Integrase Inhibitors

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Integrase Inhibitors

Subtype	B
Gene	IN
Mutation	T206S
Rx	>=1 INI
IncludeMixtures	No

References	13
Patients	31
Isolates	47

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr)	Patient	Isolate	Acc#	INIs	Wks	INIMajorDRMs	INIMinorDRMs	OtherMut	Subtype
Malet (2008)	3	3_W14		RAL	14	E92Q		R20K, A23V, I72V, T124A, I204V, T206S	B
Baldanti (2009)	PV9	PV9	GU350734	RAL	52	N155H		L101I, K127R, G193E, T206S	B
Canducci (2009)	pt2	pt2w24	EU908741	RAL	26	Y143R		S17N, V31I, L101I, T112I, S119P, T122I, T124N, T206S, T218S, Y227F, D256E	B
	pt1	pt1w4	EU908743	RAL	4			S17N, S24N, I113V, S119T, T124A, T125A, V165I, T206S, Q216H	B
		pt1W12	EU908744	RAL	13			S17N, S24N, I113V, S119T, T124A, T125A, V165I, T206S, Q216H	B
		pt1w24	EU908745	RAL	26	Y143R		S17N, S24N, I113V, S119T, T124A, T125A, V165I, T206S, Q216H	B
		pt1w48	EU908746	RAL	39	Y143R		S17SN, S24N, I113V, S119T, T124A, T125A, V165I, T206S, Q216H	B
	pt7	pt7w4	EU908766	RAL	4			S24A, L101I, T112TI, T125A, I135V, F181L, T206S, D229E, S230N, D256E	B
		pt7w8	EU908767	RAL	8			S24A, L101I, T125A, I135V, F181L, T206S, D229E, S230N, D256DE	B
		pt7w12	EU908768	RAL	13			S24A, L101I, T125A, I135V, F181L, T206S, D229E, S230N, D256E	B
		pt7w20	EU908769	RAL	21			S24A, T125A, I135V, F181L, T206S, D229E, S230N, D256E	B
		pt7w24	EU908770	RAL	26			S24A, L101LI, T125A, I135V, F181L, T206S, D229E, S230N, D256E	B
Delelis (2009)	Pt3	Pt3		RAL	16	Y143R		I113V, T124NS, T125A, T206S, I220L, Y227F	B
Garrido (2009)	Pt08	Pt08		RAL		N155H	E138ED	M50IT, L101I, L104I, T124A, A205AS, T206S, I208IL, D256E	B
	Pt12	Pt12		RAL				I72V, T112I, I113V, S119P, T122I, T206S, T218S	B
Sichtig (2009)	Pt07	5163	FJ183699	RAL	62	N155H	Q146QK	E11D, K14R, A21T, A23V, V88I, I113V, S119P, T124N, T125A, Q177R, T206S	B
Wittkop (2009)	5	5_M1	GU358392	RAL	4	G140S, Q148H		E11D, E13D, V31I, M50I, S57G, I89V, S119P, T122I, T124A, T206S, S255N, D256E, S283G	B
		5_M3	GU358393	RAL	12	G140S, Q148H		E11D, E13D, V31I, M50I, S57G, S119P, T122I, T124A, T206S, S255N, D256E, S283G	B
		5_M6	GU358394	RAL	25	G140S, Q148H		E11D, E13D, V31I, M50I, S57G, L63LI, S119P, T122I, T124A, T206S, T210TS, S255N, D256E, S283G	B
		5_M9	GU358395	RAL	39	G140S, Q148H	L74LM	E11D, E13D, V31I, K34KR, M50I, S57G, L63I, S119P, T122I, T124A, T206S, I208IL, S255N, D256E, S283G	B
Blanco (2011)	CA1556	CA124202		RAL	85	Y143C	L74M, T97A, S230R	K7R, S17N, L101I, K111Q, T112K, S119R, T206S, K211R, D256E	B
	CA25140	CA153557		RAL	86			S17N, K34R, I72V, T124A, V201I, T206S, T218S, D270E	B
	JRM_04BL	JRM_04BL		RAL		G140S, Q148H		K14R, V32I, S39C, L101I, T112I, I135V, V201I, T206S, T218S, I220V, K240R, C280S, D286N	B
Brenner (2011)	INT6	INT6_1	HQ207828	RAL		Y143C, N155H	S230R	S17N, M50I, L101I, T112I, T124N, G163E, A169S, V201I, T206S, I220L, Q221S, D279G	B
