<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Integrase Inhibitors

Subtype F
Gene IN
Mutation I72V
Rx II-naive
IncludeMixtures No
References 24
Patients 100
Isolates 103
 
Show mutation frequency as:
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# INIs WksINIMajorDRMs INIMinorDRMs OtherMutSubtype
Carr (2001)ARCH003ARCH003AY037267None  V151IE11D, S17N, I72V, I84L, L101I, T125A, K136Q, V165I, V201I, A205S, K211R, K215N, T218I, L234V, D256E, S283GF
 BOL137BOL137AY037271None  V54I, G163RE11D, V37I, I72V, I84L, L101I, S119T, T124A, T125A, K136Q, V201I, A205S, K211R, T218I, L234V, D256E, S283GF
 URTR17URTR17AY037272None  S153YS17N, I72V, I84L, L101I, S119T, T124A, T125A, K136Q, V201I, A205S, K211R, K215N, T218I, L234V, D256E, S283GF
 ARMA097ARMA097AY037280None  G163RE11D, S24N, I72V, I84L, L101I, S119T, T125A, K136Q, V201I, I204V, A205S, K211R, T218I, L234V, D256E, S283GF
 ARMA029ARMA029AY037283None   S17N, K42R, M50I, I72V, I84L, L101I, S119P, T122I, T124A, T125S, K136Q, V165I, V201I, A205S, K211R, T218I, L234V, D256E, S283GF
 URTR35URTR35AF385935None   E11D, S17N, I72V, I84L, L101I, K111R, S119P, T122S, T124A, T125A, I135V, K136Q, G163H, V201I, T218I, S230N, L234V, D256E, S283GF
Hierholzer (2002)BZ126BZ126AY173957None  G163RS17N, I72V, I84L, A91T, L101I, S119T, T124A, T125A, K136Q, V201I, A205S, T206S, T218I, Q221R, L234V, D256E, S283GF
 BZ163BZ163AY173958None  G163KS17N, C56X, I72V, I84L, A91T, L101I, S119T, T124A, T125A, K136Q, V201I, A205S, T206S, T218I, Q221R, L234V, D256E, S283GF
Thomson (2002)A027A027AF332867None   S17N, I72V, I84L, P90S, L101I, S119T, T124A, K136Q, G163S, V201I, A205S, K211R, T218I, L234V, S255N, D256E, S283GF
 A047A047AF408627None  G163RS17N, I72V, I84L, I113V, S119P, T124A, T125A, K136Q, V201I, A205S, T206S, D207E, L234V, D256E, S283GF
 A32879A32879AF408629None   E11D, S17N, I72V, I84L, L101I, K111R, S119P, T122I, S123N, T125A, K136Q, D167E, V201I, A205S, K211R, T218I, L234V, D256E, S283GF
 A32989A32989AF408630None   S17N, D64N, I72V, I84L, T112I, S119P, T124N, K136Q, G163S, D167E, V201I, A205S, K211R, T218I, L234V, D256E, S283GF
 A050A050AF408631None   S17N, I72V, I84L, L101I, S119P, T122I, T125A, K136Q, V201I, A205S, K211R, T218I, L234V, D256E, S283GF
Swanson (2003)BR57BR57AY214073None   S17N, L45V, I72V, L101I, T112I, S119A, T122I, T124N, K136Q, V201I, A205S, T218I, L234V, D256E, S283GF
 BZ126BZ126AY214074None  G163RS17N, I72V, I84L, A91T, L101I, S119T, T124A, T125A, K136Q, V201I, A205S, T206S, T218I, Q221R, L234V, D256E, S283GF
