<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Integrase Inhibitors

Subtype D
Gene IN
Mutation T125A
Rx II-naive
IncludeMixtures No
References 30
Patients 77
Isolates 79
 
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# INIs WksINIMajorDRMs INIMinorDRMs OtherMutSubtype
Alizon (1986)ELIELIK03454None   S17N, I72V, T112V, I113V, T124A, T125A, K188R, G189R, V201I, T218I, L234I, N254K, A265VD
Gao (1998)94UG11494UG114U88824None   S17N, D25E, L45V, M50L, I72G, T112V, I113V, T124A, T125A, D167E, V201I, T218I, L234V, D256ED
Carr (1999)JKC-SE6954VI6954AF075701None   S17N, M50L, I72V, K111R, T112V, I113V, T125A, K173R, V201I, K215R, L234I, D256E, A265VD
Neilson (1999)MB2059MB2059AF133821None   S17N, M50L, I72V, T112V, I113V, T124A, T125A, V201I, T218I, L234I, D256E, A265VD
Burns (2002)92UG00192UG001AF458235None   S17N, I72V, L101I, T112V, I113V, T124S, T125A, G193E, V201I, K211T, E212K, T218I, L234I, I251L, A265VD
Dowling (2002)NKU3006NKU3006AF457090None   K14R, S17N, M50L, I72V, T112V, I113V, T124A, T125A, V201I, T218I, L234I, D256ED
 KER2017KER2017AF457056None  T97AE11D, N27G, M50I, I72V, L101I, T112I, I113V, T124A, T125A, K136Q, D167E, V201I, L234I, S283GD
Koulinska (2002)TZBFL0086TZBFL0086AF442566None   E11D, K14R, S17N, L28I, S39C, M50L, I72V, T112V, I113V, T124A, T125A, V165I, A169T, V201I, I203M, T218I, L234I, D256E, S283GD
 TZBFL0011TZBFL0011AF442569None  L74MS17N, M50L, I72V, G106R, T112V, I113V, T124A, T125A, D167E, V201I, L234I, D256E, A265V, S283GD
Swanson (2003)UG270UG270AY214070None   S17N, M50L, I72V, G82S, T112V, I113V, T124A, T125A, V201I, L234I, D256E, V281MD
 UG274UG274AY214071None   S17N, M50L, I72V, T112V, I113V, S119G, T122I, T124A, T125A, G163A, V201I, T218I, L234I, D256ED
 UG95_306UG95_306AY214072None   S17N, I72V, A91T, E96D, L101I, T112V, S119G, T122I, T124A, T125A, V201I, T218I, L234I, S255ND
Vidal (2003)99TCDMN01299TCDMN012AJ488927None   D6S, K7Q, E13D, T112V, I113V, T124A, T125A, V201I, K211R, T218I, L234I, D253E, A265V, R269K, D279GD
 HIM519489HIM519489AJ519489None   D6S, K7Q, E13D, T112V, I113V, T124A, T125A, V201I, K211R, T218I, L234I, D253E, A265V, R269K, D279GD
Arroyo (2004)01TZA38701TZA387AY253316None   S17N, R20K, M50L, I72V, T112V, I113V, T124A, T125A, D167E, V201I, K211T, T218I, L234I, D256E, D270HD
Fang (2004)ML415_2_1997415_2_1997AY322189None   S17N, I72V, I84M, L101I, T112I, I113V, T124A, T125A, I135V, M154T, V201I, T206S, T218I, L234I, I251L, D256ED
 ML249_3_1997249_3_1997AY322187None   S17N, M50I, T112V, I113V, T124A, T125A, V201I, T218I, Q221R, L234I, D256E, D288ND
Kijak (2004)0009BBY01CM.0009AY371155None   I72V, F100Y, T112V, I113V, T124A, T125A, V201I, K211R, Q216H, K219N, S230N, L234ID
