Integrase Inhibitors

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Integrase Inhibitors

Subtype	B
Gene	IN
Mutation	I72V
Rx	>=1 INI
IncludeMixtures	No

References	10
Patients	35
Isolates	53

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr)	Patient	Isolate	Acc#	INIs	Wks	INIMajorDRMs	INIMinorDRMs	OtherMut	Subtype
Charpentier (2008)	Pt3	Pt3-W9		RAL	9			I72V, T124A, K156N, D167E, S283G, D288N	B
		Pt3-W11		RAL	11	Q148QR		I72V, T124A, K156N, D167E, S283G, D288N	B
		Pt3-W15		RAL	15	G140S, Q148R		I72V, T124TA, K156N, D167E, S283G, D288N	B
Malet (2008)	1a	SH1-W12	FJ538986	RAL	13	G140S, Q148H		K7Q, E11D, V31I, M50L, I72V, L101I, T124A, I135V, I200L, V201I, I220L	B
	2d	H2-W28	FJ538976	RAL	29	E92Q, N155H		E11D, V31M, V32I, S39C, I72V, L101I, K111R, S119P, I135V, G193E, V201I, T218S	B
	3	3_W14		RAL	14	E92Q		R20K, A23V, I72V, T124A, I204V, T206S	B
Baldanti (2009)	PV1	PV1	GU350727	RAL	26			R20K, I72V, T112I, S119T, V201I, S230N, D232E	B
	PV2	PV2	GU350733	RAL	51	Q148R		E10D, I72V, L101I, K156N, L234I	B
	PV3	PV3	GU350736	RAL	13	G140S, Q148H, N155H		S17N, I72V, T124A, M154I, E170A, V201I	B
Garrido (2009)	Pt04	Pt04		RAL		N155H	V151I	E11D, S17T, I72V, E198D, V201I, K211R, D270DA	B
	Pt12	Pt12		RAL				I72V, T112I, I113V, S119P, T122I, T206S, T218S	B
	Pt13	Pt13		RAL				Y15YN, S17N, N18D, A21T, M50R, G59E, I72V, L101I, S119T, T124N, V201I	B
	Pt16	Pt16		RAL				V31VI, I72V, T112V, S119G, T122I, T124A, V201I, I203M, K219N, N222K	B
Wittkop (2009)	11	11_M3	GU358372	RAL	12			V31VM, L45Q, I72V, V201I, K211Q, P233PS	B
		11_M6	GU358373	RAL	25			A23V, V31I, I72V, V201I, K211Q	B
		11_M12	GU358374	RAL	52			A23V, I72V, V201I, K211Q	B
	1	1_M6	GU358379	RAL	25	G140S, Q148H		E10D, R20K, V32I, M50I, I72V, L101I, S119G, T122I, T125A, F181L, K211R, Q221S, N222K	B
		1_M9	GU358380	RAL	39	E138EA, G140S, Q148H		E10D, R20K, V32I, L45LI, M50I, I72V, L101I, S119G, T122I, T125A, F181L, K211R, Q221S, N222K, V259VI	B
		1_M12	GU358381	RAL	52	E138EA, G140S, Q148H		E10D, R20K, V32VI, M50I, I72V, L101I, S119G, T122I, T125A, F181L, K211R, Q221S, N222K, V259VI	B
	7	7_M3	GU358385	RAL	12	N155H		S17N, I72V, L101I, S119G, T122I, T125A, A169S, T218S, I220L, Y227F	B
		7_M6	GU358386	RAL	25	Y143YCHR	T97TA, G163GR	S17N, I72V, L101I, S119G, T122I, T125A, A169S, T218TS, I220L, Y227F	B
		7_M9	GU358387	RAL	39	Y143YCHR	T97TA, G163GR	S17N, I72V, L101I, G106GA, S119G, T122I, T125A, A169FS, F185FL, S195SN, A196AT, T218TS, I220L, Y227F	B
Hatano (2010)	18	Virus19	GU121695	EVG				K7R, I72V, V88I, K111Q, I113V, T124A, T125A, G163E, I203M, I208L, L234I	B
		Virus91	GU121767	EVG				K7R, I72V, V88I, K111Q, I113V, T124A, T125A, G163E, I203IM, I208L, L234I	B
		Virus94	GU121770	EVG		E92Q		K7KR, D41DN, I72V, V88I, K111Q, I113V, T124A, T125A, G163E, I203M, I208L, E212EA, L234I	B
	17	Virus99	GU121775	EVG		E138K, S147G, Q148R		K7KR, I72V, V79VI, V88I, K111Q, I113V, T124A, T125A, G163E, I203M, I208L, L234I	B