 BZ163BZ163AY214076None  G163KS17N, I72V, I84L, A91T, L101I, G106E, S119T, T124A, T125A, K136Q, V201I, A205S, T206S, T218I, Q221R, L234V, D256E, S283GF
Sierra (2004)R140R140AY536237None   E10D, I72V, I84L, L101I, S119P, T124A, T125A, K136Q, H171Y, V201I, A205S, K211R, T218I, L234V, D256E, S283GF
 X1241X1241AY536238None  G163KS17N, I72V, I84L, L101I, S119T, T122S, T124A, T125A, K136Q, D167E, V201I, T218I, L234V, D253E, D256EF
Thomson (2004)99UFRJ_199UFRJ_1AY455778None   E11D, E13K, S17N, V31I, I72V, I84L, L101I, S119P, T122I, T125A, K136Q, K156N, V165I, V201I, A205S, K211R, T218S, L234V, D256E, S283GF
 99UFRJ_1699UFRJ_16AY455782None  G163KS17N, I72V, L101I, S119T, T122I, T124A, T125A, K136Q, V201I, A205S, L234V, D256E, S283GF
 94BR_RJ_4194BR_RJ_41AY455781None  G163RE11D, V37I, I72V, I73V, I84L, L101I, S119T, T124A, T125A, K136Q, Q168H, V201I, A205S, K211R, T218I, L234V, D256EF
Aulicino (2005)ARE933ARE933DQ189088None   E11D, S17N, I72V, I84L, L101I, V110A, S119P, T124A, T125A, A129S, K136Q, A205S, K211R, T218I, L234V, D256E, V281M, S283GF
de Sa Filho (2005)BREPM108BREPM108AY771589None  L68IE11D, S17N, I72V, L74I, I84L, L101I, K111R, S119T, T125A, M154I, V165I, Q177L, F181Y, V201I, A205S, K211R, T218I, L234V, D256E, S283GF
 BREPM119BREPM119AY771590None  L68VE11D, S17N, A21S, V31I, E48K, I72V, L74I, I84L, A98G, L101I, K111R, S119P, T122I, T125A, G163E, V165I, V201I, A205S, K211R, S230N, L234I, D256EF
de Sa Filho (2006)BREPM11948BREPM11948DQ085871None   S17N, L28I, V32I, I72V, V77A, I84L, L101I, S119P, T124A, T125A, K136Q, V201I, D207N, K211N, Y227F, L234V, D256E, S283GF
 BREPM13853BREPM13853DQ085875None   S17N, I72V, I84L, L101I, K111R, S119T, T124A, M154I, V165I, V201I, A205S, K211R, L234V, D256E, S283GF
 BREPM16704BREPM16704DQ085876None   S17N, L45V, I72V, I84L, L101I, S119T, T124A, K136Q, I141V, V201I, T218I, L234V, D256E, S283GF
Sanabani (2006)01BR04201BR042DQ358799None   S17N, V31I, I72V, I84L, L101I, S119T, T124A, T125A, K136Q, V201I, T218I, L234V, D256E, S283GF
 01BR04701BR047DQ358800None  G163RS17N, V32I, I72V, I84L, K103R, K111R, T112A, S119P, T124A, T125A, K136Q, V201I, L234V, D256E, S283GF
 01BR08701BR087DQ358801None   S17N, I72V, I84L, L101I, S119P, T124A, T125A, K136Q, H171Y, V201I, A205S, K211R, T218I, L234V, D256E, S283GF
 01BR12501BR125DQ358802None  G163KS17N, I72V, I84L, E96D, L101I, T112I, S119P, T124A, T125A, K136Q, V201I, A205S, K211R, T218I, L234V, D256E, S283GF
 01BR22601BR226DQ358803None   S17N, V32I, I72V, I84L, L101I, S119P, T122I, T124A, K136Q, V201I, A205S, K211R, T218I, L234V, D256E, S283GF
