<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Integrase Inhibitors

Subtype CRF02_AG
Gene IN
Mutation L74I
Rx II-naive
IncludeMixtures No
References 16
Patients 90
Isolates 95
 
Show mutation frequency as:
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# INIs WksINIMajorDRMs INIMinorDRMs OtherMutSubtype
Gao (1998)92NG00392NG003U88825None   E11D, K14R, V31I, I72V, L74I, T112V, T124A, T125A, V126M, G134N, K136Q, V201I, T206S, T218I, L234I, D256E, A265V, R269K, D278G, S283GCRF02_AG
Kijak (2004)0158ND01CM.0158AY371132None   K14R, A21T, V31I, I72V, L74I, L101I, T112V, S119P, T124A, T125A, G134N, I135V, K136T, V201I, T206S, T218I, L234I, R269KCRF02_AG
 0131NY01CM.0131AY371137None   V31I, L74I, L101I, T112I, T124A, T125A, G134N, I135V, K136T, V201I, T206S, T218I, L234I, A265V, R269K, D288NCRF02_AG
Meloni (2004)DDJ362DDJ362AY521632None   S24N, V31I, V32I, I72V, L74I, T112V, T124A, T125A, G134N, I135V, K136T, V165I, D167E, V201I, T206S, L234I, D279G, S283GCRF02_AG
Njai (2006)MP137899CM.1378AM279380None Q148K K14R, V31I, I72V, L74I, L101I, T112V, T124A, T125A, G134N, I135V, K136T, A169AV, V201I, T206S, Y227F, L234ICRF02_AG
 MP101498CM.1014AM279381None   K14R, A21T, I72V, L74I, L101I, T112V, T124A, T125A, G134N, I135V, K136T, V201I, K215N, T218I, L234ICRF02_AG
 MP137199CM.1371AM279390None   E11D, K14R, L28I, V32I, M50I, L74I, L101I, T112V, T124A, T125A, G134D, I135V, K136T, V201I, T206S, L234ICRF02_AG
Tatsumi (2006)GHNJ176GHNJ176AB231894None   K14R, V31I, M50I, I72V, L74I, T112V, I113V, T124A, T125A, V126M, G134D, K136Q, G163E, V165I, V201I, T206P, N222H, L234I, S283G, D288NCRF02_AG
 GHNJ193GHNJ193AB231897None   K14R, W19G, V31I, M50T, I72V, L74I, T112V, I113V, T124A, T125A, V126M, G134D, K136Q, G163E, V165I, V201I, E212A, N222H, L234I, S283G, D288NCRF02_AG
Brennan (2008)0032-20032-2EU618057None   S17C, V31I, L74I, E96D, L101I, T112V, T124A, T125A, G134N, K136T, V201I, T206S, L234I, R269KCRF02_AG
 10-1010-10EU618060None   V31I, L45I, L74I, E96ED, L101LI, T112V, I113V, T124A, T125A, I135V, V201I, T206S, T218I, L234I, A265V, D278N, S283GCRF02_AG
 104-21104-21EU618065None   K14R, V31I, L63I, L74I, L101I, T112V, T124A, T125A, G134D, I135V, K136T, V201I, T206S, L234I, S283GCRF02_AG
 1055-71055-7EU618067None   E11D, K14R, S17SC, A23AV, S24SN, V31I, I72V, L74I, L101I, T112V, T124A, T125A, G134N, I135V, K136T, V201I, T206S, L234I, R269K, D286NCRF02_AG
 1193-81193-8EU618075None   K14R, V31I, L63I, L74I, L101I, T112V, T124A, T125A, G134N, I135V, K136T, V201I, T206S, T218I, L234I, A265V, R269KCRF02_AG
 1311-391311-39EU618082None   V31VI, L74I, L101I, T112V, T124A, T125A, G134N, I135V, K136T, V201I, T206S, D207E, I220M, Y227F, L234I, S255N, A265VCRF02_AG
 263-21263-21EU618133None   K7R, K14R, V31I, L74I, I84M, L101I, T112V, T124A, T125A, G134N, I135V, K136T, G163E, V201I, T206S, I208M, L234I, R269KCRF02_AG
 382-42382-42EU618165None   E10ED, E11D, K14KR, V31I, L74I, L101I, T112V, T124A, T125A, G134N, I135V, K136T, V201I, T206S, I208IM, N222NH, L234I, A265V, D286ECRF02_AG
