<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Integrase Inhibitors

Subtype CRF02_AG
Gene IN
Mutation L74M
Rx II-naive
IncludeMixtures No
References 8
Patients 56
Isolates 58
 
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# INIs WksINIMajorDRMs INIMinorDRMs OtherMutSubtype
Peeters (1999)97CA-MP645MP97CAAJ239083None T66AL74MK14R, V31I, I72V, I84V, L101I, T112I, T125A, G134N, I135V, K136T, V201I, T206S, L234I, R269K, V281A, D286NCRF02_AG
Montavon (2000)LV3LV3AJ286133None  L74MK14R, V31I, L101I, T112V, T124A, T125A, G134N, I135V, K136T, V201I, T206S, L234I, A265VCRF02_AG
Kijak (2004)0013BBY02CM.0013AY371125None  L74MK14R, I72V, E96D, L101I, K111R, T112V, T124A, G134N, I135V, K136T, V201I, T206S, L234I, R269K, M275V, D286NCRF02_AG
 2162SA02CM.2162AY371129None  L74ME13D, V31I, L101I, T112V, T124A, T125A, G134N, K136T, V201I, T206S, L234I, R269KCRF02_AG
 1237NG01CM.1237AY371136None  L74MK14R, V31I, P90S, L101I, T112I, S123C, T124A, T125A, G134N, I135V, K136T, V201I, T206S, Y226*, L234I, R269KCRF02_AG
Njai (2006)MP57097CM.570AM279374None  L74M, T97AK14R, V31I, L101I, T112V, S119T, T124A, T125A, G134N, I135V, K136T, V201I, T206S, L234ICRF02_AG
 MP57897CM.578AM279384None  L74MK14R, V31VI, L63I, L101I, T112V, T124A, G134N, I135V, K136T, V201I, T206S, L234ICRF02_AG
 MP53896CM.538AM279389None  L74MK14R, V31I, L101I, T112V, T124A, T125A, G134N, I135V, K136T, V201I, T206S, T218I, L234ICRF02_AG
Brennan (2008)1012-281012-28EU618063None  L74M, T97AK14R, V31I, L101I, T112I, T124A, T125A, G134N, I135V, K136T, G163A, V201I, T206S, T218I, L234ICRF02_AG
 128-28128-28EU618080None  L74MK7KR, K14R, V31I, L101I, T112V, T124A, G134N, I135V, K136T, V201I, T206S, K219N, N222K, L234V, R269KCRF02_AG
 187-2187-2EU618111None  L74MK14R, V32I, S39C, L101I, T112V, T124A, T125A, G134N, I135V, K136T, D167E, V201I, T206S, L234I, R269KCRF02_AG
 192-1192-1EU618115None  L74MK14R, V31I, L101I, T112I, T124A, T125A, G134N, I135V, K136T, V201I, T206S, T218I, L234ICRF02_AG
 238-28238-28EU618122None  L74MK14R, S24N, V31I, L101I, T112V, T124A, T125A, G134N, I135V, K136T, V165I, V201I, T206S, T218I, L234I, R269K, D288NCRF02_AG
 253-21253-21EU618128None  L74MV31VI, T112V, T124A, G134N, K136T, V201I, T206S, T218TI, L234I, I251L, A265VCRF02_AG
 346-13346-13EU618154None  L74MK14R, V31I, L101I, T112I, T124A, T125A, G134N, I135V, K136T, G163A, T206S, T218I, L234I, D256E, I268L, D279ACRF02_AG
 38-338-3EU618164None  L74MK14R, R20K, V31I, M50V, I72V, L101I, T112V, T124A, G134N, I135V, K136T, V201I, T206S, I208L, L234V, R269K, S283GCRF02_AG
 4455-74455-7EU618187None  L74M, T97AS17N, A91E, L101I, T112V, S119R, T124A, G134N, I135V, K136T, V201I, T206S, D207E, K211R, L234ICRF02_AG
 449-38449-38EU618192None  L74ME11D, K14R, R20K, V31I, E87EK, L101I, K111T, T112V, S119P, T122I, T124A, T125A, G134N, I135V, K136T, E157Q, V201I, T206S, T218I, L234I, R269K, D288NCRF02_AG
