<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Integrase Inhibitors

Subtype B
Gene IN
Mutation I203M
Rx >=1 INI
IncludeMixtures No
References 9
Patients 19
Isolates 32
 
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# INIs WksINIMajorDRMs INIMinorDRMs OtherMutSubtype
Charpentier (2008)Pt1Pt1-W4 RAL4Q148R E11D, A21T, D25E, S119G, T122I, T125A, V201I, I203M, T218S, L234I, D253E, D278EB
  Pt1-W8 RAL8Q148R E11D, A21T, D25E, S119G, T122I, T125A, V201I, I203M, T218S, L234I, D253E, V259I, D278EB
  Pt1-W11 RAL11G140GS, Q148QH, N155NH E11D, A21T, A23AV, D25E, S119G, T122I, T125A, V201I, I203M, T218S, L234I, D253E, D278EB
  Pt1-W22 RAL22G140GS, Q148QH E11D, A21T, A23AV, D25E, L101LF, S119G, T122I, T125A, V201I, I203M, T218S, L234I, D253E, D256DE, D278EB
  Pt1-W39 RAL39G140GS, Q148QH E11D, A21T, A23AV, D25E, L101LF, S119G, T122I, T125A, V201I, I203M, T218S, L234I, D253E, D256DE, D278EB
Malet (2008)1bH-SH1-W8FJ538990RAL8Q148R, N155H E11D, A21T, D25E, S119G, T122I, T125A, V201I, I203M, T218S, L234I, D253E, D278EB
  H-SH1-W16FJ538991RAL15G140S, Q148H E11D, A21T, D25E, S119G, T122I, T125A, V201I, I203M, T218S, L234I, D253E, D278EB
Garrido (2009)Pt03Pt03 RAL Y143RT97AH12HN, V31I, K111T, S119T, T125A, V126L, I135V, P142A, I203M, I208L, D256EB
 Pt05Pt05 RAL N155HL74M, V151IE11D, R20K, L101I, S119P, T122I, T124A, S195T, I203M, Y227F, D253DY, S255N, D256EB
 Pt16Pt16 RAL   V31VI, I72V, T112V, S119G, T122I, T124A, V201I, I203M, K219N, N222KB
Wittkop (2009)66_M1GU358397RAL4N155NH S17N, V31I, K111T, I113V, T124Q, T125TA, I203M, S283SRB
  6_M3GU358398RAL12Y143CL74LM, Q95QK, V151VI, S230RK7KR, S17N, V31I, T97TP, K111T, I113V, T124Q, T125A, A169AV, G189GV, I203MB
  6_M6GU358399RAL26Y143YCL74LMK7KR, S17N, V31I, K111T, I113V, T124Q, T125A, G189R, I203M, D279DA, S283SGB
Hatano (2010)18Virus19GU121695EVG   K7R, I72V, V88I, K111Q, I113V, T124A, T125A, G163E, I203M, I208L, L234IB
  Virus94GU121770EVG E92Q K7KR, D41DN, I72V, V88I, K111Q, I113V, T124A, T125A, G163E, I203M, I208L, E212EA, L234IB
  Virus95GU121771EVG E92Q, Q148QRL74LMK7KR, D41DN, I72IV, V88I, K111Q, I113V, T124A, T125A, G163E, I203M, I208L, E212EA, L234IB
  Virus97GU121773EVG E92QL68LV, L74LMK7KR, D41DN, I72IV, V88I, K111Q, I113V, T124A, T125A, G163E, I203M, I208L, E212EA, L234IB
 17Virus99GU121775EVG E138K, S147G, Q148R K7KR, I72V, V79VI, V88I, K111Q, I113V, T124A, T125A, G163E, I203M, I208L, L234IB
  Virus100GU121776EVG E138K, S147G, Q148RV54VIK7KR, I72V, V79I, V88I, K111Q, I113V, T124A, T125A, G163E, I203M, I208L, L234IB
  Virus103GU121779EVG E138K, S147G, Q148RV54VIK7KR, E35EQ, I72IV, V79I, V88I, K111Q, I113V, T124A, T125A, G163E, I203M, I208L, L234IB
  Virus20GU121696EVG E138K, S147G, Q148RV54IK7KR, E35EK, I72V, V79I, V88I, K111Q, I113V, T124A, T125A, G163E, I203M, I208L, L234IB
 12Virus101GU121777RAL Y143YCT97A, S230RG4GR, R20K, T112V, I113V, T125A, H171Q, Y194YH, I200M, I203MB
Blanco (2011)CA5016CA128616 RAL29  S119G, T122I, T125A, M154L, I203M, L234I, D256EB
Brenner (2011)092204.055092204.055HQ423432RAL E138A E11D, V31I, L101I, T124N, S195T, I203M, K215N, K264RB
 092710.036092710.036HQ423433RAL E138A E11D, V31I, L101I, T124N, S195T, I203M, K215N, K264RB
 102001.076102001.076HQ423441RAL T66IT97A, G163RE11D, D25E, V31I, I60V, I72V, A91T, G106A, T112I, I113V, S119P, T124N, T125V, I203M, A205T, D256E, D278DYB
 1037910379_1HQ423444RAL E138EA, G140A, Q148R E10EQ, E11D, S24N, D25E, M50I, K111T, I203M, L234LV, V259VIB
 1080610806HQ423445RAL G140S, Q148H E11D, S24N, D25E, M50I, K111T, T112TK, I203MB
Fransen (2012)pt3pt3 RAL G140GS, Q148QHR, N155NHV151IE11D, A21T, A23AV, D25E, S119G, T122I, T125A, V201I, I203M, T218S, L234I, D253E, D278EB
Garrido (2012)BAA295914BAA295914JQ716871RAL52  D6E, S17N, V32I, L45V, T124N, I203M, D253EB
 BAA295871BAA295871JQ716889RAL52  E11D, F26Y, V31I, I60V, I72IV, T112I, T124N, T125A, V126M, G193R, I203M, Q216H, K219QB
 BAA295899BAA295899JQ716895RAL52  E11D, V32I, S39C, L74I, V201I, I203M, I208L, K215NB