 4412HAL01CM.4412AY371157None   D6S, K7E, E10D, E11D, E13D, V31I, V32I, I72V, A91S, T112V, I113V, T124A, T125A, K156N, E157Q, V201I, T218S, N222H, L234ID
 4008HAN01CM.4008AY371168None   E11D, K14R, A21T, A23V, N27G, I72V, T112V, I113V, T124A, T125A, D167E, V201I, L234I, D253E, D279G, R284GD
 0908MO01CM.0908AY371170None   K14R, V31I, I72V, G82S, T112V, I113V, T124A, T125A, K156N, E157Q, V201I, L234I, D256E, V281M, S283GD
 UGA0848399UGA08483AY304496None   M50L, I72V, L101I, T112I, I113V, T124A, T125A, I135V, F181L, V201I, Y227F, L234I, A265VD
Shi (2004)pWCML249pWCML249AY445524None   S17N, L45I, M50I, I73T, T112V, I113V, T124A, T125A, V201I, T218I, L234I, D256E, A265VD
Brown (2005)BB_93UG_06593UG_065AY713418None   S17N, M50L, I72V, T112V, I113V, T124A, T125A, V201I, L234I, D256ED
Saad (2005)SM_01YE38601YE386AY795903None   S17N, A21S, A23V, S24G, D25E, L28I, M50L, T112V, S119G, T122I, T124A, T125A, V165I, S195SN, V201I, L234I, D256ED
 SM_02YE51602YE516AY795907None   D6N, K7Q, E11D, E13D, L28I, L45Q, T112V, I113V, T124G, T125A, V201I, L234I, A265V, S283GD
Tovanabutra (2005)99US_MSC406899US_4068AY444799None   S17N, M50L, I72V, T112I, I113V, T124A, T125A, V201I, A205S, T206S, L234I, D256E, S283GD
Couto-Fernandez (2006)patient_05BRRJ09505BRRJ095DQ138974None   E10D, R20K, I72V, L74I, I84V, P90A, G106A, T112M, T124A, T125A, G193E, V201I, D207N, K211Q, L234I, N254KD
 patient_04BRRJ13504BRRJ135DQ138976None   K14R, S24N, I72V, L74I, T112V, I113A, T124A, T125A, V201I, L213FD
 patient_98BRRJ04598BRRJ045DQ141207None   S17N, L45Q, I72V, L74I, T112V, I113V, T124S, T125A, V201I, A205S, N222H, L234ID
Badreddine (2007)J11467SB_J11467DQ375280None   D6S, K7Q, E10D, E13D, V32I, T112V, S119G, T122I, T124A, T125A, K136Q, V201I, K211R, T218I, L234I, D253E, S255N, Q285PD
 J11215SB_J11215DQ848148None   D6S, K7Q, E13D, K14R, S17N, L28I, P30S, S39C, I72V, T112A, I113V, T124A, T125A, V201I, K211R, T218L, L234I, D253E, S255SN, V259VI, Q285PD
Van Baelen (2007)Pt4242-1 None   S17N, K34R, Y99F, L101I, T112V, I113V, S123G, T124A, T125A, K127R, V201I, L234I, D256ED
Brennan (2008)336-39336-39EU618153None  L74ME10D, K14R, I72V, A91E, T112V, I113V, S119R, T122I, T124A, T125A, V201I, K211R, T218I, L234I, R284GD
 3951-223951-22EU618172None   T112V, I113V, T124N, T125A, V201I, K211R, T218I, Q221QH, S230N, L234I, A265VD
 559-23559-23EU618245None   D6S, E13D, S17N, V32I, I72V, T112A, I113V, T125A, K160R, V201I, N222T, L234I, D256E, D279GD
 ABB21-96ABB21-96EU618508None  T97AD6S, E10ED, E13D, V32I, I72V, L101I, K103N, T112V, I113V, T125A, V126M, K160R, V201I, L234I, D279G, R284GD
