<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Integrase Inhibitors

Subtype D
Gene IN
Mutation I72V
Rx II-naive
IncludeMixtures No
References 28
Patients 106
Isolates 107
 
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# INIs WksINIMajorDRMs INIMinorDRMs OtherMutSubtype
Alizon (1986)ELIELIK03454None   S17N, I72V, T112V, I113V, T124A, T125A, K188R, G189R, V201I, T218I, L234I, N254K, A265VD
Gao (1998)84ZR08584ZR085U88822None  T97AI72V, T112V, I113V, T124A, V201I, T206S, K211R, L234ID
Carr (1999)JKC-SE6954VI6954AF075701None   S17N, M50L, I72V, K111R, T112V, I113V, T125A, K173R, V201I, K215R, L234I, D256E, A265VD
Neilson (1999)MB2059MB2059AF133821None   S17N, M50L, I72V, T112V, I113V, T124A, T125A, V201I, T218I, L234I, D256E, A265VD
Burns (2002)92UG00192UG001AF458235None   S17N, I72V, L101I, T112V, I113V, T124S, T125A, G193E, V201I, K211T, E212K, T218I, L234I, I251L, A265VD
Dowling (2002)NKU3006NKU3006AF457090None   K14R, S17N, M50L, I72V, T112V, I113V, T124A, T125A, V201I, T218I, L234I, D256ED
 KSM4015KSM4015AF457073None   M50L, I72V, T112V, I113V, T124A, T125V, V201I, Q216H, K219N, L234I, S283GD
 KER2017KER2017AF457056None  T97AE11D, N27G, M50I, I72V, L101I, T112I, I113V, T124A, T125A, K136Q, D167E, V201I, L234I, S283GD
Koulinska (2002)TZBFL0086TZBFL0086AF442566None   E11D, K14R, S17N, L28I, S39C, M50L, I72V, T112V, I113V, T124A, T125A, V165I, A169T, V201I, I203M, T218I, L234I, D256E, S283GD
 TZBFL0011TZBFL0011AF442569None  L74MS17N, M50L, I72V, G106R, T112V, I113V, T124A, T125A, D167E, V201I, L234I, D256E, A265V, S283GD
Swanson (2003)SE365SE365AY214069None   S17N, V32I, I72V, T112V, I113V, T124A, V201I, K211R, T218I, L234I, D256ED
 UG270UG270AY214070None   S17N, M50L, I72V, G82S, T112V, I113V, T124A, T125A, V201I, L234I, D256E, V281MD
 UG274UG274AY214071None   S17N, M50L, I72V, T112V, I113V, S119G, T122I, T124A, T125A, G163A, V201I, T218I, L234I, D256ED
 UG95_306UG95_306AY214072None   S17N, I72V, A91T, E96D, L101I, T112V, S119G, T122I, T124A, T125A, V201I, T218I, L234I, S255ND
Arroyo (2004)01TZA28001TZA280AY253311None   E11D, K14R, P30S, S39C, I72V, L101I, T112V, T124A, K156R, V201I, T206S, I208L, K211T, L234I, N254H, M275VD
 01TZA38701TZA387AY253316None   S17N, R20K, M50L, I72V, T112V, I113V, T124A, T125A, D167E, V201I, K211T, T218I, L234I, D256E, D270HD
Fang (2004)ML415_2_1997415_2_1997AY322189None   S17N, I72V, I84M, L101I, T112I, I113V, T124A, T125A, I135V, M154T, V201I, T206S, T218I, L234I, I251L, D256ED
Kijak (2004)0009BBY01CM.0009AY371155None   I72V, F100Y, T112V, I113V, T124A, T125A, V201I, K211R, Q216H, K219N, S230N, L234ID
 4412HAL01CM.4412AY371157None   D6S, K7E, E10D, E11D, E13D, V31I, V32I, I72V, A91S, T112V, I113V, T124A, T125A, K156N, E157Q, V201I, T218S, N222H, L234ID
