<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Integrase Inhibitors

Subtype CRF01_AE
Gene IN
Mutation M154I
Rx II-naive
IncludeMixtures No
References 22
Patients 65
Isolates 65
 
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# INIs WksINIMajorDRMs INIMinorDRMs OtherMutSubtype
Viputtijul (2002)99TH_MU207999_MU2079AF516184None  G140WK14R, A21T, V31I, I72V, I84V, T112V, T124A, T125A, V126M, G134N, I135V, K136R, I141D, M154I, V165I, D167E, Q177P, V201I, I203L, Q209P, Q214P, K215N, I217~, T218S, L234I, S283GCRF01_AE
Ramos (2003)TH283TH283AF468970None   K14R, A21T, V31I, S39N, T112V, T124A, T125A, G134D, I135V, K136R, M154I, D167E, K211R, Q221*, L234I, N254S, G277D, S283GCRF01_AE
Tovanabutra (2004)02THOUR840I02_840IAY358070None   K14R, A21T, V31I, I72V, T112V, T124A, T125A, G134N, I135V, K136R, M154I, D167E, V201I, L234I, S283GCRF01_AE
Watanaveeradej (2006)01TH_C325601_C3256AY945720None   K14R, A21T, V32I, I72V, T112V, T124A, T125A, G134N, I135V, K136R, M154I, D167E, V201I, L234I, S283GCRF01_AE
Hai-Long (2007)Fj066Fj066EF036535None   E11D, K14R, R20K, A21T, V31I, I72V, V79E, I84V, T112V, S123G, T124A, T125A, G134D, I135V, M154I, E157K, V165I, D167E, V201I, K211R, L234I, S283GCRF01_AE
Liao (2009)VNHCM31497VNHCM314FJ185241None   K14R, D25E, V31I, S39N, T112V, T124A, T125A, G134N, I135V, K136R, M154I, V165I, D167E, V201I, L234I, S255R, S283GCRF01_AE
 VNAG21297VNAG212FJ185252None   K14R, A21T, V31I, S39N, I72V, T112V, T125A, G134N, I135V, K136R, M154I, D167E, V201I, L234I, S283GCRF01_AE
Sichtig (2009)19241924FJ183575None   K14R, S17HN, V31I, S39N, I72V, I84V, L101LIM, T112V, T124A, T125A, G134N, I135V, K136Q, M154I, D167E, V201I, K211R, L234ICRF01_AE
Isarangkura-Na-Ayuthaya (2010)AE-Int-114AE-Int-114HM150834None   K14R, A21AT, V31I, I72V, T112V, T124A, T125A, G134N, I135V, K136R, M154I, D167E, V201I, Q216H, L234I, S283GCRF01_AE
Brenner (2011)79807980HQ207768None   K14R, V31I, S39N, I72V, I84V, T112V, T125A, V126L, G134N, I135V, K136R, M154I, D167E, V201I, L234I, S283GCRF01_AE
Nouhin (2011)1231245KCS1231245GU289847None   K14R, V31I, I72V, T112V, T125A, V126L, G134N, I135V, K136R, M154I, V201I, L234I, S283GCRF01_AE
 114VNR114GU289875None   E11G, W19R, A21R, S39N, I72V, T112V, T124A, T125A, V126L, G134N, I135V, K136R, M154I, V165I, D167E, V201I, L234I, S283GCRF01_AE
Wilantho A (2011)SL079SL079JF928952None   E11D, K14R, A21T, V31I, L63V, I72V, T112V, T124A, T125A, G134N, I135V, K136R, M154I, V165I, D167E, V201I, K215N, L234I, S283GCRF01_AE
 SL071SL071JF928973None   K14R, A21T, S39N, I72V, I84IV, E87ED, E96D, T112V, T124A, T125A, V126M, G134N, I135V, K136R, M154I, V165I, D167E, S195T, V201I, L234I, D253H, S283DG, R284RGCRF01_AE