	091811.126	091811.126	HQ423430	RAL				G70E, L101I, T112I, S119R, T124N, T125TA, V201VI, T206S, D207DE, K211R, K215KN, I217IV	B
	092112.048	092112.048	HQ423431	RAL				E11D, S17T, A23V, N27G, I113V, S119P, T124A, T206S	B
	081911.030	081911.030	HQ423437	RAL		N155H	V151I, G163GR	E11D, S24N, L101I, S119P, T206S, D207E, E212A	B
	091607.079	091607.079	HQ423440	RAL				K42KR, L101I, T124A, R187K, T206S, D232E, D256E, M275MV	B
Fransen (2012)	pt5	pt5		RAL		G140GS, Y143YR, Q148QH, N155NH	V151I, G163GR	E10D, K14R, A23V, L28I, P30A, S39C, L101I, T124A, F185Y, V201I, T206S, Q216H	B
Garrido (2012)	BAA295955	BAA295955	JQ716864	RAL	52			V31I, L45Q, L101I, T206S, N254Q	B
	BAA295958	BAA295958	JQ716866	RAL	52	G140A, Q148R		V31I, D41N, L101I, V201I, T206S, I268L, R269K	B
	BAA295893	BAA295893	JQ716870	RAL	52	G140S, Q148H		E11D, S24N, V31I, T112IM, T206S, I208L, D253DE	B
	BAA295884	BAA295884	JQ716877	RAL	52			A23AV, I72V, T112I, I113V, S119P, T122I, T206S, T218S	B
	BAA295856	BAA295856	JQ716880	RAL	52	Y143YH, N155H		S17N, E96N, L101I, S119P, T122I, T124A, K156N, V201I, T206S, I208L, Y227F, D253Y, D256E	B
	BAA295862	BAA295862	JQ716884	RAL	52			R20K, I72V, L101I, I113L, T124N, T125V, I204V, T206S	B
	BAA295867	BAA295867	JQ716886	RAL	52			S17N, A23AV, V31I, I72V, K103R, T112I, T124N, T125V, K156N, V201I, T206S, S283G	B
	BAA295870	BAA295870	JQ716888	RAL	52	Y143R	T97TA, V151VI	S17N, V31I, M50T, I72V, V75VI, T124A, K156N, T206S, I220IV, D232DN, D256E	B
	BAA295902	BAA295902	JQ716896	RAL	52	N155H		S17N, L101I, T112I, V165I, H171L, T206S, D256E	B
	BAA295905	BAA295905	JQ716898	RAL	52	G140GS, Q148QH		E10D, V31I, I72V, L101I, S119G, T122I, T125A, K156N, V201I, T206S, Q216H, Q221R, D256E	B
Parczewski (2012)	103	103_39	KC409135	RAL	12			E11D, R20K, G70D, L101I, S119R, T124N, G193E, S195T, T206S, D270N	B
		103_40	KC409136	RAL	39			E11D, R20K, G70D, L101I, S119R, T124N, G193E, S195T, T206S, D270N	B
		103_41	KC409137	RAL	54			E11D, R20K, G70D, L101I, S119R, T124N, G193E, S195T, T206S, D270N	B
		103_42	KC409138	RAL	84	G140S, Q148H		E11D, R20K, G70D, I73IV, L101I, S119R, T124N, G193E, S195T, T206S, T218TS, D270N	B
		103_43	KC409139	RAL	96	G140S, Q148H		E11D, R20K, G70D, L101I, S119R, T124N, G193E, S195T, T206S, T218TS, D270N	B
		103_46	KC409140	RAL	145	G140S, Q148H		E11D, R20K, G70D, L101I, S119R, T124N, T125TS, G193E, S195T, T206S, T218TS, D270N	B
		103_49	KC409141	RAL	180	G140S, Q148H		E11D, R20K, G70D, K71KR, L101I, S119R, T124N, T125TS, G193E, S195T, T206S, T218S, D270N	B
Souza Cavalcanti (2012)	BRSP	BR10SP296	JQ797733	RAL	130	E138K, G140C, Q148R	V54I	E11D, V31I, V32I, V37I, D41N, V79I, L101I, T125A, K136Q, V201I, T206S, L234V, D270E	B

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