<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Integrase Inhibitors

Subtype B
Gene IN
Mutation T206S
Rx >=1 INI
IncludeMixtures No
References 16
Patients 43
Isolates 62
 
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# INIs WksINIMajorDRMs INIMinorDRMs OtherMutSubtype
Malet (2008)33_W14 RAL14E92Q R20K, A23V, I72V, T124A, I204V, T206SB
Baldanti (2009)PV9PV9GU350734RAL52N155H L101I, K127R, G193E, T206SB
Canducci (2009)pt2pt2w24EU908741RAL26Y143R S17N, V31I, L101I, T112I, S119P, T122I, T124N, T206S, T218S, Y227F, D256EB
 pt1pt1w4EU908743RAL4  S17N, S24N, I113V, S119T, T124A, T125A, V165I, T206S, Q216HB
  pt1W12EU908744RAL13  S17N, S24N, I113V, S119T, T124A, T125A, V165I, T206S, Q216HB
  pt1w24EU908745RAL26Y143R S17N, S24N, I113V, S119T, T124A, T125A, V165I, T206S, Q216HB
  pt1w48EU908746RAL39Y143R S17SN, S24N, I113V, S119T, T124A, T125A, V165I, T206S, Q216HB
 pt7pt7w4EU908766RAL4  S24A, L101I, T112TI, T125A, I135V, F181L, T206S, D229E, S230N, D256EB
  pt7w8EU908767RAL8  S24A, L101I, T125A, I135V, F181L, T206S, D229E, S230N, D256DEB
  pt7w12EU908768RAL13  S24A, L101I, T125A, I135V, F181L, T206S, D229E, S230N, D256EB
  pt7w20EU908769RAL21  S24A, T125A, I135V, F181L, T206S, D229E, S230N, D256EB
  pt7w24EU908770RAL26  S24A, L101LI, T125A, I135V, F181L, T206S, D229E, S230N, D256EB
Delelis (2009)Pt3Pt3 RAL16Y143R I113V, T124NS, T125A, T206S, I220L, Y227FB
Garrido (2009)Pt08Pt08 RAL N155HE138EDM50IT, L101I, L104I, T124A, A205AS, T206S, I208IL, D256EB
 Pt12Pt12 RAL   I72V, T112I, I113V, S119P, T122I, T206S, T218SB
Sichtig (2009)Pt075163FJ183699RAL62N155HQ146QKE11D, K14R, A21T, A23V, V88I, I113V, S119P, T124N, T125A, Q177R, T206SB
Wittkop (2009)55_M1GU358392RAL4G140S, Q148H E11D, E13D, V31I, M50I, S57G, I89V, S119P, T122I, T124A, T206S, S255N, D256E, S283GB
  5_M3GU358393RAL12G140S, Q148H E11D, E13D, V31I, M50I, S57G, S119P, T122I, T124A, T206S, S255N, D256E, S283GB
  5_M6GU358394RAL25G140S, Q148H E11D, E13D, V31I, M50I, S57G, L63LI, S119P, T122I, T124A, T206S, T210TS, S255N, D256E, S283GB
  5_M9GU358395RAL39G140S, Q148HL74LME11D, E13D, V31I, K34KR, M50I, S57G, L63I, S119P, T122I, T124A, T206S, I208IL, S255N, D256E, S283GB
Blanco (2011)CA1556CA124202 RAL85Y143CL74M, T97A, S230RK7R, S17N, L101I, K111Q, T112K, S119R, T206S, K211R, D256EB
 CA25140CA153557 RAL86  S17N, K34R, I72V, T124A, V201I, T206S, T218S, D270EB
 JRM_04BLJRM_04BL RAL G140S, Q148H K14R, V32I, S39C, L101I, T112I, I135V, V201I, T206S, T218S, I220V, K240R, C280S, D286NB
Brenner (2011)INT6INT6_1HQ207828RAL Y143C, N155HS230RS17N, M50I, L101I, T112I, T124N, G163E, A169S, V201I, T206S, I220L, Q221S, D279GB
 091811.126091811.126HQ423430RAL   G70E, L101I, T112I, S119R, T124N, T125TA, V201VI, T206S, D207DE, K211R, K215KN, I217IVB
 092112.048092112.048HQ423431RAL   E11D, S17T, A23V, N27G, I113V, S119P, T124A, T206SB
 081911.030081911.030HQ423437RAL N155HV151I, G163GRE11D, S24N, L101I, S119P, T206S, D207E, E212AB
 091607.079091607.079HQ423440RAL   K42KR, L101I, T124A, R187K, T206S, D232E, D256E, M275MVB
Canducci (2011)Pt3Pt3W24JN163887RAL26Y143R S17N, S24N, I113V, S119T, T124A, T125A, V165I, V201I, T206S, E212K, Q216HB
 Pt6Pt6W24JN163894RAL19Y143R S17N, V31I, L101I, T112I, S119P, T122I, T124N, T206S, T218S, Y227F, D256E, G277CB
  Pt6W32JN163895RAL28Y143RT97AS17N, V31I, L101I, T112I, S119P, T122I, T124N, T206S, T218S, Y227F, D256EB
Armenia (2012)PT_229PT_229_MO_9JN544121RAL Y143C, N155HS230RK7R, S17N, L101I, S119P, T122I, K156N, V165I, V201I, T206S, T218S, K219N, D256E, D278A, V281VMB