 4008HAN01CM.4008AY371168None   E11D, K14R, A21T, A23V, N27G, I72V, T112V, I113V, T124A, T125A, D167E, V201I, L234I, D253E, D279G, R284GD
 0908MO01CM.0908AY371170None   K14R, V31I, I72V, G82S, T112V, I113V, T124A, T125A, K156N, E157Q, V201I, L234I, D256E, V281M, S283GD
 UGA0848399UGA08483AY304496None   M50L, I72V, L101I, T112I, I113V, T124A, T125A, I135V, F181L, V201I, Y227F, L234I, A265VD
Brown (2005)BB_93UG_06593UG_065AY713418None   S17N, M50L, I72V, T112V, I113V, T124A, T125A, V201I, L234I, D256ED
Tovanabutra (2005)99US_MSC406899US_4068AY444799None   S17N, M50L, I72V, T112I, I113V, T124A, T125A, V201I, A205S, T206S, L234I, D256E, S283GD
Couto-Fernandez (2006)patient_05BRRJ09505BRRJ095DQ138974None   E10D, R20K, I72V, L74I, I84V, P90A, G106A, T112M, T124A, T125A, G193E, V201I, D207N, K211Q, L234I, N254KD
 patient_04BRSAP1904BRSAP19DQ138975None   E10D, E11D, M50I, I72V, T112V, I113V, T124A, V201L, Q216PD
 patient_04BRRJ13504BRRJ135DQ138976None   K14R, S24N, I72V, L74I, T112V, I113A, T124A, T125A, V201I, L213FD
 patient_98BRRJ04598BRRJ045DQ141207None   S17N, L45Q, I72V, L74I, T112V, I113V, T124S, T125A, V201I, A205S, N222H, L234ID
Badreddine (2007)J11215SB_J11215DQ848148None   D6S, K7Q, E13D, K14R, S17N, L28I, P30S, S39C, I72V, T112A, I113V, T124A, T125A, V201I, K211R, T218L, L234I, D253E, S255SN, V259VI, Q285PD
Brennan (2008)129-26129-26EU618081None   D6S, K7E, E11D, E13D, I72V, T112V, I113V, T124A, D167E, V201I, K211R, T218I, L234I, A265V, D279G, R284GD
 33-3333-33EU618152None   D6S, E10D, E13D, V32I, I72V, T112V, I113V, T124A, V201I, T206S, Y227F, L234I, S255N, D256E, S283SGD
 336-39336-39EU618153None  L74ME10D, K14R, I72V, A91E, T112V, I113V, S119R, T122I, T124A, T125A, V201I, K211R, T218I, L234I, R284GD
 559-23559-23EU618245None   D6S, E13D, S17N, V32I, I72V, T112A, I113V, T125A, K160R, V201I, N222T, L234I, D256E, D279GD
 980-26980-26EU618340None   D6S, K7E, E11D, E13D, I72V, T112V, I113V, T124A, D167E, V201I, K211R, T218I, L234I, A265V, D279G, R284GD
 A1122A1122EU618351None   D6S, K7Q, E13D, K34R, L45I, I72V, T112V, I113V, T124A, V201I, K211R, L234ID
 A1221A1221EU618363None   D6S, E10D, E13D, K14R, V32I, I72V, T112V, I113V, T124N, K136Q, V201I, K211R, L234I, S283GD
 A1645A1645EU618404None   E10D, I72V, I84M, T112V, I113V, T124A, V201I, K211R, T218I, L234I, A265VD
 A1657A1657EU618411None   D6S, E10D, E11D, E13D, I72V, A91G, L101I, T112I, T124A, I135V, F181L, V201I, I208L, T218L, L234ID
 ABB21-96ABB21-96EU618508None  T97AD6S, E10ED, E13D, V32I, I72V, L101I, K103N, T112V, I113V, T125A, V126M, K160R, V201I, L234I, D279G, R284GD
 ABB123-98ABB123-98EU618595None   D6S, E10D, E13D, K34R, I72V, T112V, I113V, T124A, V201I, I208IL, K211R, L234I, A265VD