 SL011SL011JF928969None   K14R, A21T, I72V, I84V, T112V, T124A, T125A, G134N, I135V, K136QR, M154I, V165I, D167E, V201I, L234I, S283GCRF01_AE
Luu (2012)IVVI00034IVVI00034JQ288842None   K7R, E13EG, K14R, A21T, S39N, I72V, T112V, T124A, T125A, G134N, I135V, K136KR, M154I, V165I, D167E, V201I, L234I, S283GCRF01_AE
Rolland (2012)AA003b12LAA003b12LJX446691None   K14R, A21T, V31I, I72V, I84V, T112V, T124A, T125A, G134N, I135V, K136R, M154I, V165I, D167E, V201I, L234I, S283GCRF01_AE
 AA021a06LAA021a06LJX446938None   K14R, A21T, D25E, S39N, L45V, L101I, T112V, T124A, T125A, G134N, I135V, K136R, M154I, D167E, V201I, Q216N, L234I, S283GCRF01_AE
 AA029b02LAA029b02LJX447037None   K14R, A21T, I72V, T112V, T124A, T125A, G134N, I135V, K136R, M154I, D167E, V201I, K211R, T218S, L234ICRF01_AE
 AA041a01LAA041a01LJX447167None   E11D, A21T, V31I, S39H, I72V, T112V, T124A, T125A, G134D, I135V, M154I, E157D, D167E, V201I, L234I, S283GCRF01_AE
 AA054a04AA054a04JX447307None   K14R, A21T, V31I, I72V, I84V, T112V, T124A, T125A, G134N, I135V, K136R, M154I, V165I, D167E, V201I, L234I, Q252K, V259I, S283GCRF01_AE
 AA056a_WG6AA056a_WG6JX447317None   E11D, K14R, A21T, V31I, I72V, L101I, T112V, T125A, G134N, I135V, K136R, M154I, D167E, V201I, K215N, L234I, V281M, S283GCRF01_AE
 AA059a_WG3AA059a_WG3JX447355None   E11D, K14R, A21T, V31I, L45V, M50I, I72V, T112V, T124A, T125A, G134N, K136R, M154I, V165I, D167E, R187K, V201I, L234I, S283GCRF01_AE
 AA072a05AA072a05JX447504None   K14R, V31I, V32I, I72V, L101I, T112V, T124N, G134N, I135V, M154I, V165I, D167E, G189X, I191V, V201I, L234I, S283GCRF01_AE
 AA091a03LAA091a03LJX447738None   K14R, A21T, V31I, I72V, T112V, T124A, T125A, G134N, I135V, K136R, M154I, V165I, D167E, I191L, V201I, L234I, S283GCRF01_AE
 AA103a07LAA103a07LJX447952None   K14R, A21T, S39N, L45V, I72V, T112V, T124A, T125A, G134N, I135V, M154I, D167E, R187K, V201I, L234I, S283GCRF01_AE
Feng (2013)GZ070126GZ070126JX112844None   K14R, A21T, V31I, S39N, I72V, T112V, T124A, T125A, G134N, I135V, K136R, M154I, V165I, D167E, R187K, V201I, L234I, S283GCRF01_AE
Kijak (2013)05TH52258605TH522586JN248351None   E11D, K14R, A21T, V31I, S39N, I72V, T112V, T124A, T125A, G134N, I135V, K136R, M154I, V165I, D167E, V201I, K211R, L234I, S283GCRF01_AE
 04TH70432004TH704320JN248331None   K14R, A21T, V31I, S39N, I72V, T112V, T124A, T125A, G134N, I135V, K136R, M154I, V165I, V201I, L234I, S283GCRF01_AE
 05TH32756805TH327568JN248341None  L68VK14R, A21T, I72T, L101I, T112V, T124A, T125A, G134N, I135V, K136Q, M154I, D167E, V176L, V201I, L234I, S283GCRF01_AE
Kotaki (2013)IDU10IDU10KF735946None   K14R, A21T, V31I, I72V, T112V, T124A, T125A, G134N, I135V, K136R, M154I, D167E, V201I, L234I, S283GCRF01_AE
