<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Integrase Inhibitors

Subtype B
Gene IN
Mutation L74I
Rx II-naive
IncludeMixtures No
References 26
Patients 118
Isolates 120
Show mutation frequency as:
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# INIs WksINIMajorDRMs INIMinorDRMs OtherMutSubtype
Saad (2006)01UAKV25201UAKV252DQ823363None   L74I, L101I, K111T, S119P, T122IB
Andresen (2007)CTL 016CTL 016EF514704None   E11D, R20K, V32I, I72V, L74I, P90S, T112V, K156N, V165I, H171L, V201I, D256EB
 CTL 041CTL 041EF514711None   A23V, S24G, L28I, L74I, T125A, H171QB
Brennan (2007)01BAB05401BAB054EF150548None   E10D, E13D, L74I, K111R, T124A, K156H, I208L, S283GB
 01BAB09401BAB094EF150565None  T97AD6N, K7E, S39C, M50I, L74I, A91E, L101I, S119R, T125AB
 439200439200EF150610None   D6E, E10D, M50L, C56S, I72V, L74I, A91S, S119P, V201I, T218I, L234I, D288NB
Van Baelen (2007)Pt1313-1 None   E10D, M50L, L74I, L101I, S123G, T124A, T125A, K127R, I135V, E157Q, K160Q, V176L, D256EB
Buzon (2008)Pt33Pt33Y1999EU883886None   K7KR, V31I, L74I, I84V, L101I, S119PT, T125A, G163E, H171Q, T206TS, S283GB
  Pt33Y2001EU883887None   V31I, L74I, I84IV, L101I, S119PT, T125A, G163E, A169AG, H171QB
  Pt33Y2004EU883888None   K7R, V31I, L74I, I84V, L101I, S119P, T125A, G163E, H171Q, S283GB
Ibe (2008)285285AB428558None  V151VIL74I, T125A, K156N, H171L, K211RB
 329329AB428559None   L74I, T125A, K156N, H171L, K211RB
 398398AB428560None   S39SN, L74I, T125A, K156N, H171LB
 472472AB428561None   E11D, R20K, L28I, V37I, L74I, T125A, K156N, H171L, V201I, K211RB
 574574AB428562None   D6N, S17N, L28I, L74I, T125A, K156N, H171L, V201I, D270EB
Van Laethem (2008)AR04-342AR04-342EU882762None   E11D, S24N, N27G, L74I, L101I, T112V, I113V, T124A, V201I, T206S, D207E, T218TI, R224Q, L234T, S255S_G, I268V, D270NB
 AR07-1965AR07-1965EU882745None   V32L, I72V, L74I, L101I, K111Q, T112A, S119T, T124N, T125A, K156R, F181L, K219N, N222K, V259I, D286NB
Brumme (2009)INT_3533INT_3533FJ812984None   I72V, L74I, L101I, S119G, T122I, M154LB
 INT_3690INT_3690FJ813141None  V151VIS17N, V31I, I72V, L74I, T125A, H171Q, K188KR, S283GB
 INT_3694INT_3694FJ813145None  V151IS17N, V31I, V32I, D41N, I72V, L74I, I84V, T125A, H171Q, S283GB
 INT_3825INT_3825FJ813276None   E11D, S17C, L74I, T125A, H171QB
 INT_3963INT_3963FJ813414None   E11D, V31VI, I72IV, L74I, K111T, S119P, S195SC, V201IB
 D3500D3500GQ371817None   L74I, T125A, K215N, T218I, D256EB
 G8579G8579GQ371905None   S17N, S39N, L45V, M50I, I72V, L74I, L101I, T124N, T125A, A133AV, I162V, G163E, V176I, Q216H, Y227F, L234H, D256EB
 J4512J4512GQ371940None   E11D, K14R, V32I, D41N, L74I, Y99F, K111R, S119P, K136N, V201I, K211R, L234IB
 J9508J9508GQ371950None   D6E, E10D, V31I, L74I, T124A, Q216H, L234FB
 M1546M1546GQ372004None   K14KR, M50I, L74I, I84IV, M154I, V201IB
 N4510N4510GQ372033None   K7KR, S17N, V31I, L63I, I72V, L74I, L101I, K111T, S119T, T124A, I135V, K173R, V176L, T206S, D207E, D256EB