 ABB127-98ABB127-98EU618598None   S17N, L28I, I72V, T112V, I113V, T124A, G193D, V201I, I208L, K211R, T218I, L234I, D256DE, A265V, D270ND
 ABB151-98ABB151-98EU618602None   S24G, A49P, I72V, T112V, I113V, T124A, V201I, K211R, L234I, I257L, A265VD
 ABB214ABB214EU618625None   D6N, E13D, S17N, K34R, I72V, T112V, I113V, T124A, V201I, T210I, K211R, L234I, A265VD
Land (2008)ML1974ML1974EU110090None   K14R, I72V, T112V, I113V, T124A, G193E, K211R, D278S, S283G, D286ND
Eshleman (2009)99.23799.237FJ480225None   S17N, R20K, S39C, L45Q, M50L, I72V, F100Y, L101I, T112V, I113V, T124A, T125A, V201I, L234I, D256E, V259ID
 128.318128.318FJ480227None   S17N, M50L, I72V, L101I, T112V, I113V, T124A, T125V, V201I, T218I, L234I, L242X, D256E, A265VD
 151.94151.94FJ480229None   S17N, S39SN, M50L, I72V, T112V, I113V, T124A, T125A, D167E, V201I, T218TI, L234I, W243*, D256E, I268L, S283GD
 326.57326.57FJ480238None   S17SN, R20K, I72V, T112V, I113V, S119T, T124A, T125A, K156KN, E157EQ, G163GV, V201I, T206S, K211KR, T218I, L234I, A265AVD
 326.662326.662FJ480240None   S17N, M50L, I72V, T112V, S119SPRT, T122TI, T124A, T125A, V165VI, G193E, V201I, L234I, S283G, D286ND
 503.083503.083FJ480241None   K14R, S17N, L28I, M50L, I72V, T112AV, I113V, T124A, T125A, K188KR, V201I, T218I, L234I, D256E, A265VD
 2387801SS2387801SSFJ480248None   I72V, T112V, I113V, T124A, F181L, V201I, A205S, K211R, L234ID
Garrido (2009)17INT-17GU216864None   D6S, E10D, E13D, V32I, L45V, I72V, L101I, T112V, I113V, T124A, G163E, V165I, V201I, K211R, L234ID
 34INT-34GU216881None   G4X, E11D, S24N, M50I, I72V, I84L, K111R, T112V, I113V, T124A, T125A, K136Q, D167E, V201I, Q216HD
 178INT-178GU217025None   K14R, S39C, I72V, T112V, I113V, T124A, D167E, V201I, T206S, L234I, K264KND
 243INT-243GU217090None   D6DGNS, E10D, E13D, I72V, K111KR, T112V, I113V, S119P, T124A, T125A, M154ML, K159KM, V201I, K211R, L234I, R269KD
 245INT-245GU217092None   K14R, S17N, V31I, K71Q, I72V, T112V, I113V, S119R, T124AS, T125S, I135IV, K173R, K188R, V201I, T206S, L234I, A265VD
 385INT-385GU217232None   S17N, S39N, I72V, T112V, I113V, T124A, T125A, D167E, V201I, L234I, S283SGD
Holzmayer (2009)AF7741AF7741FJ712808None  E138DK14KR, V32I, M50L, I72V, K103R, T112V, I113V, T124A, T125A, V201I, I203M, L234I, D256ED
Sichtig (2009)35873587FJ183597None   S17N, M22MR, M50L, I72V, T112V, I113V, T124A, T125A, Q177L, V201I, K211R, Q221H, L234I, D256E, A265VD
 11711171FJ183599None   M50L, I72V, T112TAIV, T124A, T125TA, G193E, V201I, L234ID
 21082108FJ183600None   S17N, M50L, I72V, L101I, T112V, T124A, T125A, F181L, V201I, L234I, D256ED
 36513651FJ183601None   S17N, M50L, I72V, K111KR, T112TAIV, T124A, T125TA, G193E, V201I, L234ID
 358358FJ183603None   Q53QH, I72V, T112TI, T124A, K160KND
