<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Integrase Inhibitors

Subtype C
Gene IN
Mutation I203M
Rx II-naive
IncludeMixtures No
References 29
Patients 78
Isolates 78
 
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# INIs WksINIMajorDRMs INIMinorDRMs OtherMutSubtype
Novitsky (1999)96BW1196BW11 None   D25E, V31I, M50I, I72V, F100Y, L101I, T112I, T124A, T125A, K136Q, V201I, I203M, T218I, L234I, A265V, D278A, S283GC
Harris (2003)99ET399ET3AY255827None   D25E, V31I, L45V, I84M, F100Y, L101I, T112V, T124N, V201I, I203M, L234I, A265V, R269K, D278AC
Papathanasopoulos (2003)99ZATM1099ZATM10AY228556None   S24N, D25E, M50I, I84M, F100Y, L101I, T112V, T125A, K136Q, V201I, I203M, K215N, L234I, V260I, D278A, S283GC
 01ZATM4501ZATM45AY228557None   K7R, K14R, S24D, D25E, V31I, F100Y, L101I, T112V, T124A, T125A, K136Q, V201I, I203M, L234I, V260I, R269K, D278A, S283GC
Arroyo (2005)CO6968CO6968AY734555None   V31I, I60M, I72V, T112V, I113V, T124A, T125A, F181L, V201I, I203M, Q216R, T218L, K219Q, L234I, A265V, R269K, D278A, S283GC
Rousseau (2006)Pt3903PS073MB1DQ275649None   D6E, S17N, D25E, V31I, S39N, M50T, F100Y, L101I, T112V, T125A, K136Q, G163E, V201I, I203M, T218I, L234I, A265V, D278A, S283GC
 Pt21204SK184B1DQ056418None  T66SV31I, M50T, I72V, P90S, F100Y, L101I, T112V, S119P, T124N, T125A, K136Q, V201I, I203M, T218I, I220V, L234I, R269K, D278A, S283GC
 Pt2481214MBAY463236None   E11D, Y15H, S24N, D25E, V31I, L45I, I72V, V88X, F100Y, L101I, T112V, T125A, K136Q, V201I, I203M, T218I, L234I, N254S, A265V, R269K, D278AC
Andresen (2007)CTL 015CTL015EF514713None  G163RE11D, D25E, K34R, M50I, F100Y, L101I, T112V, T125A, K127R, K136Q, V201I, I203M, L234I, M275V, D278A, S283GC
Badreddine (2007)J11426SB_J11426DQ375264None   S24K, D25E, V31I, I60V, I84M, F100Y, L101I, T112V, T125A, G163E, V201I, I203M, K215N, T218L, K219Q, L234I, D278A, S283GC
 J11441SB_J11441DQ375266None   E11D, S24N, V31I, M50L, L101I, T112V, T124N, T125A, K136Q, G163T, D167E, V201I, I203M, K215N, T218L, L234I, D278A, S283GC
 J11460SB_J11460DQ375275None   S24N, D25E, S39C, M50I, F100Y, L101I, T124Q, T125A, K188R, V201I, I203M, K215N, T218I, L234I, I251L, R269K, D278AC
 J11214SB_J11214DQ848144None   D25E, V31I, F100Y, L101I, T112V, T124N, T125A, V165I, G193E, V201I, I203M, K215N, T218L, L234I, D278A, S283G, D288NC
Van Baelen (2007)Pt2828-1 None   D6E, E10D, D25E, S39C, F100Y, L101I, T112V, S123G, T124A, T125A, K127R, K136Q, V201I, I203M, K211R, T218I, L234I, I268L, K273Q, D278A, S283GC
Matthews (2008)12141214FJ199555None   E11D, Y15H, S24N, D25E, V31I, L45I, I72V, V88X, F100Y, L101I, T112V, T125A, K136Q, V201I, I203M, T218I, L234I, N254S, A265V, R269K, D278AC
 PS073PS073FJ199653None   D6E, S17N, D25E, V31I, S39N, M50T, F100Y, L101I, T112V, T125A, K136Q, G163E, V201I, I203M, T218I, L234I, A265V, D278A, S283GC
 SK184SK184FJ199953None  T66SV31I, M50T, I72V, P90S, F100Y, L101I, T112V, S119P, T124N, T125A, K136Q, V201I, I203M, T218I, I220V, L234I, R269K, D278A, S283GC
Van Laethem (2008)AR05-390AR05-390EU882806None   V31I, D41N, I72V, I84M, F100Y, T112V, T124N, T125A, K136Q, I200M, V201I, I203M, L234I, D256EC
