<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Integrase Inhibitors

Subtype B
Gene IN
Mutation I72V
Rx >=1 INI
IncludeMixtures No
References 12
Patients 37
Isolates 58
 
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# INIs WksINIMajorDRMs INIMinorDRMs OtherMutSubtype
Charpentier (2008)Pt3Pt3-W9 RAL9  I72V, T124A, K156N, D167E, S283G, D288NB
  Pt3-W11 RAL11Q148QR I72V, T124A, K156N, D167E, S283G, D288NB
  Pt3-W15 RAL15G140S, Q148R I72V, T124TA, K156N, D167E, S283G, D288NB
Malet (2008)1aSH1-W12FJ538986RAL13G140S, Q148H K7Q, E11D, V31I, M50L, I72V, L101I, T124A, I135V, I200L, V201I, I220LB
 2dH2-W28FJ538976RAL29E92Q, N155H E11D, V31M, V32I, S39C, I72V, L101I, K111R, S119P, I135V, G193E, V201I, T218SB
 33_W14 RAL14E92Q R20K, A23V, I72V, T124A, I204V, T206SB
Baldanti (2009)PV1PV1GU350727RAL26  R20K, I72V, T112I, S119T, V201I, S230N, D232EB
 PV2PV2GU350733RAL51Q148R E10D, I72V, L101I, K156N, L234IB
 PV3PV3GU350736RAL13G140S, Q148H, N155H S17N, I72V, T124A, M154I, E170A, V201IB
Garrido (2009)Pt04Pt04 RAL N155HV151IE11D, S17T, I72V, E198D, V201I, K211R, D270DAB
 Pt12Pt12 RAL   I72V, T112I, I113V, S119P, T122I, T206S, T218SB
 Pt13Pt13 RAL   Y15YN, S17N, N18D, A21T, M50R, G59E, I72V, L101I, S119T, T124N, V201IB
 Pt16Pt16 RAL   V31VI, I72V, T112V, S119G, T122I, T124A, V201I, I203M, K219N, N222KB
Wittkop (2009)1111_M3GU358372RAL12  V31VM, L45Q, I72V, V201I, K211Q, P233PSB
  11_M6GU358373RAL25  A23V, V31I, I72V, V201I, K211QB
  11_M12GU358374RAL52  A23V, I72V, V201I, K211QB
 11_M6GU358379RAL25G140S, Q148H E10D, R20K, V32I, M50I, I72V, L101I, S119G, T122I, T125A, F181L, K211R, Q221S, N222KB
  1_M9GU358380RAL39E138EA, G140S, Q148H E10D, R20K, V32I, L45LI, M50I, I72V, L101I, S119G, T122I, T125A, F181L, K211R, Q221S, N222K, V259VIB
  1_M12GU358381RAL52E138EA, G140S, Q148H E10D, R20K, V32VI, M50I, I72V, L101I, S119G, T122I, T125A, F181L, K211R, Q221S, N222K, V259VIB
 77_M3GU358385RAL12N155H S17N, I72V, L101I, S119G, T122I, T125A, A169S, T218S, I220L, Y227FB
  7_M6GU358386RAL25Y143YCHRT97TA, G163GRS17N, I72V, L101I, S119G, T122I, T125A, A169S, T218TS, I220L, Y227FB
  7_M9GU358387RAL39Y143YCHRT97TA, G163GRS17N, I72V, L101I, G106GA, S119G, T122I, T125A, A169FS, F185FL, S195SN, A196AT, T218TS, I220L, Y227FB
Hatano (2010)18Virus19GU121695EVG   K7R, I72V, V88I, K111Q, I113V, T124A, T125A, G163E, I203M, I208L, L234IB
  Virus91GU121767EVG   K7R, I72V, V88I, K111Q, I113V, T124A, T125A, G163E, I203IM, I208L, L234IB
  Virus94GU121770EVG E92Q K7KR, D41DN, I72V, V88I, K111Q, I113V, T124A, T125A, G163E, I203M, I208L, E212EA, L234IB
 17Virus99GU121775EVG E138K, S147G, Q148R K7KR, I72V, V79VI, V88I, K111Q, I113V, T124A, T125A, G163E, I203M, I208L, L234IB
  Virus100GU121776EVG E138K, S147G, Q148RV54VIK7KR, I72V, V79I, V88I, K111Q, I113V, T124A, T125A, G163E, I203M, I208L, L234IB
  Virus20GU121696EVG E138K, S147G, Q148RV54IK7KR, E35EK, I72V, V79I, V88I, K111Q, I113V, T124A, T125A, G163E, I203M, I208L, L234IB
