<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Integrase Inhibitors

Subtype C
Gene IN
Mutation L74I
Rx II-naive
IncludeMixtures No
References 11
Patients 58
Isolates 58
 
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# INIs WksINIMajorDRMs INIMinorDRMs OtherMutSubtype
Novitsky (2002)00BW203600BW2036AF443102None   D25E, V31I, M50I, L74I, V77A, L101I, T112V, T124A, T125A, K136Q, V201I, L234I, A265V, R269K, D278A, S283GC
Rousseau (2006)Pt3403PS059MB2DQ445634None   D25E, V31I, M50T, G70E, L74I, I84M, F100Y, L101I, T112V, T125A, K136Q, V201I, L234I, R269K, D278A, S283GC
 Pt6103PS116MB1DQ445635None   E10D, D25E, V31I, M50I, I72V, L74I, I84M, F100Y, L101I, T112V, T124A, T125A, K136Q, V201I, T218I, L234I, D253E, S255N, D270G, D278A, S283GC
 Pt9403SK039B2AY878068None   S17N, D25E, V31I, M50I, I72V, L74I, L101I, G106A, T112V, I113V, S119T, T124A, T125A, K136Q, I141V, V201I, T218I, L234I, A265V, D270E, D278A, S283GC
 Pt11003SK078B1AY901971None   V31I, M50T, I72V, L74I, I84M, E96D, L101I, T112V, T124A, T125A, K136Q, V201I, K215N, T218I, Q221R, L234I, R269K, D278A, S283GC
 Pt12203SK110B1DQ056411None   S17N, D25E, V31I, L74I, I84M, F100Y, L101I, T112V, T124A, T125A, K136Q, G163E, V201I, T206S, I208M, T218I, L234I, R269K, D278A, S283GC
 Pt14604PS177MB1DQ396394None   S24N, D25E, V31I, I72V, L74I, T112V, T125A, K136Q, V201I, Q216R, T218I, K219Q, L234I, A265V, R269K, D278A, S283GC
 Pt17404SK128B1DQ093586None   D25E, V31I, L45Q, I72V, L74I, F100Y, L101I, T112V, T124A, T125A, K136Q, G163Q, V201I, T218I, L234I, D278A, S283GC
 Pt20404SK174B1AY901980None   D25E, V31I, I72V, L74I, F100Y, L101I, T112V, S119T, T125A, K136Q, V201I, T218I, L234I, A265V, D278A, S283GC
 Pt21604SK193B1DQ396396None   D25E, K34R, M50I, L74I, A91E, F100Y, L101I, T112V, S119R, T125A, K136Q, V201I, T218I, L234I, A265V, D278A, S283GC
 Pt22304SK217B1DQ056417None   A8V, E11D, S24N, D25E, V31I, L74I, T112V, I113V, T124A, T125A, V201I, L234I, V260I, V281MC
 Pt22805SK245B1DQ369982None   S17N, D25E, V31I, M50I, I72V, L74I, I84M, F100Y, L101I, T112V, T124A, T125A, K136Q, V201I, L234I, D278A, V281M, S283DC
 Pt2381170MBAY463225None   D25E, L45I, M50I, I72V, L74I, F100Y, L101I, T112I, I113M, S119T, T124A, T125A, K136Q, V201I, T218I, L234I, A265V, S283G, D288NC
 Pt2461197MBAY463234None Y143H D25E, V31I, Q53R, L74I, F100Y, L101I, T112V, T124A, T125A, K136Q, V201I, T218I, L234I, A265V, R269K, D278AC
Sanabani (2006)04BR03804BR038AY727524None   D25E, V31I, M50I, G70N, L74I, L101I, T112V, T124N, K136Q, H171Q, V201I, L234I, I251L, A265V, R269K, D278AC
Matthews (2008)11191119FJ199535None   D25E, K34R, L63V, I72V, L74I, H78R, V79A, F100Y, L101I, K103R, T112V, S119T, T124A, T125A, K136Q, V201I, L234I, D270E, D278A, S283GC
 11701170FJ199542None   D25E, L45I, M50I, I72V, L74I, F100Y, L101I, T112I, I113M, S119T, T124A, T125A, K136Q, V201I, T218I, L234I, A265V, S283G, D288NC
 11971197FJ199551None Y143H D25E, V31I, Q53R, L74I, F100Y, L101I, T112V, T124A, T125A, K136Q, V201I, T218I, L234I, A265V, R269K, D278AC
