<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Integrase Inhibitors

Subtype CRF01_AE
Gene IN
Mutation I203M
Rx II-naive
IncludeMixtures No
References 31
Patients 90
Isolates 90
 
Show mutation frequency as:
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# INIs WksINIMajorDRMs INIMinorDRMs OtherMutSubtype
Tovanabutra (2003)99TH_R239999TH_R2399AF530576None   K14R, A21T, V31I, S39N, I72V, T112V, T124A, T125A, G134N, I135V, K136Q, D167E, I203M, L234I, S283GCRF01_AE
Watanaveeradej (2003)NP1809NP1809AY262830None   E11D, A21T, V31I, S39N, I72V, L101I, T112I, T124A, T125A, G134N, I135L, K136Q, V201I, I203M, L234I, S283G, D286NCRF01_AE
Tovanabutra (2004)01THOUR414I01_414IAY358050None   K14R, A21T, V31I, S39N, D41N, I72V, T112V, T124A, T125A, V126M, G134D, I135V, K136H, D167E, V201I, I203M, L234I, S283G, D288NCRF01_AE
 01THOUR788I01_788IAY358068None   K14R, A21T, S24G, V31I, S39N, I72V, T112V, T124A, T125A, G134N, I135V, K136Q, D167E, V201I, I203M, L234I, S283GCRF01_AE
 02THOUR847I02_847IAY358069None   K14R, A21T, V31I, S39N, I72V, T112V, T124A, T125A, G134N, I135V, K136Q, D167E, V201I, I203M, K215R, L234I, S283GCRF01_AE
Tee (2006)KL03105_031.1DQ366661None   K14R, A21T, V31I, S39N, L63V, I72V, T112V, T124A, T125A, G134N, I135V, K136R, Q137R, D167E, V201I, I203M, L234I, S283GCRF01_AE
Hai-Long (2007)Fj065Fj065EF036534None   K14R, A21T, A23V, V31I, V32I, S39N, I72V, T112V, T124A, T125A, G134N, I135V, K136R, D167E, V201I, I203M, R224Q, L234I, S283GCRF01_AE
Brumme (2009)INT_3943INT_3943FJ813394None   D6DE, K14R, A21T, A23V, S39N, L45V, W61WC, I72IV, T112V, T124A, T125A, G134N, I135V, K136R, D167E, V201I, I203M, T218TI, L234I, S283GCRF01_AE
Garrido (2009)319INT-319GU217166None   K14R, R20G, A21T, V31I, S39N, L45Q, I72V, T112V, T124A, T125A, G134N, I135V, K136Q, V165I, D167E, V201I, I203M, Q221K, P233PS, L234I, S283GCRF01_AE
Sichtig (2009)18401840FJ183567None  L74LMK14R, V31VI, V32I, A38AP, L63LV, I72IATV, T112V, T124A, T125A, G134N, I135V, K136Q, V201I, I203M, L234ICRF01_AE
 34693469FJ183576None  L74IMK14R, V31VI, V32I, L63V, T112V, T124A, T125A, G134N, I135V, K136Q, V201I, I203M, L234ICRF01_AE
Isarangkura-Na-Ayuthaya (2010)AE-Int-14AE-Int-14HM150810None   E11D, A21T, V31I, S39N, I72V, T112V, T125A, G134N, I135V, K136R, D167E, V201I, I203M, T218S, L234I, D253E, S283GCRF01_AE
 AE-Int-23AE-Int-23HM150813None   K14R, A21T, V31I, I72V, T112V, T124A, T125A, G134N, I135V, K136R, V165I, I200M, V201I, I203M, L234I, S283GCRF01_AE
 AE-Int-95AE-Int-95HM150827None   E11D, K14R, A21T, V31I, M50I, L63V, I72V, I84L, T112V, T124A, T125A, G134N, I135V, K136R, V165I, I200M, V201I, I203M, L234I, S283GCRF01_AE
 AE-Int-271AE-Int-271HM150853None   E11D, K14R, A21T, V31VI, L63V, I72V, I84L, T112V, I113V, T125A, G134N, K136Q, V201I, I203M, L234ICRF01_AE
 AE-Int-300AE-Int-300HM150867None   K14R, A21T, V31I, S39N, I72V, T112V, T124A, T125A, V126L, I135V, D167E, K188R, V201I, I203M, L234I, S283GCRF01_AE
