Integrase Inhibitors

HOME Genotype-Rx Genotype-Pheno Genotype-Clinical hivdb program

Integrase Inhibitors

Subtype	B
Gene	IN
Mutation	I203M
Rx	II-naive
IncludeMixtures	No

References	33
Patients	136
Isolates	144

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr)	Patient	Isolate	Acc#	INIs	INIMajorDRMs	INIMinorDRMs	OtherMut	Subtype
Skinner (1998)	61	ED061		None			E11D, E48Q, M50I, G106A, S119T, V201I, I203M, D256E, A265V	B
		ER061		None			E11D, E48Q, M50I, G106A, S119T, V201I, I203M, D256E, A265V	B
		LD061		None			E11D, E48Q, M50I, G106A, S119T, T124N, K160R, V201I, I203M, D256E, A265V	B
		LR061		None			E11D, E48Q, M50I, G106A, S119T, T124N, E157K, V201I, I203M, D256E, A265V	B
Saad (2006)	01UAKV167	01UAKV167	DQ823362	None			E10D, T112I, I113V, T124N, T125A, I203M	B
Sanabani (2006)	02BR008	02BR008	DQ358808	None			V31I, I72V, S119T, K136Q, I203M	B
Sanchez (2006)	PCM023	PCM023	AY561242	None			I72V, P90S, L101I, K111T, I135V, I203M, D256E	B
Brennan (2007)	01BAB097	01BAB097	EF150567	None			S17C, M50T, I72V, T122TI, T124A, T125A, I203M, I208L	B
Sa-Filho (2007)	BREPM1026	BREPM1026	EF637055	None			S17N, S57G, T124N, T125A, Q137H, G163E, V165I, V201I, I203M, T218I, L234V, D256E, S283G	B
Buzon (2008)	Pt8	Pt8Y1994	EU883816	None			S17ST, A23AV, I72V, F185FY, I203M	B
		Pt8Y2001	EU883817	None			R20RK, F185Y, I203M, T206S, I208L	B
	Pt15	Pt15Y1993	EU883834	None			I72IV, T122I, T124N, T125TA, I203M, A265V	B
		Pt15Y2000	EU883835	None			G59E, I72V, L101I, T112TI, T122I, T124N, I203M, A265V	B
	Pt19	Pt19Y2005	EU883846	None			S39C, L45V, L101I, T122I, T124N, I203M, K219Q, I220L, Y227F, D232N	B
	Pt25	Pt25Y1996	EU883862	None			D6E, E10D, M50I, I72T, S119P, T122I, I203M, K215KR, S230N, R284RG	B
		Pt25Y2000	EU883863	None			D6E, E10D, M50I, I72T, S119P, I203M, S230N, R284G	B
		Pt25Y2004	EU883864	None			D6E, E10D, M50I, I72T, I113IT, S119P, I203M, S230N	B
	Pt43	Pt43Y1995	EU883909	None			E11D, S17T, A23V, S119T, T124A, I203M, K211R	B
		Pt43Y2006	EU883910	None			E11D, S17T, A23V, S119T, T124A, I203M, K211R, S283N	B
Charpentier (2008)	Pt1	Pt1-BL		None			E11D, A21T, D25E, S119G, T122I, T125A, V201I, I203M, T218S, L234I, D253E, D256E, D278E	B
Ibe (2008)	134	134	AB428552	None			F100FC, K111T, T124A, T125A, I135V, I203M, S283G	B
Malet (2008)	1b	H-SH1-D0	FJ538989	None			E11D, A21T, D25E, S119G, T122I, T125A, V201I, I203M, T218S, L234I, D253E, D278E	B
Miura (2008)	BEC13	BEC13	EU517863	None			S24G, I72V, V77A, T124A, T125A, I203M	B
Brumme (2009)	INT_3451	INT_3451	FJ812902	None			L101I, G193GE, I203M	B
	INT_3516	INT_3516	FJ812967	None			E11D, R20RK, S24SG, S39C, L45IV, L101I, T112R, S119SPRT, T122TI, T124A, K173KR, G193E, I203M	B
	INT_3637	INT_3637	FJ813088	None		V54I	E11D, V31I, I72V, L101I, S119P, T124TA, G134S, K136KQ, V201I, I203M, D232DE, D253H, S283SG, R284RG	B
	INT_3671	INT_3671	FJ813122	None			A23AV, L28I, S39C, C56CS, S57SG, M154MI, V201I, I203M, N254NK	B
