Integrase Inhibitors

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Integrase Inhibitors

Subtype	B
Gene	IN
Mutation	T97A
Rx	>=1 INI
IncludeMixtures	No

References	9
Patients	17
Isolates	28

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr)	Patient	Isolate	Acc#	INIs	Wks	INIMajorDRMs	INIMinorDRMs	OtherMut	Subtype
Malet (2008)	H6	H6-W20	FJ538984	RAL	20	N155H	T97A, V151I	E11D, V31I, L101I, K111T, I113V, S119T, T124N, T125A, S195C, A196P, A205T, T218S, D232N	B
Canducci (2009)	pt6	pt6w20	EU908751	RAL	21	E138A	T97A, Y143K	L101I, S119R, K156N, I208L	B
		pt6W24	EU908752	RAL	26	E138EA, G140GS, Q148QH	T97A, Y143Y*KN	L101I, S119SR, K156N, I208L	B
		pt6W36	EU908753	RAL	39	G140S, Q148H	T97A	L101I, S119R, K156N, I208L	B
	pt4	pt4W24	EU908762	RAL	26	Y143C	T97A	D3Q, L101I, S119R, T124N, T125A, M154L, V165I, D256E	B
		pt4w32	EU908763	RAL	35	Y143C	T97A	D3Q, L101I, S119R, T124N, T125A, M154L, V165I, K211KR, D256E	B
		pt4w36	EU908764	RAL	39	Y143C	L74M, T97A	D3Q, L101I, S119R, T124N, T125A, M154L, V165I, K211R, D256E	B
	pt5	pt5w48	EU908777	RAL	52		T97A, Y143S, S230R	K14R, M22L, V32I, V37I, S39C, L101I, G163Q, V201I, D253E	B
Garrido (2009)	Pt03	Pt03		RAL		Y143R	T97A	H12HN, V31I, K111T, S119T, T125A, V126L, I135V, P142A, I203M, I208L, D256E	B
Sichtig (2009)	Pt01	4786	FJ183692	RAL	47	Y143R	L74M, T97A	E11D, R20K, V31I, H51HR, S119G, T122I, T125A, V201I, K215N	B
	Pt10	5150	FJ183702	RAL	106	Y143R	L74M, T97A, E138D	S17N, M22I, A23V, L28I, L45V, L101I, S119T, T218TS, L234LV, D256E, I268M	B
Hatano (2010)	4	Virus15	GU121691	RAL		Y143R	T97A	K7R, S17N, V31I, L101I, T112A, T125A, M154I, V201I	B
		Virus16	GU121692	RAL		Y143R	T97A, G163GR	K7R, S17N, V31I, L101I, T112A, S119T, T125A, M154I, V201VI	B
	12	Virus101	GU121777	RAL		Y143YC	T97A, S230R	G4GR, R20K, T112V, I113V, T125A, H171Q, Y194YH, I200M, I203M	B
Blanco (2011)	CA1556	CA124202		RAL	85	Y143C	L74M, T97A, S230R	K7R, S17N, L101I, K111Q, T112K, S119R, T206S, K211R, D256E	B
Brenner (2011)	102001.076	102001.076	HQ423441	RAL		T66I	T97A, G163R	E11D, D25E, V31I, I60V, I72V, A91T, G106A, T112I, I113V, S119P, T124N, T125V, I203M, A205T, D256E, D278DY	B
	11090	11090	HQ423447	RAL			T97A	E11D, N27S, V31I, L101I, K111T, I113V, S119P, T124N, K211N, D232E, D286N	B
Canducci (2011)	Pt1	Pt1W20	JN163877	RAL	21	E138A	T97A, Y143K	H16P, M22R, L101I, S119R, K156N, I208L	B
		Pt1W24	JN163878	RAL	26	G140S, Q148H	T97A	L101I, S119R, K156N, I161F, I208L	B
	Pt2	Pt2W24	JN163881	RAL	26	Y143C	T97A	L101I, S119R, T124N, T125A, M154L, V165I, D256E, G277C	B
		Pt2W36	JN163882	RAL	35		L74M, T97A, Y143G	L101I, S119R, T124N, T125A, M154L, V165I, K211R, D256E, G277C	B
		Pt2W37	JN163883	RAL	36		L74M, T97A, Y143G	I36V, L101I, S119R, T124N, T125A, M154L, V165I, D256E	B
		Pt2W56	JN163884	RAL	55	Y143R	T97A	L101I, S119R, T124N, T125A, M154L, V165I, K211R, D256E, G277R	B
		Pt2W64	JN163885	RAL	64	E138A, Y143C	L74M, T97A	L101I, S119R, T124N, T125A, M154L, V165I, K211R, D256E, G272E, G277R	B
	Pt5	Pt5W48	JN163892	RAL	52		T97A, Y143S, S230R	Q9H, K14R, A23G, V32I, V37I, L101I, G163Q, V201I, D253E	B
	Pt6	Pt6W32	JN163895	RAL	28	Y143R	T97A	S17N, V31I, L101I, T112I, S119P, T122I, T124N, T206S, T218S, Y227F, D256E	B
Souza Cavalcanti (2012)	BRSP	BR10SP267C	JQ797720	RAL	74	F121Y	T97A, V151I	E11D, K14R, S24D, L28I, S39C, I72V, L74I, S119P, Q137H, Q164K, R187K, V201I, D232E, L234F	B
		BR11SP363B	JQ797725	RAL	135	Y143R	T97A	E11D, E13X, K14R, S24D, L28I, S39C, K42KR, L74I, S119P, Q164K, R187K, V201I, D232E, L234I	B

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