 AE-Int-308AE-Int-308HM150868None   K14R, V31I, S39N, I72V, L101I, T112V, T124N, T125A, G134N, I135V, K136R, V165I, D167E, G193E, V201I, I203M, L234I, S283G, D286NCRF01_AE
 AE-Int-381AE-Int-381HM150879None   K14R, A21T, S39N, L45V, I72V, T112V, I113V, T124A, T125A, G134S, K136H, V165I, V201I, I203M, L234I, D256E, S283GCRF01_AE
 AE-Int-385AE-Int-385HM150881None   V31I, S39N, I72V, T112V, T124N, T125A, G134N, I135V, K136Q, V165I, D167E, V201I, I203M, L234I, S283GCRF01_AE
Sanders-Buell (2010)569M569MGQ477441None  L74MK14R, R20K, S39N, T112V, T124A, T125A, G134N, I135V, K136R, D167E, V201I, I203M, T218I, K219N, L234I, D256E, S283GCRF01_AE
Brenner (2011)62406240HQ207731None   K14R, A21T, V31I, S39N, I72V, T112V, T125A, V126L, K127KR, G134N, I135V, K136R, D167DE, V201I, I203M, L234I, S283GCRF01_AE
 73167316HQ207755None   K14R, A21T, S39N, I72V, T112V, T124A, T125A, G134N, I135V, K136R, D167E, V201I, I203M, L234I, S283GCRF01_AE
Wilantho A (2011)SL102SL102JF928955None   K14R, A21T, V31I, S39N, I72IV, T112V, I113IV, T124H, T125A, G134N, K136Q, D167E, V201I, I203M, L234I, S283GCRF01_AE
 SL065SL065JF928940None   E11D, K14R, A21T, V31I, M50L, I72IV, I84L, T112V, I113V, N117NS, T125A, G134N, E157Q, K160Q, D167E, V201I, I203M, L234I, D256E, S283GCRF01_AE
 610640610640JF928862None   K14R, A21T, A23V, V31I, S39N, L101V, T112V, T124A, T125A, I135V, K136R, D167DE, H171HQ, V201VI, I203M, K215KN, I220IL, R224RW, L234ICRF01_AE
 718019718019JF928902None   E11D, K14R, L28I, P30S, I72V, T112V, I113V, T124A, T125A, G134N, I135V, K136R, V201I, I203M, T206S, L234I, N254S, S255G, S283GCRF01_AE
 811691811691JF928990None   E11D, K14R, A21T, V31I, V32I, L101I, T112V, T124N, T125A, G134N, I135V, K136R, D167E, V201I, I203M, L234I, S283GCRF01_AE
 SL100SL100JF928953None   E11D, K14R, A21T, V31I, L45V, I72V, I84IL, T112V, T124A, T125A, G134N, I135V, K136QR, D167E, V201I, I203M, L234I, S283GCRF01_AE
 520500520500JF928846None   K14R, A21AT, V31I, I72V, K111R, T112V, T124A, T125A, G134N, I135V, K136Q, D167E, V201I, I203M, L234I, S283GCRF01_AE
 600333600333JF928855None   E11D, K14R, R20RK, A21T, V31VIM, L45Q, T112V, T124A, T125A, G134N, I135V, K136Q, V165I, V201I, I203M, K211KR, L234I, S283GCRF01_AE
An (2012)09LNA00809LNA008JX960604None   K14R, V31I, I72V, T112V, I113V, T124A, T125A, G134N, I135V, K136R, H171Q, G193E, V201I, I203M, L234I, S283G, D288NCRF01_AE
 09LNA01109LNA011JX960605None   K14R, V31I, I72V, T112V, I113V, T124A, T125A, G134N, I135V, K136R, H171Q, G193E, V201I, I203M, L234I, S283G, D288NCRF01_AE
 08LNA00308LNA003JX960606None   V31I, I72V, T112V, T124A, T125A, G134N, I135V, K136R, D167E, G193E, V201I, I203M, L234I, S283G, D288NCRF01_AE
Chow (2012)11FIR16411FIR164JX390610None   K14R, A21T, V31I, S39N, I72V, T112V, T124A, T125A, G134N, I135V, K136Q, D167E, V201I, I203M, L234I, S283GCRF01_AE