 4215-174215-17EU618178None   K14R, A21T, V31I, I72V, L74I, I84M, L101I, T112V, T124A, T125A, G134N, I135V, K136T, E157N, V201I, T206S, T218I, L234I, D256ECRF02_AG
 4456-64456-6EU618188None   V31I, L74I, T112V, T125A, G134S, K136T, V201I, T206S, L234I, R269K, D278N, S283GCRF02_AG
 46-1146-11EU618197None   S17C, V31I, L74I, L101I, T112V, I113L, T124A, T125A, G134N, K136T, V201I, T206S, L234ICRF02_AG
 477-20477-20EU618205None   K7R, K14R, L74I, L101I, T112V, T124A, T125A, G134N, I135V, K136T, F181L, K188R, V201I, T206S, L234I, A265VCRF02_AG
 5222-3B5222-3BEU618227None   K14R, A21T, V31I, I72V, L74I, L101I, T112V, T124A, T125A, G134N, I135V, K136T, E157N, V201I, T206S, T218I, L234I, D256ECRF02_AG
 606-9606-9EU618261None   K14R, A21T, L74I, L101I, T112I, T124A, T125A, G134N, K136T, V201I, T206S, L234I, I268L, R269KCRF02_AG
 623-3623-3EU618263None   K14R, V31I, L74I, L101I, T112V, S119P, T124A, T125A, G134N, I135V, K136T, V201I, T206A, L234I, V260ICRF02_AG
 651-27651-27EU618273None   V31I, L74I, L101I, T112I, T124A, T125A, G134D, I135V, K136T, V201I, T206S, T218I, L234I, A265V, R269K, D278N, S283GCRF02_AG
 671-36671-36EU618279None   V31I, L74I, L101I, T112V, I113V, T124A, T125A, G134N, K136T, V201I, T206S, T218I, L234I, A265V, R269K, D278N, S283GCRF02_AG
 696-47696-47EU618284None   K14R, V31I, L63I, L74I, L101I, T112V, T124A, G134N, K136T, G193R, V201I, T206S, T218I, L234I, A265VCRF02_AG
 939-14939-14EU618331None   K14R, V31I, L74I, L101I, T112V, T124A, T125A, G134D, I135V, K136T, V201I, T206S, L234I, R269K, S283G, E287QCRF02_AG
 943-32943-32EU618333None   S17C, V31I, L74I, I84M, L101I, T112V, T124A, T125S, G134N, K136T, V201I, T206S, D207E, K211R, L234I, R269K, D288NCRF02_AG
 952-34952-34EU618336None   S17C, V31I, L74I, I84M, L101I, T112V, T124A, T125S, G134N, K136T, V201I, T206S, D207E, K211R, L234I, R269K, D288NCRF02_AG
 A1220A1220EU618362None  T97AK14R, V31I, M50I, I72V, L74I, T112V, T125A, V126M, K136Q, E157Q, V201I, T206S, Q221Q*R, L234I, R269K, S283GCRF02_AG
 A1265A1265EU618373None  T97AK14R, V31I, L74I, L101I, T112V, T124A, T125A, G134N, I135V, K136T, V201I, T206S, L234I, D256E, R269K, S283GCRF02_AG
 A1655A1655EU618410None   E11ED, K14R, V31I, L63I, L74I, T112V, T124A, T125A, G134N, I135V, K136T, V201I, T206S, L234I, A265V, R269KCRF02_AG
 A1660A1660EU618414None   V31I, I72V, L74I, E96D, L101I, T112V, T124A, T125A, G134N, I135V, K136T, V201I, T206S, T218I, L234I, A265V, R269K, D278N, S283GCRF02_AG
 A1700A1700EU618416None   V31I, M50I, L74I, L101I, T112V, T125V, G134N, K136T, V201I, T206S, T218I, D229E, L234I, A265V, R269K, D288NCRF02_AG
 A1751A1751EU618424None   K14R, A21T, V31I, I72V, L74I, E96ED, L101I, T112V, T124A, T125A, G134N, I135V, K136T, V201I, T206S, Q221T, L234I, D256E, R269KCRF02_AG
 A1771A1771EU618439None   K14R, V31I, S57G, L74I, E96D, L101I, T112V, T124A, T125A, G134N, I135V, K136T, V201I, T206S, T218I, I220V, L234ICRF02_AG
 A1778A1778EU618445None   K14R, V31I, L74I, L101I, T112V, T124A, T125A, G134D, K136T, V201I, T206S, T218I, Q221QKR, L234ICRF02_AG