 R4517R4517GQ372132None   D3N, S17N, I72V, L74I, L101M, T112V, G163E, F185X, V201I, E212A, Q216H, D256E, R262RKB
 S0531S0531GQ372147None  A128ATI72V, L74I, T122I, T124A, I208LB
 S6507S6507GQ372160None   E11D, V32I, S39C, I72V, L74I, L101I, G163E, H171Q, V201I, I220V, K240RB
 T2534T2534GQ372179None   E11D, S24N, L74I, E96ED, L101LI, T112A, T125A, V176L, K211RB
 W1523W1523GQ372223None   E11D, S17T, L45I, I72V, L74I, I89L, T124N, K173R, V176L, D256EB
Garrido (2009)18INT-18GU216865None   S17N, V31I, I72V, L74I, K111R, T122I, T124A, T125A, K156N, Y227F, L234V, D256EB
 38INT-38GU216885None   D6DA, E11D, S17T, I72V, L74I, I84V, T112I, K156N, D256E, D279NB
 75INT-75GU216922None   S17N, I72V, L74I, L101I, I113L, T124A, T125A, I203M, K215N, I220L, Q221S, D256EB
 130INT-130GU216977None   E10D, L28I, L45LV, L74I, E152G, G163E, K188KR, V201I, L234H, D256E, G277GSB
 167INT-167GU217014None   S24G, D25E, S39ST, L74I, I89L, L101I, S119G, T122I, T124N, V201I, N222T, L242LFB
 220INT-220GU217067None   E11D, V32I, D41N, M50I, L74I, A91T, K111T, T124A, V201IB
 234INT-234GU217081None   E11D, S24G, D25E, F26Y, V31I, S39C, L74I, I89L, L101I, S119G, T122I, T124N, Q216H, R262RGB
 288INT-288GU217135None   S17N, P30S, V31I, S39C, I60V, I72IV, L74I, T124A, T125A, I203M, D253EB
 307INT-307GU217154None   H16PS, S17N, A23AP, V31I, I72V, L74I, K111R, T124G, T125A, V126L, K156N, N222I, Y227F, L234V, D256EB
 357INT-357GU217204None   E11D, E13D, D25E, P30S, V31I, I60V, L74I, S119P, T122I, T124N, S195T, V201I, I203M, D256EB
Low (2009)G-4G-4FJ786304None   S39C, I72V, L74I, T124A, K156R, K215N, T218I, L234IB
van Hal (2009)W7W7FJ554680None   S17N, S39C, L74I, T112V, K211RB
 W50W50FJ554723None   S17N, S39C, L74I, T112V, K211R, S283GB
 W59W59FJ554732None   S39C, L74I, S119P, T122I, T125A, V176L, Q216HB
 W64W64FJ554737None   E11D, E13D, L74I, L101I, K111T, I113V, T122I, T124A, V201I, T206S, D232E, D253H, D256E, D279G, Q285PB
Wang (2009)CR0164UCR0164UFJ469702None   E11D, S17T, M22I, L28M, V32I, S39R, I72V, L74I, I89L, S119G, T124N, K173R, V176L, D256EB
 CR0192WCR0192WFJ469704None  F121SE11D, L74I, S119P, A265VB
 CR0276ZCR0276ZFJ469714None   M22I, I73V, L74I, Y99L, I113V, T125A, K211R, D256EB
Wittkop (2009)33_J0GU358388None   E10D, V31I, C56A, I60V, I72V, L74I, T124TA, I135IV, F181L, V201I, D256E, Q285Q*B
Arruda (2010)EI028EI028GQ864180None   E10D, S39C, L74I, S119P, T124A, V165I, V201I, A205S, K211R, T218I, L234V, D256E, S283GB
 EI077EI077GQ864218None  V151IE11D, V31I, I72V, L74I, S119P, T122I, V201I, T206S, K219Q, R224Q, D256E, R269K, S283GB
Hatano (2010)2Virus93GU121769None   L63I, I73V, L74I, E96D, L101I, T112IV, I208L, D232EB
Rangel (2010)HIV146pHIV146pGU797501None   L28I, V31I, V37I, L74I, L101I, G163E, T210I, D256E, S283G, Q285PB
 HIV235bHIV235bGU797519None  V54IG70GE, L74I, S119P, M154MI, V201I, D256E, V281MB
 HIV238bHIV238bGU797520None   V31I, L74I, A91T, L101I, S119K, T125A, G163E, D256EB
 HIV238pHIV238pGU797521None   V31I, L74I, A91T, L101I, S119K, T125A, G163E, D256EB