Brennan (2007)182189182189EF150617None   S17N, I72V, I84L, S119T, T124G, T125A, K136Q, G163S, V201I, L234V, D256E, S283GF
 01BAB03201BAB032EF150618None  G163KE10D, M50I, I72V, A91G, L101I, T112A, I113V, S119T, T124A, T125A, K136Q, G193E, I208L, L234V, D253E, D256E, D279GF
 01GOB03901GOB039EF150627None   S17N, S24N, M50T, S57G, I72V, L74I, I84L, L101I, K111R, S119P, M154I, V165I, V201I, A205S, K211R, T218I, L234V, D256E, S283GF
 01CEB09201CEB092EF150630None  L74LIM, T97AS17N, L28I, P30A, I72V, V77VA, I84L, L101I, S119T, T124A, T125A, K136Q, V165I, V201I, L234V, D256E, S283GF
 3781137811EF150631None  E138DS17C, I72V, I84L, L101I, S119T, T124A, T125A, K136Q, V201I, A205S, K211R, T218I, L234V, D256E, S283GF
Brennan (2008)0031-10031-1EU618056None   K14R, V31I, I72V, A98G, L101I, T112I, T125A, K136Q, G163T, V201I, Y227F, L234I, S255N, D256E, A265V, D288NF
Brumme (2009)H2522H2522GQ371911None   E11D, V37I, I72V, I84L, L101I, S119P, T122V, T124A, T125A, K136Q, G163QF
Eshleman (2009)182.189182.189FJ480231None   S17N, I72V, I84L, S119T, T124GS, T125A, K136Q, G163NS, V201I, L234V, D256E, S283GF
 3781137811FJ480243None  E138DS17C, I72V, I84L, L101I, S119T, T124A, T125A, I135IV, K136Q, G163GS, V201I, A205S, K211R, T218I, L234V, D256E, S283GF
 ARG1649ARG1649FJ480320None   S17N, I72V, I84L, L101I, S119T, T124A, T125A, K136Q, V201I, A205S, T218I, L234V, D256E, S283GF
 ARG2795ARG2795FJ480321None   E11D, S17T, V37I, I72V, I84L, A98G, L101I, T112V, S119P, T125A, K136Q, G163S, D167E, V201I, K211R, T218I, L234V, D256EF
 BrRJ96-034BrRJ96-034FJ480330None  V151IE11D, S17T, I72V, V77VA, I84L, L101I, V201I, A205S, K211R, E212V, T218I, L234V, D256E, S283GF
Garrido (2009)29INT-29GU216876None   S17N, V32I, D41N, I72V, I84L, L101I, K111R, S119T, T124A, K136Q, V165I, V201I, A205S, K211R, T218I, L234V, D256EF
 120INT-120GU216967None   A49AP, I72V, I84L, L101I, S119T, T122S, T124A, T125A, K136Q, Q177R, V201I, A205S, K211R, T218I, L234V, D256EF
 197INT-197GU217044None  G163KG47R, I72V, I84L, L101I, S119P, T125A, K136Q, K160Q, V201I, A205S, K211R, T218I, Q221T, L234V, D256EF
 408INT-408GU217255None  L68VE11D, S17N, V32I, I72V, L74I, I84L, E96D, L101I, S119T, K136Q, V165I, V201I, K211R, T218I, Q221R, R231RK, L234V, V250VA, D256E, S283GF
Passaes (2009)BR.RJ.FT12BR.RJ.FT12HM026838None   S17N, V32I, K42R, I72V, L101I, S119P, T124A, T125A, K136Q, V165I, V201I, K211R, T218I, L234V, D256EF
 BR.RJ.FT42BR.RJ.FT42HM026840None   S17N, S24N, L45I, I72V, F100Y, L101I, S119P, T124A, T125A, K136Q, V165I, V201I, T218I, L234V, D256E, S283GF
 BR.RJ.FT99BR.RJ.FT99HM026844None  G163KS17N, R20K, I72V, I84L, P90S, L101I, K111R, S119T, T124A, T125A, K136Q, V201I, A205S, I208L, K211R, T218I, L234V, D256E, S283GF