 60-E60-EFJ183634None   K34R, I60IM, I72V, I84M, T112V, I113V, S119P, T124A, T125A, I182IV, V201I, T206S, I208L, K211Q, L234ID
van Hal (2009)W15W15FJ554688None   V31I, S57C, I72V, L101I, S119G, T122I, T124A, E152K, K188R, G193E, V201I, T206S, K211R, R231K, A265VD
 W63W63FJ554736None   S17N, V31I, S57C, I72V, L101I, S119G, T122I, T124A, E152K, K188R, G193E, V201I, T206S, K211R, R231K, A265VD
 W92W92FJ554765None   S17N, I72V, T122I, T124A, R166K, V201I, V250I, A265VD
Tovanabutra (2010)KECst_015KECst_015FJ623490None   S17N, I72V, T112V, I113V, T124A, T125A, G134D, D167E, G193D, T206S, L234I, S255N, R269K, D270H, D278A, S283GD
Brenner (2011)188NB188NBHQ207723None   S17N, I72V, L74LI, T112V, I113V, T124A, M154MI, V201I, K211R, L234I, A265VD
Sanabani (2011)BR1067BR1067JN692456None   S17N, I72V, L101I, S119T, T124A, M154I, V165I, V201I, T218I, L234V, D256E, S283GD
Monleau (2012)SK4064SK4064JQ250527None   D6S, K7E, E10D, E13D, I72V, L101I, T112V, I113V, T124G, T125P, E157EQ, K160X, V201I, Y227F, L234I, D253H, D256E, D279G, R284GD
 SK1002SK1002JQ250540None   S24G, I72V, T112V, I113V, T124A, T125A, K188KR, V201I, T206S, K211KR, L234I, A265AV, I268IL, D270H, S283GD
 DRC-MBTDRC-MBTJQ250584None  L74M, T97AK14R, R20K, I72V, K111T, T112V, I113V, T124G, T125A, V165I, V201I, T218I, L234I, D256E, S283G, D288ND
 CIR CIRCIR CIRJQ250595None  T97AA23V, L28I, I72V, T112V, T124A, T125A, V126L, I135V, K160R, G163T, Q177H, F181L, V201I, T218I, L234I, A265V, D278A, C280VD
Parczewski (2012)2020_10JQ305769None   E11ED, S17C, M50L, I72V, T112A, I113IV, T124TA, T125A, G193E, V201I, I203M, T218I, L234V, D256ED
  20_51KC409146None   S17N, M50L, I72V, T112A, I113IV, T125A, G193E, V201I, I203M, L234V, D256E, D286DND
 258_1258_1JQ305770None   E10D, M50L, I72V, I84M, T112V, I113V, T124A, T125A, G163V, V201I, I203M, T218TI, L234V, D256ED
 467_1467_1JQ305771None   M50L, I72V, T112V, I113V, T124A, T125A, V201I, I203M, L234V, D256ED
 504_1504_1JQ305772None  E138DS17N, M50L, I72V, T112V, I113V, T124A, T125A, V201I, I203M, L234V, D256E, V260VIM, R284RGD
 508_1508_1JQ305773None  E138DS17N, M50L, I72V, T112V, I113V, T124A, T125A, V201I, I203M, T218I, L234V, D256ED
 546546_15JQ305774None   E11D, M50L, I72V, T112V, I113V, T122I, T125A, W132W*, D167E, V201I, I203M, T218I, L234I, D256ED
 558_1558_1JQ305775None   C56S, I72V, L101LF, T112V, I113V, T124A, T125A, G134D, V201I, I203M, T218I, L234VD
 559_2559_2JQ305776None   M50ML, I72V, L101I, K111Q, T112V, I113V, T124TA, V201I, I203M, T218TI, L234V, D256ED
 562_2562_2JQ305777None   E11D, M50L, I72V, T112V, I113V, S119G, T122I, T125A, D167E, V201I, I203M, T218I, L234I, D256ED
 643643_1JQ305778None   K7Q, E11D, E13D, I72V, T112A, I113V, T124A, T125A, G193E, V201I, I203M, L234V, D256E, D286ND
