<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Integrase Inhibitors

Subtype CRF02_AG
Gene IN
Mutation E157Q
Rx II-naive
IncludeMixtures No
References 9
Patients 39
Isolates 42
 
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# INIs WksINIMajorDRMs INIMinorDRMs OtherMutSubtype
Njai (2006)MP80297CM.802AM279382None   K14R, V31I, L101I, T112V, T124A, T125A, G134N, I135V, K136T, E157Q, K160Q, V201I, T206S, D207E, T218I, L234ICRF02_AG
Badreddine (2007)J11456SB_J11456DQ375272None   K14R, S57G, I72V, E96D, L101I, T112V, T124A, T125V, G134N, I135V, K136T, E157Q, V201I, T206S, D232E, L234I, D256E, S283GCRF02_AG
Brennan (2008)1049-11049-1EU618066None   V31I, D41N, L101I, T112I, T124A, T125A, G134N, I135V, K136T, E157Q, V201I, T206S, T218I, L234I, R269K, S283GCRF02_AG
 145-01145-01EU618089None   K14R, V31I, A91E, L101I, T112V, S119R, T124A, T125A, G134N, I135V, K136T, E157Q, V201I, T206S, L234I, A265V, R269K, S283GCRF02_AG
 323-41323-41EU618148None   K14R, V31I, I72IV, Y99F, L101I, T112V, T124A, T125A, G134N, I135V, K136T, E157Q, K160Q, V201I, T206S, L234I, R269K, S283GCRF02_AG
 370-03370-03EU618160None   K14R, V31I, L101I, T112V, T124A, T125A, G134N, I135V, K136T, E157Q, V201I, T206S, L234I, R269K, S283GCRF02_AG
 396-26396-26EU618174None   V31I, D41N, L101I, T112I, T124A, T125A, G134N, I135V, K136T, E157Q, V201I, T206S, T218I, L234I, R269K, S283GCRF02_AG
 449-38449-38EU618192None  L74ME11D, K14R, R20K, V31I, E87EK, L101I, K111T, T112V, S119P, T122I, T124A, T125A, G134N, I135V, K136T, E157Q, V201I, T206S, T218I, L234I, R269K, D288NCRF02_AG
 466-27466-27EU618200None   K14R, V31I, L101I, T112V, T124A, T125A, G134N, I135V, K136T, E157Q, K160Q, V201I, T206S, L234I, I251L, R269K, S283GCRF02_AG
 483-44483-44EU618206None  L74MK14R, S17N, V31I, M50I, L101I, T112TI, T124A, T125A, G134N, I135V, K136T, E157Q, K160Q, V201I, T206S, T218I, L234I, A265V, R269K, S283G, D288NCRF02_AG
 4843-24843-2EU618209None   K14R, V31I, I72V, E96D, L101I, T112V, T124A, T125A, G134N, I135V, K136T, E157Q, K160Q, V201I, T206S, L234I, A265V, R269K, S283GCRF02_AG
 49-1849-18EU618212None   K14R, V31I, L101I, T112V, T124A, T125A, G134N, K136T, E157Q, K160Q, V201I, T206S, D207E, T218I, L234I, D256E, S283GCRF02_AG
 5511-215511-21EU618242None   E11D, K14R, S24N, V31I, V32I, L101I, T112V, T124A, T125A, G134N, I135V, K136T, E157Q, K160Q, V201I, T206S, L234I, A265V, S283G, D286NCRF02_AG
 5787-35787-3EU618256None   E11D, K14R, S24N, V31I, I72V, L101I, T112V, T124A, T125A, G134N, I135V, K136T, E157Q, K160Q, V201I, T206S, L234I, A265V, S283GCRF02_AG
 625-21625-21EU618266None   K14R, V31I, S39N, Q95P, L101I, K111Q, T112V, T124A, T125A, G134N, K136T, E157Q, V201I, A205S, T206S, L234I, S283GCRF02_AG
 A1220A1220EU618362None  T97AK14R, V31I, M50I, I72V, L74I, T112V, T125A, V126M, K136Q, E157Q, V201I, T206S, Q221Q*R, L234I, R269K, S283GCRF02_AG
 A1759A1759EU618431None   K14R, V31I, E96D, L101I, G106A, T112V, S119P, T122I, T124A, T125A, G134N, I135V, K136T, E157Q, V201I, T206S, L234I, R269K, S283GCRF02_AG
 AB660AB660EU618485None   K14R, V31I, L101I, T112V, T124A, T125A, G134N, I135V, K136T, E157Q, V201I, T206S, L234I, S255G, A265V, R269K, S283GCRF02_AG
 AB732AB732EU618487None   K14R, V31I, L101I, T112V, T124G, T125A, G134N, I135V, K136T, E157Q, K160Q, V201I, T206S, I208M, L234I, A265V, S283GCRF02_AG
 ABB06-96ABB06-96EU618495None   E11D, K14R, A21T, V31I, I72V, L74I, L101I, T112V, T124A, T125A, G134N, I135V, K136T, E157Q, V201I, T206S, L234I, R269K, M275VCRF02_AG
 ABB79-96ABB79-96EU618564None   E11D, K14R, D25E, V31I, L101I, T112V, T124A, T125A, G134N, I135V, K136T, E157Q, V201I, T206S, L234I, R269K, S283GCRF02_AG
