<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Integrase Inhibitors

Subtype CRF01_AE
Gene IN
Mutation L74I
Rx II-naive
IncludeMixtures No
References 15
Patients 33
Isolates 33
 
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# INIs WksINIMajorDRMs INIMinorDRMs OtherMutSubtype
Meloni (2004)DDI579DDI579AY521629None  T97AK14R, A21T, V31I, I72V, L74I, T112V, T124A, T125A, V126M, G134N, D167E, V201I, L234I, V260I, S283GCRF01_AE
 DDJ360DDJ360AY521630None   K14R, A21T, V31I, I72V, L74I, T112V, T124A, T125A, V126M, G134D, D167E, V201I, L234I, V260I, S283GCRF01_AE
 DDJ369DDJ369AY521631None   K14R, A21T, V31I, M50K, I72V, L74I, T112V, T124A, T125A, G134N, K136Q, D167E, V201I, K211Q, T218I, L234I, S283GCRF01_AE
Tovanabutra (2004)01THOUR642I01_642IAY358041None   E11D, K14R, A21T, V31I, S39N, I72V, L74I, E96D, T112V, T124A, T125A, G134N, I135V, K136R, D167E, V201I, L234I, S283GCRF01_AE
Brennan (2008)124-33124-33EU618078None   K14R, A21T, S39C, L63I, I72V, L74I, T112V, I113V, S119ST, T124A, T125A, V126M, G134N, I135V, D167E, V201I, K211R, Q216H, L234I, S283GCRF01_AE
 476-16476-16EU618204None   K14R, A21T, V31I, I72V, L74I, T112I, T124G, T125A, G134N, K136T, D167E, V201I, L234I, S283GCRF01_AE
Niama (2009)97CD.MBFE185CD.MBFE185FN392874None   V31I, L74I, T112V, S119P, T124A, T125A, G134N, K136Q, D167E, V201I, L234I, L241LP, S283GCRF01_AE
Wilantho A (2011)chan11chan11JF928881None   K14R, A21T, S24SG, E35Q, S39N, L45LI, L63LV, I72V, L74I, E96D, T112V, I113V, T124N, T125A, G134N, K136R, K160N, D167E, V201I, L234I, D256E, S283GCRF01_AE
 SL003SL003JF928929None   E11D, K14R, A21T, A23V, V31VI, V32I, L63I, I72T, L74I, P109PR, T112V, T125A, V126L, K127KR, G134N, I135V, K136R, V201I, T218S, L234I, V281M, S283GCRF01_AE
Chow (2012)10MYKJ06710MYKJ067JX390612None   K14R, A21T, A23V, S39N, L63V, I72V, L74I, E96D, T112V, T124A, T125A, G134N, K136Q, D167E, V201I, T206S, K211KR, L234I, S283DCRF01_AE
Rolland (2012)AA038a_WG3AA038a_WG3JX447132None   K14R, A21T, V31I, I72V, L74I, Q95N, T112V, T124A, T125A, G134N, K136Q, D167E, H171Q, V201I, L234I, P261S, S283G, Q285PCRF01_AE
 AA042a07LAA042a07LJX447193None   E11D, A21T, V31I, S39N, I72V, L74I, T112V, T125A, V126L, G134N, I135V, K136Q, G163E, V201I, L234I, S255NCRF01_AE
Zeng (2012)CN0699CN0699JQ028211None   E11D, A21T, V31I, S39N, I72T, L74I, T112V, T125A, G134N, I135V, K136R, D167E, V176L, V201I, L234I, S283GCRF01_AE
Kotaki (2013)IDU12IDU12KF735948None   E11D, A21T, V31I, S39N, I72V, L74I, T112V, I113V, S119T, T125A, V126M, G134N, I135V, K136Q, D167E, V201I, L234I, S283GCRF01_AE
 SM51SM51KF735923None   E11D, A21T, V31I, S39N, M50I, I72V, L74I, E96D, T112V, T124A, T125A, G134N, I135V, K136R, D167E, V201I, L234I, S283GCRF01_AE
