<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Integrase Inhibitors

Subtype C
Gene IN
Mutation L74I
Rx II-naive
IncludeMixtures No
References 17
Patients 61
Isolates 61
 
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# INIs WksINIMajorDRMs INIMinorDRMs OtherMutSubtype
Rousseau (2006)Pt3403PS059MB2DQ445634None   D25E, V31I, M50T, G70E, L74I, I84M, F100Y, L101I, T112V, T125A, K136Q, V201I, L234I, R269K, D278A, S283GC
 Pt11003SK078B1AY901971None   V31I, M50T, I72V, L74I, I84M, E96D, L101I, T112V, T124A, T125A, K136Q, V201I, K215N, T218I, Q221R, L234I, R269K, D278A, S283GC
 Pt12203SK110B1DQ056411None   S17N, D25E, V31I, L74I, I84M, F100Y, L101I, T112V, T124A, T125A, K136Q, G163E, V201I, T206S, I208M, T218I, L234I, R269K, D278A, S283GC
 Pt14604PS177MB1DQ396394None   S24N, D25E, V31I, I72V, L74I, T112V, T125A, K136Q, V201I, Q216R, T218I, K219Q, L234I, A265V, R269K, D278A, S283GC
 Pt22304SK217B1DQ056417None   A8V, E11D, S24N, D25E, V31I, L74I, T112V, I113V, T124A, T125A, V201I, L234I, V260I, V281MC
 Pt2461197MBAY463234None Y143H D25E, V31I, Q53R, L74I, F100Y, L101I, T112V, T124A, T125A, K136Q, V201I, T218I, L234I, A265V, R269K, D278AC
Sanabani (2006)04BR03804BR038AY727524None   D25E, V31I, M50I, G70N, L74I, L101I, T112V, T124N, K136Q, H171Q, V201I, L234I, I251L, A265V, R269K, D278AC
Matthews (2008)11191119FJ199535None   D25E, K34R, L63V, I72V, L74I, H78R, V79A, F100Y, L101I, K103R, T112V, S119T, T124A, T125A, K136Q, V201I, L234I, D270E, D278A, S283GC
 11971197FJ199551None Y143H D25E, V31I, Q53R, L74I, F100Y, L101I, T112V, T124A, T125A, K136Q, V201I, T218I, L234I, A265V, R269K, D278AC
 J143MJ143MFJ199577None   E10D, V31I, M50I, L63V, L74I, I84M, A91G, E96D, T112V, T124A, T125A, K136Q, V201IC
 PS059PS059FJ199640None   D25E, V31I, M50T, G70E, L74I, I84M, F100Y, L101I, T112V, T125A, K136Q, V201I, L234I, R269K, D278A, S283GC
 PS097PS097FJ199672None   D25E, V31I, M50I, L63I, I72V, L74I, I89L, F100Y, L101I, T112V, T124A, T125A, K136Q, V201I, T218I, L234I, A265V, R269K, D278A, S283GC
 PS140PS140FJ199706None   E10X, D25E, K34R, M50I, L74I, F100Y, L101I, T112V, T124A, T125A, K136Q, E157D, D167E, V201I, I208M, K215R, L234I, S255G, D278A, S283GC
 SK078SK078FJ199882None   V31I, M50T, I72V, L74I, I84M, E96D, L101I, T112V, T124A, T125A, K136Q, V201I, K215N, T218I, Q221R, L234I, R269K, D278A, S283GC
 SK103SK103FJ199893None   V31I, M50I, L74I, I84M, Y99F, L101I, T112V, T124A, T125A, K136Q, R166G, V201I, A205T, K215N, T218I, R228G, L234I, A265V, R269K, D278A, S283G, D288NC
 SK110SK110FJ199897None   S17N, D25E, V31I, L74I, I84M, F100Y, L101I, T112V, T124A, T125A, K136Q, G163E, V201I, T206S, I208M, T218I, L234I, R269K, D278A, S283GC
 SK217SK217FJ199972None   A8V, E11D, S24N, D25E, V31I, L74I, T112V, I113V, T124A, T125A, V201I, L234I, V260I, V281MC
Passaes (2009)BR.RS.HC25BR.RS.HC25HM026793None   D25E, V31I, M50T, L74I, T112V, T124N, K136Q, K173R, V201I, K211R, T218I, L234I, I251L, A265V, R269K, D278A, V281M, S283N, D286NC
 BR.RS.RGS89BR.RS.RGS89HM026816None   V31I, M50T, L74I, A91T, L101I, K111T, T112V, S119G, T124N, K136Q, V201I, T218I, L234I, I251L, A265V, R269K, D278A, V281MC