 ABB208ABB208EU618623None   E10D, L101I, T112V, I113V, T124A, T125A, V201I, L234ID
Yamaguchi (2008)J11245J11245EU697911None   S17N, V31I, M50L, L74I, T112I, I113V, T124N, T125A, G163E, D167E, V201I, T206S, L234I, D256ED
Brumme (2009)INT_3756INT_3756FJ813207None   E11D, V37I, M50L, L101I, T112V, I113V, T125A, V201I, T206TS, K211KR, T218I, L234V, D256ED
Eshleman (2009)99.23799.237FJ480225None   S17N, R20K, S39C, L45Q, M50L, I72V, F100Y, L101I, T112V, I113V, T124A, T125A, V201I, L234I, D256E, V259ID
 151.94151.94FJ480229None   S17N, S39SN, M50L, I72V, T112V, I113V, T124A, T125A, D167E, V201I, T218TI, L234I, W243*, D256E, I268L, S283GD
 205.586205.586FJ480233None   S17N, M50L, G106GA, K111Q, T112V, I113V, S119T, T124N, T125A, V201I, T218I, Q221R, L234I, D256ED
 326.57326.57FJ480238None   S17SN, R20K, I72V, T112V, I113V, S119T, T124A, T125A, K156KN, E157EQ, G163GV, V201I, T206S, K211KR, T218I, L234I, A265AVD
 326.662326.662FJ480240None   S17N, M50L, I72V, T112V, S119SPRT, T122TI, T124A, T125A, V165VI, G193E, V201I, L234I, S283G, D286ND
 503.083503.083FJ480241None   K14R, S17N, L28I, M50L, I72V, T112AV, I113V, T124A, T125A, K188KR, V201I, T218I, L234I, D256E, A265VD
 ABB021-96ABB021-96FJ480272None  T97TAD6S, E10ED, E13D, V32I, I72IV, L101I, T112V, I113V, T124TN, T125A, V126M, K160KR, G163GE, V201I, L234I, D279G, R284GD
 ABB208ABB208FJ480318None   E10D, L101I, T112V, I113V, T124A, T125A, V201I, L234ID
Garrido (2009)34INT-34GU216881None   G4X, E11D, S24N, M50I, I72V, I84L, K111R, T112V, I113V, T124A, T125A, K136Q, D167E, V201I, Q216HD
 243INT-243GU217090None   D6DGNS, E10D, E13D, I72V, K111KR, T112V, I113V, S119P, T124A, T125A, M154ML, K159KM, V201I, K211R, L234I, R269KD
 385INT-385GU217232None   S17N, S39N, I72V, T112V, I113V, T124A, T125A, D167E, V201I, L234I, S283SGD
Holzmayer (2009)AF7741AF7741FJ712808None  E138DK14KR, V32I, M50L, I72V, K103R, T112V, I113V, T124A, T125A, V201I, I203M, L234I, D256ED
Sichtig (2009)35873587FJ183597None   S17N, M22MR, M50L, I72V, T112V, I113V, T124A, T125A, Q177L, V201I, K211R, Q221H, L234I, D256E, A265VD
 39303930FJ183598None   S17N, S39C, P90PS, L101I, T112V, I113V, T124A, T125A, D167E, K173R, V201I, I203M, T218I, L234I, A265VD
 21082108FJ183600None   S17N, M50L, I72V, L101I, T112V, T124A, T125A, F181L, V201I, L234I, D256ED
 60-E60-EFJ183634None   K34R, I60IM, I72V, I84M, T112V, I113V, S119P, T124A, T125A, I182IV, V201I, T206S, I208L, K211Q, L234ID
Tovanabutra (2010)KECst_015KECst_015FJ623490None   S17N, I72V, T112V, I113V, T124A, T125A, G134D, D167E, G193D, T206S, L234I, S255N, R269K, D270H, D278A, S283GD
 KECst_01414-strain2FJ623495None   S17N, L101V, T112V, T124A, T125A, V201I, T206S, T218I, L234I, D256E, A265V, R269KD