		Virus100	GU121776	EVG		E138K, S147G, Q148R	V54VI	K7KR, I72V, V79I, V88I, K111Q, I113V, T124A, T125A, G163E, I203M, I208L, L234I	B
		Virus20	GU121696	EVG		E138K, S147G, Q148R	V54I	K7KR, E35EK, I72V, V79I, V88I, K111Q, I113V, T124A, T125A, G163E, I203M, I208L, L234I	B
	5	Virus27	GU121703	RAL		G140S, Q148H		S17N, I72V, L101I, K156N, V201I, D207DG, I208L	B
		Virus28	GU121704	RAL		E138EK, G140GS, Q148QH		S17N, I72V, L101LI, K156N, V201I, I208L, D286DN	B
	8	Virus30	GU121706	RAL		G140GS, Q148QH		S17N, I72V, A98AT, L101I, K156KN, V201I, I208L, D286DN	B
		Virus32	GU121708	RAL		E138EK, G140GS, Q148QH	N155ND	S17N, I72V, L101LI, K156KN, V201I, I208L, D256DE, D286DN	B
	7	Virus120	GU121796	RAL			V151I	D25E, I72V, H78HR, K211R, K215N, L234LF	B
		Virus129	GU121805	RAL		G140S, Q148H	V151I	D25E, I72V, K211R, K215N	B
Blanco (2011)	CA794	CA124207		RAL	1			K14KR, R20K, I72V, L101I, I113L, G193E, I203IM, S230N, D278A	B
		CA124206		RAL	3			K14R, R20K, I72V, L101I, I113L, E170EK, G193E, S230N, D278A	B
		CA124208		RAL	17			R20K, I72V, L101I, I113L, G193E, S230N, D278A	B
	CA25140	CA153557		RAL	86			S17N, K34R, I72V, T124A, V201I, T206S, T218S, D270E	B
Brenner (2011)	INT3	INT3_1	HQ207824	RAL				E11D, S24N, V31I, L45V, I72V, T112V, S119P, T122I, T125A, I203IM, K215N	B
	INT9	INT9_1	HQ207832	RAL		G140GS, Q148H		V31I, I72V, T124N, V126M, I135V, A265V	B
	102001.076	102001.076	HQ423441	RAL		T66I	T97A, G163R	E11D, D25E, V31I, I60V, I72V, A91T, G106A, T112I, I113V, S119P, T124N, T125V, I203M, A205T, D256E, D278DY	B
Garrido (2012)	BAA295879	BAA295879	JQ716868	RAL	52	E138EK		E11D, S24G, D25E, S39C, E69EK, I72V, L101I, R107RK, E152EK, M154MI, V201I, S283SG	B
	BAA295881	BAA295881	JQ716874	RAL	52			K14R, V31I, M50I, I72V, L101I, S119G, T122I, G163E, H171Q, V201I	B
	BAA295883	BAA295883	JQ716876	RAL	52			K14R, S17N, N18D, A21T, M50R, G59E, I72V, L101I, S119T, T124N, V201I, S283SG	B
	BAA295884	BAA295884	JQ716877	RAL	52			A23AV, I72V, T112I, I113V, S119P, T122I, T206S, T218S	B
	BAA295885	BAA295885	JQ716878	RAL	52			V31I, I72V, T112V, S119G, T122I, T124A, V201I, K219N, N222K	B
	BAA295862	BAA295862	JQ716884	RAL	52			R20K, I72V, L101I, I113L, T124N, T125V, I204V, T206S	B
	BAA295867	BAA295867	JQ716886	RAL	52			S17N, A23AV, V31I, I72V, K103R, T112I, T124N, T125V, K156N, V201I, T206S, S283G	B
	BAA295870	BAA295870	JQ716888	RAL	52	Y143R	T97TA, V151VI	S17N, V31I, M50T, I72V, V75VI, T124A, K156N, T206S, I220IV, D232DN, D256E	B
	BAA295905	BAA295905	JQ716898	RAL	52	G140GS, Q148QH		E10D, V31I, I72V, L101I, S119G, T122I, T125A, K156N, V201I, T206S, Q216H, Q221R, D256E	B
	BAA295908	BAA295908	JQ716899	RAL	52		R263K	M50I, I72V, S119P, T124A, V201I, I220L	B
	BAA295906	BAA295906	JQ716918	RAL	52			H51Q, I72V, L101I, T112I, T122I, T124DN, H171Q, I220L, A265V	B
Souza Cavalcanti (2012)	BRSP	BR10SP267C	JQ797720	RAL	74	F121Y	T97A, V151I	E11D, K14R, S24D, L28I, S39C, I72V, L74I, S119P, Q137H, Q164K, R187K, V201I, D232E, L234F	B

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