 A1782A1782EU618448None   E11D, K14R, A21T, V31I, M50T, L63I, L74I, E96D, L101I, T112V, T124A, T125A, G134N, I135V, K136T, T206S, L234ICRF02_AG
 A1789A1789EU618454None   K14R, L63I, L74I, L101I, T112V, T124A, T125A, G134N, I135V, K136T, V201I, A205S, T206S, D207E, L234ICRF02_AG
 A1801A1801EU618463None   K7KR, E11D, K14R, V31I, L74I, L101I, T112V, T124A, T125A, G134N, I135V, K136T, G163E, V201I, T206S, I220V, L234I, R269KCRF02_AG
 A790A790EU618469None   E11D, K14R, A21T, V31I, I72V, L74I, L101I, T112V, T124A, T125A, G134N, I135V, K136T, D167E, V201I, T206S, L234I, R269KCRF02_AG
 AB1076AB1076EU618475None  T97AV31I, M50I, L74I, L101I, T112V, S119G, T124A, T125A, G134N, I135V, K136T, F181L, V201I, T206S, T218I, L234I, A265V, R269K, S283G, D288NCRF02_AG
 ABB06-96ABB06-96EU618495None   E11D, K14R, A21T, V31I, I72V, L74I, L101I, T112V, T124A, T125A, G134N, I135V, K136T, E157Q, V201I, T206S, L234I, R269K, M275VCRF02_AG
 ABB07-96ABB07-96EU618496None   K14R, I72V, L74I, L101I, T112V, T124A, G134N, K136T, G163E, V201I, T206S, L234I, R269KCRF02_AG
 ABB10-96ABB10-96EU618498None   K14R, S24SN, V31I, L74I, L101I, T112V, T124A, T125A, G134N, I135V, K136T, K160KN, V201I, T206S, T218I, L234I, D270ECRF02_AG
 ABB11-96ABB11-96EU618499None   E11D, K14R, A21T, P30S, V31I, L63I, L74I, L101I, T112V, T124A, T125A, G134N, I135V, K136T, V201I, T206S, L234I, E287KCRF02_AG
 ABB19-96ABB19-96EU618506None   K7R, E11D, K14R, V31I, I72V, L74I, I84V, L101I, T112I, T124A, T125A, G134N, I135V, K136T, V201I, T206S, T218I, L234I, A265V, R269K, D286NCRF02_AG
 ABB46-96ABB46-96EU618533None   E11D, V31I, L74I, L101I, T112V, T124A, T125A, G134N, I135V, K136T, F181L, V201I, T206S, L234I, A265V, R269KCRF02_AG
 ABB89-96ABB89-96EU618574None   K14R, V31I, I72V, L74I, L101I, T112V, I113L, T124A, K136Q, H183Y, V201I, T206S, L234I, A265V, R269K, D286NCRF02_AG
 ABB92-96ABB92-96EU618577None   V31I, L74I, L101I, T112V, T124A, G134N, K136T, S153A, V201I, T206S, T218I, L234I, A265V, R269KCRF02_AG
 ABB94-96ABB94-96EU618579None   K14R, A21T, V31I, I72V, L74I, L101I, T112V, T124A, G134N, I135V, K136T, V201I, T206S, L234I, D256E, R269KCRF02_AG
 ABB96-97ABB96-97EU618581None   E11D, K14R, V31I, L74I, L101I, T112V, T124A, T125A, G134N, I135V, K136T, V201I, T218I, L234I, A265V, R269KCRF02_AG
 ABB100-97ABB100-97EU618585None   K14R, V31I, L74I, L101I, T112V, T124S, T125A, G134N, I135V, K136T, V201I, T206S, L234I, R269K, D270HCRF02_AG
 ABB162-98ABB162-98EU618604None   K14R, S17C, V31I, I72V, L74I, E96D, L101I, T112V, T124A, T125A, G134N, I135V, K136T, E157Q, V201I, T206S, L234I, A265V, R269K, D286NCRF02_AG
 ADB-11ADB-11EU618626None   E10D, K14R, V31I, S39C, L74I, L101I, T112V, T124A, T125A, G134N, I135V, K136T, V201I, T206S, I208IM, Q216R, K219Q, S230N, L234I, A265V, R269KCRF02_AG
Eshleman (2009)ABB06-96ABB06-96FJ480265None   E11ED, K14R, A21T, V31I, I72V, L74I, L101I, T112V, T124A, T125A, G134N, I135V, K136T, E157Q, V201I, T206S, L234I, R269K, M275MVCRF02_AG
