<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Integrase Inhibitors

Subtype B
Gene IN
Mutation S230N
Rx >=1 INI
IncludeMixtures No
References 11
Patients 93
Isolates 117
 
Show mutation frequency as:
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# INIs WksINIMajorDRMs INIMinorDRMs OtherMutSubtype
Baldanti (2009)PV1PV1GU350727RAL26  R20K, I72V, T112I, S119T, V201I, S230N, D232EB
Canducci (2009)pt7pt7w4EU908766RAL4  S24A, L101I, T112TI, T125A, I135V, F181L, T206S, D229E, S230N, D256EB
  pt7w8EU908767RAL8  S24A, L101I, T125A, I135V, F181L, T206S, D229E, S230N, D256DEB
  pt7w12EU908768RAL13  S24A, L101I, T125A, I135V, F181L, T206S, D229E, S230N, D256EB
  pt7w20EU908769RAL21  S24A, T125A, I135V, F181L, T206S, D229E, S230N, D256EB
  pt7w24EU908770RAL26  S24A, L101LI, T125A, I135V, F181L, T206S, D229E, S230N, D256EB
Garrido (2009)Pt10Pt10 RAL   E10D, V32I, S39C, L101I, T218S, S230N, D253EB
Sichtig (2009)Pt044833FJ183697RAL41N155HV151VI, G163GRS17N, V31I, T112V, T124N, T125A, V126L, S230N, D256EB
  4951FJ183698RAL50N155HV151I, G163RS17N, V31I, T112V, T124N, T125A, V126L, S230N, D256EB
Blanco (2011)CA794CA124207 RAL1  K14KR, R20K, I72V, L101I, I113L, G193E, I203IM, S230N, D278AB
  CA124206 RAL3  K14R, R20K, I72V, L101I, I113L, E170EK, G193E, S230N, D278AB
  CA124208 RAL17  R20K, I72V, L101I, I113L, G193E, S230N, D278AB
DeJesus (2012)72997299_2 EVG32G140C, Q148R K14R, S17N, K34R, G59E, S119P, T124N, T125A, H183HP, V201I, S230N, D256EB
 74767476_2 EVG16T66TI, E92EQ, N155NH K14R, S24N, C65CG, L101V, K111R, T112V, T124A, V126M, E157EQ, K160Q, D167E, V201I, K211R, S230NB
  7476_3 EVG20T66TI, E92EQ, N155NH K14R, S24N, C65CG, G70GR, L101V, K111R, T112V, T124A, V126M, E157EQ, K160Q, D167E, V201I, K211R, S230NB
Garrido (2012)BAA295858BAA295858JQ716881RAL52  E10D, V32I, S39C, L101I, T218S, S230N, D253EB
 BAA295859BAA295859JQ716882RAL52  E10D, V32I, S39C, L101I, T218S, S230N, D253EB
 BAA295860BAA295860JQ716883RAL52  E10D, V32I, S39C, L101I, T218S, S230N, D253EB
 BAA295864BAA295864JQ716885RAL52  K7R, K14R, L101I, T112I, S230NB
Molina (2012)30943094_2 EVG36  E11D, D25E, V31I, S39SI, I60IT, P90PS, K111T, I113IV, S119T, T125TA, V126M, V201I, S230N, A248AT, I251IL, A265VB
 40924092_2 RAL17N155H K14R, V31I, T124TNDA, T125TA, K215N, S230N, R231K, D253E, N254Q, S255G, D256E, K258N, V259L, V260LB
 41624162_2 RAL24  E11D, S24G, D25E, L28I, S39C, K71R, K215N, S230NB
 33263326_2 RAL42G140S, Q148H E11D, S24N, K34R, I72IV, I84M, A91T, L101I, T125V, I161T, V201I, K211KR, S230N, V260L, P261F, S283GB
  3326_3 RAL48G140S, Q148H E11D, S24N, K34R, I72IV, I84M, A91T, L101I, T125V, I161IT, V201I, K211R, S230N, S283GB
 41034103_2 RAL94  E11D, S24N, S39C, T124TA, V201I, S230N, R284RGB
 40204020_2 EVG73  V31I, P90S, T112AV, T124A, G134GS, M154L, K211R, T218S, S230N, S283GB
 34563456_2 RAL73N155NH K14R, V32I, L101I, T124N, M154MI, V201I, N222H, S230N, D256EB
 32773277_2 RAL19 A128TE11D, E13D, M50L, L101I, K111T, T125A, Y227F, S230N, L241LF, D256E, A265VB