 IDU4IDU4KF735941None   E11D, K14R, A21T, V31I, I72V, L74I, I84V, Q95T, T112V, T125A, G134N, I135V, K136R, M154I, V165I, D167E, V201I, L234I, S283GCRF01_AE
Li (2013)28572857JQ901066None   K14KR, A21T, A23V, V31I, T112V, T124A, T125A, G134N, I135V, K136R, M154I, D167E, V201I, L234I, S283GCRF01_AE
Li (2013)20032003JQ302546None   E11D, A21T, V31I, T112V, T125A, G134N, I135V, K136R, Q148Q*, M154I, D167E, R187K, V201I, L234I, D256E, S283GCRF01_AE
 22152215JQ302683None   N27G, V31I, S39N, L63V, I72V, T112V, T124A, T125A, G134N, I135V, K136Q, M154I, D167E, F181L, V201I, L234ICRF01_AE
Nerrienet (2014)T1022129T1022129JN675734None  E92EKL2I, K14R, V31I, I84V, T112V, T124A, T125A, V126L, G134N, I135V, K136R, M154I, V165I, V201I, L234ICRF01_AE
 U0223070U0223070JN675735None   K14R, A21T, V31I, I72V, I84V, T112I, T124A, T125A, G134N, I135V, K136R, M154I, V165I, D167E, S195SR, V201I, L234I, S283GCRF01_AE
Hora (2015)DE00111JP003DE00111JP003KF859741None   E11D, K14R, A21T, V31I, E35K, S39Q, E85K, E96D, L101I, T112V, T124A, T125A, G134N, I135V, K136Q, M154I, V165I, D167E, V201I, L234I, S283GCRF01_AE
Van Tran (2016)VI-129VI-129LC100996None   K14R, V31I, I72V, T112V, T124A, T125A, G134N, I135V, K136R, M154I, D167E, R187K, V201I, K211T, L234I, S283GCRF01_AE
 VI-245VI-245LC101099None   K14R, A21T, V31I, Q95H, K103KR, T112V, T124A, T125A, G134N, I135V, K136R, M154I, D167DE, V201I, L234I, S283GCRF01_AE
 VI-391VI-391LC101239None   K14R, A21T, V31I, I84V, L101I, T112V, T124A, T125A, G134N, I135V, K136R, M154I, V165I, D167E, V201I, L234I, S283G, R284GCRF01_AE
 VI-215VI-215LC101074None  L74ME11D, K14R, A21T, V32I, D41N, I72V, I84V, T112V, T125A, G134N, I135V, K136R, M154I, D167E, V201I, K211R, I217V, L234I, S283G, R284G, D286NCRF01_AE
 VI-104VI-104LC100971None   K14R, A21T, A23AV, S39N, L45LV, I72V, T112V, T124A, T125A, G134N, I135V, K136R, M154I, D167E, V201I, L234I, S283GCRF01_AE
 VI-112VI-112LC100979None   D3N, K14R, V31I, I72V, T112V, T124A, T125A, G134N, I135V, K136R, M154I, V165I, D167E, S195T, V201I, L234I, S283GCRF01_AE
 VI-224VI-224LC101080None   E11D, K14R, A21T, V31I, S39N, I72V, I84IV, V88VI, T112V, T125A, V126L, G134N, I135V, K136R, M154I, V165I, R199RK, V201I, L234I, S283GCRF01_AE
 VI-358VI-358LC101211None   K14R, A21T, V31I, S39N, T112V, T124TA, T125A, G134N, I135V, K136R, M154I, D167E, V201I, L234I, S283GCRF01_AE
 VI-287VI-287LC101136None   K14R, A21T, V31VI, S39SN, M50IL, I72V, I84IV, T112V, T124A, T125A, G134N, I135V, K136R, M154I, D167E, V201I, L234I, S283GCRF01_AE
 VI-013VI-013LC101186None   E11D, K14R, A21T, V31I, I72V, I84V, Q95H, V110VI, T112V, T124AG, T125A, K127KR, G134N, I135V, K136R, M154I, V165I, D167E, V201I, L234I, S283CG, R284GCRF01_AE
 VI-119VI-119LC100986None   K14R, A21T, V31I, I72V, T112V, T124A, T125A, G134N, I135V, K136R, M154I, D167E, V201I, L234I, S283SCT, R284RSCRF01_AE