Canducci (2011)Pt10Pt10blJN163904None   S24N, L74I, A91T, L101I, T125A, V201I, Q216HB
Kim (2011)p8p8HM051424None   S17N, V31I, I60M, I72V, L74I, I84M, T124S, T125A, G163E, A205T, G277C, V281MB
Rolland (2011)0524consensus_0524JF320008None   E13D, R20K, D41N, L74I, K111T, T124A, T125A, V201I, K211RB
 2349consensus_2349JF320028None   L63I, L74I, T112I, V201I, D256EB
 0227consensus_0227JF320036None   I72V, L74I, T124TA, V201I, T206S, I208L, K211KR, E212A, K215NB
 2667consensus_2667JF320145None   S17N, V31I, L45Q, L74I, L101I, T124A, T125M, G163E, V201I, Q221K, N222K, S255KB
 0491consensus_0491JF320183None   K7R, E11D, V32I, L74I, L101I, K111T, S119G, T124A, V201IB
 0841consensus_0841JF320196None   M50I, L74I, V79A, L101I, V201I, I220VB
Sanabani (2011)BR1013BR1013JN692432None   D6N, K7Q, S17N, V32I, I72V, L74I, S119P, T124N, T125A, S153A, V176L, T218I, K219N, I220L, N222K, N254S, S255GB
 BR1064BR1064JN692433None   S17N, S39N, I72V, L74I, T125A, I135V, V201I, I203M, T206S, I208L, T218I, D256E, S283GB
 BR1082BR1082JN692465None   D6E, V31I, L74I, T122I, T124A, A175V, V259IB
 BR1097BR1097JN692472None   D6E, E11D, S24N, V31I, L74I, T122I, T124A, G163EB
Brockman (2012)AEHIV13AEHIV13JQ080097None   E11D, E13D, V31I, S57N, I60V, I72V, L74I, I89M, S119P, T122I, T124A, S195T, V201I, I203IM, S283SGB
Iamarino (2012)BF.BR.1365BF.BR.1365JN234043None  V151IE11D, N18S, S24G, L28I, I72V, L74I, E96D, V150A, I208L, E212A, K215Q, N254H, D256E, S283GB
 B.BR.0935B.BR.0935JN234110None   M22L, V37I, S39C, L45I, I72T, L74I, T218S, S230H, D232E, V281MB
Molina (2012)30623062_1 None   D6E, E11D, S17N, V31I, L63I, L74I, E96D, L101I, T112V, T124N, T125A, G134N, K136T, E157Q, K160N, V201I, T206S, K211R, L234I, R269K, S283G, D288NB
 40964096_1 None   D6E, K7KR, S17N, L74I, L101I, T124A, T125TA, G163D, F181FL, R187K, K188KR, K211T, E212A, Q221SB
 33183318_1 None   I72IV, L74I, E96D, L101LI, D256DEB
 40874087_1 None   D6DE, K14R, S24N, L74I, T112IV, T124N, T125A, G134N, K136T, V201I, T206S, L234I, S255N, D256E, S283G, R284G, D286NB
Reigadas (2013)2828JX425496None   D6E, E10D, V31I, V32I, L74I, L101I, G163E, Q216HB
 4444JX425512None   S17N, I72V, L74I, S119T, T124A, T125A, E157Q, K160Q, G193E, V201I, D207N, K211T, D256E, R284G, D288NB
 5151JX425519None   K7R, I72V, L74I, K111Q, I113V, T124A, S283GB
 9898JX425566None   K14R, S17N, A23V, L28I, P30A, E35EK, S39C, I72V, L74I, K103KR, I113V, T124A, V201I, T206S, S230N, I251LB
 101101JX425569None   K14R, V31I, S39C, L74I, L101I, I113L, T125A, H171Q, V201I, Q216H, I220L, Y226YC, N254SB
 105105JX425573None  L68VK14R, S17N, V31I, S39C, L74I, L101I, S119T, T125A, G163E, H171Q, V201I, Q216HB
 113113JX425581None   L74I, L101LI, K111T, S119G, T122TI, T124A, T125TAMV, S230NB
 152152JX425619None   E10D, V31I, I72V, L74I, T112I, S123C, T124N, K211R, D232E, A265VB
 176176JX425643None   S17N, I72V, L74I, I84V, L101I, M154I, V165I, H171L, T218S, I251IT, D256DEB
 255255JX425722None   S17N, V32I, L74I, I84L, S119P, T125A, V201I, K219N, N222KB