	INT_3682	INT_3682	FJ813133	None			D6E, E10A, E11D, S17N, A23AV, V31I, K111KT, S119PT, T124N, T125A, I203M, T206S	B
	INT_3691	INT_3691	FJ813142	None			D6E, S17N, V31I, V32VI, I72V, T124N, T125A, E198Q, I203M, I204IV, T206S, S230SN, S283SN	B
	INT_3692	INT_3692	FJ813143	None			T122TI, I203M	B
	INT_3709	INT_3709	FJ813160	None			E11D, A21T, L101I, I135IV, I203M	B
	INT_3749	INT_3749	FJ813200	None			D6E, K14KR, S17SN, V32I, I72IV, T124N, T125A, E198Q, I203M, I204V, T206S, S230SN, L234LV	B
	INT_3783	INT_3783	FJ813234	None			D6E, S17N, V32I, I72V, L101LI, T124N, T125A, E198Q, I203M, T206S	B
	INT_3798	INT_3798	FJ813249	None			E11D, A21T, L101I, I191IV, I203M, A265V	B
	INT_3808	INT_3808	FJ813259	None			E11D, A21T, L101I, I203M, A265AV	B
	INT_3895	INT_3895	FJ813346	None			S24SG, S39C, L45V, L101I, T112R, T124A, K173R, G193E, I203M, T218S, S283SG	B
	INT_3901	INT_3901	FJ813352	None			S24G, S39C, L45V, L101I, T112R, S119SG, T122TI, T124A, K173R, G193E, I203M, T218S, S283G	B
	INT_3933	INT_3933	FJ813384	None		L68LV	K14R, I72T, I84L, I113V, T124A, K156KR, I203M, D256E	B
	INT_3939	INT_3939	FJ813390	None			I84M, L101I, T124A, V201VI, I203M, A265V	B
	INT_3957	INT_3957	FJ813408	None		L68LI	L101I, S119SG, T122TI, T124TADN, T125TA, V126VA, K127KR, I203M, Q216H, A265V, D286DN	B
	INT_3960	INT_3960	FJ813411	None			T122I, T124A, T125A, K127KR, I203M	B
	INT_4023	INT_4023	FJ813474	None			L45I, I84L, L101I, I113V, I203M, A265V	B
	INT_4025	INT_4025	FJ813476	None			E11D, S39C, I72V, T112S, T124A, G193E, I203M, D278G	B
	D2575	D2575	GQ371816	None			T112V, N117NK, I162IM, I203M, E212A, Q216H, T218S	B
	D3579	D3579	GQ371820	None			E11D, D25E, V31I, V32I, L101V, S119T, K188R, V201I, I203M, T206S	B
	F3524	F3524	GQ371867	None			I72V, L101M, T112V, T124A, T125A, Q164QH, D167E, K173KM, V176VL, I182IF, I203M, T218I	B
	F4508	F4508	GQ371870	None			I72V, T112V, S119P, T125A, V126L, V201I, I203M, D256E, S283G, R284G	B
	K7576	K7576	GQ371970	None			E11D, S24N, D25E, S57N, Q95P, L101I, S119P, K136N, K156N, Q177L, V201I, I203M, I208L, T218S	B
	Q4546	Q4546	GQ372111	None		T97A, P145PL	A91E, L101I, G106A, T112TA, S119R, T124AD, I135V, I203M, I208L, K211R, E212IK, D256E, S283G	B
	R5508	R5508	GQ372134	None			I72V, L101I, S119T, T124A, I135V, F181L, G193R, E198EK, I203M, K211N, L234I, R262RK, A265V	B
	S0540	S0540	GQ372148	None			I72V, T124A, K188R, G193E, I203M, I208L, K211T, E212EQ, Q221R, R262RK, D286N	B
	T9524	T9524	GQ372194	None			V31I, T125M, K156N, E157Q, V201I, I203M, K211R, I217V	B
Garrido (2009)	1	INT-1	GU216848	None			S17N, L28I, P30A, S39C, I60V, V77A, L101I, T124TA, K173KR, I203M	B
	23	INT-23	GU216870	None			V75M, T93S, L101I, T124A, I203M, D279DN	B
	26	INT-26	GU216873	None		V151I	K14R, S17N, L28I, P30A, S39C, I60V, L101I, T124A, V150G, E152R, I203M, L234I, D253E	B
	33	INT-33	GU216880	None			V75M, T93S, L101I, T124A, I203M, D279DN	B
	46	INT-46	GU216893	None			T125A, V126M, G193D, I203M	B
	65	INT-65	GU216912	None			S17N, I72V, K111KQ, S119G, T122I, T124A, T125A, I203M, D256DE, D279DN	B