 IDU18IDU18KF735953None   E11D, A21T, V31I, S39N, M50I, I72V, L74I, E96D, G106R, T112V, T124A, T125A, G134N, I135V, K136R, D167E, V201I, L234I, S283GCRF01_AE
 IDU17IDU17KF735952None   E11D, A21T, V31I, S39N, M50I, I72V, L74I, E96D, T112V, T124A, T125A, G134N, I135V, K136R, D167E, V201I, L234I, S283GCRF01_AE
 IDU4IDU4KF735941None   E11D, K14R, A21T, V31I, I72V, L74I, I84V, Q95T, T112V, T125A, G134N, I135V, K136R, M154I, V165I, D167E, V201I, L234I, S283GCRF01_AE
 IDU8IDU8KF735944None   E11D, A21T, V31I, S39N, M50I, I72V, L74I, E96D, T112V, T124A, T125A, G134N, I135V, K136R, D167E, S195I, R199I, V201I, L234I, S283GCRF01_AE
Li (2013)22542254JQ302717None   K14R, A21T, A23V, N27G, S39N, L45LI, I72V, L74I, T112V, T124A, T125A, V126L, G134N, I135V, K136R, D167E, V201I, L234I, I267IV, S283GCRF01_AE
 22652265JQ302727None   K14R, A21T, V31I, S39N, I72V, L74I, T112V, T124A, T125A, G134N, I135V, K136R, D167E, V201I, L234I, S283GCRF01_AE
 21192119JQ302619None   K14R, V31I, I72V, L74I, T112V, T125A, V126F, G134N, I135V, K136Q, K173R, V201I, L234I, S283GCRF01_AE
 20162016JQ302555None   K14R, A21T, V31I, S39N, L63V, I72V, L74I, T112V, T124A, T125A, G134N, I135V, K136R, H171Y, V201I, L234I, S283GCRF01_AE
Reigadas (2013)101099101099JX451927None   K14R, A21T, I72V, L74I, T112V, T124A, T125A, G134S, K136Q, D167E, V201I, D229DG, L234I, S283GCRF01_AE
Cheong (2015)11MYJJ74111MYJJ741KR019775None  E92EKK14R, V31I, V32I, S39N, D41N, L63V, I72T, L74I, T112V, I113V, T125A, G134N, K136Q, D167E, V201L, I217FCRF01_AE
 11MYPR41611MYPR416KR019772None   V31I, V32I, L63V, I72V, L74I, T112V, I113V, T124A, T125A, G134N, K136Q, D167E, H171Y, V201I, L234I, D279N, S283GCRF01_AE
 10MYPR26810MYPR268KR019771None   S17N, L63V, I72V, L74I, T112I, I113V, T124A, T125A, G134N, G163E, D167E, V201I, L234I, S283GCRF01_AE
 10MYKJ01610MYKJ016KR019773None   K14R, S39N, L63V, I72V, L74I, T112V, I113V, T125A, G134N, K136Q, D167E, V201I, N222YCRF01_AE
Grossmann (2015)SE601017SE601017KP411840None   S17N, V32I, L63V, I72V, L74I, T112V, T124A, T125A, G134N, I135V, K136Q, D167E, V201I, L234I, I268N, D270N, K273N, M275ICRF01_AE
Li (2016)CN-053CN-053KU050249None   K14R, A21T, A23V, V31I, S39N, D41N, L63I, L74I, T112V, T124N, T125A, G134N, I135V, K136R, V165I, V201I, L234I, D256E, S283GCRF01_AE
 CN-067CN-067KU050263None   K14R, A21T, A23V, V31I, S39N, L63V, I72V, L74I, T112V, T124A, T125A, G134N, I135V, K136Q, V176L, V201I, L234I, S283GCRF01_AE
Van Tran (2016)VI-257VI-257LC101110None   K14R, A21T, V31I, S39N, I72V, L74I, T112V, T124A, T125A, G134N, I135V, K136R, D167E, V201I, L234I, S283GCRF01_AE
 VI-071VI-071LC100944None   V31I, L74I, T112V, T124A, T125A, G134N, I135V, S153A, V176L, V201I, L234I, S283GCRF01_AE