<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Integrase Inhibitors

Subtype CRF01_AE
Gene IN
Mutation L74I
Rx II-naive
IncludeMixtures No
References 11
Patients 26
Isolates 26
 
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# INIs WksINIMajorDRMs INIMinorDRMs OtherMutSubtype
Tovanabutra (2004)01THOUR642I01_642IAY358041None   E11D, K14R, A21T, V31I, S39N, I72V, L74I, E96D, T112V, T124A, T125A, G134N, I135V, K136R, D167E, V201I, L234I, S283GCRF01_AE
Zarandia (2006)03GEMZ03703GEMZ037DQ207944None   D3E, R20K, V31I, I72V, L74I, T112V, I113V, S119P, T124S, T125A, G134D, K136Q, D167E, V201I, T218I, L234I, S255NCRF01_AE
Kousiappa (2009)CY107CY107FJ388926None   K14R, A21T, I60M, I72V, L74I, T112V, I113V, T124A, T125A, V126F, G134N, I135V, K136Q, K173R, V176L, V201I, L234I, S283GCRF01_AE
Avi (2010)N69N69GQ926814None   R20K, V31I, I72V, L74I, T112V, T124A, T125A, G134N, K136T, V201I, T206S, T218I, L234I, S255NCRF01_AE
 N103N103GQ926848None   D3E, K14R, R20K, V31I, I72V, L74I, L101I, T112V, T124A, T125A, G134N, K136T, D167E, G193E, V201I, T218I, L234I, S255N, S283GCRF01_AE
Wilantho A (2011)chan11chan11JF928881None   K14R, A21T, S24SG, E35Q, S39N, L45LI, L63LV, I72V, L74I, E96D, T112V, I113V, T124N, T125A, G134N, K136R, K160N, D167E, V201I, L234I, D256E, S283GCRF01_AE
 SL003SL003JF928929None   E11D, K14R, A21T, A23V, V31VI, V32I, L63I, I72T, L74I, P109PR, T112V, T125A, V126L, K127KR, G134N, I135V, K136R, V201I, T218S, L234I, V281M, S283GCRF01_AE
Chow (2012)10MYKJ06710MYKJ067JX390612None   K14R, A21T, A23V, S39N, L63V, I72V, L74I, E96D, T112V, T124A, T125A, G134N, K136Q, D167E, V201I, T206S, K211KR, L234I, S283DCRF01_AE
Rolland (2012)AA038a_WG3AA038a_WG3JX447132None   K14R, A21T, V31I, I72V, L74I, Q95N, T112V, T124A, T125A, G134N, K136Q, D167E, H171Q, V201I, L234I, P261S, S283G, Q285PCRF01_AE
 AA042a07LAA042a07LJX447193None   E11D, A21T, V31I, S39N, I72V, L74I, T112V, T125A, V126L, G134N, I135V, K136Q, G163E, V201I, L234I, S255NCRF01_AE
Zeng (2012)CN0699CN0699JQ028211None   E11D, A21T, V31I, S39N, I72T, L74I, T112V, T125A, G134N, I135V, K136R, D167E, V176L, V201I, L234I, S283GCRF01_AE
Kotaki (2013)IDU12IDU12KF735948None   E11D, A21T, V31I, S39N, I72V, L74I, T112V, I113V, S119T, T125A, V126M, G134N, I135V, K136Q, D167E, V201I, L234I, S283GCRF01_AE
 SM51SM51KF735923None   E11D, A21T, V31I, S39N, M50I, I72V, L74I, E96D, T112V, T124A, T125A, G134N, I135V, K136R, D167E, V201I, L234I, S283GCRF01_AE
 IDU18IDU18KF735953None   E11D, A21T, V31I, S39N, M50I, I72V, L74I, E96D, G106R, T112V, T124A, T125A, G134N, I135V, K136R, D167E, V201I, L234I, S283GCRF01_AE
 IDU17IDU17KF735952None   E11D, A21T, V31I, S39N, M50I, I72V, L74I, E96D, T112V, T124A, T125A, G134N, I135V, K136R, D167E, V201I, L234I, S283GCRF01_AE
 IDU4IDU4KF735941None   E11D, K14R, A21T, V31I, I72V, L74I, I84V, Q95T, T112V, T125A, G134N, I135V, K136R, M154I, V165I, D167E, V201I, L234I, S283GCRF01_AE
 IDU8IDU8KF735944None   E11D, A21T, V31I, S39N, M50I, I72V, L74I, E96D, T112V, T124A, T125A, G134N, I135V, K136R, D167E, S195I, R199I, V201I, L234I, S283GCRF01_AE
Li (2013)22542254JQ302717None   K14R, A21T, A23V, N27G, S39N, L45LI, I72V, L74I, T112V, T124A, T125A, V126L, G134N, I135V, K136R, D167E, V201I, L234I, I267IV, S283GCRF01_AE
 22652265JQ302727None   K14R, A21T, V31I, S39N, I72V, L74I, T112V, T124A, T125A, G134N, I135V, K136R, D167E, V201I, L234I, S283GCRF01_AE
 21192119JQ302619None   K14R, V31I, I72V, L74I, T112V, T125A, V126F, G134N, I135V, K136Q, K173R, V201I, L234I, S283GCRF01_AE
 20162016JQ302555None   K14R, A21T, V31I, S39N, L63V, I72V, L74I, T112V, T124A, T125A, G134N, I135V, K136R, H171Y, V201I, L234I, S283GCRF01_AE
Reigadas (2013)453453JX425786None   V31I, M50I, K71Q, I72V, L74I, T112V, T124A, T125A, V126M, G134D, I135V, K136Q, D167E, V201I, A205S, T218S, L234I, V260I, S283GCRF01_AE
 454454JX425787None   K14R, A21T, V31I, I72V, L74I, T112V, I113V, T124A, T125A, V126M, G134N, K136Q, D167E, V201I, L234I, S283GCRF01_AE
 607607JX425852None   K14R, V31I, L45Q, I72V, L74I, E96D, T112V, T124A, T125A, V126M, G134N, I135V, K136Q, V201I, T206S, E212HQ, L234I, D256E, S283G, D286ECRF01_AE
 612612JX425856None   K14R, V31I, M50I, L63I, L74I, T112I, T124A, T125A, V126M, K136Q, G163E, S195C, V201I, E212A, I217V, T218S, L234I, D279GCRF01_AE
 101099101099JX451927None   K14R, A21T, I72V, L74I, T112V, T124A, T125A, G134S, K136Q, D167E, V201I, D229DG, L234I, S283GCRF01_AE