<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Integrase Inhibitors

Subtype C
Gene IN
Mutation L74M
Rx II-naive
IncludeMixtures No
References 5
Patients 5
Isolates 5
 
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# INIs WksINIMajorDRMs INIMinorDRMs OtherMutSubtype
Rousseau (2006)Pt16104PS205B1DQ093599None  L74MS17N, V31I, K46R, M50I, I72V, L101I, T112V, T124A, K136Q, K211R, T218I, L234I, A265V, D278A, S283GC
Matthews (2008)PS205PS205FJ199761None  L74MS17N, V31I, K46R, M50I, I72V, L101I, T112V, T124A, K136Q, K211R, T218I, L234I, A265V, D278A, S283GC
Eshleman (2009)23939602393960FJ480251None  L74MS17N, V31I, M50I, I72V, L101I, T112V, T124A, T125A, I135L, K136Q, V201I, T218I, L234I, A265V, R269K, D278A, S283GC
Monleau (2012)102-1113102-1113JQ250554None  L74ME10Q, E11D, E13D, V31I, M50I, I72V, L101I, T112V, I113V, T124N, F181L, K188R, G193E, V201I, T218I, L234I, A265V, R269K, D278AC
Bessong (2013)08MB73ZA08MB73ZAHM569338None  L74MS24N, D25E, K34R, I72V, F100Y, L101I, T112V, S119T, T125A, K136Q, K188R, V201I, T218I, L234I, D256E, D278A, S283GC