<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Integrase Inhibitors

Subtype B
Gene IN
Mutation L74I
Rx >=1 INI
IncludeMixtures No
References 7
Patients 42
Isolates 48
 
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# INIs WksINIMajorDRMs INIMinorDRMs OtherMutSubtype
Hatano (2010)2Virus114GU121790RAL G140S, Q148H L63I, I73V, L74I, E96D, L101I, T112I, I208L, D232E, L234LFB
  Virus8GU121684RAL G140S, Q148H L63I, I73V, L74I, E96D, L101I, T112I, I208L, D232EB
Canducci (2011)Pt10Pt10w20JN163905RAL21Q148R S24N, L74I, L101I, T125A, V201I, Q216HB
  Pt10w32JN163907RAL35G140S, Q148H S24N, D41N, L74I, A91T, L101I, T125A, V201I, Q216H, N254SB
Garrido (2012)BAA295899BAA295899JQ716895RAL52  E11D, V32I, S39C, L74I, V201I, I203M, I208L, K215NB
Molina (2012)30623062_2 EVG12E92EQ D6E, E11D, S17N, V31I, L63I, L74I, E96D, L101I, T112V, T124N, T125A, G134N, K136T, E157Q, K160N, V201I, T206S, T210TI, K211R, L234I, R269K, S283G, D288NB
  3062_3 EVG25E92EQ, G140GA, Q148QRL68LVD6E, E11D, S17N, V31I, L63I, L74I, E96D, L101I, T112V, T124N, T125A, G134N, K136T, E157Q, K160N, V201I, T206S, T210TI, K211R, L234I, R269K, S283G, D288NB
 40964096_2 RAL20  D6E, K7KR, S17N, L74I, L101I, T124A, T125A, G163D, R187K, K188KR, K211T, E212A, Q221SB
  4096_3 RAL48  D6E, K7KR, S17N, L74I, L101I, T124A, T125A, G163D, R187K, K188KR, K211T, E212A, Q221SB
 33183318_2 EVG20  V31VI, I72IV, L74I, E96D, L101LI, K160KN, D256DEB
  3318_3 EVG29  I72IV, L74I, E96D, D256DEB
 40874087_2 EVG29  K14R, S24NT, M50MI, L74I, T112IV, T124N, T125A, G134N, K136T, V201I, T206S, L234I, S255N, D256E, D279DG, S283G, R284G, D286NB
Souza Cavalcanti (2012)BRSPBR10SP267CJQ797720RAL74F121YT97A, V151IE11D, K14R, S24D, L28I, S39C, I72V, L74I, S119P, Q137H, Q164K, R187K, V201I, D232E, L234FB
  BR11SP363BJQ797725RAL135Y143RT97AE11D, E13X, K14R, S24D, L28I, S39C, K42KR, L74I, S119P, Q164K, R187K, V201I, D232E, L234IB
de Souza Cavalcanti (2014)BRSP2821BRSP2821 RAL G140S, Q148H S17N, V32I, I72IV, L74I, T124A, T125M, K136Q, V165I, V201I, L234V, D256E, V259I, S283GB
 BRSP380BRSP380 RAL N155HE138D, V151IE11D, D25E, L28I, V37I, S39C, M50L, L74I, L101LF, T124A, E157Q, K160T, I203M, I208M, D232N, L234I, D253E, N254GB
 BRSP267BRSP267 RAL F121YT97A, V151IE11D, K14R, S24D, L28I, S39C, I72V, L74I, S119P, Q137H, Q164K, R187K, V201I, D232E, L234FB
 BRSP148BRSP148 RAL G140S, Q148H S17N, A21S, D25E, V31I, L63LI, L74I, L101I, K111R, I113L, S119P, T122I, T125A, G163E, H171Q, T218S, S283GB
 BRSP584BRSP584 RAL   D6N, K14R, S17N, S24D, D25E, L28I, S39C, L45I, M50I, L74I, D279H, S283GB
 BRSP263BRSP263 RAL   D6N, K7E, V31I, L74I, T112I, T125A, F181L, T206S, L234I, D288NB
 BRSP239BRSP239 RAL E138K, S147G, Q148RV151I, G163RK14R, L74I, V75M, V79I, S119P, T122I, T124A, T125A, K156N, V201I, T218I, L234V, D256E, S283G, R284GB
Hurt (2014)IN_2589IN_2589 RAL Y143CT97A, S230RK14R, L63LI, L74I, L101I, S119ST, G134GE, D167E, I208L, K211QB
 IN_2414IN_2414 RAL Y143CV54I, T97A, S230RS17N, V31VI, L74I, L101I, T112A, S119T, T124A, R187K, K188R, K211R, D256EB