 41254125_2 EVG16  G4GE, E11D, S24N, V31VM, V32VI, L101I, I135IV, K136T, T206S, I208L, T218S, S230N, D232E, I251IMB
  4125_3 EVG20  E11D, S24N, I72IV, L101I, I135V, K136T, T206S, I208L, T218S, S230N, D232DEB
  4125_4 EVG37  E11D, S24N, L101I, I135IV, K136T, T206S, I208L, T218S, S230N, D232DEB
 33433343_2 RAL8  S17N, V31VI, S57G, K111KR, T124N, T125TA, K211KQ, T218S, K219N, N222K, S230NB
  3343_3 RAL16  H16HY, S17N, V31VI, S57G, P90PS, K111KR, T124N, T125TA, T174TA, K211KQ, T218S, K219N, N222K, S230NB
 30513051_2 RAL32  K14R, L28I, S39C, A91T, T124NS, G193E, V201I, T218S, S230N, D279NB
 30523052_2 EVG85S147SG V31I, G106A, K156KR, S230N, D232EB
 34733473_2 EVG32  M50I, L101I, G193E, V201VI, S230N, D256E, D286NB
  3473_3 EVG91  M50I, G70GE, L101I, G193E, V201I, S230N, D256E, D286NB
 32823282_2 EVG15  K14R, S17N, N18D, A21T, T124A, S195C, I203M, S230N, L234H, D278A, R284GB
  3282_3 EVG35  K14R, S17N, N18D, A21T, T124A, Q164K, S195C, I203M, S230N, L234LH, D278A, R284GB
  3282_4 EVG48S147SG K14R, S17N, N18D, A21T, V88VI, P90PS, T124A, S195C, I203M, S230N, L234LH, D278A, R284GB
 31533153_2 RAL17  V31I, K136N, V201I, I203IM, S230N, D256EB
 31333133_2 RAL71G140S, Q148H S24G, D25E, L28I, E35Q, L45V, T125A, V201I, S230N, S283R, R284GB
  3133_3 RAL81G140S, Q148H S24G, D25E, L28I, E35Q, L45V, T125A, V201I, S230N, S283R, R284GB
 34633463_2 EVG96  L101I, K111T, I135V, K173R, V176L, A205T, K211R, T218S, S230N, D256E, D270EB
 41584158_2 EVG16  D25E, G70GE, P90PS, T124TA, V201I, S230NB
  4158_3 EVG23  D25E, V79VI, P90PS, T112TIM, T124TA, V201I, S230NB
  4158_4 EVG100  D25E, D55DN, P90PS, T112TIM, V201I, S230NB
 33043304_2 EVG20  E11D, V31I, P90S, T112IV, S119SG, T122I, A196P, V201I, K215N, S230NB
  3304_3 EVG26  E11D, V31I, P90S, T112V, S119SG, T122I, A196P, V201I, K215N, S230NB
Parczewski (2012)307307_18KC409156RAL196N155H E10D, L101I, T112I, T124N, T125A, E157Q, K160Q, K219T, I220L, S230N, L234I, D253E, D256E, D278GB
  307_xKC409158RAL201N155H E10D, L101I, T112I, T124N, T125A, E157Q, K160Q, K219T, I220L, S230N, L234I, D253E, D256E, D278GB
 549549_24KC409174RAL94  P90PS, L101I, T112I, E157Q, K160Q, K215KN, S230N, L234I, A265VB
  549_25KC409175RAL122  L101I, T112I, E157Q, K160Q, K215KN, S230N, L234I, A265V, S283SGB
 6060_40KC409182RAL246  L101I, T112I, E157Q, K160Q, K173R, I200L, V201I, S230N, L234I, L242LF, A265VB
  60_42KC409183RAL290  L101I, T112I, S119SN, E157Q, K160Q, K173R, I200L, V201I, S230N, L234I, A265V, G277GDB
  60_45KC409184RAL362  L101I, T112I, E157Q, K160Q, K173R, I200L, V201I, S230N, L234I, A265VB
 828828_7KC409201RAL82  E10D, M50I, L101I, T112I, E157Q, K160Q, S230N, L234I, D253E, D256EB
  828_8KC409202RAL107  E10D, M50I, L101I, T112I, E157Q, K160Q, S230N, L234I, D253E, D256EB
de Souza Cavalcanti (2014)BRSP94BRSP94 RAL N155HT97A, V151ID6E, E10D, A21S, A23V, S39R, M50I, L101I, S119P, T122I, K156R, A169V, S230N, L234I, S283NB
 BRSP73BRSP73 RAL N155H D25E, V31I, M154I, S230NB
Hurt (2014)IN_937IN_937 RAL G140S, Q148H K7Q, E11D, R20RK, V31I, I113V, T124N, T125A, G193E, T218I, S230N, D256E, D286NB
