<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Integrase Inhibitors

Subtype B
Gene IN
Mutation V201I
Rx >=1 INI
IncludeMixtures No
References 18
Patients 72
Isolates 115
 
Show mutation frequency as:
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# INIs WksINIMajorDRMs INIMinorDRMs OtherMutSubtype
Charpentier (2008)Pt1Pt1-W4 RAL4Q148R E11D, A21T, D25E, S119G, T122I, T125A, V201I, I203M, T218S, L234I, D253E, D278EB
  Pt1-W8 RAL8Q148R E11D, A21T, D25E, S119G, T122I, T125A, V201I, I203M, T218S, L234I, D253E, V259I, D278EB
  Pt1-W11 RAL11G140GS, Q148QH, N155NH E11D, A21T, A23AV, D25E, S119G, T122I, T125A, V201I, I203M, T218S, L234I, D253E, D278EB
  Pt1-W22 RAL22G140GS, Q148QH E11D, A21T, A23AV, D25E, L101LF, S119G, T122I, T125A, V201I, I203M, T218S, L234I, D253E, D256DE, D278EB
  Pt1-W39 RAL39G140GS, Q148QH E11D, A21T, A23AV, D25E, L101LF, S119G, T122I, T125A, V201I, I203M, T218S, L234I, D253E, D256DE, D278EB
Malet (2008)1aSH1-W12FJ538986RAL13G140S, Q148H K7Q, E11D, V31I, M50L, I72V, L101I, T124A, I135V, I200L, V201I, I220LB
 1bH-SH1-W8FJ538990RAL8Q148R, N155H E11D, A21T, D25E, S119G, T122I, T125A, V201I, I203M, T218S, L234I, D253E, D278EB
  H-SH1-W16FJ538991RAL15G140S, Q148H E11D, A21T, D25E, S119G, T122I, T125A, V201I, I203M, T218S, L234I, D253E, D278EB
 2aH3-W24FJ538978RAL24N155H E10D, L101I, G106A, K156N, V165I, S195C, V201I, I220VB
 2bH5-W18FJ538982RAL17N155HG163RV32I, S39C, M50I, T112I, I113V, T124N, V201I, L234V, S255RB
 2dH2-W28FJ538976RAL29E92Q, N155H E11D, V31M, V32I, S39C, I72V, L101I, K111R, S119P, I135V, G193E, V201I, T218SB
 44_W8 RAL8  E11D, A21T, A23V, D25E, E157Q, V201IB
 H1H1-W12FJ538974RAL13N155H L2W, K7R, R20K, V31I, L101I, T112V, T124A, T125A, F181L, V201I, K219N, N222KB
 HSH2H-SH2-W12FJ538993RAL16N155H S17N, R20K, L28I, S39C, T124A, T125A, V201I, I208LB
  H-SH2-W22FJ538994RAL22G140S, Q148HG163RS17N, R20K, L28I, S39C, G70R, T124A, T125A, V201I, I208LB
Baldanti (2009)PV1PV1GU350727RAL26  R20K, I72V, T112I, S119T, V201I, S230N, D232EB
 PV5PV5GU350729RAL26G140S, Q148H E13D, L101I, M154L, V165I, A196P, V201I, I208L, L234V, D256EB
 PV4PV4GU350730RAL4  E10D, L101I, S119P, T122I, T125A, V165I, V201I, I208L, K215N, D256EB
 PV11PV11GU350732RAL26  K7R, K156N, V201IB
 PV3PV3GU350736RAL13G140S, Q148H, N155H S17N, I72V, T124A, M154I, E170A, V201IB
Canducci (2009)pt3pt3w4EU908756RAL4 V54IV31I, I113V, T124A, T125A, V201I, K215NB
  pt3w12EU908757RAL13 V54IV31I, I113V, T124A, T125A, V201I, K215NB
  pt3w24EU908758RAL26G140S, Q148HV54IV31I, I113V, T124A, T125A, V201I, K215NB
 pt5pt5w4EU908772RAL4  K14R, M22L, V32I, V37I, S39C, I72IV, L101I, G163Q, V201I, D253EB
  pt5W12EU908774RAL13 Y143SK14R, M22L, V32I, V37I, S39C, L101I, G163Q, V201I, D253EB
  pt5w24EU908775RAL26N155NHV151IK14R, M22L, V32I, V37I, S39C, L101I, T125A, G163Q, E170Q, V201I, D253EB
  pt5w48EU908777RAL52 T97A, Y143S, S230RK14R, M22L, V32I, V37I, S39C, L101I, G163Q, V201I, D253EB
