<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Integrase Inhibitors

Subtype CRF01_AE
Gene IN
Mutation M154I
Rx II-naive
IncludeMixtures No
References 14
Patients 31
Isolates 31
 
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# INIs WksINIMajorDRMs INIMinorDRMs OtherMutSubtype
Tovanabutra (2004)02THOUR840I02_840IAY358070None   K14R, A21T, V31I, I72V, T112V, T124A, T125A, G134N, I135V, K136R, M154I, D167E, V201I, L234I, S283GCRF01_AE
Watanaveeradej (2006)01TH_C325601_C3256AY945720None   K14R, A21T, V32I, I72V, T112V, T124A, T125A, G134N, I135V, K136R, M154I, D167E, V201I, L234I, S283GCRF01_AE
Liao (2009)VNHCM31497VNHCM314FJ185241None   K14R, D25E, V31I, S39N, T112V, T124A, T125A, G134N, I135V, K136R, M154I, V165I, D167E, V201I, L234I, S255R, S283GCRF01_AE
 VNAG21297VNAG212FJ185252None   K14R, A21T, V31I, S39N, I72V, T112V, T125A, G134N, I135V, K136R, M154I, D167E, V201I, L234I, S283GCRF01_AE
Sichtig (2009)19241924FJ183575None   K14R, S17HN, V31I, S39N, I72V, I84V, L101LIM, T112V, T124A, T125A, G134N, I135V, K136Q, M154I, D167E, V201I, K211R, L234ICRF01_AE
Isarangkura-Na-Ayuthaya (2010)AE-Int-114AE-Int-114HM150834None   K14R, A21AT, V31I, I72V, T112V, T124A, T125A, G134N, I135V, K136R, M154I, D167E, V201I, Q216H, L234I, S283GCRF01_AE
Brenner (2011)70347034HQ207747None  Q148LPK14R, A23AG, V31I, G59GR, A80S, Q95P, T112V, T124N, T125A, K136Q, N144ND, M154I, E157Q, K160Q, A169AG, G193GR, S195SR, V201I, L234I, S283GCRF01_AE
 79807980HQ207768None   K14R, V31I, S39N, I72V, I84V, T112V, T125A, V126L, G134N, I135V, K136R, M154I, D167E, V201I, L234I, S283GCRF01_AE
Nouhin (2011)1231245KCS1231245GU289847None   K14R, V31I, I72V, T112V, T125A, V126L, G134N, I135V, K136R, M154I, V201I, L234I, S283GCRF01_AE
Wilantho A (2011)SL079SL079JF928952None   E11D, K14R, A21T, V31I, L63V, I72V, T112V, T124A, T125A, G134N, I135V, K136R, M154I, V165I, D167E, V201I, K215N, L234I, S283GCRF01_AE
 SL071SL071JF928973None   K14R, A21T, S39N, I72V, I84IV, E87X, E96D, T112V, T124A, T125A, V126M, G134N, I135V, K136R, M154I, V165I, D167E, S195T, V201I, L234I, D253H, S283DG, R284RGCRF01_AE
 SL011SL011JF928969None   K14R, A21T, I72V, I84V, T112V, T124A, T125A, G134N, I135V, K136QR, M154I, V165I, D167E, V201I, L234I, S283GCRF01_AE
Luu (2012)IVVI00034IVVI00034JQ288842None   K7R, E13EG, K14R, A21T, S39N, I72V, T112V, T124A, T125A, G134N, I135V, K136KR, M154I, V165I, D167E, V201I, L234I, S283GCRF01_AE
Rolland (2012)AA003b12LAA003b12LJX446691None   K14R, A21T, V31I, I72V, I84V, T112V, T124A, T125A, G134N, I135V, K136R, M154I, V165I, D167E, V201I, L234I, S283GCRF01_AE