 J143MJ143MFJ199577None   E10D, V31I, M50I, L63V, L74I, I84M, A91G, E96D, T112V, T124A, T125A, K136Q, V201IC
 PS001PS001FJ199584None   E10A, K14R, D25E, V31I, K34R, L45I, M50T, I72V, L74I, E96D, F100Y, L101I, T112V, S119T, T124A, T125A, K136Q, V201I, T218M, L234I, A265V, R269K, D278A, S283GC
 PS059PS059FJ199640None   D25E, V31I, M50T, G70E, L74I, I84M, F100Y, L101I, T112V, T125A, K136Q, V201I, L234I, R269K, D278A, S283GC
 PS097PS097FJ199672None   D25E, V31I, M50I, L63I, I72V, L74I, I89L, F100Y, L101I, T112V, T124A, T125A, K136Q, V201I, T218I, L234I, A265V, R269K, D278A, S283GC
 PS116PS116FJ199688None   E10D, D25E, V31I, M50I, I72V, L74I, I84M, F100Y, L101I, T112V, T124A, T125A, K136Q, V201I, T218I, L234I, D253E, S255N, D270G, D278A, S283GC
 PS140PS140FJ199706None   E10X, D25E, K34R, M50I, L74I, F100Y, L101I, T112V, T124A, T125A, K136Q, E157D, D167E, V201I, I208M, K215R, L234I, S255G, D278A, S283GC
 SK039SK039FJ199865None   S17N, D25E, V31I, M50I, I72V, L74I, L101I, G106A, T112V, I113V, S119T, T124A, T125A, K136Q, I141V, V201I, T218I, L234I, A265V, D270E, D278A, S283GC
 SK078SK078FJ199882None   V31I, M50T, I72V, L74I, I84M, E96D, L101I, T112V, T124A, T125A, K136Q, V201I, K215N, T218I, Q221R, L234I, R269K, D278A, S283GC
 SK085SK085FJ199886None   K7R, D25E, V31I, M50T, I72V, L74I, F100Y, L101I, T112V, S119P, T124A, T125Q, K136Q, F181S, V201I, T218I, K219Q, L234I, D278A, D286NC
 SK103SK103FJ199893None   V31I, M50I, L74I, I84M, Y99F, L101I, T112V, T124A, T125A, K136Q, R166G, V201I, A205T, K215N, T218I, R228G, L234I, A265V, R269K, D278A, S283G, D288NC
 SK107SK107FJ199895None   D6E, K14R, D25E, K34R, I72V, L74I, L101I, T112V, I113L, T124A, T125A, H171Q, V201I, T206S, T218I, L234I, D278A, S283G, R284GC
 SK110SK110FJ199897None   S17N, D25E, V31I, L74I, I84M, F100Y, L101I, T112V, T124A, T125A, K136Q, G163E, V201I, T206S, I208M, T218I, L234I, R269K, D278A, S283GC
 SK128SK128FJ199906None   D25E, V31I, L45Q, I72V, L74I, F100Y, L101I, T112V, T124A, T125A, K136Q, G163Q, V201I, T218I, L234I, D278A, S283GC
 SK174SK174FJ199945None   D25E, V31I, I72V, L74I, F100Y, L101I, T112V, S119T, T125A, K136Q, V201I, T218I, L234I, A265V, D278A, S283GC
 SK193SK193FJ199958None   D25E, K34R, M50I, L74I, A91E, F100Y, L101I, T112V, S119R, T125A, K136Q, V201I, T218I, L234I, A265V, D278A, S283GC
 SK217SK217FJ199972None   A8V, E11D, S24N, D25E, V31I, L74I, T112V, I113V, T124A, T125A, V201I, L234I, V260I, V281MC
 SK245SK245FJ199990None   S17N, D25E, V31I, M50I, I72V, L74I, I84M, F100Y, L101I, T112V, T124A, T125A, C130X, K136Q, V201I, L234I, D278A, V281M, S283DC
Passaes (2009)BR.RS.HC25BR.RS.HC25HM026793None   D25E, V31I, M50T, L74I, T112V, T124N, K136Q, K173R, V201I, K211R, T218I, L234I, I251L, A265V, R269K, D278A, V281M, S283N, D286NC
 BR.RS.RGS89BR.RS.RGS89HM026816None   V31I, M50T, L74I, A91T, L101I, K111T, T112V, S119G, T124N, K136Q, V201I, T218I, L234I, I251L, A265V, R269K, D278A, V281MC
Fish (2010)P1309ZAP13GQ872469None   E11D, K14R, D25E, V31I, L63I, L74I, E96D, L101I, G106A, T112V, T124A, T125A, G134D, K136Q, D167E, V201I, T218I, L234I, R269K, D278A, S283GC