Eshleman (2009)23942062394206FJ480252None  L74LIME10D, L45I, I84IM, F100Y, L101I, G106A, T112V, S119SG, T122TI, T124A, T125A, K136Q, Q137QH, V201I, I203M, T218I, L234I, A265AV, R269K, D278A, V281M, S283GC
Garrido (2009)237INT-237GU217084None   V31I, L45I, G47R, E48G, M50I, I72V, F100Y, L101I, K111R, T112V, T124A, T125A, K136Q, D167E, K188R, V201I, I203M, T218I, L234I, A265V, R269KC
 363INT-363GU217210None   E11D, S24N, D25E, V31I, L45Q, M50I, F100Y, L101I, T112V, S119P, T125A, K136Q, V201I, I203M, T206S, T218I, L234I, W243R, D278A, S283GC
Graf (2011)SC96SC96JF773871None   D25E, V31I, V32I, L45V, L101V, T112V, S119P, T124N, K136Q, V165I, V201I, I203M, T218I, L234I, I251L, A265V, R269K, D278A, D288NC
 SC99SC99JF773873None   D25E, V32I, M50T, L101I, T112A, T124N, K136Q, I203M, T218I, L234I, R269K, D278A, V281MC
Wilantho A (2011)421377421377JF928827None   S24N, D25E, V31I, S39C, I60M, I72V, I84M, F100Y, L101I, T112V, T125A, D167E, K173KR, K188R, V201I, I203M, T206S, K215N, T218L, L234I, I268IL, R269K, D278A, S283GC
 421376421376JF928826None   K14KIRT, S24N, D25E, V31I, V32I, S39C, I60M, I72V, I84M, F100Y, L101I, T112V, T125A, D167E, K173R, K188R, V201I, I203M, T206S, K215N, T218L, L234I, I268L, R269K, D278A, S283GC
Oliveira (2012)GA10GA10JQ670797None   D6E, E10D, D25E, V31I, L45M, I84M, A91T, F100Y, L101I, T112V, T124A, T125A, K136Q, V201I, I203M, L234I, R269K, D278A, S283GC
 GC42GC42JQ670834None   S17N, D25E, V31I, F100Y, L101I, G106A, T112V, T124A, T125A, K136Q, D167E, V201I, I203M, T218I, L234I, S283GC
Bessong (2013)08BBVCT3808BBVCT38HM569284None   D25E, V31I, M50I, I72V, L74I, F100Y, L101I, T112V, T124A, T125A, K136Q, D167E, V201I, I203M, K211R, T218I, L234I, N254H, A265V, R269K, D278A, V281M, S283GC
Grossmann (2015)SE600415SE600415KP411838None   D6E, N18K, D25E, V31I, G59E, I72V, F100Y, L101I, T112V, T124N, T125A, V201I, I203M, T218I, L234I, A265V, R269K, D278A, S283GC
Hora (2015)DEMC00IN008DEMC00IN008KP109483None   V31I, K42Q, I84L, F100Y, L101I, G106A, T112A, T124A, T125A, K136Q, V165I, I203M, T218I, L234I, S255N, R269K, D278A, S283GC
 DEMC00IN010DEMC00IN010KP109485None   V31I, K42Q, L101I, T112V, T124A, T125A, K136Q, I203M, T218I, L234I, R269K, D278A, S283GC
 DEMC99IN003DEMC99IN003KP109488None E138K V31I, V32I, I84M, L101I, T112V, T125A, K136Q, I162V, D167E, V201I, I203M, K215N, L234I, D278A, S283GC
 DEMC99IN004DEMC99IN004KP109489None   V31I, K42Q, I72A, L74I, I84L, L101I, T112I, I113V, T124A, T125A, K136Q, I203M, T218I, L234I, D278A, S283G, R284G, D286NC
Li (2015)12521252KP235009None   V31I, K42Q, I84M, L101I, T112V, T124A, T125A, I135V, K136Q, V201I, I203M, L234I, R269K, D278A, S283GC
 11751175KP234954None   K14R, V31I, K42Q, I84M, L101I, T112V, T124A, T125A, K136Q, K188R, I203M, L234I, S255R, R269K, D278A, S283GC
Mulu (2015)ETH-G-5596ETH-G-5596KF959755None   S24N, D25E, V31I, L74I, F100Y, L101I, G106A, T112V, T124N, T125A, G163E, K188R, V201I, I203M, K215N, L234I, V260VGC
 ETH-G-5496ETH-G-5496KF959735None   Q44QR, Q53E, I72V, F100Y, L101I, T112V, T124S, T125A, K136Q, L158LS, D167E, K188R, V201I, I203M, K215N, T218L, L234I, V260L, I267N, R269KC