Chikata (2014)KI-817KI-817AB874142None   V31I, S39C, S57N, L74I, I84M, S119T, T124A, G163GE, H171HQ, V201I, T206SB
 KI-983KI-983AB874270None   E11D, S17T, L45V, M50I, L74I, T124N, T125A, G163E, E198D, V201I, A205SB
 KI-581KI-581AB873981None   K7R, S17N, L28I, L45I, L74I, K156N, R228RG, D256EB
 KI-580KI-580AB873953None   E11D, V31I, V32I, S39C, L74I, L101I, S119T, I203M, T206S, K211KR, K215NB
 KI-647KI-647AB873992None   L28I, L45I, E69EK, L74I, K156N, R187KB
 KI-752KI-752AB874081None   I72V, L74I, K156NB
 KI-530KI-530AB873932None   V31I, L74I, A86AT, E87ED, V88VI, I141IV, K156NB
 KI-915KI-915AB874210None   L28I, L45I, L74I, L101I, K156N, H171Y, D256E, D286NB
 KI-656KI-656AB874012None   L45V, L74I, L101LI, N120ND, G163E, V176L, K211R, D256EB
 KI-783KI-783AB874111None   K7KR, L74I, T125TA, K156N, H171HQ, D256DEB
 KI-742KI-742AB874073None   V31I, L74I, T125A, M154L, K160KT, G163E, V165I, H171HQ, S195C, V201I, K215N, S230N, L234V, D279GB
 KI-681KI-681AB874033None   V31I, L74I, L101I, V201I, I203L, K215N, Q221S, N222K, D256E, R269KB
 KI-652KI-652AB873993None   L28I, L45LI, M50MI, L74I, T112TI, G163GE, V201I, T206S, T218I, L234I, D286NB
 KI-741KI-741AB874072None   S24A, L45V, L74I, V176L, K211R, D256EB
 KI-795KI-795AB874122None   K14KR, S17SN, L28LM, V31VI, V32I, I72IV, L74I, H171HQ, V201I, K215N, Q221S, N222K, D256E, R269RKB
 KI-806KI-806AB874126None   D6E, S24G, D25E, L45V, L74I, K215S, D256EB
 KI-636KI-636AB873997None   L28I, L45I, M50I, L74I, K156N, R187KB
 KI-730KI-730AB874062None   L45I, L74I, K156NB
 KI-697KI-697AB874047None   D25E, I72T, L74I, L101V, K103R, T124A, K156N, V165I, I200L, V201I, T218SB
 KI-663KI-663AB874018None   L28I, L45I, L74I, K156N, R187KB
 KI-586KI-586AB873947None   E10D, V31I, S57N, L74I, I84M, L101I, G106A, S119T, T124A, G163E, V201I, T206SB
 KI-654KI-654AB874009None   L68M, L74I, E96D, L101V, K103R, T124A, K156N, I200L, V201I, A205S, T218S, A276AV, C280CGB
 KI-891KI-891AB874191None   L74I, L101I, K156N, I208LB
 KI-921KI-921AB874218None   S17N, L28I, S39C, L74I, K111KR, T125A, M154MI, K156N, I162V, K173KR, V201I, T218SB
Stekler (2014)PIC1884PGX51PIC1884PGX51 None   S39C, L74I, T124A, I161ILM, V201IB
 PIC1916PHI49PIC1916PHI49 None   E10D, M50T, L74I, A91E, K111T, S119R, T124N, V165I, V201I, E212A, K215Q, D279G, R284GB
 ACTU9182PHI54ACTU9182PHI54 None   E11D, V31I, V32I, V37I, I72AT, L74I, S119P, T124A, T125A, K136N, D167E, V201I, T218I, L234IB
 PIC1835PHI52PIC1835PHI52 None   E11D, V31I, V32I, V37I, I72T, L74I, S119P, T124A, T125A, K136N, D167E, V201I, T218I, L234IB
 ACTU9176PHI55ACTU9176PHI55 None   E11D, V31I, V32I, V37I, I72T, L74I, S119P, T124A, T125A, K136N, D167E, V201I, T218I, L234IB
 PIC1850PHD50PIC1850PHD50 None   E11D, V31I, V32I, V37I, I72T, L74I, T124A, T125A, K136N, D167E, V201I, T218I, L234IB
 PIC1884PHD51PIC1884PHD51 None   S39C, L74I, T124A, I161ILM, G163GA, V201IB
 PIC1810PFQ50PIC1810PFQ50 None   E11D, K14R, S39C, I72V, L74I, L101I, S119P, V176T, S195T, V201I, I203IM, S230NB