<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Integrase Inhibitors

Subtype B
Gene IN
Mutation I203M
Rx >=1 INI
IncludeMixtures No
References 13
Patients 50
Isolates 67
 
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# INIs WksINIMajorDRMs INIMinorDRMs OtherMutSubtype
Charpentier (2008)Pt1Pt1-W4 RAL4Q148R E11D, A21T, D25E, S119G, T122I, T125A, V201I, I203M, T218S, L234I, D253E, D278EB
  Pt1-W8 RAL8Q148R E11D, A21T, D25E, S119G, T122I, T125A, V201I, I203M, T218S, L234I, D253E, V259I, D278EB
  Pt1-W11 RAL11G140GS, Q148QH, N155NH E11D, A21T, A23AV, D25E, S119G, T122I, T125A, V201I, I203M, T218S, L234I, D253E, D278EB
  Pt1-W22 RAL22G140GS, Q148QH E11D, A21T, A23AV, D25E, L101LF, S119G, T122I, T125A, V201I, I203M, T218S, L234I, D253E, D256DE, D278EB
  Pt1-W39 RAL39G140GS, Q148QH E11D, A21T, A23AV, D25E, L101LF, S119G, T122I, T125A, V201I, I203M, T218S, L234I, D253E, D256DE, D278EB
Malet (2008)1bH-SH1-W8FJ538990RAL8Q148R, N155H E11D, A21T, D25E, S119G, T122I, T125A, V201I, I203M, T218S, L234I, D253E, D278EB
  H-SH1-W16FJ538991RAL15G140S, Q148H E11D, A21T, D25E, S119G, T122I, T125A, V201I, I203M, T218S, L234I, D253E, D278EB
Garrido (2009)Pt03Pt03 RAL Y143RT97AH12HN, V31I, K111T, S119T, T125A, V126L, I135V, P142A, I203M, I208L, D256EB
 Pt05Pt05 RAL N155HL74M, V151IE11D, R20K, L101I, S119P, T122I, T124A, S195T, I203M, Y227F, D253DY, S255N, D256EB
 Pt16Pt16 RAL   V31VI, I72V, T112V, S119G, T122I, T124A, V201I, I203M, K219N, N222KB
Wittkop (2009)66_M1GU358397RAL4N155NH S17N, V31I, K111T, I113V, T124Q, T125TA, I203M, S283SRB
  6_M3GU358398RAL12Y143CL74LM, Q95QK, V151VI, S230RK7KR, S17N, V31I, T97TP, K111T, I113V, T124Q, T125A, A169AV, G189GV, I203MB
  6_M6GU358399RAL26Y143YCL74LMK7KR, S17N, V31I, K111T, I113V, T124Q, T125A, G189R, I203M, D279DA, S283SGB
Hatano (2010)18Virus19GU121695EVG   K7R, I72V, V88I, K111Q, I113V, T124A, T125A, G163E, I203M, I208L, L234IB
  Virus94GU121770EVG E92Q K7KR, D41DN, I72V, V88I, K111Q, I113V, T124A, T125A, G163E, I203M, I208L, E212EA, L234IB
  Virus95GU121771EVG E92Q, Q148QRL74LMK7KR, D41DN, I72IV, V88I, K111Q, I113V, T124A, T125A, G163E, I203M, I208L, E212EA, L234IB
  Virus97GU121773EVG E92QL68LV, L74LMK7KR, D41DN, I72IV, V88I, K111Q, I113V, T124A, T125A, G163E, I203M, I208L, E212EA, L234IB
 17Virus99GU121775EVG E138K, S147G, Q148R K7KR, I72V, V79VI, V88I, K111Q, I113V, T124A, T125A, G163E, I203M, I208L, L234IB
  Virus100GU121776EVG E138K, S147G, Q148RV54VIK7KR, I72V, V79I, V88I, K111Q, I113V, T124A, T125A, G163E, I203M, I208L, L234IB
  Virus103GU121779EVG E138K, S147G, Q148RV54VIK7KR, E35EQ, I72IV, V79I, V88I, K111Q, I113V, T124A, T125A, G163E, I203M, I208L, L234IB