 6969_10JQ305780None   S17N, M50L, I72V, G106A, T112V, I113V, T124A, T125A, V201I, I203M, L234LV, D256ED
 711_1711_1JQ305781None   E11D, M50L, C56S, I72V, T112V, I113V, T124A, V201I, I203M, T218TI, L234I, D256ED
 743_1743_1JQ305782None   E11D, M50L, C56S, I72V, G106A, T112V, I113V, T124A, G134GD, V201I, I203M, I208IL, K211KR, T218TI, L234V, D256ED
 744_1744_1JQ305783None  L68LIE11D, M50L, C56S, I72V, T112V, I113V, T124A, H171HQ, V201I, I203M, T218I, L234I, D256ED
 766_1766_1JQ305784None   E11D, M50L, C56S, I72V, T112V, I113V, V201I, I203M, T218I, L234I, D256ED
 781_1781_1JQ305785None   E11D, M50L, C56S, I72V, K111KR, T112V, I113V, V201I, I203M, T218TI, L234I, D256ED
 787_1787_1JQ305786None   S17N, A21T, M50L, I72V, T112A, T125A, G193E, V201I, I203M, L234V, D256E, Q285*, D286ND
 837_1837_1JQ305787None   E11D, K14KR, M50L, C56S, I72V, T112V, I113V, T124A, V201I, I203M, L234I, D256ED
 894_1894_1JQ305788None   E11ED, D41DN, M50L, C56S, I60V, I72V, K111KR, T112V, I113IV, T124A, R187RK, K188KT, V201I, I203M, T218I, Y227YN, L234I, S255SG, D256E, R262RSD
 911911_1JQ305789None   E11D, M50L, C56S, I72V, T112V, I113V, V201I, I203M, L234I, D256ED
 931_1931_1JQ305790None   E11D, R20K, M50L, C56S, I72V, T112V, I113V, T124A, V201I, I203M, T206TS, L234V, D256ED
 934_1934_1JQ305791None   A49P, M50L, C56S, I72V, T112V, I113V, V201I, I203M, T218TI, L234I, D256ED
 748_1748_1KC409199None   E11D, R20RK, M50L, C56S, I72V, T124A, G193E, V201I, I203M, T218TI, L234V, D256E, D288ND
 900_1900_1KC409206None   E11ED, M50L, C56S, L63LV, I72V, T112V, I113V, S119P, T122I, T124N, V201I, I203M, K211KR, T218TI, L234V, D256ED
Reigadas (2013)602602JX425847None   K14R, S24H, I72V, L101I, T112V, S119P, T124A, I135V, K136Q, K173R, V201I, T206S, K215R, T218I, L234I, D256E, S283GD
 700700JX425867None   E11D, L45Q, G47E, E69K, I72V, T112V, T124A, T125A, V126L, G134D, M154I, E157K, G163T, R166K, V201I, T218I, L234I, A265V, D278A, S283GD
 701701JX425868None   K7R, S17N, I72V, I84M, L101I, T112I, I113V, S119P, T124A, K136Q, K173R, V201I, T206S, I208L, Y227F, L234I, D256ED
 702702JX425869None   E11D, K14R, A21T, M50MT, I72V, A91G, L101I, K103KR, T112V, I113V, T124A, K136KQ, V201I, K211R, E212I, T218M, K219Q, S230SN, L234ID
 704704JX425871None   S17N, I72V, T112V, I113V, S119P, T122I, T124A, T125A, V201I, L234ID
 708708JX425875None   S17N, K34R, I72V, T112A, I113V, T124A, I141V, K188R, S195T, V201I, T206S, L234ID
 100048100048JX451879None   E11D, M22L, D25E, L28I, V37I, S39C, I72V, G106A, T112I, I113V, S119G, T125A, V126M, I135V, G163T, V201I, K215N, L234I, D278A, S283G, R284GD
 101016101016JX451922None   L2W, D3Y, E11D, S17NT, M50V, I72V, P90A, T112V, I113IV, S119R, T125A, I135V, V201I, S230SN, L234I, D256ED