 4599-114599-11EU618196None  L74M, T97AE11D, K14R, V31I, S57SG, L101I, T112I, T124A, T125A, G134N, I135V, K136T, V201I, T206S, T218I, I220V, L234I, R269KCRF02_AG
 483-44483-44EU618206None  L74MK14R, S17N, V31I, M50I, L101I, T112TI, T124A, T125A, G134N, I135V, K136T, E157Q, K160Q, V201I, T206S, T218I, L234I, A265V, R269K, S283G, D288NCRF02_AG
 519-29519-29EU618226None  L74ML101I, T112I, T124A, G134N, I135V, K136T, V165I, V201I, T206S, D207E, L234I, R269K, D270H, D286ACRF02_AG
 626-2626-2EU618267None  L74M, T97AS17SR, V31I, I72IV, L101I, T112V, T124A, T125TA, G134DN, I135IV, K136T, V201I, T206S, I208L, T218I, L234I, I251L, A265V, R269K, D286NCRF02_AG
 653-11653-11EU618275None  L74MK14R, V31I, L101I, T112V, T124A, T125A, G134N, I135V, K136T, V201I, T206S, T218TI, L234I, A265V, R269KCRF02_AG
 815-14815-14EU618304None  L74MK14R, S24N, V31I, S39C, L101I, T112V, T124A, T125A, G134N, I135V, K136T, V201I, T206S, L234ICRF02_AG
 A1102A1102EU618346None  L74M, T97AE11D, V31I, L101I, T112V, T124A, G134N, I135V, K136T, V201I, T206S, L234I, R269KCRF02_AG
 A1117A1117EU618347None  L74MK14R, V31I, L101LI, T112V, T124A, T125A, G134N, K136T, V201I, T206S, T218I, L234I, A265V, D286ACRF02_AG
 A1123A1123EU618352None  L74MK14R, V31I, S57G, E96D, L101I, T112V, T124A, T125A, G134N, I135V, K136T, V201I, T206S, K215N, L234I, R269K, D288NCRF02_AG
 A1264A1264EU618372None  L74MK14R, S24N, V31I, S39C, L101I, T112V, T124A, T125A, G134N, I135V, K136T, V201I, T206S, L234ICRF02_AG
 A1266A1266EU618374None  L74MK14R, V31I, I72V, I84V, P90S, L101I, T112V, T124A, T125A, G134N, I135V, K136T, V201I, T206S, T218I, L234I, R269K, S283GCRF02_AG
 A1659A1659EU618413None  L74MK14R, V31I, L101I, T112I, T124A, T125A, G134N, I135V, K136T, V201I, T206S, T218I, L234I, I251V, A265VCRF02_AG
 A1701A1701EU618417None  L74MK14R, V31I, L101I, T112V, T124A, T125V, G134N, I135V, K136T, D167E, V201I, T206S, T218I, L234I, A265V, R269KCRF02_AG
 A1752A1752EU618425None  L74MK14R, V31I, V32I, L101I, T112V, T124A, T125P, G134N, I135V, K136T, V201I, T206S, L234I, R269K, D270HCRF02_AG
 A1753A1753EU618426None  L74ME11D, K14KR, V31I, L101I, T112V, T124A, T125A, G134N, I135V, K136T, V201I, T206S, T218I, L234I, A265V, R269K, S283G, D288NCRF02_AG
 A1755A1755EU618428None  L74MK14R, V31I, E96D, L101I, T112V, T124A, G134D, K136T, V201I, T206S, L234I, A265V, R269KCRF02_AG
 A1764A1764EU618436None  L74MK14R, V31I, S57G, E96D, L101I, T112V, T124A, T125A, G134N, I135V, K136T, V201I, T206S, K215N, L234I, R269K, D288NCRF02_AG
 A1772A1772EU618440None  L74M, T97AK14R, S24N, V31I, L101I, T112V, T124A, T125A, G134N, I135V, K136T, V201I, T206S, T218TI, L234I, R269KCRF02_AG
 AB618AB618EU618484None  L74MK14R, V31I, L101LI, T112V, T124A, T125A, G134N, I135V, K136T, V201I, T206S, L234I, R269KCRF02_AG
 AB712AB712EU618486None  L74MK14R, V31I, S57G, L101I, T112V, T124A, T125A, G134N, I135V, K136T, V201I, T206S, I217V, T218I, L234I, D256E, A265V, S283GCRF02_AG