  Virus20GU121696EVG E138K, S147G, Q148RV54IK7KR, E35EK, I72V, V79I, V88I, K111Q, I113V, T124A, T125A, G163E, I203M, I208L, L234IB
 12Virus101GU121777RAL Y143YCT97A, S230RG4GR, R20K, T112V, I113V, T125A, H171Q, Y194YH, I200M, I203MB
Blanco (2011)CA5016CA128616 RAL29  S119G, T122I, T125A, M154L, I203M, L234I, D256EB
Brenner (2011)092204.055092204.055HQ423432RAL E138A E11D, V31I, L101I, T124N, S195T, I203M, K215N, K264RB
 092710.036092710.036HQ423433RAL E138A E11D, V31I, L101I, T124N, S195T, I203M, K215N, K264RB
 102001.076102001.076HQ423441RAL T66IT97A, G163RE11D, D25E, V31I, I60V, I72V, A91T, G106A, T112I, I113V, S119P, T124N, T125V, I203M, A205T, D256E, D278DYB
 1037910379_1HQ423444RAL E138EA, G140A, Q148R E10EQ, E11D, S24N, D25E, M50I, K111T, I203M, L234LV, V259VIB
 1080610806HQ423445RAL G140S, Q148H E11D, S24N, D25E, M50I, K111T, T112TK, I203MB
DeJesus (2012)74257425_2 EVG71E92Q S17N, I84L, V88VL, T124S, K156N, I203M, D256EB
Fransen (2012)pt3pt3 RAL G140GS, Q148QHR, N155NHV151IE11D, A21T, A23AV, D25E, S119G, T122I, T125A, V201I, I203M, T218S, L234I, D253E, D278EB
Garrido (2012)BAA295914BAA295914JQ716871RAL52  D6E, S17N, V32I, L45V, T124N, I203M, D253EB
 BAA295871BAA295871JQ716889RAL52  E11D, F26Y, V31I, I60V, I72IV, T112I, T124N, T125A, V126M, G193R, I203M, Q216H, K219QB
 BAA295899BAA295899JQ716895RAL52  E11D, V32I, S39C, L74I, V201I, I203M, I208L, K215NB
Molina (2012)41124112_2 EVG12  K14R, V31I, L101I, T112I, T124A, T125A, G134N, I135V, K136T, V201I, I203M, T206S, Y227F, L234I, S255N, D256E, S283GB
 42044204_2 EVG91  E11D, V32VI, V37I, S39SC, D41DN, I60V, S119G, T122TI, T124N, T125A, V201I, I203MB
 32403240_2 EVG41  S17SN, L45V, I89L, L101I, K111R, T112I, T124N, T125A, I203M, T206S, D256EB
 32923292_1 EVG52  E11D, S24N, D25E, V31I, I84M, Q95P, Y99F, L101I, T112A, S119P, K136N, K160R, V201I, I203M, I208L, T218S, L234H, D253EB
  3292_2 EVG84  E11D, S24N, D25E, V31I, I84M, Q95P, Y99F, L101I, G106GA, T112A, S119P, K136N, K160KR, V180VI, V201I, I203M, I208L, T218S, L234H, A239AV, D253DEB
 32823282_2 EVG15  K14R, S17N, N18D, A21T, T124A, S195C, I203M, S230N, L234H, D278A, R284GB
  3282_3 EVG35  K14R, S17N, N18D, A21T, T124A, Q164K, S195C, I203M, S230N, L234LH, D278A, R284GB
  3282_4 EVG48S147SG K14R, S17N, N18D, A21T, V88VI, P90PS, T124A, S195C, I203M, S230N, L234LH, D278A, R284GB
 33903390_2 RAL25  S17SN, A21AT, G59A, L101I, T124S, T125A, K136N, V201I, I203M, L234LF, L241LP, A248AT, I251IL, S255SRB
 40684068_2 EVG88  S17N, I84L, T112I, T124S, T125A, V201I, I203M, L234I, D256E, A265VB
 32663266_2 EVG32  S17N, S39C, L101I, T124N, I203M, T206S, D253E, D256EB