 VI-213VI-213LC101073None  L74MK14R, V31I, S39SN, I72V, I84V, T112V, T124A, T125A, G134N, I135V, K136R, M154I, D167E, R187K, I203IM, K211T, L234I, S283GCRF01_AE
 VI-127VI-127LC100994None   E11D, K14R, A21T, V31I, I72V, I84V, T112V, T124A, T125A, G134N, I135V, K136R, M154I, D167E, V201I, L234I, S283GCRF01_AE
 VI-183VI-183LC101046None   K14R, A21T, E35Q, S39N, I72V, I84V, T112V, T124A, T125A, G134N, I135V, K136R, M154I, D167E, V201I, D207N, K211T, L234I, S283G, R284GCRF01_AE
Hachiya (2017)C13-2093GM3906LC160518LC160518None   E11D, K14R, A21T, V31I, S39Q, E96D, L101I, T112V, T124A, T125A, G134N, I135V, K136R, M154I, V165I, D167E, V201I, L234I, S283GCRF01_AE
 C13-51111423LC160680LC160680None   A21T, V31I, S39N, I72V, L101I, T112V, T124A, T125A, G134N, I135V, K136R, M154I, V165I, D167E, V201I, L234I, S283GCRF01_AE
 C13-51111426LC160683LC160683None   K14R, V31I, S39N, I72V, L101I, T112V, T124A, T125A, G134N, I135V, K136R, M154I, V165I, D167E, V201I, L234I, S283GCRF01_AE
 C13-51111541LC160798LC160798None   K14R, A21T, V31I, S39N, I72V, I84V, T112V, T124A, T125A, G134N, I135V, K136R, M154I, V165I, D167E, V201I, K211R, L234I, S283GCRF01_AE
 C15-51111673LC160930LC160930None   K14R, A21T, S39N, I72V, L101I, T112V, T124A, T125A, G134N, I135V, K136R, M154I, V165I, D167E, V201I, L234I, S283GCRF01_AE
 C15-55553032LC161126LC161126None   K14R, S17SN, A21AT, V31I, S39SN, I72V, I84V, T112V, T124A, T125A, G134N, I135V, K136Q, M154I, V165I, D167E, V201I, K211R, L234I, S283GCRF01_AE
 H13-2060136LC161227LC161227None   E11D, K14R, A21T, V31I, S39Q, E96D, L101I, T112V, T124A, T125A, G134N, I135V, K136Q, M154I, V165I, D167E, V201I, L234I, S283GCRF01_AE
 E13-50911376LC161357LC161357None   E11D, K14R, A21T, V31I, S39Q, E96D, L101I, T112V, T124A, T125A, G134N, I135V, K136X, M154I, V165I, D167E, V201I, L234I, S283GCRF01_AE
 E15-50911720LC161459LC161459None  H114HYK14R, V31I, I72IV, I84V, T112V, T124X, T125A, V126M, G134D, I135V, K136R, M154I, V165VI, D167E, V201I, T206TS, K211KR, T218TS, L234I, S283GCRF01_AE
 C13-2069007LC170951LC170951None   K14KR, A21T, V31I, S39N, I72V, L101I, T112V, T124A, T125A, G134N, I135V, K136R, M154I, V165I, D167E, V201I, L234I, S283GCRF01_AE
 C13-2069008LC170952LC170952None   K14KR, S17SN, A21AT, V31I, S39N, I72V, L101I, T112V, T124A, T125A, G134N, I135V, K136X, M154I, V165I, D167E, V201I, L234I, S283GCRF01_AE
 C14-2069034LC171058LC171058None   K14R, A21T, S39N, L45V, I72V, E96D, T112V, T124A, T125A, G134N, I135V, K136R, M154I, V165I, D167E, V201I, L234I, S283GCRF01_AE
 C14-2069112LC171124LC171124None   E11ED, K14R, A21AT, D25DE, V31I, V32I, L101I, T112V, T124A, T125A, G134N, I135V, K136Q, M154I, V165I, D167E, V201I, L234I, V259I, S283GCRF01_AE