 ABB07-96ABB07-96FJ480266None   K14R, I72V, L74I, L101I, T112V, T124A, G134N, K136T, G163E, V201I, T206S, L234I, R269RKCRF02_AG
 ABB11-96ABB11-96FJ480269None   E11D, K14R, A21T, P30S, V31I, L63I, L74I, L101I, T112V, T124A, T125A, G134N, I135V, K136T, V201I, T206S, L234I, E287KCRF02_AG
 ABB028-96ABB028-96FJ480275None   K14R, V31I, I72V, L74I, P90PS, A98G, L101I, T112V, T124A, K136Q, V201I, T206S, L234I, R269K, D286NCRF02_AG
 ABB046-96ABB046-96FJ480280None   E11D, V31I, L74I, L101I, T112V, T124A, T125A, G134N, I135V, K136T, F181L, V201I, T206S, L234I, A265V, R269KCRF02_AG
 ABB89-96ABB89-96FJ480292None   K14R, V31I, I72V, L74I, L101I, T112V, I113L, T124A, K136Q, V201I, T206S, L234I, A265V, R269K, D286NCRF02_AG
 ABB94-96ABB94-96FJ480294None   K14R, A21T, V31I, I72V, L74I, L101I, T112V, T124A, G134N, I135V, K136T, V201I, T206S, L234I, D256E, R269KCRF02_AG
Garrido (2009)48INT-48GU216895None   K14R, V31I, L63I, I72V, L74I, E96D, L101I, G106GA, T112V, T124A, G134N, I135V, K136T, V201I, T206S, L234I, R269KCRF02_AG
 64INT-64GU216911None   E11D, K14R, V31I, S57G, L74I, A91E, L101I, T112V, S119R, T125A, G134N, I135V, K136T, F181FL, K188R, V201I, T206S, L234I, I268LCRF02_AG
 181INT-181GU217028None   E11D, K14R, S17T, S39C, L74I, L101I, T112V, T125A, G134N, I135V, K136T, V201I, T206S, Q216N, K219Q, L234ICRF02_AG
 202INT-202GU217049None   V31I, I72V, L74I, L101I, T112V, I113V, T124A, T125A, G134N, I135V, K136T, F181L, K188KR, V201I, T206S, T218TI, L234I, A265V, R269KCRF02_AG
Sichtig (2009)Pt064901FJ183627None   S17N, V31I, M50MI, I72V, L74I, L101I, T112V, I113L, T124A, T125A, G134D, I135V, V201I, T206S, L234ICRF02_AG
Avi (2010)N14N14GQ926760None   E11D, S24N, V31I, L45Q, L63I, L74I, L101I, T112V, T125A, G134N, K136T, V201I, T206S, T218I, L234I, S255N, D256E, D279GCRF02_AG
 N19N19GQ926765None   K14R, S24N, V31I, L63I, L74I, L101I, T112V, T124A, G134N, K136Q, V201I, T206S, T218I, L234I, D256E, S283GCRF02_AG
 N32N32GQ926778None   V31I, L45Q, L63I, L74I, L101I, T112V, T122I, T124A, G134N, K136T, V201I, T206S, T218I, L234I, S255NCRF02_AG
 N33N33GQ926779None   V31I, L45Q, L63I, L74I, L101I, T112V, T124A, T125A, G134N, D167E, V201I, T206S, T218I, L234I, S255NCRF02_AG
 N41N41GQ926787None   K14R, S24N, V31I, L45Q, I72V, L74I, T112V, I113V, T124S, T125A, G134N, K136Q, T206S, T218I, L234I, D256E, S283G, D286NCRF02_AG
Carr (2010)0144ND01CM.0144NDGU201495None   K14R, A21T, V31I, I72V, L74I, L101I, T112V, S119P, T122I, T124A, T125A, G134N, I135V, K136T, V201I, T206S, T218I, Q221S, L234I, R269KCRF02_AG
 0119MA01CM.0119MAGU201498None   E11D, S17C, V31I, L74I, Q95S, L101I, T112I, T124A, T125A, G134N, K136T, V201I, T206S, L234V, R269KCRF02_AG
 3153MN02CM.3153MNGU201513None   E11D, K14R, A21T, V31I, L74I, L101I, T112V, T124A, T125A, G134N, I135V, K136T, V201I, T206S, T218I, L234I, A265V, R269K, D278N, S283GCRF02_AG
Brenner (2011)1008210082HQ207707None   K14R, A21T, V31I, S57G, L74I, A98G, L101I, T112V, T124A, T125A, G134N, I135V, K136T, V201I, T206S, L234I, D256E, I268L, S283GCRF02_AG