Garrido (2009)Pt02Pt02 RAL G140S, Q148R E11D, V31VI, V32I, V37I, L101I, V201I, D232E, D256EB
 Pt04Pt04 RAL N155HV151IE11D, S17T, I72V, E198D, V201I, K211R, D270DAB
 Pt09Pt09 RAL N155H E11D, R20K, L28I, S39C, L101I, S119P, T122I, F181L, V201I, Y227F, L234V, D256EB
 Pt11Pt11 RAL   L28I, K34R, V37I, V201I, L234I, D253EB
 Pt13Pt13 RAL   Y15YN, S17N, N18D, A21T, M50R, G59E, I72V, L101I, S119T, T124N, V201IB
 Pt15Pt15 RAL   E13D, V31I, V79I, L101I, V201IB
 Pt16Pt16 RAL   V31VI, I72V, T112V, S119G, T122I, T124A, V201I, I203M, K219N, N222KB
 Pt17Pt17 RAL   E11ED, K14KR, V32I, S119P, V201I, K211R, K219N, N222KB
Sichtig (2009)Pt013-KoelnFJ183691RAL31G140GA, Q148QR S119G, T122I, T125A, V201I, K215NB
  4786FJ183692RAL47Y143RL74M, T97AE11D, R20K, V31I, H51HR, S119G, T122I, T125A, V201I, K215NB
 Pt025068FJ183700RAL35G140S, Q148HG163KS17N, R20K, L28I, S39C, L45V, I113V, T124N, T125A, V201I, V259IB
  5864FJ183701RAL79G140S, Q148HG163EKQS17N, R20K, L28I, S39C, L45V, I113L, T124N, T125A, V201IB
 Pt085255FJ183703RAL76N155HV151VI, G163GRT112I, T124N, M154I, V201I, D232DNB
 Pt095358FJ183704RAL106N155HV151IK14KR, I72IV, T124A, I162V, E170AT, S195SR, I200L, V201I, I220L, L234I, I251ILB
Wittkop (2009)1111_M3GU358372RAL12  V31VM, L45Q, I72V, V201I, K211Q, P233PSB
  11_M6GU358373RAL25  A23V, V31I, I72V, V201I, K211QB
  11_M12GU358374RAL52  A23V, I72V, V201I, K211QB
 22_M6GU358401RAL25G140S, Q148H D3DN, E10ED, R20K, K160R, V201IB
  2_M9GU358402RAL39G140S, Q148H D3DN, R20K, K160R, V201IB
Hatano (2010)1Virus3GU121679RAL   S17N, S24D, S39C, L101I, T124N, D167E, V201I, E212EA, R284RG, D286NB
  Virus4GU121680RAL G140S, Q148H S17N, S24D, S39C, L45LQ, L101I, T124N, D167E, V201I, E212A, R284G, D286NB
  Virus5GU121681RAL G140S, Q148H S17N, S24D, S39C, L45LQ, L101I, T124N, D167E, V201I, E212A, R284G, D286NB
 3Virus9GU121685RAL N155HV151ID6E, E10D, A23S, V31I, L101I, T124A, K156N, V201I, D232N, M275VB
  Virus10GU121686RAL N155HV151ID6E, E10D, A23S, V31I, L101I, T124A, K156N, V201I, D232N, M275VB
  Virus11GU121687RAL N155HV151ID6E, E10D, A23S, V31I, L101I, T124A, K156N, V201I, D232N, M275VB
  Virus12GU121688RAL N155HV151ID6E, E10D, A23S, V31I, L101I, T124A, K156N, V201I, D232N, M275VB
 4Virus15GU121691RAL Y143RT97AK7R, S17N, V31I, L101I, T112A, T125A, M154I, V201IB
 15Virus76GU121752EVG E92EQ K7KR, S17N, V31I, L101I, T112V, G193D, V201I, T218S, D256E, D279DGB
  Virus79GU121755EVG E92EQQ146QLK7KR, S17N, V31I, I84IM, L101I, T112V, I135IV, G193D, V201I, T218S, D256E, D279DGB
 5Virus27GU121703RAL G140S, Q148H S17N, I72V, L101I, K156N, V201I, D207DG, I208LB
  Virus28GU121704RAL E138EK, G140GS, Q148QH S17N, I72V, L101LI, K156N, V201I, I208L, D286DNB
 8Virus30GU121706RAL G140GS, Q148QH S17N, I72V, A98AT, L101I, K156KN, V201I, I208L, D286DNB
  Virus32GU121708RAL E138EK, G140GS, Q148QHN155NDS17N, I72V, L101LI, K156KN, V201I, I208L, D256DE, D286DNB
