<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Integrase Inhibitors

Subtype B
Gene IN
Mutation L74I
Rx >=1 INI
IncludeMixtures No
References 5
Patients 11
Isolates 14
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# INIs WksINIMajorDRMs INIMinorDRMs OtherMutSubtype
Hatano (2010)2Virus114GU121790RAL G140S, Q148H L63I, I73V, L74I, E96D, L101I, T112I, I208L, D232E, L234LFB
  Virus8GU121684RAL G140S, Q148H L63I, I73V, L74I, E96D, L101I, T112I, I208L, D232EB
Canducci (2011)Pt10Pt10w20JN163905RAL21Q148R S24N, L74I, L101I, T125A, V201I, Q216HB
  Pt10w32JN163907RAL35G140S, Q148H S24N, D41N, L74I, A91T, L101I, T125A, V201I, Q216H, N254SB
Garrido (2012)BAA295899BAA295899JQ716895RAL52  E11D, V32I, S39C, L74I, V201I, I203M, I208L, K215NB
Souza Cavalcanti (2012)BRSPBR10SP267CJQ797720RAL74F121YT97A, V151IE11D, K14R, S24D, L28I, S39C, I72V, L74I, S119P, Q137H, Q164K, R187K, V201I, D232E, L234FB
  BR11SP363BJQ797725RAL135Y143RT97AE11D, E13X, K14R, S24D, L28I, S39C, K42KR, L74I, S119P, Q164K, R187K, V201I, D232E, L234IB
de Souza Cavalcanti (2014)BRSP2821BRSP2821 RAL G140S, Q148H S17N, V32I, I72IV, L74I, T124A, T125M, K136Q, V165I, V201I, L234V, D256E, V259I, S283GB
 BRSP380BRSP380 RAL N155HE138D, V151IE11D, D25E, L28I, V37I, S39C, M50L, L74I, L101LF, T124A, E157Q, K160T, I203M, I208M, D232N, L234I, D253E, N254GB
 BRSP267BRSP267 RAL F121YT97A, V151IE11D, K14R, S24D, L28I, S39C, I72V, L74I, S119P, Q137H, Q164K, R187K, V201I, D232E, L234FB
 BRSP148BRSP148 RAL G140S, Q148H S17N, A21S, D25E, V31I, L63LI, L74I, L101I, K111R, I113L, S119P, T122I, T125A, G163E, H171Q, T218S, S283GB
 BRSP584BRSP584 RAL   D6N, K14R, S17N, S24D, D25E, L28I, S39C, L45I, M50I, L74I, D279H, S283GB
 BRSP263BRSP263 RAL   D6N, K7E, V31I, L74I, T112I, T125A, F181L, T206S, L234I, D288NB
 BRSP239BRSP239 RAL E138K, S147G, Q148RV151I, G163RK14R, L74I, V75M, V79I, S119P, T122I, T124A, T125A, K156N, V201I, T218I, L234V, D256E, S283G, R284GB