	70	INT-70	GU216917	None			S17N, C43C*, I72V, T122I, T124N, T125A, K188R, I203M, Q274QH	B
	75	INT-75	GU216922	None			S17N, I72V, L74I, L101I, I113L, T124A, T125A, I203M, K215N, I220L, Q221S, D256E	B
	95	INT-95	GU216942	None		L68V	V31I, K111T, S119T, T125A, V126L, I135V, I203M, A265E, R269RT	B
	100	INT-100	GU216947	None			E11D, E13D, K14KR, R20K, L28I, L45Q, I72IV, G193E, S195T, I203M, D279GS	B
	112	INT-112	GU216959	None			K14KR, R20K, V31I, T112TI, T124A, V201I, I203M, T206S, S230N, D279DN	B
	114	INT-114	GU216961	None			E11D, E13ED, L101I, S119P, T122I, T124A, S195T, I203M, Y227F, S255N, D256E	B
	126	INT-126	GU216973	None		L68V	V31I, K111T, S119T, T125A, V126L, I135V, I203M, G245GA	B
	129	INT-129	GU216976	None			V31I, G70E, I72V, L101LP, I113V, S119R, T124N, T125A, I203M, K215N, T218I, D256E	B
	133	INT-133	GU216980	None			E11D, S24G, S39C, I60V, I72V, L101I, K111R, I113V, S119P, T124A, I203M, T206S, I220F, Q221H, D279DN	B
	150	INT-150	GU216997	None			E11D, R20K, L101I, S119P, T122I, T124A, S195T, I203M, Y227F, S255N, D256E	B
	158	INT-158	GU217005	None			R20RK, V32I, S119P, T124N, T125A, V126L, I203M, Q221S, N222K	B
	159	INT-159	GU217006	None			E11D, E13ED, R20RK, L101I, S119P, T122I, T124A, S195T, I203M, Y227F, S255N, D256E	B
	171	INT-171	GU217018	None			E11D, S24N, V31I, M50L, I203M, I208M, S230N, D232E, D256E	B
	173	INT-173	GU217020	None			S17N, I72V, L101I, K156N, V201I, I203M, N254S, S255G, D279DN	B
	185	INT-185	GU217032	None			P30S, V31I, S39C, I60V, I72V, V201I, I203M	B
	198	INT-198	GU217045	None			D25E, T125A, V126M, G193D, I203M	B
	235	INT-235	GU217082	None			S17N, S39N, L101I, K111T, I113V, S119G, T124N, T125A, V201I, I203M, I208L, Y227F, S230N, L234F, D256E	B
	250	INT-250	GU217097	None			I72V, P90S, L101I, T124N, G193E, I203M, I220L, Y227F	B
	257	INT-257	GU217104	None			K14R, S39C, I72IV, I113V, S119P, T124N, I203M, T206S, D207E, S230N, D256E, V260VI	B
	271	INT-271	GU217118	None			E11D, V31I, V32I, I72V, P90S, I113V, T124N, V201I, I203M, I208L	B
	285	INT-285	GU217132	None			E11D, S17T, A23V, M50ML, I72V, T124A, G163IT, I203M	B
	286	INT-286	GU217133	None			T112I, T122I, T124N, I203M, A265V	B
	288	INT-288	GU217135	None			S17N, P30S, V31I, S39C, I60V, I72IV, L74I, T124A, T125A, I203M, D253E	B
	291	INT-291	GU217138	None			E11D, S17T, M22I, A23V, L28I, M50L, I72V, T112TA, T124A, T125A, I203M, K215N	B
	317	INT-317	GU217164	None		L68I	K7Q, E11D, P30S, I60V, I72V, I73V, L101I, S119T, T124A, V201I, I203M, T206S, I208L, D279G, S283G	B
	341	INT-341	GU217188	None			E10A, S17N, I72V, I113V, T124A, T125A, I203M, A265V	B
	342	INT-342	GU217189	None			I72T, I73V, I84IL, T93TA, I113V, T124N, T125AV, D167E, I203M, N254Q, S255SG	B
	349	INT-349	GU217196	None			E11D, V31I, M50I, V77A, K111T, S119P, T125V, S195T, I203M, T210I	B
	357	INT-357	GU217204	None			E11D, E13D, D25E, P30S, V31I, I60V, L74I, S119P, T122I, T124N, S195T, V201I, I203M, D256E	B
