<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Integrase Inhibitors

Subtype C
Gene IN
Mutation L74M
Rx II-naive
IncludeMixtures No
References 13
Patients 20
Isolates 20
 
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# INIs WksINIMajorDRMs INIMinorDRMs OtherMutSubtype
Rousseau (2006)Pt16104PS205B1DQ093599None  L74MS17N, V31I, K46R, M50I, I72V, L101I, T112V, T124A, K136Q, K211R, T218I, L234I, A265V, D278A, S283GC
Matthews (2008)PS205PS205FJ199761None  L74MS17N, V31I, K46R, M50I, I72V, L101I, T112V, T124A, K136Q, K211R, T218I, L234I, A265V, D278A, S283GC
Eshleman (2009)23939602393960FJ480251None  L74MS17N, V31I, M50I, I72V, L101I, T112V, T124A, T125A, I135L, K136Q, V201I, T218I, L234I, A265V, R269K, D278A, S283GC
Monleau (2012)102-1113102-1113JQ250554None  L74ME10Q, E11D, E13D, V31I, M50I, I72V, L101I, T112V, I113V, T124N, F181L, K188R, G193E, V201I, T218I, L234I, A265V, R269K, D278AC
Bessong (2013)08MB73ZA08MB73ZAHM569338None  L74MS24N, D25E, K34R, I72V, F100Y, L101I, T112V, S119T, T125A, K136Q, K188R, V201I, T218I, L234I, D256E, D278A, S283GC
Li (2015)12451245KP235003None  L74MK42Q, T112V, T125A, K136Q, V201I, L234I, R269K, D278A, S283GC
Mulu (2015)ETH-G-5681ETH-G-5681KF959763None  L74MD25E, V31I, L101I, T112V, T124A, T125A, G134GD, K136Q, G163V, T218I, L234IC
Novitsky (2015)mpp_160mpp_160KR860943None  L74MD25E, M50I, L101I, T112V, T125P, K136Q, D167E, V201I, T218I, L234V, A265VC
 mpp_155mpp_155KR860938None  L74MK14R, D25E, L28I, L45Q, I72V, I84M, P90T, F100Y, L101I, T112V, T124A, T125A, K136Q, V201I, T218I, L234I, A265V, R269KC
Billings (2016)CO6838V1CO6838V1KX907424None  L74MD25E, V31I, L45Q, M50I, I72V, I84M, A91E, F100Y, L101I, T112V, S119R, T125A, K136Q, V201I, T218I, L234I, D278A, S283GC
Chen (2016)PK009PK009KX232602None  L74MM50T, L101I, T112V, T124N, T125A, V126T, G134D, K136Q, G163S, V201I, L234I, R269K, D278A, S283G, R284G, D286NC
Sachithanandham (2016)12C/47812C/478KF870743None  L74MK14R, V31I, K42Q, L101I, T112V, I113V, T124A, T125A, G163E, V165I, T218I, L234I, D278AC
 07/55207/552KF870753None  L74MK14R, V31I, K42Q, F100Y, L101I, T112V, T124A, T125A, K127R, K136Q, K188R, V201I, L234I, R269K, D278AC
 08/2408/24KF870768None  L74MV31I, L45Q, F100Y, L101I, T112V, T124A, T125A, K136Q, F181L, K188R, E198D, V201I, T218L, Q221S, L234I, D278AC
 DR11/10DR11/10KF870805None  L74MV31I, K42Q, I84M, L101I, T112V, T124A, T125A, G134D, K136Q, V201I, I203M, L234I, D278AC
 09/101009/1010KF870816None  L74MK14R, V32I, L101I, K103R, T112V, T124A, T125A, K136Q, I200L, V201I, I203M, T218I, L234I, D278AC
 DR10/04DR10/04KF870826None  L74MV31I, K42Q, I84M, F100Y, L101I, T112V, T122I, T124A, T125A, V201I, I203M, I208L, L234I, R269K, D278AC
Chehadeh (2017)33593359KY888227None  L74MS24R, V32I, K42Q, A49AS, V77A, A80AT, P90S, L101I, T112V, T124S, T125A, K127R, K136N, V201I, I203M, T218M, I220V, L234I, D278A, S283GC
 48284828KY888264None  L74ME10D, V31I, I72V, P90S, L101I, T112V, T124G, T125A, K127R, K136N, V165I, V201I, I203M, I208L, Q221H, L234I, S255G, R269K, D278A, S283GC
Inzaule (2018)SAMMHPM105SAMMHPM105MG693955None  L74MD25E, V31I, M50I, I72V, K111R, T112V, T124N, T125A, K136Q, V201I, L234I, R269K, D278A, S283GC