<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Integrase Inhibitors

Subtype B
Gene IN
Mutation L74M
Rx >=1 INI
IncludeMixtures No
References 9
Patients 46
Isolates 48
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# INIs WksINIMajorDRMs INIMinorDRMs OtherMutSubtype
Canducci (2009)pt4pt4w36EU908764RAL39Y143CL74M, T97AD3Q, L101I, S119R, T124N, T125A, M154L, V165I, K211R, D256EB
Garrido (2009)Pt05Pt05 RAL N155HL74M, V151IE11D, R20K, L101I, S119P, T122I, T124A, S195T, I203M, Y227F, D253DY, S255N, D256EB
Sichtig (2009)Pt014786FJ183692RAL47Y143RL74M, T97AE11D, R20K, V31I, H51HR, S119G, T122I, T125A, V201I, K215NB
 Pt105150FJ183702RAL106Y143RL74M, T97A, E138DS17N, M22I, A23V, L28I, L45V, L101I, S119T, T218TS, L234LV, D256E, I268MB
Blanco (2011)CA1556CA124202 RAL85Y143CL74M, T97A, S230RK7R, S17N, L101I, K111Q, T112K, S119R, T206S, K211R, D256EB
 JGG_03BLJGG_03BL RAL Y143RL74M, E138DV31I, T125V, D232EB
Canducci (2011)Pt2Pt2W36JN163882RAL35 L74M, T97A, Y143GL101I, S119R, T124N, T125A, M154L, V165I, K211R, D256E, G277CB
  Pt2W37JN163883RAL36 L74M, T97A, Y143GI36V, L101I, S119R, T124N, T125A, M154L, V165I, D256EB
  Pt2W64JN163885RAL64E138A, Y143CL74M, T97AL101I, S119R, T124N, T125A, M154L, V165I, K211R, D256E, G272E, G277RB
Garrido (2012)BAA295956BAA295956JQ716865RAL52Y143RL74MK7R, V31I, L101I, T112I, T125V, K219N, N222KB
Molina (2012)40104010_2 RAL25 L74M, T97AD6DN, E10D, S39SG, M50I, L101I, T112I, S119P, T124A, T125A, I135L, T206S, D279NB
de Souza Cavalcanti (2014)BRSP08BRSP08 RAL  L74M, T97A, V151I, G163RK14R, V31I, I72A, L101I, I113L, S119G, T122I, T124TN, K156KN, E157Q, V201I, T206S, S283GB
 BRSP222BRSP222 RAL Y143RL74M, T97A, E138DE10D, V31I, M50I, L101I, T112V, S119P, T122I, T124N, T125A, I135V, E157Q, I203M, I208L, T218S, I220L, D253VB
 BRSP553BRSP553 RAL E92QL74M, V151IE10D, A21S, M50I, K211RB
 BRSP318BRSP318 RAL E138K, G140C, Q148RV54I, L74MD6T, K7E, K14R, V31I, I72V, V79I, S119P, K156KN, E157Q, K160KT, V201I, T218S, R284GB
Hurt (2014)IN_1331IN_1331 RAL E92QL74MS39C, L45Q, L63I, I72L, Q216N, L234I, D270H, R284GB
 IN_1019IN_1019 RAL T66TI, N155HL74M, T97A, V151ID6E, S17N, M50I, I72V, L101LI, S119R, K156N, V201VI, I208M, E212AB
 IN_954IN_954 RAL Y143RL74M, Q95K, T97AD6E, E10D, S17T, A23V, A91T, L101I, S119P, T122I, T124A, T125AB
 IN_1160IN_1160 RAL  L74M, T97A, Y143AS, S230RS17N, V31I, K34R, S39R, S119T, T124A, T206S, D229EB
 IN_1169IN_1169 RAL Y143RL74ME11D, S24N, V31I, L101I, T112A, S119ST, E157EQ, K160KI, V201I, T218L, K219Q, L234IB
 IN_800IN_800 RAL Y143RL74M, T97AS17N, S119T, E157Q, K160Q, V201I, D256E, R284GB
 IN_508IN_508 RAL  L74M, T97A, Y143S, S230RS17N, V31VI, K34R, S39R, S119T, T124A, I204IV, T206S, D229EB
 IN_1752IN_1752 RAL E138K, Y143CL74M, T97A, A128T, S230RE13D, K14KR, S17N, V31I, L63LI, L101I, T112A, S119R, K156N, I208L, Q252K, D288NB