 BR.RJ.SB67BR.RJ.SB67HM026846None   E11D, S17N, I72V, I84L, L101I, S119T, T124A, T125A, K136H, V165I, V180I, V201I, A205S, K211R, T218I, L234V, A265VF
 BR.RJ.SB106BR.RJ.SB106HM026847None  G163RH16P, I72V, I84L, P90S, L101I, S119T, T124A, T125A, K136Q, K156N, V201I, A205S, T218I, S230SC, L234V, D256E, V281R, S283SGF
 BR.RJ.SB120BR.RJ.SB120HM026849None   E11D, K14R, N18Y, V32I, I72V, I84L, L101I, S119T, T124A, T125A, K136Q, V165I, V201I, T218I, L234V, D256E, S283GF
 BR.RJ.SB137BR.RJ.SB137HM026851None   E11D, S17N, V31I, M50I, I72V, I84L, I113V, S119T, T124A, T125A, K136Q, V165I, V201I, K211R, T218I, L234V, D256EF
 BR.RJ.SB159BR.RJ.SB159HM026852None   S17N, V31I, I72V, I84L, L101I, T112I, S119T, K136Q, V201I, L234V, D256E, S283GF
 BR.RJ.TR13BR.RJ.TR13HM026854None   S17N, I72V, I84L, L101I, T112I, S119T, T124A, T125A, K136Q, V201I, A205S, K211R, T218I, L234I, A265V, D278N, S283GF
 BR.RJ.TRBR.RJ.TRHM026856None   S17N, V31I, I72V, V77A, I84L, L101I, S119T, T124A, T125A, I135V, K136Q, V201I, T218I, L234V, D256E, S283GF
 BR.RJ.TR97BR.RJ.TR97HM026857None   S17N, I72V, I84L, L101I, T112A, S119P, T124A, T125A, K136Q, H171Y, V201I, A205S, T218I, L234V, D256E, S283GF
 BR.RJ.TR1BR.RJ.TR1HM026858None  G163RS17N, I72V, I84L, T112I, S119T, T122S, T124A, T125A, K136Q, V201I, K211R, L234V, G247R, D256E, R269K, S283GF
 BR.RJ.UD0BR.RJ.UD0HM026859None   E11D, V37I, L45Q, I72V, I84L, L101I, K111R, S119T, T124A, T125A, K136Q, V201I, A205S, K211R, T218I, L234V, D256E, S283GF
 BR.RJ.UD097BR.RJ.UD097HM026860None   S17N, I72V, I84L, L101I, T112A, S119P, T124A, T125A, K136Q, H171Y, V201I, A205S, T218I, L234V, D256E, S283GF
 BR.RJ.UD258BR.RJ.UD258HM026861None   S17N, V32I, I72V, A76V, I84L, L101I, S119P, T124A, T125A, G134S, K136Q, V165I, V201I, A205S, T206S, T218I, L234V, D256E, S283GF
 BR.RJ.UD329BR.RJ.UD329HM026862None   L45Q, I72V, I84L, L101I, S119T, T125M, K136Q, V201I, A205S, K211R, T218I, L234V, D256E, G272R, S283G, D286NF
 BR.RJ.UD406BR.RJ.UD406HM026863None   E11D, L45Q, I72V, I84L, L101I, S119T, T125M, K136Q, V201I, A205S, K211R, T218I, L234V, D256E, S283G, D286NF
 BR.RJ.UD508BR.RJ.UD508HM026864None   S17N, V31I, I72V, V77A, I84L, L101I, S119P, T124A, T125A, K136Q, D167E, V201I, A205S, T206S, E212I, T218I, L234V, D256E, S283GF
Sanabani (2009)8202BR082FJ771006None  G163RS17N, I72V, I84L, L101I, T112I, S119T, T122I, T124A, T125P, K136Q, H171Y, V201I, A205S, K211R, T218I, L234V, D256E, S283GF
 56406BR564FJ771008None   S17N, D25E, L68S, I72V, I84L, L101I, T112V, S119T, T124A, T125A, A129V, V201I, A205S, K211R, T218I, L234V, D256E, S283GF