Manak (2012)79_LH0179_LH01JN687693None   E11D, K14R, S24N, V31I, L63I, L74I, E96D, L101I, T112V, T124A, T125A, G134N, I135V, K136T, V201I, T206S, L234I, R269KCRF02_AG
Monleau (2012)SK3015SK3015JQ250524None   K14R, R20K, L74I, L101I, T112TI, T124A, T125A, G134D, K136Q, V201I, I208IL, K211KRT, R224RW, L234I, S255N, D256E, D279G, S283GCRF02_AG
 SK1023SK1023JQ250541None   K14R, V31I, L74I, L101I, T112V, T124A, T125A, G134D, I135V, K136T, K188KR, V201I, T206S, T218TI, L234I, A265V, R269RK, D279GCRF02_AG
 ETI ETIETI ETIJQ250608None   K14R, S57G, L74I, E96D, L101I, T112I, T124G, T125A, G134N, I135V, V201I, T206S, Q221T, L234ICRF02_AG
Oliveira (2012)GA08GA08JQ670795None   E11D, D25E, F26Y, V31VI, V37I, I72V, L74I, L101I, T112V, T124A, T125A, G134N, I135V, K136T, V201I, T206S, L234I, M275MV, D279G, S283GCRF02_AG
Reigadas (2013)401401JX425734None   K14R, V31I, L63I, C65CW, L74I, V88VG, E96D, L101I, G106A, T112V, T124A, T125A, G134N, I135V, K136T, V201I, T206S, L234I, R269K, D279GCRF02_AG
 407407JX425740None   K14R, A21T, V31I, L63I, L74I, E96D, L101I, T112V, T124A, T125A, G134N, I135V, K136T, V201I, T206S, L234I, R269KCRF02_AG
 418418JX425751None  Q95KK14R, L45IV, M50I, L74I, A91E, L101I, T112V, T124A, T125A, G134N, I135V, K136S, V201I, T206S, I208M, L234I, D256E, R269K, S283G, R284G, D288NCRF02_AG
 432432JX425765None   K14R, S24N, D25E, V31I, L63I, L74I, L101I, K103R, T112V, T124A, T125A, G134N, I135V, K136T, E157Q, K160Q, V201I, T206S, Q216H, L234I, S283GCRF02_AG
 450450JX425783None   K14R, S17N, V31I, L74I, L101I, T112I, T124A, T125A, G134N, I135V, K136T, G163E, V201I, T206S, L234I, N254K, S255G, S283GCRF02_AG
 456456JX425789None   K14R, R20K, V31I, V32I, M50T, L74I, E96D, L101I, T112V, T124A, T125A, G134N, K136T, K173R, V201I, T206S, T218I, K219N, N222K, L234I, S283GCRF02_AG
 469469JX425802None   K14R, S17N, E35Q, S39N, I72T, I73V, L74I, L101I, T112V, T124A, T125A, G134D, I135V, K136T, E157Q, K160G, K173R, V201I, I203M, T206S, Q216H, Y227F, L234I, D256E, R269K, D278G, S283GCRF02_AG
 471471JX425804None  T97AK7R, V31I, E35EK, V37VG, L63LI, L74I, L101I, T112V, T124A, T125A, G134N, I135V, F181L, R187RK, V201I, T206S, I217IV, R224RW, L234I, D253DY, S283GCRF02_AG
 480480JX425813None   K14R, V31I, I72V, L74I, L101I, T112V, I113L, T124A, T125A, G134N, I135V, K136T, V201VI, T206S, I208IL, L234I, D256E, R269KCRF02_AG
 483483JX425816None   L74I, L101I, K103R, T112V, T124A, T125A, G134D, I135V, K136T, V201I, T206S, L234I, D270E, D278N, S283GCRF02_AG
 484484JX425817None  T97AE11D, S17N, V31I, I72V, L74I, L101I, T112V, T124A, T125TA, G134N, K136T, Q137H, K160KHNQ, V201I, T206S, T218IL, I220IL, L234I, R269K, D286NCRF02_AG
 4216542165JX451941None   E11D, K14R, V31I, I72V, L74I, L101I, T112V, I113V, T124A, T125A, G134D, I135V, G163E, V201I, T206S, K211N, E212K, L234I, N254K, R269K, S283GCRF02_AG
 100983100983JX451948None   K14KR, S24N, V31I, L63V, L74I, L101I, K111T, T112V, T124A, T125A, G134N, I135V, K136T, V201I, T206S, L234I, R269K, S283G, D286NCRF02_AG