<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Integrase Inhibitors

Subtype G
Gene IN
Mutation L74I
Rx II-naive
IncludeMixtures No
References 11
Patients 16
Isolates 16
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# INIs WksINIMajorDRMs INIMinorDRMs OtherMutSubtype
Carr (1998)SE6165SE6165AF061642None   K14R, S17N, V31I, L74I, L101I, K111T, T112V, T124A, T125A, G134N, K136T, V201I, T206S, L234V, S255N, D256E, S283GG
Brennan (2008)252-14252-14EU618127None   E11ED, S17SN, V31I, L74I, L101I, T112V, T124A, T125A, G134N, K136Q, V201I, T206S, L234I, S283GG
 516-15516-15EU618223None   K14R, S24SG, L74I, A91E, L101I, T112V, S119R, T124A, T125A, G134D, I135V, V201I, T206S, Y227F, L234I, A265V, S283GG
 ABB28-96ABB28-96EU618515None   K14R, V31I, I72V, L74I, P90S, A98G, L101I, T112V, T124A, K136Q, V201I, T206S, L234I, R269K, D286NG
Van Laethem (2008)AR06-009AR06-009EU882797None   K14R, S17N, V31I, L74I, L101I, T112V, I113L, T124A, T125A, G134N, K136T, V201I, T206S, T218I, L234I, S255N, D256EG
Garrido (2009)15INT-15GU216862None   K7E, E11D, S24N, I72V, L74I, T112I, T124A, T125A, V126M, K136Q, M154ML, V201I, T206S, Q209R, L234I, S255N, D256EG
 45INT-45GU216892None   L45I, I60V, L74I, T112V, T124A, T125A, I135V, K136R, G193R, V201I, T206S, I208L, L234IG
Sichtig (2009)2657rc2657rcFJ183690None   K14R, V31I, L63V, L74I, T112V, T124S, T125A, G134N, K136T, V201I, K211R, Y227F, L234I, S255N, D256EG
Avi (2010)N61N61GQ926806None   E11D, S24N, V31I, L74I, T112V, I113V, S119P, T124S, T125A, G134N, K136Q, V201I, T206S, T218I, L234V, D256EG
Charurat (2012)09NG.SC2109NG.SC21JN248584None   E11D, K14R, V31I, L74I, Y99F, L101I, T112V, I113V, S119P, T124A, T125A, G134D, K136T, V201I, T206S, I208L, K211R, T218I, L234I, S255N, D256E, A265T, R269K, D278G, S283GG
 08NG.SC1308NG.SC13JN248582None   K14R, K34R, L74I, G82S, L101I, T124N, G134N, K136T, V201I, T206S, L234I, D256E, M275V, S283G, D286AG
Oliveira (2012)GA57GA57JQ670824None   K14R, V31I, L74I, G106A, T112V, S119P, T125A, K136Q, D167E, V201I, T206S, D207E, L234I, S255N, D256E, C280Y, S283GG
Reigadas (2013)319319JX425440None   S24N, V31I, L63I, I72V, L74I, K111KQ, T112MV, T124A, T125A, G134N, K136T, D167E, V201I, T206S, E212A, L234I, D256E, S283GG
 490490JX425823None   K14R, S24N, L74I, T112I, T124N, T125A, G134N, K136T, V201I, T206S, L213Q, D232N, L234I, S255N, D256E, S283G, R284G, D286NG
Hora (2015)DEURF10CM020DEURF10CM020KP109502None   K14R, V32I, L45I, L74I, I84M, Q95P, L101I, T124N, G134N, K136T, V201I, T206S, L234I, D256E, S283GG
Wilkinson (2015)TV546TV546KJ948662None   K14R, V31I, L74I, T112V, T124Q, T125A, G134S, K136T, V201I, L234I, S255N, D256E, I267V, I268L, S283GG