 57906BR579FJ771009None   S17N, L45Q, I72V, I84L, L101I, K103R, S119T, T124A, T125A, K136R, F181L, K188R, V201I, T218L, L234V, D256E, I268L, D270H, S283GF
Sichtig (2009)21492149FJ183557None  G163RP30PL, I72V, I84L, S119T, T122S, T124A, T125A, K136Q, G193E, V201I, T218I, L234V, D256EF
 30443044FJ183593None   S17N, R20K, L28I, L45V, I72V, I84L, L101I, T112I, S119P, T122I, T124A, T125V, K136Q, K156R, D167E, V201I, A205S, K211R, T218L, L234V, D256EF
 31103110FJ183594None   I72V, I84L, L101I, T112I, S119P, T122I, T124A, T125V, K136Q, K156R, D167E, N184NI, V201I, A205S, K211R, T218L, Y227YH, L234V, D256EF
 12851285FJ183606None   K7R, K14R, S17N, I72V, L101I, T112I, T124A, T125A, K136Q, F181FL, V201I, A205S, L234V, D256EF
 14171417FJ183607None   K7R, K14R, S17N, R20RG, I72V, L101I, T112I, T124A, T125A, I135IV, K136Q, F181FL, V201I, A205S, L234V, D256EF
 13201320FJ183610None   I72V, L101I, T112IV, T124N, T125V, K136Q, G163T, V165VI, V201I, Y227F, L234V, S255D, D256EF
Vidal (2009)KTB119KTB119FM877777None   E11D, S24N, V31I, I60V, I72V, L101I, T112V, T124A, G134N, K136Q, D167E, T210S, Q216H, I220L, L234I, S283G, D286NF
 KS069KS069FM877780None  F121LE11D, S24H, V32I, D41N, M50I, I60V, I72V, L101I, T112I, T124A, G134D, K136Q, D167E, I203M, T218I, L234I, S283GF
 LBTB084LBTB084FM877781None   E11D, A21T, V31I, M50I, I60V, I72V, L101I, T112V, T124A, G134N, D167E, G193E, V201I, I208L, L234I, D256E, D270N, S283GF
 MBTB047MBTB047FM877782None   E11D, S24N, V31I, V37I, M50I, I60V, I72V, I84M, L101I, K111R, T112V, I113V, T124A, T125A, G134N, K136Q, D167E, V201I, K211R, T218I, L234I, S283GF
Arruda (2010)EI034EI034GQ864182None   S17N, L28I, L45V, I72V, I84L, L101I, S119P, T124A, T125A, K136Q, Q177L, V201I, L234V, D256E, S283GF
 EI039EI039GQ864185None   V31I, I72V, I84L, L101I, T112I, S119P, K136Q, V201I, A205S, K211R, T218I, L234V, D256E, S283GF
 EI088EI088GQ864228None   S17N, I72V, I84L, L101I, S119T, T124A, T125A, K136Q, E152K, R187K, V201I, I203M, T218I, L234V, D256EF
 EI091EI091GQ864231None   E11D, S17N, I72V, I84L, L101I, K111R, T112I, S119P, T122V, T125A, K136Q, V165I, I182V, V201I, K211R, T218I, S230N, L234V, D256E, S283GF
Sanabani (2010)78307BR_FPS783HM026458None  G163KS17N, S39N, I72V, E96D, L101I, S119T, T124A, T125A, I135V, K136N, G193D, V201I, A205S, K211R, T218I, L234V, D256E, I268L, D270H, S283GF
 81207BR_FPS812HM026460None   S17N, V32I, I72V, I84L, L101I, S119P, T124A, T125A, G134N, K136Q, V201I, T206S, I208M, K211R, T218I, L234V, D256E, V259I, S283GF