 ABB82-96ABB82-96EU618567None   E10D, K14R, R20K, V31I, M50I, I72V, Q95H, T112V, T124A, T125A, V126M, I135V, K136Q, E157Q, K160Q, V201I, T206S, L234I, A265V, S283GCRF02_AG
 ABB99-97ABB99-97EU618584None  T97AK14R, V31I, A91E, L101I, T112V, S119R, T124A, T125A, G134N, I135V, K136T, E157Q, V201I, T206S, L234I, S283GCRF02_AG
 ABB162-98ABB162-98EU618604None   K14R, S17C, V31I, I72V, L74I, E96D, L101I, T112V, T124A, T125A, G134N, I135V, K136T, E157Q, V201I, T206S, L234I, A265V, R269K, D286NCRF02_AG
 ABB195ABB195EU618618None   K14R, A23V, V31I, L101I, T112V, T124A, T125A, G134N, I135V, K136T, E157Q, K160Q, D167E, V201I, T206S, Q221R, L234I, A265V, S283GCRF02_AG
 ABB198ABB198EU618620None   K14R, S17N, V31I, L101I, T112V, T124G, T125A, G134N, I135V, K136T, E157Q, K160Q, V201I, T206S, L234I, S283GCRF02_AG
Eshleman (2009)ABB06-96ABB06-96FJ480265None   E11ED, K14R, A21T, V31I, I72V, L74I, L101I, T112V, T124A, T125A, G134N, I135V, K136T, E157Q, V201I, T206S, L234I, R269K, M275MVCRF02_AG
 ABB99-97ABB99-97FJ480297None  T97AK14R, V31I, A91E, L101I, T112V, S119R, T124A, T125A, G134N, I135V, K136T, E157Q, V201I, T206S, L234I, S283GCRF02_AG
 ABB198ABB198FJ480315None   K14R, S17N, V31I, L101I, T112V, T124G, T125A, G134N, I135V, K136T, E157Q, K160Q, V201I, T206S, L234I, S283GCRF02_AG
Low (2009)ahi62ahi62_06FJ786329None   E11D, V31I, L101I, T112V, S119R, T124A, T125A, G134N, I135V, K136T, E157Q, K160Q, V201I, I203M, T206S, I208L, T218I, L234I, A265V, S283G, D288NCRF02_AG
 ahi107ahi107_06FJ786375None   K14R, V31I, L101I, T112V, T124A, T125A, G134N, I135V, K136T, E157Q, K160Q, V201I, I203M, T206S, I208L, T218I, L234I, A265V, S283G, D288NCRF02_AG
Brenner (2011)90739073HQ207786None   K14R, V31I, M50T, L101I, T112V, T124N, T125A, G134N, I135V, K136T, E157Q, V201I, T206S, T218I, L234I, R269K, S283GCRF02_AG
 97109710HQ207804None   K14R, V31I, M50T, L101I, T112V, T124N, T125A, G134N, I135V, K136T, E157Q, V201I, T206S, T218I, L234I, R269K, S283GCRF02_AG
Rolland (2011)2696consensus_2696JF320295None   K14R, V31I, L101I, T112V, T124A, T125A, G134N, I135V, K136T, E157Q, K160Q, V201I, I203M, T206S, I208L, T218I, L234I, A265V, S283G, D288NCRF02_AG
Monleau (2012)DON DONDON DONJQ250597None  R263KK14R, V31I, M50T, P90S, Q95S, L101I, T112V, T124A, T125A, G134N, I135V, K136T, E157Q, V201I, T206S, L234I, E246D, S255G, A265S, Y271DCRF02_AG
Reigadas (2013)402402JX425735None   E11ED, K14R, S24N, V31I, I72V, L101I, T112V, T124G, T125A, G134N, I135V, K136T, E157Q, K160KT, V201I, T206S, L234I, R269KCRF02_AG
 432432JX425765None   K14R, S24N, D25E, V31I, L63I, L74I, L101I, K103R, T112V, T124A, T125A, G134N, I135V, K136T, E157Q, K160Q, V201I, T206S, Q216H, L234I, S283GCRF02_AG
 458458JX425791None   K14R, V31I, I72V, L101I, T112V, T124A, T125A, G134N, I135V, K136T, E157Q, K160Q, V201I, I203M, T206S, K219N, N222K, L234I, A265V, R269KCRF02_AG
 469469JX425802None   K14R, S17N, E35Q, S39N, I72T, I73V, L74I, L101I, T112V, T124A, T125A, G134D, I135V, K136T, E157Q, K160G, K173R, V201I, I203M, T206S, Q216H, Y227F, L234I, D256E, R269K, D278G, S283GCRF02_AG
 503503JX425836None   E11D, K14R, S24N, D25E, V31I, M50I, L101I, T112V, T124A, T125A, G134N, I135V, K136T, E157Q, K160Q, V201I, T206S, T218I, L234I, R269K, S283GCRF02_AG
 505505JX425838None   D3N, K14R, W19*, N27S, V31I, D41N, D64N, L101I, T112V, T124A, T125A, G134N, I135V, K136T, E157Q, K160Q, F181L, K188R, V201I, T206S, L234I, A265V, S283GCRF02_AG
 101101101101JX451926None   E11D, K14R, V31I, I72V, Q95S, L101I, T112V, S119P, T124A, T125A, G134N, I135V, K136T, E157Q, V201I, T206S, L234I, A265V, R269K, S283GCRF02_AG