 ETH-G-5479ETH-G-5479KF959731None   A21AS, S24N, D25E, V31I, G47GR, L74I, S81SR, F100Y, L101I, G106A, T112V, S119A, T124N, T125A, G163E, K188R, V201I, I203M, K215N, L234I, L242LI, W243X, D253DE, I257IRC
 ETH-G-5499ETH-G-5499KF959737None   S24N, D25E, V31I, L74I, F100Y, L101I, G106A, T112V, S119A, T124N, T125A, G163E, K188R, V201I, I203M, K215N, L234IC
 ETH-G-5672ETH-G-5672KF959757None   D6E, S24N, D25E, I72IV, A76S, F100Y, L101I, K111KR, T112V, S119P, T124N, T125A, K136R, D167E, K173R, K188R, I191L, V201I, I203M, K215N, T218L, I220V, L234I, R269KC
Novitsky (2015)mpp_064mpp_064KR860850None   K14R, S24N, D25E, V31I, I84M, F100Y, L101I, T112V, T124N, T125A, K136Q, K156R, V201I, I203M, A205S, T218I, K219N, N222K, L234I, A265VC
 mpp_380mpp_380KR861148None   S17N, D25E, V31I, I84M, F100Y, L101I, T112V, T124A, T125A, K136Q, V201I, I203M, T218I, L234I, A265VC
 bcpp_194bcpp_194KR860684None  V54IK14R, D25E, V31I, M50I, I60T, I72V, F100Y, L101I, T112V, T122V, T124A, T125A, K136Q, V150A, K188R, V201I, I203M, K211R, T218I, L234I, A265V, R269KC
 bcpp_163bcpp_163KR860666None   E11D, D25E, V31I, L45Q, M50I, I60T, I72V, F100Y, L101I, T112I, T125Q, K136Q, G163V, I203M, T218I, L234I, R269KC
 bcpp_300bcpp_300KR860725None   S24N, D25E, V31I, M50T, F100Y, L101I, T112V, T124A, T125A, K136Q, K188R, V201I, I203M, K215N, L234I, A265VC
Amogne (2016)ET167ET167KU319550None   D6E, D25E, V31I, I60V, I84M, F100Y, L101I, T112V, T124N, G163E, V201I, I203M, K215N, Q216K, T218L, K219N, L234I, D278NC
Li (2016)33893389JQ235014None   V31I, K42Q, L101I, T112V, T124A, T125A, I135L, K136Q, V201I, I203M, L234S, R269K, D278A, S283GC
Sachithanandham (2016)07/33907/339KF870716None   E11D, V31I, V32I, V37I, S39N, K42Q, I84L, L101I, T112V, T124A, K136Q, K188R, V201I, I203M, L234I, D278AC
 08/0308/03KF870718None   V31I, D41N, K42Q, L45Q, L74I, I84M, E96D, L101I, T112V, T124A, T125A, K136Q, H171Q, V201I, I203M, A205S, K211R, Q221S, L234I, D278AC
 11C/44711C/447KF870722None   K14R, L28I, V31I, V32I, K42Q, I60V, I84M, F100Y, L101I, T112I, T124A, T125A, K136Q, I203M, K211Q, L234I, I251L, D278AC
 11C/144111C/1441KF870729None   K42Q, L45V, L101I, I113V, T124A, T125A, I135V, V201I, I203M, L234IC
 11N/130411N/1304KF870734None  Q95KD41N, K42Q, I72V, L101I, K111R, T124S, T125A, G134D, K136R, V201I, I203M, L234I, D278AC
 12C/53512C/535KF870744None   V31I, K42Q, I84M, F100Y, L101I, T112I, T124A, T125A, K136Q, I203M, L234I, D278AC
 08/0808/08KF870749None  Q95KL45Q, I84L, F100Y, L101I, T112V, T124A, T125A, V165I, I200L, V201I, I203M, L234V, D278AC
 07/52907/529KF870752None   K14R, V31I, K42Q, L45Q, I72V, L74I, I84M, L101I, T112V, T124A, T125S, G134N, K136Q, V201I, I203M, T218L, L234I, R269K, D278AC
 07/55607/556KF870754None   E10A, S17N, L28I, D41N, K42Q, I60V, F100Y, L101I, T112V, I113L, T124A, T125A, G134D, K188R, S195C, V201I, I203M, T218I, L234I, D278AC
 07/58807/588KF870757None   V31I, D41N, K42Q, L45Q, I84M, P90S, F100Y, L101I, T112V, T124A, T125A, K136Q, K188R, V201I, I203M, K211R, L234I, R269K, D278AC
 07/60907/609KF870758None   K14R, V32I, S39C, L101V, T112V, T125A, K136Q, H171Q, V201I, I203M, I208L, L234I, D278AC
