Integrase Inhibitors

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Integrase Inhibitors

Subtype	B
Gene	IN
Mutation	I203M
Rx	>=1 INI
IncludeMixtures	No

References	9
Patients	19
Isolates	32

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr)	Patient	Isolate	Acc#	INIs	Wks	INIMajorDRMs	INIMinorDRMs	OtherMut	Subtype
Charpentier (2008)	Pt1	Pt1-W4		RAL	4	Q148R		E11D, A21T, D25E, S119G, T122I, T125A, V201I, I203M, T218S, L234I, D253E, D278E	B
		Pt1-W8		RAL	8	Q148R		E11D, A21T, D25E, S119G, T122I, T125A, V201I, I203M, T218S, L234I, D253E, V259I, D278E	B
		Pt1-W11		RAL	11	G140GS, Q148QH, N155NH		E11D, A21T, A23AV, D25E, S119G, T122I, T125A, V201I, I203M, T218S, L234I, D253E, D278E	B
		Pt1-W22		RAL	22	G140GS, Q148QH		E11D, A21T, A23AV, D25E, L101LF, S119G, T122I, T125A, V201I, I203M, T218S, L234I, D253E, D256DE, D278E	B
		Pt1-W39		RAL	39	G140GS, Q148QH		E11D, A21T, A23AV, D25E, L101LF, S119G, T122I, T125A, V201I, I203M, T218S, L234I, D253E, D256DE, D278E	B
Malet (2008)	1b	H-SH1-W8	FJ538990	RAL	8	Q148R, N155H		E11D, A21T, D25E, S119G, T122I, T125A, V201I, I203M, T218S, L234I, D253E, D278E	B
		H-SH1-W16	FJ538991	RAL	15	G140S, Q148H		E11D, A21T, D25E, S119G, T122I, T125A, V201I, I203M, T218S, L234I, D253E, D278E	B
Garrido (2009)	Pt03	Pt03		RAL		Y143R	T97A	H12HN, V31I, K111T, S119T, T125A, V126L, I135V, P142A, I203M, I208L, D256E	B
	Pt05	Pt05		RAL		N155H	L74M, V151I	E11D, R20K, L101I, S119P, T122I, T124A, S195T, I203M, Y227F, D253DY, S255N, D256E	B
	Pt16	Pt16		RAL				V31VI, I72V, T112V, S119G, T122I, T124A, V201I, I203M, K219N, N222K	B
Wittkop (2009)	6	6_M1	GU358397	RAL	4	N155NH		S17N, V31I, K111T, I113V, T124Q, T125TA, I203M, S283SR	B
		6_M3	GU358398	RAL	12	Y143C	L74LM, Q95QK, V151VI, S230R	K7KR, S17N, V31I, T97TP, K111T, I113V, T124Q, T125A, A169AV, G189GV, I203M	B
		6_M6	GU358399	RAL	26	Y143YC	L74LM	K7KR, S17N, V31I, K111T, I113V, T124Q, T125A, G189R, I203M, D279DA, S283SG	B
Hatano (2010)	18	Virus19	GU121695	EVG				K7R, I72V, V88I, K111Q, I113V, T124A, T125A, G163E, I203M, I208L, L234I	B
		Virus94	GU121770	EVG		E92Q		K7KR, D41DN, I72V, V88I, K111Q, I113V, T124A, T125A, G163E, I203M, I208L, E212EA, L234I	B
		Virus95	GU121771	EVG		E92Q, Q148QR	L74LM	K7KR, D41DN, I72IV, V88I, K111Q, I113V, T124A, T125A, G163E, I203M, I208L, E212EA, L234I	B
		Virus97	GU121773	EVG		E92Q	L68LV, L74LM	K7KR, D41DN, I72IV, V88I, K111Q, I113V, T124A, T125A, G163E, I203M, I208L, E212EA, L234I	B
	17	Virus99	GU121775	EVG		E138K, S147G, Q148R		K7KR, I72V, V79VI, V88I, K111Q, I113V, T124A, T125A, G163E, I203M, I208L, L234I	B
		Virus100	GU121776	EVG		E138K, S147G, Q148R	V54VI	K7KR, I72V, V79I, V88I, K111Q, I113V, T124A, T125A, G163E, I203M, I208L, L234I	B
		Virus103	GU121779	EVG		E138K, S147G, Q148R	V54VI	K7KR, E35EQ, I72IV, V79I, V88I, K111Q, I113V, T124A, T125A, G163E, I203M, I208L, L234I	B
		Virus20	GU121696	EVG		E138K, S147G, Q148R	V54I	K7KR, E35EK, I72V, V79I, V88I, K111Q, I113V, T124A, T125A, G163E, I203M, I208L, L234I	B
	12	Virus101	GU121777	RAL		Y143YC	T97A, S230R	G4GR, R20K, T112V, I113V, T125A, H171Q, Y194YH, I200M, I203M	B
Blanco (2011)	CA5016	CA128616		RAL	29			S119G, T122I, T125A, M154L, I203M, L234I, D256E	B
Brenner (2011)	092204.055	092204.055	HQ423432	RAL		E138A		E11D, V31I, L101I, T124N, S195T, I203M, K215N, K264R	B
	092710.036	092710.036	HQ423433	RAL		E138A		E11D, V31I, L101I, T124N, S195T, I203M, K215N, K264R	B
	102001.076	102001.076	HQ423441	RAL		T66I	T97A, G163R	E11D, D25E, V31I, I60V, I72V, A91T, G106A, T112I, I113V, S119P, T124N, T125V, I203M, A205T, D256E, D278DY	B
	10379	10379_1	HQ423444	RAL		E138EA, G140A, Q148R		E10EQ, E11D, S24N, D25E, M50I, K111T, I203M, L234LV, V259VI	B
	10806	10806	HQ423445	RAL		G140S, Q148H		E11D, S24N, D25E, M50I, K111T, T112TK, I203M	B
Fransen (2012)	pt3	pt3		RAL		G140GS, Q148QHR, N155NH	V151I	E11D, A21T, A23AV, D25E, S119G, T122I, T125A, V201I, I203M, T218S, L234I, D253E, D278E	B
Garrido (2012)	BAA295914	BAA295914	JQ716871	RAL	52			D6E, S17N, V32I, L45V, T124N, I203M, D253E	B
	BAA295871	BAA295871	JQ716889	RAL	52			E11D, F26Y, V31I, I60V, I72IV, T112I, T124N, T125A, V126M, G193R, I203M, Q216H, K219Q	B
	BAA295899	BAA295899	JQ716895	RAL	52			E11D, V32I, S39C, L74I, V201I, I203M, I208L, K215N	B

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