 5Virus27GU121703RAL G140S, Q148H S17N, I72V, L101I, K156N, V201I, D207DG, I208LB
  Virus28GU121704RAL E138EK, G140GS, Q148QH S17N, I72V, L101LI, K156N, V201I, I208L, D286DNB
 8Virus30GU121706RAL G140GS, Q148QH S17N, I72V, A98AT, L101I, K156KN, V201I, I208L, D286DNB
  Virus32GU121708RAL E138EK, G140GS, Q148QHN155NDS17N, I72V, L101LI, K156KN, V201I, I208L, D256DE, D286DNB
 7Virus120GU121796RAL  V151ID25E, I72V, H78HR, K211R, K215N, L234LFB
  Virus129GU121805RAL G140S, Q148HV151ID25E, I72V, K211R, K215NB
Blanco (2011)CA794CA124207 RAL1  K14KR, R20K, I72V, L101I, I113L, G193E, I203IM, S230N, D278AB
  CA124206 RAL3  K14R, R20K, I72V, L101I, I113L, E170EK, G193E, S230N, D278AB
  CA124208 RAL17  R20K, I72V, L101I, I113L, G193E, S230N, D278AB
 CA25140CA153557 RAL86  S17N, K34R, I72V, T124A, V201I, T206S, T218S, D270EB
Brenner (2011)INT3INT3_1HQ207824RAL   E11D, S24N, V31I, L45V, I72V, T112V, S119P, T122I, T125A, I203IM, K215NB
 INT9INT9_1HQ207832RAL G140GS, Q148H V31I, I72V, T124N, V126M, I135V, A265VB
 102001.076102001.076HQ423441RAL T66IT97A, G163RE11D, D25E, V31I, I60V, I72V, A91T, G106A, T112I, I113V, S119P, T124N, T125V, I203M, A205T, D256E, D278DYB
Canducci (2011)Pt8Pt8w12JN163901RAL13Y143R, N155H S17N, A49S, I72V, T124A, M154I, E170A, V201I, G277RB
Armenia (2012)PT_84PT_84_MO_2JN544107RAL Q148QR D6S, K7E, S17N, I72V, V201I, D256EB
  PT_84_MO_4JN544109RAL G140S, Q148R D6S, K7E, S17N, I72V, V201I, D256EB
  PT_84_MO_5JN544110RAL G140S, Q148QR D6S, K7E, S17N, I72V, Q164QR, V201I, D256E, A276ATB
  PT_84_MO_9sJN544111RAL   D6S, K7E, S17N, I72V, V201I, D256EB
Garrido (2012)BAA295879BAA295879JQ716868RAL52E138EK E11D, S24G, D25E, S39C, E69EK, I72V, L101I, R107RK, E152EK, M154MI, V201I, S283SGB
 BAA295881BAA295881JQ716874RAL52  K14R, V31I, M50I, I72V, L101I, S119G, T122I, G163E, H171Q, V201IB
 BAA295883BAA295883JQ716876RAL52  K14R, S17N, N18D, A21T, M50R, G59E, I72V, L101I, S119T, T124N, V201I, S283SGB
 BAA295884BAA295884JQ716877RAL52  A23AV, I72V, T112I, I113V, S119P, T122I, T206S, T218SB
 BAA295885BAA295885JQ716878RAL52  V31I, I72V, T112V, S119G, T122I, T124A, V201I, K219N, N222KB
 BAA295862BAA295862JQ716884RAL52  R20K, I72V, L101I, I113L, T124N, T125V, I204V, T206SB
 BAA295867BAA295867JQ716886RAL52  S17N, A23AV, V31I, I72V, K103R, T112I, T124N, T125V, K156N, V201I, T206S, S283GB
 BAA295870BAA295870JQ716888RAL52Y143RT97TA, V151VIS17N, V31I, M50T, I72V, V75VI, T124A, K156N, T206S, I220IV, D232DN, D256EB
 BAA295905BAA295905JQ716898RAL52G140GS, Q148QH E10D, V31I, I72V, L101I, S119G, T122I, T125A, K156N, V201I, T206S, Q216H, Q221R, D256EB
 BAA295908BAA295908JQ716899RAL52 R263KM50I, I72V, S119P, T124A, V201I, I220LB
 BAA295906BAA295906JQ716918RAL52  H51Q, I72V, L101I, T112I, T122I, T124DN, H171Q, I220L, A265VB
Souza Cavalcanti (2012)BRSPBR10SP267CJQ797720RAL74F121YT97A, V151IE11D, K14R, S24D, L28I, S39C, I72V, L74I, S119P, Q137H, Q164K, R187K, V201I, D232E, L234FB