Monleau (2012)SK1002SK1002JQ250540None   S24G, I72V, T112V, I113V, T124A, T125A, K188KR, V201I, T206S, K211KR, L234I, A265AV, I268IL, D270H, S283GD
 DRC-MBTDRC-MBTJQ250584None  L74M, T97AK14R, R20K, I72V, K111T, T112V, I113V, T124G, T125A, V165I, V201I, T218I, L234I, D256E, S283G, D288ND
 CIR CIRCIR CIRJQ250595None  T97AA23V, L28I, I72V, T112V, T124A, T125A, V126L, I135V, K160R, G163T, Q177H, F181L, V201I, T218I, L234I, A265V, D278A, C280VD
Parczewski (2012)2020_10JQ305769None   E11ED, S17C, M50L, I72V, T112A, I113IV, T124TA, T125A, G193E, V201I, I203M, T218I, L234V, D256ED
  20_51KC409146None   S17N, M50L, I72V, T112A, I113IV, T125A, G193E, V201I, I203M, L234V, D256E, D286DND
 258_1258_1JQ305770None   E10D, M50L, I72V, I84M, T112V, I113V, T124A, T125A, G163V, V201I, I203M, T218TI, L234V, D256ED
 467_1467_1JQ305771None   M50L, I72V, T112V, I113V, T124A, T125A, V201I, I203M, L234V, D256ED
 504_1504_1JQ305772None  E138DS17N, M50L, I72V, T112V, I113V, T124A, T125A, V201I, I203M, L234V, D256E, V260VIM, R284RGD
 508_1508_1JQ305773None  E138DS17N, M50L, I72V, T112V, I113V, T124A, T125A, V201I, I203M, T218I, L234V, D256ED
 546546_15JQ305774None   E11D, M50L, I72V, T112V, I113V, T122I, T125A, W132W*, D167E, V201I, I203M, T218I, L234I, D256ED
 558_1558_1JQ305775None   C56S, I72V, L101LF, T112V, I113V, T124A, T125A, G134D, V201I, I203M, T218I, L234VD
 562_2562_2JQ305777None   E11D, M50L, I72V, T112V, I113V, S119G, T122I, T125A, D167E, V201I, I203M, T218I, L234I, D256ED
 643643_1JQ305778None   K7Q, E11D, E13D, I72V, T112A, I113V, T124A, T125A, G193E, V201I, I203M, L234V, D256E, D286ND
 6969_10JQ305780None   S17N, M50L, I72V, G106A, T112V, I113V, T124A, T125A, V201I, I203M, L234LV, D256ED
 787_1787_1JQ305786None   S17N, A21T, M50L, I72V, T112A, T125A, G193E, V201I, I203M, L234V, D256E, Q285*, D286ND
Reigadas (2013)700700JX425867None   E11D, L45Q, G47E, E69K, I72V, T112V, T124A, T125A, V126L, G134D, M154I, E157K, G163T, R166K, V201I, T218I, L234I, A265V, D278A, S283GD
 704704JX425871None   S17N, I72V, T112V, I113V, S119P, T122I, T124A, T125A, V201I, L234ID
 706706JX425873None   S17N, V31I, S39N, S57N, T112V, I113V, T124N, T125A, V201I, K211R, T218L, K219N, N222K, L234I, A265VD
 707707JX425874None   E11D, E13D, S39C, V88I, T112V, I113V, T124A, T125A, V126M, G163T, V176VL, V201I, L234I, S283GD
 100048100048JX451879None   E11D, M22L, D25E, L28I, V37I, S39C, I72V, G106A, T112I, I113V, S119G, T125A, V126M, I135V, G163T, V201I, K215N, L234I, D278A, S283G, R284GD
 101016101016JX451922None   L2W, D3Y, E11D, S17NT, M50V, I72V, P90A, T112V, I113IV, S119R, T125A, I135V, V201I, S230SN, L234I, D256ED