	366	INT-366	GU217213	None			E10D, L45I, I72V, I113V, T124N, T125V, V165I, I203M, K211Q, Q216R, N254Q, S255G	B
Kousiappa (2009)	CY149	CY149	FJ388940	None			E10D, R20K, Q44H, I72V, V201I, I203M, T218S, I220L, Y227F, S230N, D256E	B
Low (2009)	ahi9	ahi9_02	FJ786276	None			K14R, L28I, P30A, S39C, I72V, T124A, I203M, T206S, I208L, S283G	B
	ahi61	ahi61_06	FJ786328	None			Q9QP, E10D, L45V, I72V, K156N, V201I, I203M, I208L, E212A, S255R	B
	ahi81	ahi81_05	FJ786349	None			L101I, T124A, G193E, I203M, Q216R, D256E	B
	ahi99	ahi99_04	FJ786367	None			L28I, S39C, I72V, T124N, I135V, I203M, Q216H	B
	mdr10	mdr10	FJ786395	None			E11D, A23V, M50R, T124N, T125A, I135V, K156R, G193E, I203M	B
	ahi111	ahi111_02	FJ786400	None			K7R, I72V, T112V, I203M	B
Sichtig (2009)	985	985	FJ183509	None			L101I, S119G, T122I, G193D, I203M, D256E	B
	43-E	43-E	FJ183539	None			E11D, V31I, M50T, L101I, G193E, I203M	B
	5747	5747	FJ183673	None			E11D, E13D, R20K, V31I, L45V, L101I, S119P, T122I, T124A, K127R, G193D, V201I, I203M, D256E	B
van Hal (2009)	W4	W4	FJ554677	None			E11D, A91T, S119R, T125A, G193E, I203M, K240R, D256E	B
	W40	W40	FJ554713	None			S17N, V31I, V77A, T124A, G193E, I203M, K211R, S230N, S255T	B
	W47	W47	FJ554720	None			E11D, M50L, A91T, S119R, T125A, G193E, I203M, K240R, D256E	B
	W129	W129	FJ554802	None			V31I, V77A, T124A, G193E, I203M, K211R, S230N, S255T	B
Wang (2009)	CR0222X	CR0222X	FJ469709	None			S17N, V31I, V32I, L45I, I60V, L101I, I203M, D256E	B
	CR0234	CR0234	FJ469711	None			L28I, P30T, S39C, I72V, I84M, L101I, T125A, I200M, V201I, I203M, T206S, I208L	B
	L8107	L8107	FJ469739	None			E11D, A21T, V31I, I72V, I113V, T124A, I203M, I204V, I220L	B
	PRLS04	PRLS04	FJ469755	None			E11D, K14R, A21T, V31I, I72V, I113V, T125A, I203M, T218S, I220L	B
	SH8233	SH8233	FJ469770	None			E11D, P30S, V31I, I60V, L101I, V201I, I203M	B
Wittkop (2009)	6	6_J0	GU358396	None			K7KR, S17N, V31I, K111T, I113V, T124Q, T125A, I203M	B
Arruda (2010)	EI049	EI049	GQ864194	None		V151I	V31I, I72V, Q95S, E96D, G106A, S119T, T124N, T125A, V126L, I203M, D207E, K211Q	B
	EI050	EI050	GQ864195	None			E11D, V31I, V32I, V37I, S39C, I72V, L101I, I113V, S119P, T122I, T125P, V201I, I203M, L234I	B
Hatano (2010)	18	Virus89	GU121765	None			K7KR, G59GE, I72V, V88I, K111Q, I113V, T124A, T125A, G163E, I203M, I208L, L234I	B
Rangel (2010)	N457p	N457p	GU797494	None			V31I, T93N, L101I, I113V, K156N, V201I, I203M, Q216H	B
Brenner (2011)	10106	10106	HQ207708	None			E11D, S24N, D25E, M50I, K111T, I203M	B
	5326	5326	HQ207726	None			K7R, E11D, K14R, V31I, V32I, M50L, L101I, T124N, S195T, I203M, I220L, Y227F	B
	7651	7651	HQ207760	None			E11D, V31I, L101I, K111T, S119P, T122I, T124A, T125S, V201I, I203M, I208M, D256E	B
	9599	9599	HQ207796	None			E11D, S24N, D25E, M50I, K111T, I203M	B
	INT4	INT4	HQ207825	None			E11D, V31I, A49P, E96D, L101I, K111T, S119G, T122I, T124N, T125A, I203M, I208L, T218TA	B
	10379	10379	HQ207716	None	E138EA, G140A, Q148R		E10EQ, E11D, S24N, D25E, M50I, K111T, I203M, L234LV, V259VI	B