Liu (2012)M043M043DQ354113None   K14R, A21T, S24G, E35Q, S39N, I72V, L101I, T112V, T125A, G134N, I135V, K136Q, D167E, V201I, I203M, L234I, S283GCRF01_AE
Rolland (2012)AA006a03AA006a03JX446737None   E11D, K14R, A21T, V31I, V32I, S39N, T112V, T124N, T125A, G134N, I135V, K136R, D167E, V201I, I203M, L234I, S283GCRF01_AE
 AA008a_LH15AA008a_LH15JX446769None   K14R, A21T, A23V, V31I, S39N, L45V, I72V, T112V, T124A, T125A, G134N, I135V, K136R, D167E, K188R, V201I, I203M, L234I, S283GCRF01_AE
 AA009b03LAA009b03LJX446787None   K14R, A21T, V32I, I72V, T112V, T124A, T125A, G134N, I135V, K136Q, V165I, V201I, I203M, L234I, S283GCRF01_AE
 AA044a_LH20AA044a_LH20JX447218None   E11D, A21T, V31I, I72V, T112V, T124A, T125A, G134N, I135V, K136R, D167E, V201I, I203M, L234I, S283DCRF01_AE
 AA108a_WG2AA108a_WG2JX448029None   E11D, K14R, A21T, V31I, I72V, T112V, T124A, T125A, G134N, I135V, K136R, V165I, D167E, V201I, I203M, L234I, S283GCRF01_AE
 AA112a05LAA112a05LJX448068None   D6N, K14R, A21T, V31I, L45Q, I72V, T112V, T124A, T125A, G134N, I135V, K136R, D167E, V201I, I203M, K215R, L234I, S283GCRF01_AE
 AA129a07LAA129a07LJX448284None   K14R, A21T, V31I, S39N, T112V, T125A, G134N, I135V, K136R, D167E, V201I, I203M, L234I, S283GCRF01_AE
Zeng (2012)CN1255CN1255JQ028355None   K14R, A21T, V31I, S39N, I72V, T112V, T124A, T125A, G134N, I135V, K136R, D167E, V201I, I203M, L234I, S283GCRF01_AE
 CN1304CN1304JQ028363None   K14R, A21T, S39N, I72V, T112V, T124A, T125A, G134N, I135V, K136R, D167E, V201I, I203M, L234I, S283GCRF01_AE
Feng (2013)FJ070033FJ070033JX112813None   K14R, S39N, L45V, I72T, T112V, T124A, T125A, G134N, I135V, K136R, V165I, D167E, S195T, V201I, I203M, L234I, S283G, R284GCRF01_AE
 CYM154CYM154JX112808None   K14R, V31I, I72V, T112V, T124A, T125A, G134N, I135V, K136R, D167E, G193E, V201I, I203M, L234I, S283GCRF01_AE
 CYM105CYM105JX112798None   K14R, A21T, V31I, T112V, T124A, T125A, G134N, I135V, K136R, D167E, V201I, I203M, L234I, S283GCRF01_AE
Kijak (2013)04TH42799004TH427990JN248327None   E11D, V32I, I72V, T112V, T125A, V126M, G134N, I135V, K136R, D167E, S195T, V201I, I203M, L234I, S283GCRF01_AE
Kotaki (2013)SM2SM2KF735917None   E11D, A21T, V31I, M50I, Q95N, L101I, T112V, T124A, T125A, G134N, I135V, K136N, D167E, V201I, I203M, L234ICRF01_AE
Li (2013)28042804JQ901025None   K14R, A21T, V31I, V32I, T112V, T124A, T125A, G134N, I135V, K136R, D167E, V201I, I203M, L234I, S283GCRF01_AE
 28902890JQ901092None   K14R, V31I, V32VI, I72V, L101I, T112V, T124N, T125A, G134N, I135V, K136R, D167E, V201I, I203M, D232E, L234I, S283GCRF01_AE
Li (2013)21812181JQ302660None   K14R, A21T, V31I, I72V, T112V, T124A, T125A, G134N, I135V, K136R, D167E, V201I, I203M, L234I, S283GCRF01_AE
 20322032JQ302564None   K14R, A21T, S39N, I72V, T112V, T124A, T125A, G134N, I135V, K136Q, V165I, D167E, V201I, I203M, L234I, S283GCRF01_AE
 20782078JQ302598None   A21T, V31I, S39N, I72V, T112V, T124A, T125A, G134N, I135V, K136R, D167E, V201I, I203M, L234I, V249A, S283GCRF01_AE