  3266_3 EVG48  S17N, S39C, L101I, T112TI, T124N, I203M, T206S, D253DE, D256EB
de Souza Cavalcanti (2014)BRSP222BRSP222 RAL Y143RL74M, T97A, E138DE10D, V31I, M50I, L101I, T112V, S119P, T122I, T124N, T125A, I135V, E157Q, I203M, I208L, T218S, I220L, D253VB
 BRSP17BRSP17 RAL G140A, Q148R E10D, V31I, M50I, V79I, L101I, K111T, S119T, T124Q, T125A, I135V, I203M, I208L, L234LV, V259VIB
 BRSP380BRSP380 RAL N155HE138D, V151IE11D, D25E, L28I, V37I, S39C, M50L, L74I, L101LF, T124A, E157Q, K160T, I203M, I208M, D232N, L234I, D253E, N254GB
 BRSP322BRSP322 RAL   D6T, K7Q, E10D, R20K, G59GE, I72V, S119P, T122V, T125A, I203M, T206S, I208IL, L234LH, D278E, S283GB
 BRSP458BRSP458 RAL E138AT, G140S, Q148H D6NS, K7E, S17N, V31I, L101I, T124TN, T125A, K156N, K160KR, I203M, Q221K, N222K, D256E, R284GB
Hurt (2014)IN_1156IN_1156 RAL G140S, Q148HV151VAE11D, K14KR, L101I, F139FY, S195T, I203M, R284GB
 IN_1083IN_1083 RAL G140S, Q148H V31I, K111T, I113V, T125A, G189GR, G197GR, I203MB
 IN_612IN_612 RAL E138A, G140A, Q148R K14R, L101I, S119P, T124A, K136T, P142T, I203M, I208M, T218S, Y227F, L234I, D256EB
 IN_1378IN_1378 RAL G140S, Q148H R20K, D25DE, S39C, L101I, S119P, V201I, I203MB
 IN_1402IN_1402 RAL G140S, Q148H K7R, R20K, V31I, I60V, I72IV, E96D, L101I, T112I, T124N, T125V, I135V, I182V, V201I, I203M, Q216H, D256EB
 IN_353IN_353 RAL N155HV151IS39C, M50I, T125A, V126M, E157Q, K160Q, G193E, I203M, I208IM, D232N, D286NB
 IN_1477IN_1477 RAL N155H R20K, S39C, Q95QR, I203M, T206S, D207DE, I208IL, K211KR, D232EB
 IN_866IN_866 RAL  S147SNI72V, T112R, S119P, T124N, T125A, S153SA, K188RT, I200M, V201I, I203M, I220L, Q221S, A265V, R284RGB
 IN_2616IN_2616 RAL N155HV151I, G163KV31I, L101I, T112TA, E157EQ, K160KT, K188R, I203M, L234IB
 IN_2322IN_2322 RAL N155HE138DD6E, P30S, L45Q, M50MI, I60V, L101I, I135V, V165VI, F181L, I203M, I208IM, I220IV, N254K, S255G, I268ILB
 IN_1905IN_1905 RAL N155H S17N, I72V, L101I, T124N, E157Q, K160Q, I203M, K211R, T218I, K219Q, N222K, D232N, A265VB
 IN_2312IN_2312 RAL G140S, Q148H E11D, L45Q, A91T, L101I, S195C, I203MB
 IN_2250IN_2250 RAL Y143CT97A, S230RS17N, C56CR, I72V, F100Y, L101I, K111T, I113L, T124R, T125A, I203M, T206S, I208L, E212L, T218SB
 IN_2253IN_2253 RAL E138K, G140A, Q148K E11D, A21T, V31I, L45V, L101I, K111T, I113V, T125A, G163T, I203M, T218S, K219KT, D253E, D256E, D279GB
 IN_286IN_286 RAL Y143CS230RE11D, R20RK, D25E, Q95N, L101I, G106A, S119T, I135V, E157Q, K160Q, G193E, I203M, I208L, D256E, D286NB
 IN_3143IN_3143 RAL Y143YCHRV54VIV31VI, M50I, L101I, K111T, S119T, I203M, Y227F, K236KR, D253Y, S283GB
 IN_1337IN_1337 RAL G140S, Q148H S17SN, V31I, L101I, S119SG, K156N, K173R, I203M, T206S, D207E, I208L, Y227F, D253YB