 IN_421IN_421 RAL G140S, Q148HL74MA23V, L101I, S283SGB
 IN_212IN_212 RAL Y143RL74M, T97AS17N, R20K, V31I, T112S, I113V, S119ST, T124S, T125A, E157Q, K160Q, V201I, K211R, R284GB
 IN_1642IN_1642 RAL Y143RL74M, T97AS17N, L101I, S119G, T122I, T124A, T125A, L234V, V259IB
 IN_81IN_81 RAL G140S, Q148RL74MS17SN, I72V, F100S, L101I, K111T, S119P, T124A, T125A, E157Q, K160KINB
 IN_3091IN_3091 RAL E92QL74M, E138DE11D, S24N, D25E, K211R, K215N, I220L, S230N, D256E, D278DNB
 IN_848IN_848 RAL Y143RL74MS17N, V31VI, L63LI, I72N, L101I, T112I, S119P, V201I, D256E, V259VI, R284RGB
 IN_1564IN_1564 RAL  L74M, T97A, Y143G, G163GRS17N, S39N, L101I, T112A, S119R, T124A, T125A, I135V, Y194L, S195H, A196T, K211KR, S230SN, I268L, D270H, R284RGB
 IN_2493IN_2493 RAL Y143CL74M, T97A, S230RS17N, V31I, D41N, L63I, L101I, S119R, T124A, G163T, T218S, K219N, N222K, D229DG, S283GB
 IN_1569IN_1569 RAL  L68V, L74M, E92L, T97AK34R, M50I, V88VI, T112TA, T125A, V201I, T218S, S230NB
 IN_214IN_214 RAL Y143RL74M, Q95QK, T97AE10D, V31I, L101I, T112A, S119T, T124A, T125A, I135VB
 IN_266IN_266 RAL Y143RL68V, L74M, T97AV31I, L101I, S119T, G163Q, F181L, T206SB
 IN_1599IN_1599 RAL Y143RL74M, Q95QK, T97AE11D, V31I, I72V, I113V, S119T, T124A, T125TA, F181L, V201I, A205S, T206S, D207E, K211R, K219N, N222KB
 IN_1235IN_1235 RAL Y143RL74M, Q95QK, T97TAE11D, S24N, V31I, L101I, T112A, I113LV, T124A, T206S, I208M, D278DNB
 IN_995IN_995 RAL G140C, Q148RL74M, E138GS17N, L101I, T124A, T125A, D167E, D253EB
 IN_2774IN_2774 RAL N155HL74M, V151I, G163KS17N, L68T, L101I, T124A, V201I, T218S, I220L, Y227F, D253N, D256E, R284GB
 IN_341IN_341 RAL E92QL68V, L74M, T97AE10D, V31I, M50I, I73V, E96D, L101I, S119T, T124N, T125A, I135V, E157Q, K160T, I208M, S230N, D232E, L234F, D253E, D256E, E287EAB
 IN_574IN_574 RAL N155HL74M, V151IK7R, E11D, V31I, M50I, I113V, S119P, T122I, T124TN, I208L, K211Q, E212A, Q216N, I220IMB
 IN_1608IN_1608 RAL E138EK, Y143RL74M, T97AK14R, S17N, A23V, L28I, P30A, S39C, Q95QR, L101I, T112V, S119G, T122I, T125Q, V201I, T206S, K240R, V259VIB
 IN_787IN_787 RAL E92QL68V, L74M, T97AE10D, V31I, M50I, I73V, E96D, L101I, S119T, T124N, T125A, I135V, E157Q, K160KPQT, I208M, S230N, D232E, L234F, D253E, D256EB
 IN_487IN_487 RAL Y143RL74M, Q95QK, T97AE10D, V31I, L63LI, L101I, T112A, S119T, T124A, T125A, I135VB
 IN_1453IN_1453 RAL E92QL74MV31I, M50I, I60M, Y99F, G106A, T112M, T124A, D167E, T206S, S230N, D256E, R269KB
 IN_422IN_422 RAL G140S, Q148HL74MA23V, L101I, S283SGB
 IN_2519IN_2519 RAL Y143HL74M, T97A, G163RE11D, K14R, A21T, S24G, D25E, S39C, L45V, L101I, S119G, T122I, T125A, E170EG, T206TS, Q216H, S283SNB
 IN_1820IN_1820 RAL Y143CL74M, T97A, G163R, S230RL63LV, S119T, T124A, I203IM, K211KRB
 IN_315IN_315 RAL T66AL74M, V151VI, G163RV31I, V75VI, L101V, T112V, T125A, V126L, V165I, V201I, K211R, K215N, D229DN, S230N, D256E, S283GB