Iamarino (2012)BF.BR.0869BF.BR.0869JN234024None   S17N, I72V, I84L, L101I, S119T, T124A, K136Q, V201I, T218I, L234V, D256E, S283GF
 BF.BR.0870BF.BR.0870JN234025None  G163RS17N, S24G, D25E, E35A, S39N, L45V, I72V, I84M, K111R, S119T, T125A, K136Q, V201I, A205S, K211R, L234V, D256E, S283GF
 BF.BR.0534BF.BR.0534JN234027None  V54IE11D, S17N, M50I, I72V, S119T, T124A, T125A, K136Q, V201I, A205S, K211R, L234V, D256E, S283GF
 BF.BR.1094BF.BR.1094JN234028None  V54I, T97A, G163RE11D, S17N, A21S, I72V, I84L, L101I, S119T, T124A, T125A, K136Q, S153A, V201I, A205S, K211R, Y227F, L234V, D256E, S283GF
 BF.BR.1235BF.BR.1235JN234029None   S17N, R20K, I72V, I84L, S119T, T124A, K136Q, V201I, K211R, T218I, L234V, D256E, S283GF
 BF.BR.1467BF.BR.1467JN234031None   S17N, V31I, I72V, I84L, L101I, S119P, T124A, K136Q, F139Y, V201I, A205S, T218S, D232E, L234V, D256E, S283GF
 BF.BR.1458BF.BR.1458JN234032None  V54IS17N, S39N, I72V, I84L, S119T, T124A, K136Q, G163S, V165I, V201I, A205S, L234V, D256E, S283GF
 BF.BR.0683BF.BR.0683JN234036None   S17N, G59E, I72V, L101I, S119P, T124A, T125A, V201I, A205S, K211R, L234V, D256E, S283GF
 BF.BR.0724BF.BR.0724JN234038None   S17N, V31I, I72V, I84L, L101I, S119P, T124A, K136L, S283GF
 F.BR.1485F.BR.1485JN234069None   E11D, S17N, I72V, K103R, I113V, S119P, T124A, T125A, K136Q, V165I, V201I, A205S, T218I, L234V, D256E, S283GF
 F.BR.1526F.BR.1526JN234071None   E10D, E13D, V32I, D41N, I72V, I84L, L101I, T112V, S119T, T124A, K136Q, V165I, V201I, A205S, T218I, L234V, D256E, S283GF
 F.BR.1521F.BR.1521JN234072None   K14R, R20K, S24N, I72V, L101I, S119T, T124A, T125A, I135V, K136Q, V165I, V201I, A205S, T218I, L234I, D256E, S283GF
 F.BR.1522F.BR.1522JN234073None   R20K, I72V, L101I, T112I, S119T, T124A, T125A, I135V, K136Q, V165I, R199K, V201I, A205S, T218I, L234I, D256E, S283GF
Monleau (2012)DRC-810DRC-810JQ250590None   Q9QL, E11D, A23AV, V37I, I72V, K111R, T112L, T124N, T125A, K136Q, V201I, T206S, L234V, D256E, S283GF
 DES DESDES DESJQ250596None  G163KE11D, V37I, C56S, I72V, I84L, L101I, T112I, I113V, S119P, T122S, T124A, T125A, K136Q, V201I, K211R, T218I, L234V, D256E, S283GF
Reigadas (2013)306306JX425427None  L74MV32I, L45V, M50I, I72V, T112I, K136Q, G163N, V165I, V201I, T218S, Y227F, L234I, S255N, D256E, S283G, R284G, D288NF
 4224142241JX451877None   S17N, V32I, K42R, I72V, L101I, S119P, T122I, T124A, T125A, I135V, K136Q, V165I, V201I, T218I, L234V, P238S, D256E, S283GF
 101058101058JX451886None   S17N, V32I, K42R, I72V, I84L, L101I, S119P, T122I, T124A, T125A, I135V, K136Q, V165I, G190R, V201I, T218I, L234V, D256E, S283GF