 AB733AB733EU618488None  L74MK14R, V31I, L45I, G59E, L101I, T112V, T124A, T125A, G134N, K136T, V201I, T206S, L234I, R269K, D270HCRF02_AG
 ABB01-96ABB01-96EU618490None  L74ME11D, S24N, V31I, L101I, T112V, T124A, G134N, K136T, V201I, T206S, L234I, A265VCRF02_AG
 ABB20-96ABB20-96EU618507None  L74ME11D, K14R, S24N, V31I, L101I, T112V, T124A, T125A, G134N, I135V, K136T, V201I, T206S, T218I, L234I, R269K, S283G, D286ECRF02_AG
 ABB23-96ABB23-96EU618510None  L74MK14R, V31I, I72V, L101I, T112V, T124A, T125A, G134N, I135V, K136T, V201I, T206S, T218I, L234I, R269K, D286NCRF02_AG
 ABB34-96ABB34-96EU618521None  L74MK14R, V31I, L101I, T112V, T124A, T125A, G134N, I135V, K136T, F181FL, V201I, T206S, Q221R, L234I, A265AVCRF02_AG
 ABB59-96ABB59-96EU618545None  L74M, T97AK14R, S24N, V31I, I72V, L101LI, T112V, T124A, T125A, G134N, I135V, K136T, G193GE, V201I, T206S, T218I, L234I, R269K, S283GCRF02_AG
 ABB80-96ABB80-96EU618565None  L74MV31I, I72V, L101I, T112V, T124A, G134N, I135V, K136T, V201I, T206S, L234I, A265V, R269K, D286NCRF02_AG
 ABB93-96ABB93-96EU618578None  L74MK14R, L101I, T112V, T124A, G134N, I135V, K136T, G163E, V201I, T206S, L234I, D270NCRF02_AG
 ABB101-97ABB101-97EU618586None  L74MK14R, S17N, V31I, V32I, T112V, T124A, T125A, G134N, K136T, V201I, T206S, T218I, L234ICRF02_AG
 ABB117-98ABB117-98EU618593None  L74MK14R, V31I, L101I, T112V, T124A, G134N, I135V, K136T, V201I, T206S, I208M, T218I, L234I, A265V, R269KCRF02_AG
Eshleman (2009)ABB01-96ABB01-96FJ480262None  L74ME11D, S24N, V31I, L101I, T112V, T124A, G134N, K136T, V201I, T206S, R224RW, L234I, A265V, D286DGCRF02_AG
 ABB020-96ABB020-96FJ480271None  L74ME11D, K14R, S24N, V31I, L101I, T112V, T124A, T125A, G134N, I135V, K136T, V201I, T206S, T218I, L234I, R269K, S283G, D286ECRF02_AG
 ABB101-97ABB101-97FJ480298None  L74MK14R, S17N, V31I, V32I, R107RG, T112V, T124A, T125A, G134N, K136T, V201I, T206S, T218I, L234ICRF02_AG
 ABB117-96ABB117-96FJ480303None  L74MK14R, V31I, L101I, T112V, T124A, G134N, I135V, K136T, V201I, T206S, I208M, T218I, L234I, A265V, R269KCRF02_AG
Carr (2010)2172SA02CM.2172SAGU201512None  L74MS17N, V31I, L101I, T112V, T124A, T125A, G134N, K136T, V201I, T206S, L234I, R269K, D286NCRF02_AG
Reigadas (2013)428428JX425761None  L74M, T97AK14R, S57G, L101I, T112V, S119T, T124A, T125A, G134N, I135V, K136T, K188R, V201I, T206S, T218I, L234I, A265V, R269K, S283G, D286NCRF02_AG
 444444JX425777None  L74MK14R, V31I, L101I, T112V, T124A, T125A, G134N, I135V, K136T, V201I, T206S, K215N, T218I, L234I, R269K, S283G, D288NCRF02_AG
 478478JX425811None  L74MK14KR, V31L, L45Q, L101I, T112V, T124S, G134N, K136T, V201I, T206S, T218TI, R224RW, L234I, V259I, R269K, D270HCRF02_AG
 487487JX425820None  L74MV31I, M50I, T112V, S119P, T124A, T125A, G134N, I135V, K136T, V201I, T206S, D207E, Q221T, L234I, S255G, S283GCRF02_AG
 4187941879JX451958None  L74MK14R, S17SN, V31I, K71KAET, L101I, T112V, T124A, T125TA, G134N, I135V, K136T, V165I, V201I, T206S, T218I, K219N, N222K, L234I, D256E, A265AITV, R269KCRF02_AG