 21832183JQ302662None   K14R, V31I, I72V, T112V, T124A, T125A, G134N, I135V, K136R, V165I, D167E, G193E, V201I, I203M, T210N, L234I, S283G, D288NCRF01_AE
Li (2013)hntk1hntk1KC988059None   K14R, A21T, A23V, V31I, S39N, I72V, T112V, T124A, T125A, G134N, I135V, K136R, D167E, V201I, I203M, L234V, S283GCRF01_AE
Chow (2014)10MYKJ03610MYKJ036KC522035None  L74MK14R, A21T, V31I, L45Q, K103R, T112V, T124A, T125A, G134N, I135V, K136R, V165I, D167E, V201I, I203M, K215N, L234I, S283GCRF01_AE
Nerrienet (2014)U0302042U0302042JN675736None   V31I, L63V, I72V, T112V, T124A, T125A, G134N, I135V, D167E, V201I, I203M, I208L, L234I, S283GCRF01_AE
Hora (2015)DE00110TH001DE00110TH001KP109513None   K14R, A21T, V31I, S39N, I72V, V88I, T112V, T125A, V126M, A133V, G134N, I135V, K136R, D167E, K173R, V201I, I203M, L234I, S283DCRF01_AE
Li (2016)CN-027CN-027KU050223None   D6E, E11D, A21T, A23V, V31I, S39N, I72V, T112V, T124A, T125A, G134N, I135V, K136R, D167E, V201I, I203M, L234I, V260I, S283GCRF01_AE
Van Tran (2016)VI-292VI-292LC101139None   K14R, A21T, V31I, S39N, I72V, T112V, T124A, T125A, G134N, I135V, K136R, E157Q, K160T, D167E, V201I, I203M, I208L, L234I, S283GCRF01_AE
 VI-254VI-254LC101107None  T97AK14R, S39N, I72V, T112V, T124A, T125A, G134N, I135V, K136R, V165I, D167E, K173R, S195T, V201I, I203M, L234I, S283GCRF01_AE
 VI-006VI-006LC100906None   K14R, A21T, V31I, S39N, I72V, T112V, T125A, K127R, G134N, I135V, K136R, D167E, V201I, I203M, L234I, S283GCRF01_AE
 VI-159VI-159LC101025None   K14R, A21T, V31I, S39N, I72V, T112V, T124A, T125A, G134N, I135V, K136R, V165I, D167E, V201I, I203M, L234I, D256E, S283GCRF01_AE
 VI-102VI-102LC100969None   K14R, A21T, V31I, I72V, T112V, S119SG, T124G, T125A, G134N, I135V, K136R, V165I, D167E, V201I, I203M, L234I, K236R, S283GCRF01_AE
 VI-014VI-014LC101187None   D6E, K14R, S17N, S39N, I72V, L101I, T112V, T124G, T125A, G134N, I135V, K136R, D167E, V201I, I203M, K211T, E212A, L234I, K273R, S283GCRF01_AE
 VI-133VI-133LC101000None   K14R, A21T, V31I, S39N, M50I, I72T, T112V, T124A, T125A, G134N, I135V, K136Q, D167E, V201I, I203M, L234I, S255T, S283GCRF01_AE
 VI-173VI-173LC101037None   K14R, A21T, V31I, S39N, L101V, T112V, T124A, T125A, G134N, I135V, K136R, D167E, V201I, I203M, L234I, S283GCRF01_AE
 VI-339VI-339LC101177None  L74MK14R, A21T, V31I, S39N, A91T, L101I, T112V, T124A, T125A, G134N, I135V, K136R, V165I, D167E, S195T, V201I, I203M, Q209QH, L234I, K236KE, S283GCRF01_AE
 VI-136VI-136LC101005None  L74ME11ED, K14R, A21T, V31I, V32VI, L63V, I72V, T112V, T124A, T125A, G134N, I135V, K136Q, D167E, V201I, I203M, L234I, S283GCRF01_AE
Bradley-Stewart (2017)WoSSVC_INT14WoSSVC_INT14MF442453None   E11D, V32VI, I72V, I73IV, T112V, S119T, T124A, T125A, V126M, G134N, I135V, K136R, D167E, G193E, V201I, I203M, I208L, L234I, S283G, D286NCRF01_AE
Chehadeh (2017)89358935KY888217None   K14R, A21T, V32I, I72V, T112V, T124A, T125A, G134N, I135V, K136R, D167E, V201I, I203M, N222K, L234I, Q252L, S283GCRF01_AE