 AA021a06LAA021a06LJX446938None   K14R, A21T, D25E, S39N, L45V, L101I, T112V, T124A, T125A, G134N, I135V, K136R, M154I, D167E, V201I, Q216N, L234I, S283GCRF01_AE
 AA029b02LAA029b02LJX447037None   K14R, A21T, I72V, T112V, T124A, T125A, G134N, I135V, K136R, M154I, D167E, V201I, K211R, T218S, L234ICRF01_AE
 AA041a01LAA041a01LJX447167None   E11D, A21T, V31I, S39H, I72V, T112V, T124A, T125A, G134D, I135V, M154I, E157D, D167E, V201I, L234I, S283GCRF01_AE
 AA054a04AA054a04JX447307None   K14R, A21T, V31I, I72V, I84V, T112V, T124A, T125A, G134N, I135V, K136R, M154I, V165I, D167E, V201I, L234I, Q252K, V259I, S283GCRF01_AE
 AA056a_WG6AA056a_WG6JX447317None   E11D, K14R, A21T, V31I, I72V, L101I, T112V, T125A, G134N, I135V, K136R, M154I, D167E, V201I, K215N, L234I, V281M, S283GCRF01_AE
 AA059a_WG3AA059a_WG3JX447355None   E11D, K14R, A21T, V31I, L45V, M50I, I72V, T112V, T124A, T125A, G134N, K136R, M154I, V165I, D167E, R187K, V201I, L234I, S283GCRF01_AE
 AA072a05AA072a05JX447504None   K14R, V31I, V32I, I72V, L101I, T112V, T124N, G134N, I135V, M154I, V165I, D167E, G189X, I191V, V201I, L234I, S283GCRF01_AE
 AA091a03LAA091a03LJX447738None   K14R, A21T, V31I, I72V, T112V, T124A, T125A, G134N, I135V, K136R, M154I, V165I, D167E, I191L, V201I, L234I, S283GCRF01_AE
 AA103a07LAA103a07LJX447952None   K14R, A21T, S39N, L45V, I72V, T112V, T124A, T125A, G134N, I135V, M154I, D167E, R187K, V201I, L234I, S283GCRF01_AE
Kijak (2013)05TH52258605TH522586JN248351None   E11D, K14R, A21T, V31I, S39N, I72V, T112V, T124A, T125A, G134N, I135V, K136R, M154I, V165I, D167E, V201I, K211R, L234I, S283GCRF01_AE
 04TH70432004TH704320JN248331None   K14R, A21T, V31I, S39N, I72V, T112V, T124A, T125A, G134N, I135V, K136R, M154I, V165I, V201I, L234I, S283GCRF01_AE
 05TH32756805TH327568JN248341None  L68VK14R, A21T, I72T, L101I, T112V, T124A, T125A, G134N, I135V, K136Q, M154I, D167E, V176L, V201I, L234I, S283GCRF01_AE
Kotaki (2013)IDU10IDU10KF735946None   K14R, A21T, V31I, I72V, T112V, T124A, T125A, G134N, I135V, K136R, M154I, D167E, V201I, L234I, S283GCRF01_AE
 IDU4IDU4KF735941None   E11D, K14R, A21T, V31I, I72V, L74I, I84V, Q95T, T112V, T125A, G134N, I135V, K136R, M154I, V165I, D167E, V201I, L234I, S283GCRF01_AE
Li (2013)28572857JQ901066None   K14KR, A21T, A23V, V31I, T112V, T124A, T125A, G134N, I135V, K136R, M154I, D167E, V201I, L234I, S283GCRF01_AE
Li (2013)20032003JQ302546None   E11D, A21T, V31I, T112V, T125A, G134N, I135V, K136R, Q148Q*, M154I, D167E, R187K, V201I, L234I, D256E, S283GCRF01_AE
 22152215JQ302683None   N27G, V31I, S39N, L63V, I72V, T112V, T124A, T125A, G134N, I135V, K136Q, M154I, D167E, F181L, V201I, L234ICRF01_AE