Kim (2011)	p1	p1	HM051417	None			D6E, E11D, K14R, L28I, V31I, V32I, V37I, I72V, L101I, T124N, I135V, I200L, V201I, I203M, L241I, D286E	B
	p7	p7	HM051423	None			D6E, E11D, V31I, V37I, L101I, S119G, T122I, T124N, T125A, G163E, V201I, I203M, D256E, D278E	B
	p11	p11	HM051427	None			D6E, E11D, K14R, L28I, V31I, V32I, V37I, I72V, L101I, T124N, I135V, I200L, V201I, I203M, L241I, D286E	B
	p20	p20	HM051436	None			E11D, L28I, V37I, S39C, I72V, L101I, T124N, I135V, V201I, I203M	B
	p43	p43	HM051459	None		V151I	E11D, K14R, A21T, V31I, T124N, T125A, I135V, I203M	B
	p67	p67	HM051483	None			R20K, V31I, V37I, M50L, L101I, I113V, T124N, I135V, I200L, V201I, I203M, R284G	B
Rolland (2011)	1174	consensus_1174	JF320044	None			E11D, S17T, A23V, I72V, I113V, S119P, T122I, T125A, H171Q, I203M, K211R	B
	2008	consensus_2008	JF320482	None			E11D, R20K, V31I, K42KR, L45Q, S195T, I203M, N222K, S230N, R284G	B
Sanabani (2011)	BR1064	BR1064	JN692433	None			S17N, S39N, I72V, L74I, T125A, I135V, V201I, I203M, T206S, I208L, T218I, D256E, S283G	B
	BR1115	BR1115	JN692479	None		T97A	V31I, S119T, T124N, T125A, V126L, I141V, I203M, D256E	B
Brockman (2012)	AEHIV21	AEHIV21	JQ080105	None			E11D, A23V, N27G, V31I, L101I, S119G, T122I, T124A, G193E, V201I, I203M, D278S	B
	AEHIV31	AEHIV31	JQ080115	None			V31I, I72V, P90S, L101I, K111Q, T124A, I135V, F181L, I203M	B
	AEHIV43	AEHIV43	JQ080127	None			V31I, V88I, K111T, S119T, T124A, T125A, I203M, S230N	B
Garrido (2012)	BAA295945	BAA295945	JQ716858	None			V31I, I72V, T112V, S119G, T122I, T124A, V201I, I203M, K219N, N222K	B
	BAA295948	BAA295948	JQ716861	None			D3DE, V31I, K111T, S119T, T125A, V126L, I135V, I203M, I208L, D256E, D278DA, S283G	B
	BAA295925	BAA295925	JQ716908	None			K7Q, E11D, E13ED, R20RK, L101I, S119P, T122I, T124A, S195T, I203M, Y227F, S255N, D256E	B
	BAA295934	BAA295934	JQ716910	None			K7R, M50I, I72V, L101I, I203M, A265V	B
	BAA295940	BAA295940	JQ716914	None			E11D, E13D, V31I, V32I, S39C, M50I, I60V, L101I, I113V, T122I, T124N, I203M, I208L	B
Iamarino (2012)	BF.BR.0694	BF.BR.0694	JN234049	None			K7R, E11D, A21S, V32I, I72V, I203M, S283N	B
	B.BR.0513	B.BR.0513	JN234091	None			K14R, V31I, S39C, K71R, I72V, E87D, S119P, T125A, H171Q, K173R, V201I, I203M, D253E	B
	B.BR.0605	B.BR.0605	JN234097	None			E13Q, K14R, L28I, S39C, I203M	B
	B.BR.0649	B.BR.0649	JN234101	None			E11D, S24N, L28I, S39C, I72V, T112M, I203M, V249I	B
Kijak (2012)	05TH429730	05TH429730	JN248347	None			K71Q, S119R, T125S, F181L, I203M, K211R, S230N, A265V	B
Parczewski (2012)	923_1	923_1	KC409217	None			E11D, L101I, K111T, S119T, K136N, V201I, I203M, A205S, E212A	B
Rolland (2012)	AA115c04L	AA115c04L	JX448097	None			R20K, I72V, L101I, T125A, I135V, G163E, F181L, I203M, N222H, L234I, D256E	B
Li (2013)	2875	2875	JQ901081	None			S17N, L28I, L45I, I72V, L101I, S119G, T122I, T125A, K156N, D167E, V201I, I203M, D253H	B

Integrase Inhibitors

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