 P1409ZAP14GQ872470None   S17N, D25E, V31I, M50I, I72V, L74I, F100Y, L101I, T112V, T124A, T125A, K136Q, V201I, T218I, L234I, D278A, S283GC
 P4609ZAP46GQ872502None   S17N, V31I, M50I, L74I, L101I, K111R, T112V, T125A, K136Q, V201I, K219N, N222K, L234I, S283GC
 FV2505ZAFV25GQ872532None  T97AE11D, V31I, M50I, L74I, L101V, T112V, T124A, T125A, V126F, G134D, K136Q, D167E, V201I, L234I, D278A, S283GC
Graf (2011)SC116SC116JF773883None   E11D, D25E, V31I, M50T, L74I, L101I, K111Q, T112V, T124N, K136Q, T218I, L234I, I251L, A265V, R269K, D278AC
Manak (2012)18_LH0118_LH01JN687646None   D6E, E10D, E11D, K14R, S24N, D25E, V31I, M50I, L74I, L101I, K111R, T112V, T124A, K136Q, G163E, K173R, V201I, L234I, V260I, D278A, S283GC
 34_LH0134_LH01JN687653None   D25E, V31I, M50I, L74I, F100Y, L101I, T112V, S119A, T124A, T125A, K136Q, D167E, V201I, L234I, D253E, R269K, D278A, S283GC
Monleau (2012)DRCL-BS0DRCL-BS0JQ250569None   D25E, V31I, M50I, L74I, L101I, T112IV, T124A, T125A, K136Q, D167E, K188KR, V201I, Q216R, T218I, K219Q, L234I, A265AV, R269K, D278A, S283GC
Oliveira (2012)GA11GA11JQ670798None   S17N, D25E, V31I, M50I, L63I, I72IV, L74I, F100Y, L101I, T112V, T124TA, T125Q, K136Q, V201I, T218L, L234I, A265V, R269K, D278A, S283DGC
 GA50GA50JQ670819None   D25E, V31I, I72V, L74I, F100Y, L101I, T112V, T124A, T125A, K136Q, V201I, K215N, T218I, L234I, A265V, R269K, D278A, S283G, D288NC
 GA59GA59JQ670826None   E11D, S17N, D25E, M50I, L74I, I84M, E96D, L101I, T112V, T124A, T125A, K136Q, V201I, T218TI, N222NT, R224RQ, L234I, D270DN, S283G, D286NC
 GA60GA60JQ670827None   D6E, E10ED, E11EA, E13ED, D25E, V31I, L74I, I84M, Q95QH, T112V, T124A, T125A, K136Q, V201I, Q216H, K219KQ, L234I, D278A, S283GC
 GB65GB65JQ670833None   V31I, M50T, L63I, I72V, L74I, L101I, T112V, T124A, T125A, K136Q, D167E, V201I, T218I, L234I, S283G, R284G, D288NC
 GD58GD58JQ670843None   V31I, M50I, L74I, F100Y, L101I, T112V, T125A, K136Q, G163E, K188R, V201I, K215N, T218I, L234I, A265V, R269K, D278A, S283G, D288NC
Bessong (2013)08BBVCT14ZA08BBVCT14ZAHM569277None   D25E, K34R, I72V, L74I, F100Y, L101I, T112V, S119T, T124A, T125A, K136Q, V201I, T218I, L234I, D278A, S283GC
 08BBVCT1608BBVCT16HM569278None   D6E, E10D, D25E, V31I, L63I, L74I, A91T, T93TS, F100Y, L101I, G106A, T112V, T124A, T125A, K136Q, V201I, L234I, R269K, D278A, S283GC
 08BBVCT3808BBVCT38HM569284None   D25E, V31I, M50I, I72V, L74I, F100Y, L101I, T112V, T124A, T125A, K136Q, D167E, V201I, I203M, K211R, T218I, L234I, N254H, A265V, R269K, D278A, V281M, S283GC
 08BBVCT53ZA08BBVCT53ZAHM569291None   L45Q, L63I, L74I, I84M, E96D, L101I, T112V, T124N, K136Q, V201I, T218I, L234I, D256E, D270E, D278A, S283GC
 08MB47ZA08MB47ZAHM569323None   E10D, V31I, L74I, L101I, G106A, T112V, T124A, T125A, K136Q, V201I, T218I, L234I, A265V, R269K, D278A, S283G, R284GC
 08BBVCT50ZA08BBVCT50ZAHM569348None   S17N, V31I, M50I, L74I, I84M, F100Y, L101I, T112V, S119T, T124A, T125A, G163EC
 08MB42ZA08MB42ZAHM569358None   L74I, L101I, T112V, T125P, K136Q, V201I, K211R, T218I, K219Q, L234I, S283G, D288NC