Tzitzivacos (2009)99ZALT499ZALT4EU293444None   D25E, V31I, M50I, I72V, L74I, I84M, F100Y, L101I, T112V, S119P, T124A, T125A, K136Q, V201I, L234V, D253E, R269K, D278A, S283GC
Fish (2010)P4609ZAP46GQ872502None   S17N, V31I, M50I, L74I, L101I, K111R, T112V, T125A, K136Q, V201I, K219N, N222K, L234I, S283GC
 FV2505ZAFV25GQ872532None  T97AE11D, V31I, M50I, L74I, L101V, T112V, T124A, T125A, V126F, G134D, K136Q, D167E, V201I, L234I, D278A, S283GC
Graf (2011)SC116SC116JF773883None   E11D, D25E, V31I, M50T, L74I, L101I, K111Q, T112V, T124N, K136Q, T218I, L234I, I251L, A265V, R269K, D278AC
Kousiappa (2011)CY203CY203JF683755None  Q95KD6H, E11Q, K14R, R20K, S24I, D25E, V32I, L63I, L74I, A91E, F100Y, L101I, T112V, S119P, T125A, K136Q, V201I, T218S, I220V, N222K, L234V, S283G, R284GC
Oliveira (2012)GA11GA11JQ670798None   S17N, D25E, V31I, M50I, L63I, I72IV, L74I, F100Y, L101I, T112V, T124TA, T125Q, K136Q, V201I, T218L, L234I, A265V, R269K, D278A, S283DGC
 GA59GA59JQ670826None   E11D, S17N, D25E, M50I, L74I, I84M, E96D, L101I, T112V, T124A, T125A, K136Q, V201I, T218TI, N222NT, R224RQ, L234I, D270DN, S283G, D286NC
 GA60GA60JQ670827None   D6E, E10ED, E11EA, E13ED, D25E, V31I, L74I, I84M, Q95QH, T112V, T124A, T125A, K136Q, V201I, Q216H, K219KQ, L234I, D278A, S283GC
Bessong (2013)08BBVCT1608BBVCT16HM569278None   D6E, E10D, D25E, V31I, L63I, L74I, A91T, T93TS, F100Y, L101I, G106A, T112V, T124A, T125A, K136Q, V201I, L234I, R269K, D278A, S283GC
 08BBVCT53ZA08BBVCT53ZAHM569291None   L45Q, L63I, L74I, I84M, E96D, L101I, T112V, T124N, K136Q, V201I, T218I, L234I, D256E, D270E, D278A, S283GC
 08MB47ZA08MB47ZAHM569323None   E10D, V31I, L74I, L101I, G106A, T112V, T124A, T125A, K136Q, V201I, T218I, L234I, A265V, R269K, D278A, S283G, R284GC
 08BBVCT50ZA08BBVCT50ZAHM569348None   S17N, V31I, M50I, L74I, I84M, F100Y, L101I, T112V, S119T, T124A, T125A, G163EC
 08MB42ZA08MB42ZAHM569358None   L74I, L101I, T112V, T125P, K136Q, V201I, K211R, T218I, K219Q, L234I, S283G, D288NC
Hora (2015)DEMC11ZM008DEMC11ZM008KP109496None   S17N, D25E, V31I, L74I, T93S, F100Y, L101I, T112V, T124A, T125A, K136Q, V201I, T218I, L234I, A265V, R269K, D278A, S283GC
 DEMC09ZM004DEMC09ZM004KF716466None   K14R, S24N, D25E, M50V, I72V, L74I, F100Y, L101I, T112V, S119T, T124A, T125A, K136Q, V201I, T218I, L234I, D278A, S283GC
 DEMC99IN004DEMC99IN004KP109489None   V31I, K42Q, I72A, L74I, I84L, L101I, T112I, I113V, T124A, T125A, K136Q, I203M, T218I, L234I, D278A, S283G, R284G, D286NC
Li (2015)12531253KP235010None   K14R, V31I, K42Q, L74I, I84M, L101I, T112V, T124A, T125A, I135V, K136R, D167E, V201I, L234I, R269K, D278A, S283GC
 12101210KP234978None  E138DV31I, K42Q, L74I, I84M, L101I, T112V, T125A, K136Q, V201I, L234S, I251V, D278A, S283DC
 13721372KP235072None   K14R, V31I, K42Q, L74I, I84M, Q95H, E96D, L101I, T112V, T124A, T125A, I135V, K136Q, D167E, V201I, L234S, R269K, D278A, S283GC
 sc62sc62KP235186None   S39C, K42Q, L74I, I84M, L101I, T112V, T124A, T125A, K173R, V201I, L234I, R269K, D278A, S283GC
 13531353KP235058None   L28M, K42Q, L45I, I72V, L74I, I84M, L101I, T112V, T124A, T125A, I135V, K136Q, V165I, V201I, L234S, R269K, D278A, S283GC
