<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Integrase Inhibitors

Subtype C
Gene IN
Mutation T125V
Rx II-naive
IncludeMixtures No
References 12
Patients 25
Isolates 25
 
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# INIs WksINIMajorDRMs INIMinorDRMs OtherMutSubtype
Rousseau (2006)Pt10703SK072B1DQ093593None   V31I, M50I, L101I, T112V, T124A, T125V, K136Q, V201I, T218I, L234I, A265V, R269K, M275V, D278A, S283GC
Matthews (2008)11561156FJ199537None   D25E, K34R, M50I, I72V, I84M, L101I, T112V, T124A, T125V, K136Q, V201I, T218IC
 PS024PS024FJ199605None   D25E, V31I, M50I, I72T, F100Y, L101I, T112V, T125V, K136Q, E152K, K159R, V201I, L234I, A265V, R269K, D278A, S283GC
 SK072SK072FJ199879None   V31I, M50I, L101I, T112V, T124A, T125V, K136Q, V201I, T218I, L234I, A265V, R269K, M275V, D278A, S283GC
Passaes (2009)BR.RS.RS20BR.RS.RS20HM026821None   V31I, M50T, L101I, T112V, T124N, T125V, K136Q, V201I, T218I, L234I, I251L, A265V, R269K, D278A, V281MC
Fish (2010)P4909ZAP49GQ872503None   D25E, V31I, I72V, I84M, E96D, L101I, G106A, T112V, T125V, K136Q, V201I, K215Q, L234I, D278A, S283GC
 FV2905ZAFV29GQ872535None   S17N, D25E, V31I, I84M, L101I, T112I, T124A, T125V, K136Q, V165I, V201I, T206S, T218I, L234I, A265V, R269K, D278A, S283GC
Papathanasopoulos (2010)1733207ZA17332GU253436None  Y143YFE11D, D25E, V31I, I72V, L101I, T112R, T125V, K136Q, V201I, L234I, D256E, R269K, D278A, S283G, R284GC
Brenner (2011)96989698HQ207803None   N27H, V31I, I84LM, L101I, T112V, T124N, T125V, K136Q, V201I, T218I, L234I, A265V, R269K, D278A, R284GC
Oliveira (2012)GA09GA09JQ670796None   D25E, V31I, M50I, H51HQ, I72V, L101I, T112V, T124A, T125V, K136Q, D167DE, V201I, K211KR, T218K, L234I, A265V, R269K, D278A, S283G, R284G, D288NC
Zeng (2012)CN1004CN1004JQ028301None   V31I, K42Q, I84M, L101I, T112V, T124A, T125V, K136H, K211R, T218I, L234I, D278A, S283GC
Bessong (2013)08MB14ZA08MB14ZAHM569302None   V31I, M50I, I72V, L101I, T112V, T124S, T125V, K136Q, G163V, V201I, T206S, T218I, L234I, I251L, A265V, R269K, D278A, S283GC
 08MB21ZA08MB21ZAHM569307None   K7Q, S17N, V31I, S39N, M50I, I72V, L101I, T112I, T125V, K136Q, V201I, K211R, Y227F, L234I, N254K, S255G, R269K, D278A, V281M, S283GC
 08MB62ZA08MB62ZAHM569330None   D25E, V31I, I72T, T112V, T125V, K136Q, D167E, V201I, L234I, S283GC
Grossmann (2015)SE600213SE600213KP411834None   D25E, V31I, L101I, T112V, T124Q, T125V, V126M, K173R, V201I, K215N, T218L, L234I, A265V, R269K, D278A, V281M, S283G, R284IC
Mulu (2015)ETH-G-5732ETH-G-5732KF959768None   E11D, R20K, D25E, V31I, S39N, I72V, L101I, T112V, T125V, K136KN, D167E, K173R, G193E, V201IK, K215N, T218L, L234IC
 ETH-G-5525ETH-G-5525KF959741None   E11A, S24N, D25E, V31I, I60V, I72V, I84M, L101I, T112V, T125V, V150A, V165I, V201I, K211R, K215N, T218L, L234IC
 ETH-G-5837ETH-G-5837KF959774None   E11A, S24N, D25E, V31I, I60V, I72V, I84M, L101I, T112V, T125V, V150A, V165I, V201I, K211R, K215N, T218L, L234IC
 ETH-G-5493ETH-G-5493KF959734None   S17N, S24D, D25E, L45V, M50I, V77E_NSRIPYTPPP, L101I, T112V, T124A, T125V, K136Q, G163GE, K211KR, Y227F, L234I, W243WGC
 ETH-G-5524ETH-G-5524KF959740None   E11A, S24N, D25E, V31I, I60V, I72V, I84M, L101I, T112V, T125V, V150A, V165I, V201I, K211R, K215N, T218L, L234IC
Novitsky (2015)bcpp_129bcpp_129KR860654None   S17N, S24D, D25E, E35Q, S39C, M50I, I72V, F100Y, L101I, T112V, T124A, T125V, K136Q, V201I, K211R, L234I, A265VC
 mpp_144mpp_144KR860927None   D25E, V31I, I60V, F100Y, L101I, T112V, T124A, T125V, K136Q, G163Q, V201I, D207N, N222H, L234I, D256EC
 mpp_102mpp_102KR860885None   D25E, V31I, L45Q, M50I, I72V, T112V, S119G, T125V, K136Q, V201I, K211R, T218I, L234I, A265V, R269KC
 bcpp_261bcpp_261KR860709None  T97AE11D, S24N, D25E, V31I, M50I, I72V, I84M, L101I, T112V, T124A, T125V, K136Q, V201I, D207E, L234I, R269KC
 mpp_150mpp_150KR860933None   K14R, D25E, V31I, M50I, I72V, I84M, L101I, K111R, T112I, T125V, K136Q, H171Q, V201I, K211R, T218I, S230N, L234I, A265V, R269KC