D, I293V, P294T, E312N, Q332P, G335DA
Lwembe (2007)NYU3030FJAN04DQ679544AZT, 3TC, DDIEFVD67G, K70R, V75E, F77L, K219QL100I, K103NK20R, V35T, V60I, D76I, K122E, D123S, I135T, K173L, Q174K, D177E, T200A, Q207A, R211SA
  30FAPR04DQ679543AZT, 3TC, DDIEFVD67G, K70R, K219QL100I, K103NV35T, V60I, K122E, D123S, I135T, E138Q, K173L, Q174K, D177E, T200A, Q207A, R211SA
Dau (2010)11741A11741AGU582052NRTINNRTID67DG, T69DN, K70R, V75VIM, M184MV, T215TI, K219QL100I, K103NE6D, V8VI, K20R, V35T, T39A, V60I, K122E, D123S, I135T, K173S, Q174K, D177EG, V179I, T200A, Q207A, R211S, F214L, D218E, L228HR, V245Q, E248D, D250E, T286A, E291D, I293V, P294T, E297K, G335D, M357R, G359S, A371V, I375V, A376V, T377M, T386A, A400TA
Theys (2013)52485248KC219402NRTI, TDFNNRTID67DG, K70KR, M184IV, K219HL100I, K103NV60I, T69N, K122E, D123S, I135T, S162H, K173S, Q174K, D177E, I178L, V179L, Q207A, R211N, L228RA
Van Zyl (2013)O7211935KC423520AZT, D4T, 3TC, TDFNVP, EFVL74V, M184VL100I, K103NK20R, V35T, T39G, K49R, D121H, K122E, I135T, T139S, E169D, K173S, Q174K, D177E, T200A, E203ED, Q207DEKN, R211K, F214LA
Aghokeng (2014)CM-1-057CM-1-057KC350321NRTINNRTID67G, K70R, L74I, M184V, T215F, K219EL100I, K103N, K238TK11T, T27S, E28A, V35T, S48T, K64R, T69N, K122E, D123N, I135T, S162A, K173S, Q174K, V179I, I202V, Q207A, V245Q, E248D, T286A, E291D, I293V, P294A, E312D, S322A, Q334H, G335DA
Meini (2015)109273109273KM438240AZT, 3TC, DDIEFVM41L, L74V, M184V, T215YL100I, K103NE28A, K32Q, V35T, T39A, V60I, S68SG, D123E, I135T, K173A, Q174K, D177E, I178IM, V179T, T200A, Q207A, R211SA
 109266109266KM438248D4T, DDIEFVM41L, D67N, K70R, T215FL100I, K103NL34I, V35T, T39TA, K49R, V60I, V90VI, A98S, V118I, T139K, K173LS, V179I, T200A, Q207A, R211S, V245KA
Brooks (2016)2052A2052AKU900870TDF, 3TCEFVK65R, K70T, M184IL100I, K103NK11Q, V35T, T39I, K49R, V60I, S68G, V90I, K122E, D123S, I135T, T165I, K173S, Q174K, D177E, T200A, I202V, Q207A, R211SA
Ndahimana (2016)12891289KU922889TDF, 3TCNVPA62V, K65R, M184VL100I, Y181C, G190AT39TA, K101R, V111I, K122E, D123S, I135T, I142V, T165I, K173S, D177E, V179I, T200A, Q207A, R211S, H221Y, V245QA