 12301230KP234992None   K14R, V31I, K42Q, L74I, I84M, L101I, T112V, I113L, T125A, H171Q, V201I, T206S, L234I, R269K, D278A, S283GC
 sc79sc79KP235195None   K14R, L28I, D41N, K42Q, L74I, I84M, L101I, T112V, T125A, K136Q, H171Q, V201I, L234S, R269K, D278A, S283GC
 11901190KP234966None   K14R, K42Q, L63I, L74I, I84M, L101I, T112V, T124A, T125A, I135V, K136Q, D167E, V201I, L234S, R269K, D278A, S283GC
 sc35sc35KP235173None   K14R, V31I, K42Q, L74I, I84M, L101I, T112I, T124S, T125A, I135V, K136R, K173R, V201I, T206S, R269K, D278A, S283GC
 942942KP235131None   K14R, K42Q, L63I, L74I, I84M, L101I, T112V, T124A, T125A, I135V, K136Q, V201I, L234S, R269K, D278A, S283GC
 972972KP235152None   K14R, V31I, D41N, K42Q, G70S, L74I, I84M, L101I, T112V, T124A, T125A, K136Q, V201I, L234S, R269K, D278A, S283GC
Mulu (2015)ETH-G-5596ETH-G-5596KF959755None   S24N, D25E, V31I, L74I, F100Y, L101I, G106A, T112V, T124N, T125A, G163E, K188R, V201I, I203M, K215N, L234I, V260VGC
 ETH-G-5479ETH-G-5479KF959731None   A21AS, S24N, D25E, V31I, G47GR, L74I, S81SR, F100Y, L101I, G106A, T112V, S119A, T124N, T125A, G163E, K188R, V201I, I203M, K215N, L234I, L242LI, W243X, D253DE, I257IRC
 ETH-G-5499ETH-G-5499KF959737None   S24N, D25E, V31I, L74I, F100Y, L101I, G106A, T112V, S119A, T124N, T125A, G163E, K188R, V201I, I203M, K215N, L234IC
 ETH-G-5544ETH-G-5544KF959744None   S24N, D25E, V31I, L74I, F100Y, L101I, G106A, T112V, T124A, T125A, K136Q, F181L, V201I, T218I, L234IC
Novitsky (2015)bcpp_138bcpp_138KR860656None   D25E, V31I, L74I, L101I, T112V, S119P, T124A, T125A, K136Q, D167E, I182V, K188R, V201I, I220L, Y227F, L234I, A265VC
 mpp_133mpp_133KR860916None   E11D, S17N, D25E, V31I, M50I, I72V, L74I, I84M, F100Y, L101I, T112V, T124A, T125A, K136Q, V201I, T218I, L234I, A265V, R269KC
 mpp_029mpp_029KR860818None   E11D, S24N, D25E, L28I, M50I, L74I, I84M, L101I, T112I, T125A, D167E, V201I, T218I, L234IC
 mpp_077mpp_077KR860863None   D25E, V31I, L74I, I84M, E96D, L101I, T112V, T124A, T125A, K136Q, K173R, V201I, T218L, L234I, R269KC
 bcpp_046bcpp_046KR860620None   S17N, V31I, M50I, I72V, L74I, F100Y, L101I, K111R, T112V, T124G, T125P, K136Q, V201I, T206S, T218I, K219Q, L234IC
 bcpp_136bcpp_136KR860655None   E11D, S24N, D25E, V31I, C56Y, L74I, L101I, T112I, T124A, T125A, K136Q, G163E, V201I, L234IC
Amogne (2016)ET145ET145KU319540None   S17N, D25E, V31I, L68M, L74I, I84M, F100Y, L101I, T112V, T124Q, T125A, D167E, K215N, T218L, L234I, A265V, D278AC
Billings (2016)CO6647V5CO6647V5KX907416None   V31I, L74I, I84M, E96D, L101I, T112V, T124N, K136Q, K173R, V201I, T206S, K219Q, L234I, D278AC
 CO6631V3CO6631V3KX907413None   K14R, S24N, D25E, V31I, M50I, D55N, L74I, F100Y, L101I, T112V, S119A, T124A, T125A, K136Q, V201I, T206S, K215N, T218I, L234I, D278A, S283GC
 CO3800V5CO3800V5KX907385None   E11D, S17N, D25E, V31I, I72V, L74I, E96D, F100Y, L101I, G106A, T112V, T124A, T125A, K136Q, V201I, T218I, L234I, A265V, D278A, S283GC
Rodgers (2017)CG-0151-02VCG-0151-02VKY392767None   E10D, K14R, V31I, L74I, I84M, L101I, K111Q, T112V, T124A, T125A, K136Q, G193E, V201I, L234I, N254K, S255G, D278A, S283GC