 IN_867IN_867 RAL N155H A23V, S24G, L28I, I72V, T112A, S119P, T124N, T125A, V165L, I182V, S230N, R231KB
 IN_241IN_241 RAL N155H E11D, D25E, P58PS, L101I, K111T, T122I, S230NB
 IN_79IN_79 RAL E138K, G140GS, S147SG, Q148KR E11D, V79VI, T93S, L101I, G189R, V201I, K211Q, Q216H, T218S, N222K, S230N, L234I, A265V, K273QB
 IN_65IN_65 RAL E138K, S147G, Q148R K7R, K14R, K71N, V79VI, A91AT, S119R, T124N, T125A, K156N, G193E, V201I, N222K, S230N, L234VB
 IN_819IN_819 RAL Y143RG163RV31I, I72V, V75M, T206S, S230NB
 IN_2852IN_2852 RAL G140S, Q148H D25E, P30A, L101I, T112A, T125A, V201I, S230N, R231K, S283GB
 IN_1273IN_1273 RAL E138EK, S147SG, Q148QRV151VID25DE, V31VI, I72V, T124TA, I182V, V201I, I208IM, S230N, I251IL, D256E, R284GB
 IN_265IN_265 RAL E138K, G140S, Q148H K14R, V31I, S39C, M50I, L101I, T124A, M154I, V201I, K211Q, S230N, L234I, D253EB
 IN_301IN_301 RAL N155H S17N, M50I, Y99YH, L101V, T124A, T125A, K156N, V165I, Y194C, V201I, T206S, N222K, S230N, S255T, I268L, K273Q, D278AB
 IN_118IN_118 RAL N155HL68LV, V151VIE11D, K34R, S119T, T125A, K156N, E157Q, V180VI, V201VI, I208IL, S230N, E287EAB
 IN_2535IN_2535 RAL N155H D6E, E10D, S17N, V31I, I72IV, L101I, S230N, A265VB
 IN_501IN_501 RAL E92Q, N155HA128AT, E138ED, V151VIV31I, I72V, L101I, T125M, F181L, V201I, S230N, A265AV, I268ILB
 IN_880IN_880 RAL G140S, Y143H, Q148H S17N, K34R, T124R, T125A, V201I, S230NB
 IN_494IN_494 RAL N155H E11D, R20K, V31I, M50I, I72V, S195T, I204V, T206S, S230N, D232E, A265VB
 IN_824IN_824 RAL N155HG163GRD6E, E10D, S17N, A23V, V31I, S39N, L45V, I72IV, V201I, D229DN, S230N, D232DN, S283G, D286DNB
 IN_216IN_216 RAL N155HV151I, G163RS17N, V31I, S39N, I84M, L101I, I113V, T124A, T125A, E157Q, K160T, I208IM, K211T, S230N, A265AV, R269RK, D270HB
 IN_3091IN_3091 RAL E92QL74M, E138DE11D, S24N, D25E, K211R, K215N, I220L, S230N, D256E, D278DNB
 IN_1016IN_1016 RAL G140GS, Q148H K14R, I84V, T112A, I113IV, T125A, K136KR, M154I, S230N, L234VB
 IN_2296IN_2296 RAL G140SQ148NM50I, T112I, K211Q, I217V, S230N, R231KB
 IN_1269IN_1269 RAL N155H D6DE, E10D, S17SN, I72IV, S119P, T122I, T124A, T125A, V201I, I208M, Y227F, S230N, D253Y, D256E, R284GB
 IN_1456IN_1456 RAL E138A, G140S, Q148H S17N, S39SN, L101I, T124A, V165I, V201I, K211R, K219N, N222K, S230N, A265AV, I267IV, I268IL, K273Q, D278NB
 IN_370IN_370 RAL E92Q E11ED, K14R, V31I, K111T, V201I, T218S, S230N, D256EB
 IN_1964IN_1964 RAL N155HA128ATE13D, K14R, R20K, I72IV, L101I, S119P, T122I, T124A, G193E, V201I, T206S, I217V, T218S, S230N, D256E, D279G, S283SNB
 IN_548IN_548 RAL G140S, Q148H V31I, L101I, I161T, G163E, I182V, V201I, T218S, S230N, D256EB
 IN_827IN_827 RAL E92Q, N155H E11D, S24N, M50MI, I72V, K111R, I113V, T206S, S230N, N254Q, S255GB
 IN_3184IN_3184 RAL G140S, Q148H K7KR, S17N, S24N, L101I, T112I, T124N, T125A, T206S, S230N, D256E, A265AV, D286DNB
 IN_2231IN_2231 RAL  T97A, Y143GE11D, V31I, V32I, V37I, L63I, I72IV, L74I, L101I, T112TK, T115S, S119R, T124TN, V201I, S230NB
 IN_1722IN_1722 RAL N155H T93N, L101I, D167E, S230N, D232N, A265VB