  PT_229_MO_11JN544122RAL Y143C, N155HS230RK7R, S17N, E69EQ, L101I, S119P, T122I, K156N, V165I, V201I, T206S, T218S, K219N, N222NK, D256DE, D278A, V281VMB
Fransen (2012)pt5pt5 RAL G140GS, Y143YR, Q148QH, N155NHV151I, G163GRE10D, K14R, A23V, L28I, P30A, S39C, L101I, T124A, F185Y, V201I, T206S, Q216HB
Garrido (2012)BAA295955BAA295955JQ716864RAL52  V31I, L45Q, L101I, T206S, N254QB
 BAA295958BAA295958JQ716866RAL52G140A, Q148R V31I, D41N, L101I, V201I, T206S, I268L, R269KB
 BAA295893BAA295893JQ716870RAL52G140S, Q148H E11D, S24N, V31I, T112IM, T206S, I208L, D253DEB
 BAA295884BAA295884JQ716877RAL52  A23AV, I72V, T112I, I113V, S119P, T122I, T206S, T218SB
 BAA295856BAA295856JQ716880RAL52Y143YH, N155H S17N, E96N, L101I, S119P, T122I, T124A, K156N, V201I, T206S, I208L, Y227F, D253Y, D256EB
 BAA295862BAA295862JQ716884RAL52  R20K, I72V, L101I, I113L, T124N, T125V, I204V, T206SB
 BAA295867BAA295867JQ716886RAL52  S17N, A23AV, V31I, I72V, K103R, T112I, T124N, T125V, K156N, V201I, T206S, S283GB
 BAA295870BAA295870JQ716888RAL52Y143RT97TA, V151VIS17N, V31I, M50T, I72V, V75VI, T124A, K156N, T206S, I220IV, D232DN, D256EB
 BAA295902BAA295902JQ716896RAL52N155H S17N, L101I, T112I, V165I, H171L, T206S, D256EB
 BAA295905BAA295905JQ716898RAL52G140GS, Q148QH E10D, V31I, I72V, L101I, S119G, T122I, T125A, K156N, V201I, T206S, Q216H, Q221R, D256EB
Parczewski (2012)103103_39KC409135RAL12  E11D, R20K, G70D, L101I, S119R, T124N, G193E, S195T, T206S, D270NB
  103_40KC409136RAL39  E11D, R20K, G70D, L101I, S119R, T124N, G193E, S195T, T206S, D270NB
  103_41KC409137RAL54  E11D, R20K, G70D, L101I, S119R, T124N, G193E, S195T, T206S, D270NB
  103_42KC409138RAL84G140S, Q148H E11D, R20K, G70D, I73IV, L101I, S119R, T124N, G193E, S195T, T206S, T218TS, D270NB
  103_43KC409139RAL96G140S, Q148H E11D, R20K, G70D, L101I, S119R, T124N, G193E, S195T, T206S, T218TS, D270NB
  103_46KC409140RAL145G140S, Q148H E11D, R20K, G70D, L101I, S119R, T124N, T125TS, G193E, S195T, T206S, T218TS, D270NB
  103_49KC409141RAL180G140S, Q148H E11D, R20K, G70D, K71KR, L101I, S119R, T124N, T125TS, G193E, S195T, T206S, T218S, D270NB
Souza Cavalcanti (2012)BRSPBR10SP296JQ797733RAL130E138K, G140C, Q148RV54IE11D, V31I, V32I, V37I, D41N, V79I, L101I, T125A, K136Q, V201I, T206S, L234V, D270EB
de Souza Cavalcanti (2014)BRSP446BRSP446 RAL Q148R L101I, K111T, S119P, T122I, T124A, V201I, T206SB
 BRSP138BRSP138 RAL   S24G, D25E, S39C, L45V, L101I, S119P, T122I, T125P, T206S, S255RB
 BRSP08BRSP08 RAL  L74M, T97A, V151I, G163RK14R, V31I, I72A, L101I, I113L, S119G, T122I, T124TN, K156KN, E157Q, V201I, T206S, S283GB
 BRSP263BRSP263 RAL   D6N, K7E, V31I, L74I, T112I, T125A, F181L, T206S, L234I, D288NB
 BRSP208BRSP208 RAL   E11D, V31I, K42KR, L101I, K111T, I113V, S119P, T125A, I135V, F181L, V201I, I204IV, T206S, E212A, T218S, K219T, N222K, N254NK, C280SB
 BRSP359BRSP359 RAL N155HV151ID6T, K7E, E10D, V31I, K71KQ, I72V, I84M, A91R, L101I, T112I, V201I, T206S, D279DNB
 BRSP95BRSP95 RAL N155HT97A, V151ID6N, K7E, M50I, L101I, S119P, V201I, T206S, I208L, K211R, E212L, D232NB
 BRSP296BRSP296 RAL E138K, G140C, Q148RV54IE11D, V31I, V32I, V37I, D41N, V79I, L101I, T125A, K136Q, V201I, T206S, L234V, D270EB
 BRSP322BRSP322 RAL   D6T, K7Q, E10D, R20K, G59GE, I72V, S119P, T122V, T125A, I203M, T206S, I208IL, L234LH, D278E, S283GB
 BRSP164BRSP164 RAL G140GS, Q148QH A23AT, D41DN, I72IV, T206S, I208LB