  Virus34GU121710RAL E138EA, G140GS, Q148QH S17N, I72IV, L101I, K156KN, V201I, I208LB
  Virus38GU121714RAL E138EA, G140GS, Q148QH S17N, I72IV, Y83YC, L101I, K156KN, V201I, I208LB
 14Virus142GU121818RAL N155NHT97TA, V151VI, G163GRD6E, K14KR, S17N, R20K, D25E, S39C, L45AITV, L101I, S119SR, T124A, K160T, V201I, K211R, D288NB
Blanco (2011)CA4825CA128619 RAL21N155HG163KE11D, S24N, V31I, L101I, I113V, S119P, T122I, T124N, T125A, V201I, K211KRB
 CA14192CA128613 RAL35  T112V, M154L, V201IB
 CA25140CA153557 RAL86  S17N, K34R, I72V, T124A, V201I, T206S, T218S, D270EB
 JRM_04BLJRM_04BL RAL G140S, Q148H K14R, V32I, S39C, L101I, T112I, I135V, V201I, T206S, T218S, I220V, K240R, C280S, D286NB
 GCC_10BLGCC_10BL RAL N155HV151IA21S, M22I, A23V, S24G, I84V, M154I, V165I, V201I, D232NB
Brenner (2011)INT6INT6_1HQ207828RAL Y143C, N155HS230RS17N, M50I, L101I, T112I, T124N, G163E, A169S, V201I, T206S, I220L, Q221S, D279GB
 092807.021092807.021HQ423434RAL G140S, Q148H E11D, M50I, G193E, V201I, D232DN, D256E, D286DNB
 093107.007093107.007HQ423436RAL G140S, Q148HG163EKV31I, L45I, L101I, S119G, T122I, E157Q, K160Q, V176L, V201I, I208M, K215N, L234I, D253H, D256EB
 090808.001090808.001HQ423438RAL G140S, Q148H E11D, V31VIM, L101I, K111AS, T125TA, I135V, K156N, R187K, V201I, I220IV, S283SGB
Canducci (2011)Pt3Pt3W24JN163887RAL26Y143R S17N, S24N, I113V, S119T, T124A, T125A, V165I, V201I, T206S, E212K, Q216HB
 Pt4Pt4W24JN163889RAL26G140S, Q148HV54IV31I, I113V, T124A, T125A, V201I, K215N, G277CB
 Pt5Pt5W12JN163891RAL13 Y143S, S230RQ9H, K14R, A23G, V32I, V37I, L101I, G163Q, V201I, D253EB
  Pt5W48JN163892RAL52 T97A, Y143S, S230RQ9H, K14R, A23G, V32I, V37I, L101I, G163Q, V201I, D253EB
 Pt8Pt8w12JN163901RAL13Y143R, N155H S17N, A49S, I72V, T124A, M154I, E170A, V201I, G277RB
 Pt10Pt10w20JN163905RAL21Q148R S24N, L74I, L101I, T125A, V201I, Q216HB
  Pt10w28JN163906RAL30G140S, Q148H S24N, L101I, T125A, V201I, Q216HB
  Pt10w32JN163907RAL35G140S, Q148H S24N, D41N, L74I, A91T, L101I, T125A, V201I, Q216H, N254SB
Armenia (2012)PT_229PT_229_MO_9JN544121RAL Y143C, N155HS230RK7R, S17N, L101I, S119P, T122I, K156N, V165I, V201I, T206S, T218S, K219N, D256E, D278A, V281VMB
  PT_229_MO_11JN544122RAL Y143C, N155HS230RK7R, S17N, E69EQ, L101I, S119P, T122I, K156N, V165I, V201I, T206S, T218S, K219N, N222NK, D256DE, D278A, V281VMB
 PT_141PT_141_MO_6JN544113RAL N155HV151I, G163GRD6T, K7E, E11D, K14R, V31I, M50I, I72IV, I113V, S119SR, T125A, V201I, D256E, V281VMB
 PT_84PT_84_MO_2JN544107RAL Q148QR D6S, K7E, S17N, I72V, V201I, D256EB
  PT_84_MO_4JN544109RAL G140S, Q148R D6S, K7E, S17N, I72V, V201I, D256EB
  PT_84_MO_5JN544110RAL G140S, Q148QR D6S, K7E, S17N, I72V, Q164QR, V201I, D256E, A276ATB
  PT_84_MO_9sJN544111RAL   D6S, K7E, S17N, I72V, V201I, D256EB
 PT_81PT_81_MO_3JN544105RAL N155H H16P, L28I, T112I, S119P, K156N, V201IB
Fransen (2012)pt1pt1 RAL E92EQ, Y143YR, N155NHV151VI, G163GKS17N, S39C, L101I, T124N, V201I, L234V, W243LB