 1161711617KY888221None   K14R, A21T, I72V, T112V, T124A, T125A, G134N, I135V, K136Q, V165I, I200L, V201I, I203M, I208L, T218I, L234I, S283GCRF01_AE
 61346134KY888235None   K14R, A21T, D25N, S39N, K103R, T112V, T124A, T125A, G134N, I135V, K136R, G163E, V201I, I203M, L234I, S283GCRF01_AE
 1353613536KY888241None   K14R, A21T, A23V, S39N, I72V, T112V, T124A, T125A, G134N, I135V, K136R, D167E, R187RK, V201I, I203M, L234I, S283GCRF01_AE
 2042520425KY888256None   K14R, A21T, V31I, V32I, S39N, I72V, T112V, T124N, T125A, G134N, I135V, K136R, V165I, K188R, V201I, I203M, L234I, S283GCRF01_AE
Hachiya (2017)C15-50594694392LC160477LC160477None  L74MV31I, S39N, I72V, Q95QP, T112V, T124N, T125A, V126L, G134N, I135V, K136R, G163E, V201I, I203M, L234I, S283GCRF01_AE
 C13-2091C17LC160485LC160485None   E11D, K14R, A21T, A23V, V31I, L63V, I72T, L74I, A91T, T112V, T124A, T125A, G134N, I135V, K136Q, V201I, I203M, L234I, S283GCRF01_AE
 C13-2083GM3983LC160542LC160542None   E11D, K14R, A21T, V31I, V32I, S39N, L63V, I72V, T112V, T125A, G134N, I135V, K136R, D167E, I203M, L234I, S283GCRF01_AE
 C13-51111441LC160698LC160698None   K14R, V31I, A49P, I72V, T112V, T124A, T125A, G134N, I135V, K136R, D167E, G193E, V201I, I203M, K211R, L234I, S283GCRF01_AE
 C15-51111689LC160946LC160946None   V31I, L101I, T112V, T124A, T125A, G134N, I135V, K136Q, D167E, G193E, V201I, I203M, L234I, D253H, S283G, D286NCRF01_AE
 C15-5555465LC161203LC161203None   E11D, K14R, V31I, I72V, G106GA, K111KT, T112V, I113IV, T124A, T125A, G134N, I135V, K136KE, D167E, S195T, V201I, I203M, T206TS, D207E, T218TI, L234I, S283GCRF01_AE
 C14-305144LC161259LC161259None   K14R, R20RK, A21T, V31VI, S39N, I72IV, T112V, T124A, T125A, G134N, I135V, K136Q, D167DE, V201I, I203M, Q216N, L234I, D270DN, S283GCRF01_AE
 G15-202223LC161303LC161303None   K14R, A21T, V31I, S39N, L45Q, I72V, T112V, T124TA, T125A, G134N, I135V, K136R, D167E, V201I, I203M, L234I, D278DA, S283GCRF01_AE
 F14-20082229LC161515LC161515None   K14R, A21T, V31I, L63LV, I72V, L74X, I84IL, T112V, T124A, T125A, G134N, I135V, K136X, D167DE, H171HY, V201I, I203M, K211R, L234I, S283GCRF01_AE
 H13-2011306LC161549LC161549None   E11D, A21T, V32I, S39SN, T112V, T124A, T125A, G134N, I135V, K136Q, D167E, V201I, I203M, L234I, D286NCRF01_AE
 C13-2069027LC170970LC170970None   E11D, K14R, A21T, V31I, V32I, S39N, L63V, I72V, T112V, T125A, G134N, I135V, K136R, D167E, I203M, L234I, S283GCRF01_AE
 C13-2069072LC171008LC171008None   K14R, R20K, V31VI, S39C, L63I, T97TP, T112V, T124A, T125A, G134N, I135V, K136R, G193E, V201I, I203M, L234I, V281M, S283G, D286NCRF01_AE
 C13-2069079LC171014LC171014None   K14R, M22MI, V31I, L101V, T112V, T124A, T125A, G134N, I135V, K136Q, K160R, M178MK, V201I, I203M, L234I, S283GCRF01_AE
 C14-2069044LC171068LC171068None  L74MK14R, A21T, V31I, S39N, I72V, T112V, T124A, T125A, G134S, I162L, V165I, D167E, V201I, I203M, N222K, L234I, S255N, S283GCRF01_AE