<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Integrase Inhibitors

Subtype B
Gene IN
Mutation L74M
Rx >=1 INI
IncludeMixtures No
References 7
Patients 12
Isolates 14
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# INIs WksINIMajorDRMs INIMinorDRMs OtherMutSubtype
Canducci (2009)pt4pt4w36EU908764RAL39Y143CL74M, T97AD3Q, L101I, S119R, T124N, T125A, M154L, V165I, K211R, D256EB
Garrido (2009)Pt05Pt05 RAL N155HL74M, V151IE11D, R20K, L101I, S119P, T122I, T124A, S195T, I203M, Y227F, D253DY, S255N, D256EB
Sichtig (2009)Pt014786FJ183692RAL47Y143RL74M, T97AE11D, R20K, V31I, H51HR, S119G, T122I, T125A, V201I, K215NB
 Pt105150FJ183702RAL106Y143RL74M, T97A, E138DS17N, M22I, A23V, L28I, L45V, L101I, S119T, T218TS, L234LV, D256E, I268MB
Blanco (2011)CA1556CA124202 RAL85Y143CL74M, T97A, S230RK7R, S17N, L101I, K111Q, T112K, S119R, T206S, K211R, D256EB
 JGG_03BLJGG_03BL RAL Y143RL74M, E138DV31I, T125V, D232EB
Canducci (2011)Pt2Pt2W36JN163882RAL35 L74M, T97A, Y143GL101I, S119R, T124N, T125A, M154L, V165I, K211R, D256E, G277CB
  Pt2W37JN163883RAL36 L74M, T97A, Y143GI36V, L101I, S119R, T124N, T125A, M154L, V165I, D256EB
  Pt2W64JN163885RAL64E138A, Y143CL74M, T97AL101I, S119R, T124N, T125A, M154L, V165I, K211R, D256E, G272E, G277RB
Garrido (2012)BAA295956BAA295956JQ716865RAL52Y143RL74MK7R, V31I, L101I, T112I, T125V, K219N, N222KB
de Souza Cavalcanti (2014)BRSP08BRSP08 RAL  L74M, T97A, V151I, G163RK14R, V31I, I72A, L101I, I113L, S119G, T122I, T124TN, K156KN, E157Q, V201I, T206S, S283GB
 BRSP222BRSP222 RAL Y143RL74M, T97A, E138DE10D, V31I, M50I, L101I, T112V, S119P, T122I, T124N, T125A, I135V, E157Q, I203M, I208L, T218S, I220L, D253VB
 BRSP553BRSP553 RAL E92QL74M, V151IE10D, A21S, M50I, K211RB
 BRSP318BRSP318 RAL E138K, G140C, Q148RV54I, L74MD6T, K7E, K14R, V31I, I72V, V79I, S119P, K156KN, E157Q, K160KT, V201I, T218S, R284GB