 07/61407/614KF870759None   V31I, D41N, K42Q, L74I, I84L, F100Y, L101I, T112V, S119P, T124A, T125A, G134D, K136R, V201I, I203M, L234I, D278AC
 08/70308/703KF870777None  Q95KK14R, V31I, D41N, K42Q, G70R, I84M, P90S, L101I, T112V, T124A, T125A, K136Q, V201I, I203M, A205S, I208L, L234I, R269K, D278AC
 10/50710/507KF870779None   L28I, K42Q, I84L, F100Y, L101I, K111R, T112V, T124A, T125A, K136Q, K188R, G193E, V201I, I203M, L234I, D253E, D278AC
 10/132010/1320KF870785None   E10D, V31I, D41N, K42Q, L45Q, I84M, F100Y, L101I, T112V, T124A, T125A, K136Q, V165I, K188R, V201I, I203M, L234I, R269K, D278AC
 DR11/10DR11/10KF870805None  L74MV31I, K42Q, I84M, L101I, T112V, T124A, T125A, G134D, K136Q, V201I, I203M, L234I, D278AC
 DR11/15DR11/15KF870807None   V31I, K42Q, L74I, L101I, T112V, T124A, T125A, K136Q, V165I, V201I, I203M, L234I, I251L, D278AC
 09/101009/1010KF870816None  L74MK14R, V32I, L101I, K103R, T112V, T124A, T125A, K136Q, I200L, V201I, I203M, T218I, L234I, D278AC
 DR10/04DR10/04KF870826None  L74MV31I, K42Q, I84M, F100Y, L101I, T112V, T122I, T124A, T125A, V201I, I203M, I208L, L234I, R269K, D278AC
 11N/58811N/588KF870831None   V31I, D41N, K42Q, I84L, F100Y, L101I, T112V, T124S, T125A, K136Q, V201I, I203M, Q221S, L234I, D278AC
Su (2016)14CN.SCYB1114CN.SCYB11KU992935None   V31I, K42Q, K71R, I84M, L101I, T112V, T124A, T125A, K136Q, E157Q, V201I, I203M, L234S, R269K, D278A, S283GC
Bradley-Stewart (2017)WoSSVC_INT63WoSSVC_INT63MF442502None   S17N, V31I, V32I, E35EQ, S39SN, F100Y, L101I, T112V, T124A, T125A, K136Q, V201I, I203M, T218I, N222NT, L234I, R269K, D278A, S283GC
Chehadeh (2017)33593359KY888227None  L74MS24R, V32I, K42Q, A49AS, V77A, A80AT, P90S, L101I, T112V, T124S, T125A, K127R, K136N, V201I, I203M, T218M, I220V, L234I, D278A, S283GC
 38473847KY888228None   E13EG, V31I, V32I, D41N, K42Q, I60V, I72V, L74I, V77A, P90Q, F100Y, L101I, T112V, T124A, T125P, A175T, R187K, K188R, V201I, I203M, T218I, I220V, L234I, R269K, D278A, S283G, R284GC
 62136213KY888244None   V31I, V32I, S39C, M50I, F100Y, L101I, T112V, T124A, T125A, K136Q, V201I, I203M, Q216H, I220IL, L234I, R269K, D278A, S283GC
 48284828KY888264None  L74ME10D, V31I, I72V, P90S, L101I, T112V, T124G, T125A, K127R, K136N, V165I, V201I, I203M, I208L, Q221H, L234I, S255G, R269K, D278A, S283GC
Hachiya (2017)C15-305171LC161290LC161290None  L68LIV31I, D41N, K42Q, I72V, I84M, E96D, L101I, T112X, T124N, T125A, G134GA, K136Q, V201I, I203M, L234I, R269K, D278A, S283GC
Inzaule (2018)ZACHCPM060ZACHCPM060MG694118None   K14R, D25E, V31I, L101I, T124A, I135V, K136H, K173R, V201I, I203M, L234I, S255G, A265V, K273Q, D278A, S283GC
 UGJCRPM095UGJCRPM095MG694026None   S24N, D25E, F100Y, T112V, S119P, T124N, T125A, K136Q, K188R, V201I, I203M, D207E, L234I, D278A, S283G, R284GC
 SAACCPM144SAACCPM144MG693929None   D25E, V31I, I72V, I84M, F100Y, L101V, T112V, S119P, T124A, T125A, K136Q, V201I, I203M, L234I, R269K, D278A, S283GC
 SAACCPM043SAACCPM043MG693913None   E11D, S24N, D25E, K34R, F100Y, L101I, T112V, T124A, T125A, V201I, I203M, T218I, L234I, D278A, S283G, R284GC