 IN_1808IN_1808 RAL N155HV151I, G163KD6E, E11D, S24N, V31I, K42R, M50I, I73V, L74I, I84L, Q95H, L101I, I113L, T124HQ, E157Q, K160Q, V201I, T206S, K211R, L234LV, K240RB
 IN_920IN_920 RAL N155HV151IL45I, M50R, E69D, I72V, L74I, I84L, L101I, T112R, T125A, E157Q, K160Q, G163V, V201I, E212A, K215N, D256E, R284GB
 IN_385IN_385 RAL N155HV151IE11D, S24N, V31VI, M50I, L68F, L74I, T112R, I113V, S119P, T122I, T124N, E157Q, K160Q, V201I, I203IM, T206S, I208L, K211KR, E212AB
 IN_2999IN_2999 RAL Y143YCHRT97TAK7R, S17N, V31I, L74I, F100Y, L101I, K111T, S119T, T124TA, T125A, T206S, T218TS, D256EB
 IN_2024IN_2024 RAL N155H L74I, G163E, I208IM, Q216H, Q221R, L234H, S255SRB
 IN_2095IN_2095 RAL E138K, S147G, Q148RV54VI, V151VIV31I, A49P, L74I, V79I, L101I, T124TA, I141V, I203IM, I204IVB
 IN_1998IN_1998 RAL Y143YCHRT97TAV31I, I60IM, L74I, T112I, T124A, T125A, V126M, E157Q, K160Q, F181L, T206S, N254Q, S255SGB
 IN_1770IN_1770 RAL Y143R D25E, V31I, M50MI, L74I, K111KR, S119T, T125A, G163Q, V201VI, T218SB
 IN_2231IN_2231 RAL  T97A, Y143GE11D, V31I, V32I, V37I, L63I, I72IV, L74I, L101I, T112TK, T115S, S119R, T124TN, V201I, S230NB
 IN_2021IN_2021 RAL Y143RT97AV31I, I60M, L74I, T112I, T124A, T125A, V126M, E157Q, K160Q, F181L, T206S, N254QB
 IN_3306IN_3306 RAL G140S, Q148R S17N, V31I, L63I, L74I, L101I, T112TA, I113IL, K156N, Q216H, L234LV, D256EB
 IN_758IN_758 RAL Y143RT97AV31I, L74I, T112I, T124A, T125A, V126M, E157Q, K160Q, F181L, T206S, N254Q, S255SG, V259VI, S283SGB
 IN_425IN_425 RAL E138KT, G140S, Q148H K7KR, E11D, S24N, V31I, L74I, S119R, S123C, T124N, K156N, G163GE, T218IL, L234IV, N254NKB
 IN_2785IN_2785 RAL E92QT97A, V151IE11D, K14R, S24N, D41DN, L63I, L74I, L101I, T112S, T125A, G163E, V201I, I208M, L234V, D279GB
 IN_1952IN_1952 RAL G140GS, Q148QHKNG163GRS17N, V31VI, I72V, L74I, I89IL, I113IL, T124A, T125A, K156N, D167E, V201I, I220L, Y227F, S230N, D256EB
 IN_1550IN_1550 RAL N155NH S39SC, M50I, L74I, L101I, K111T, T124TA, E157Q, K160S, G193R, V201I, D253E, I268LB
 IN_1596IN_1596 RAL N155NHT97TAV31I, M50T, I72V, L74I, K111T, T112V, T206S, D207DEB
 IN_2739IN_2739 RAL G140S, Q148RG163RL63V, I72V, L74I, T112TI, T124A, K156N, I182V, V201I, N254Q, V259IB
 IN_3034IN_3034 RAL N155HV151IS17N, V31I, I72V, L74I, L101I, I113V, T124S, T125A, I135IV, K156N, H171Q, F181L, V201I, T206S, Q221R, D232DN, A265V, R284IB
 IN_3296IN_3296 RAL E92EQT97TA, V151VIE11D, K14R, S24N, L63LI, L74I, L101I, T112TS, T125A, I135IV, G163E, R166RK, V201I, T210TI, L234V, D279G, D286DNB
 IN_119IN_119 RAL  T97A, Y143SS17N, V31I, M50I, L74I, L101I, K111R, S119R, T124N, I135V, K188R, S230N, K264RB
 IN_1993IN_1993 RAL N155HV151IK14KR, V31VI, M50I, L74I, L101I, T124S, I135V, E157Q, K160T, F181L, Y194YC, V201I, T206S, K211KR, T218S, I220L, Y227F, D253Y, I268L, S283GB
 IN_994IN_994 RAL G140S, Q148R K14R, V31I, K42KR, M50T, L63LV, L74I, K111T, T206S, D256DE, V259VIB
 IN_2186IN_2186 RAL Y143RT97AK7R, M50V, I72V, L74I, L101I, S119P, I135V, G163GE, H171QB
 IN_347IN_347 RAL E92V, N155H D6E, K34R, L74I, T124A, H171Y, V201I, K211R, S230N, M275VB