 IN_3174IN_3174 RAL T66TAIV S17N, V31VIM, I72IV, P90ST, A91AV, L101I, K111T, T124NS, T125V, I135IV, V165I, V201I, S230N, D256EB
 IN_299IN_299 RAL N155H S17N, I72IV, L101I, S119P, T122I, Y227F, S230N, L234H, D256E, R284GB
 IN_1569IN_1569 RAL  L68V, L74M, E92L, T97AK34R, M50I, V88VI, T112TA, T125A, V201I, T218S, S230NB
 IN_160IN_160 RAL  L74LM, T97TA, Y143GS17SN, S39N, L101I, I113IL, T124N, T125TA, G163T, T218S, K219N, N222K, D229N, S230N, D253E, D256EB
 IN_3168IN_3168 RAL  N155NDK7R, L101I, G163E, G197GE, S230N, S283GB
 IN_1302IN_1302 RAL G140S, Q148H T124A, T125A, K156N, R187K, V201I, S230N, A276APB
 IN_1336IN_1336 RAL G140S, Q148H E11D, S24N, D25E, K34R, M50T, V201I, T218S, S230N, V259VI, S283GB
 IN_684IN_684 RAL G140S, Q148H S17SN, L101I, S119P, T122TI, K211R, Y227F, S230N, S255SN, D256E, A265VB
 IN_2012IN_2012 RAL Y143RT97A, G163EKK7Q, E10A, E11D, K14R, V31I, L45V, L101I, T125A, E170EQ, G193R, V201I, I208M, E212A, Q216H, K219Q, S230N, D256EB
 IN_1373IN_1373 RAL N155NH R20RK, V31VI, K156KN, V201I, S230NB
 IN_2063IN_2063 RAL G140GS, Q148QH I72IV, V201I, S230N, L234IN, A265V, R269KB
 IN_2511IN_2511 RAL G140S, Q148R V31I, M50I, L101I, T124N, D167E, T206S, Y227F, S230N, D256E, A265VB
 IN_1386IN_1386 RAL E138A, G140S, Q148H E11D, D25E, S39T, L45Q, I60IM, I84L, G94A, L101I, T124N, G163A, K188R, Y194C, V201I, N222K, S230N, I268L, R284RGB
 IN_2139IN_2139 RAL N155NH D6N, K7E, K14R, S17N, V31I, S39R, P90PS, T112V, S119SR, T124A, T125A, I135V, S230N, N254Q, S255GB
 IN_341IN_341 RAL E92QL68V, L74M, T97AE10D, V31I, M50I, I73V, E96D, L101I, S119T, T124N, T125A, I135V, E157Q, K160T, I208M, S230N, D232E, L234F, D253E, D256E, E287EAB
 IN_1952IN_1952 RAL G140GS, Q148QHKNG163GRS17N, V31VI, I72V, L74I, I89IL, I113IL, T124A, T125A, K156N, D167E, V201I, I220L, Y227F, S230N, D256EB
 IN_746IN_746 RAL E138K, Q148R E13ED, L45AV, K111R, T112TI, T124A, T125A, V126L, K211R, S230N, R284RGB
 IN_676IN_676 RAL E138EK, Q148QR V31VIM, M50MI, K188KR, G193GDE, V201I, S230N, A265V, D270DNB
 IN_755IN_755 RAL G140S, Q148H S17N, M50I, I72IV, I84IV, L101I, K111T, T124A, T125A, K156N, D167E, G193R, V201I, T206S, Q216N, S230N, D232DNB
 IN_787IN_787 RAL E92QL68V, L74M, T97AE10D, V31I, M50I, I73V, E96D, L101I, S119T, T124N, T125A, I135V, E157Q, K160KPQT, I208M, S230N, D232E, L234F, D253E, D256EB
 IN_2845IN_2845 RAL G140GS, Q148QH, N155NHE138EDD41DN, L101LI, I113IV, G193GE, S230N, R284GB
 IN_298IN_298 RAL N155HV151VIE11D, D25DE, S119P, T122I, E170EG, S195T, V201I, S230N, S283GB
 IN_536IN_536 RAL G140SQ148NM50I, T112I, K211Q, I217V, S230N, R231KB
 IN_119IN_119 RAL  T97A, Y143SS17N, V31I, M50I, L74I, L101I, K111R, S119R, T124N, I135V, K188R, S230N, K264RB
 IN_1453IN_1453 RAL E92QL74MV31I, M50I, I60M, Y99F, G106A, T112M, T124A, D167E, T206S, S230N, D256E, R269KB
 IN_396IN_396 RAL G140S, Q148H I72V, Y99F, T124N, M154I, R187K, V201I, K211R, S230NB
 IN_347IN_347 RAL E92V, N155H D6E, K34R, L74I, T124A, H171Y, V201I, K211R, S230N, M275VB
 IN_315IN_315 RAL T66AL74M, V151VI, G163RV31I, V75VI, L101V, T112V, T125A, V126L, V165I, V201I, K211R, K215N, D229DN, S230N, D256E, S283GB