 pt2pt2 RAL Y143YR, N155NHQ95QK, V151I, G163GRE10D, V31I, L101I, M154I, V165I, V201IB
 pt3pt3 RAL G140GS, Q148QHR, N155NHV151IE11D, A21T, A23AV, D25E, S119G, T122I, T125A, V201I, I203M, T218S, L234I, D253E, D278EB
 pt5pt5 RAL G140GS, Y143YR, Q148QH, N155NHV151I, G163GRE10D, K14R, A23V, L28I, P30A, S39C, L101I, T124A, F185Y, V201I, T206S, Q216HB
Garrido (2012)BAA295958BAA295958JQ716866RAL52G140A, Q148R V31I, D41N, L101I, V201I, T206S, I268L, R269KB
 BAA295879BAA295879JQ716868RAL52E138EK E11D, S24G, D25E, S39C, E69EK, I72V, L101I, R107RK, E152EK, M154MI, V201I, S283SGB
 BAA295881BAA295881JQ716874RAL52  K14R, V31I, M50I, I72V, L101I, S119G, T122I, G163E, H171Q, V201IB
 BAA295883BAA295883JQ716876RAL52  K14R, S17N, N18D, A21T, M50R, G59E, I72V, L101I, S119T, T124N, V201I, S283SGB
 BAA295885BAA295885JQ716878RAL52  V31I, I72V, T112V, S119G, T122I, T124A, V201I, K219N, N222KB
 BAA295856BAA295856JQ716880RAL52Y143YH, N155H S17N, E96N, L101I, S119P, T122I, T124A, K156N, V201I, T206S, I208L, Y227F, D253Y, D256EB
 BAA295867BAA295867JQ716886RAL52  S17N, A23AV, V31I, I72V, K103R, T112I, T124N, T125V, K156N, V201I, T206S, S283GB
 BAA295889BAA295889JQ716890RAL52G140S, Q148H D6E, K14R, S17SN, V31I, L101I, K111KE, A128AV, I135V, G163Q, G193E, V201I, D256EB
 BAA295892BAA295892JQ716893RAL52  D6T, K7E, E13D, V31I, V79I, L101I, V201IB
 BAA295899BAA295899JQ716895RAL52  E11D, V32I, S39C, L74I, V201I, I203M, I208L, K215NB
 BAA295905BAA295905JQ716898RAL52G140GS, Q148QH E10D, V31I, I72V, L101I, S119G, T122I, T125A, K156N, V201I, T206S, Q216H, Q221R, D256EB
 BAA295908BAA295908JQ716899RAL52 R263KM50I, I72V, S119P, T124A, V201I, I220LB
 BAA295912BAA295912JQ716901RAL52  K7R, S17N, V31I, S39C, L101I, G163E, K173R, V201I, D232EB
Lee (2012)350841205A.8JQ666926RAL30N155HV151ID6E, E10D, A23S, V31I, L101I, T124A, K156N, V201I, D232N, M275VB
 318041193A.8JQ666905RAL28G140S, Q148H S17N, S24D, S39C, L45LQ, L101I, T124N, D167E, V201I, E212A, R284G, D286NB
 324241133A.3JQ666890RAL48E138EA, G140GS, Q148QH S17N, I72IV, L101LI, K156KN, V201I, I208L, D286DNB
Parczewski (2012)6060_40KC409182RAL246  L101I, T112I, E157Q, K160Q, K173R, I200L, V201I, S230N, L234I, L242LF, A265VB
  60_42KC409183RAL290  L101I, T112I, S119SN, E157Q, K160Q, K173R, I200L, V201I, S230N, L234I, A265V, G277GDB
  60_45KC409184RAL362  L101I, T112I, E157Q, K160Q, K173R, I200L, V201I, S230N, L234I, A265VB
Souza Cavalcanti (2012)BRSPBR10SP267CJQ797720RAL74F121YT97A, V151IE11D, K14R, S24D, L28I, S39C, I72V, L74I, S119P, Q137H, Q164K, R187K, V201I, D232E, L234FB
  BR10SP296JQ797733RAL130E138K, G140C, Q148RV54IE11D, V31I, V32I, V37I, D41N, V79I, L101I, T125A, K136Q, V201I, T206S, L234V, D270EB
  BR11SP363BJQ797725RAL135Y143RT97AE11D, E13X, K14R, S24D, L28I, S39C, K42KR, L74I, S119P, Q164K, R187K, V201I, D232E, L234IB
Underwood (2012)14Virus14GU121690RAL   D6E, E10D, A23S, V31I, L101I, T124A, K156N, V201I, M275VB