Integrase Inhibitors

HOME Genotype-Rx Genotype-Pheno Genotype-Clinical hivdb program

Integrase Inhibitors

Subtype	B
Gene	IN
Mutation	V201I
Rx	>=1 INI
IncludeMixtures	No

References	18
Patients	72
Isolates	115

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr)	Patient	Isolate	Acc#	INIs	Wks	INIMajorDRMs	INIMinorDRMs	OtherMut	Subtype
Charpentier (2008)	Pt1	Pt1-W4		RAL	4	Q148R		E11D, A21T, D25E, S119G, T122I, T125A, V201I, I203M, T218S, L234I, D253E, D278E	B
		Pt1-W8		RAL	8	Q148R		E11D, A21T, D25E, S119G, T122I, T125A, V201I, I203M, T218S, L234I, D253E, V259I, D278E	B
		Pt1-W11		RAL	11	G140GS, Q148QH, N155NH		E11D, A21T, A23AV, D25E, S119G, T122I, T125A, V201I, I203M, T218S, L234I, D253E, D278E	B
		Pt1-W22		RAL	22	G140GS, Q148QH		E11D, A21T, A23AV, D25E, L101LF, S119G, T122I, T125A, V201I, I203M, T218S, L234I, D253E, D256DE, D278E	B
		Pt1-W39		RAL	39	G140GS, Q148QH		E11D, A21T, A23AV, D25E, L101LF, S119G, T122I, T125A, V201I, I203M, T218S, L234I, D253E, D256DE, D278E	B
Malet (2008)	1a	SH1-W12	FJ538986	RAL	13	G140S, Q148H		K7Q, E11D, V31I, M50L, I72V, L101I, T124A, I135V, I200L, V201I, I220L	B
	1b	H-SH1-W8	FJ538990	RAL	8	Q148R, N155H		E11D, A21T, D25E, S119G, T122I, T125A, V201I, I203M, T218S, L234I, D253E, D278E	B
		H-SH1-W16	FJ538991	RAL	15	G140S, Q148H		E11D, A21T, D25E, S119G, T122I, T125A, V201I, I203M, T218S, L234I, D253E, D278E	B
	2a	H3-W24	FJ538978	RAL	24	N155H		E10D, L101I, G106A, K156N, V165I, S195C, V201I, I220V	B
	2b	H5-W18	FJ538982	RAL	17	N155H	G163R	V32I, S39C, M50I, T112I, I113V, T124N, V201I, L234V, S255R	B
	2d	H2-W28	FJ538976	RAL	29	E92Q, N155H		E11D, V31M, V32I, S39C, I72V, L101I, K111R, S119P, I135V, G193E, V201I, T218S	B
	4	4_W8		RAL	8			E11D, A21T, A23V, D25E, E157Q, V201I	B
	H1	H1-W12	FJ538974	RAL	13	N155H		L2W, K7R, R20K, V31I, L101I, T112V, T124A, T125A, F181L, V201I, K219N, N222K	B
	HSH2	H-SH2-W12	FJ538993	RAL	16	N155H		S17N, R20K, L28I, S39C, T124A, T125A, V201I, I208L	B
		H-SH2-W22	FJ538994	RAL	22	G140S, Q148H	G163R	S17N, R20K, L28I, S39C, G70R, T124A, T125A, V201I, I208L	B
Baldanti (2009)	PV1	PV1	GU350727	RAL	26			R20K, I72V, T112I, S119T, V201I, S230N, D232E	B
	PV5	PV5	GU350729	RAL	26	G140S, Q148H		E13D, L101I, M154L, V165I, A196P, V201I, I208L, L234V, D256E	B
	PV4	PV4	GU350730	RAL	4			E10D, L101I, S119P, T122I, T125A, V165I, V201I, I208L, K215N, D256E	B
	PV11	PV11	GU350732	RAL	26			K7R, K156N, V201I	B
	PV3	PV3	GU350736	RAL	13	G140S, Q148H, N155H		S17N, I72V, T124A, M154I, E170A, V201I	B
Canducci (2009)	pt3	pt3w4	EU908756	RAL	4		V54I	V31I, I113V, T124A, T125A, V201I, K215N	B
		pt3w12	EU908757	RAL	13		V54I	V31I, I113V, T124A, T125A, V201I, K215N	B
		pt3w24	EU908758	RAL	26	G140S, Q148H	V54I	V31I, I113V, T124A, T125A, V201I, K215N	B
	pt5	pt5w4	EU908772	RAL	4			K14R, M22L, V32I, V37I, S39C, I72IV, L101I, G163Q, V201I, D253E	B
		pt5W12	EU908774	RAL	13		Y143S	K14R, M22L, V32I, V37I, S39C, L101I, G163Q, V201I, D253E	B
		pt5w24	EU908775	RAL	26	N155NH	V151I	K14R, M22L, V32I, V37I, S39C, L101I, T125A, G163Q, E170Q, V201I, D253E	B
		pt5w48	EU908777	RAL	52		T97A, Y143S, S230R	K14R, M22L, V32I, V37I, S39C, L101I, G163Q, V201I, D253E	B
Garrido (2009)	Pt02	Pt02		RAL		G140S, Q148R		E11D, V31VI, V32I, V37I, L101I, V201I, D232E, D256E	B
	Pt04	Pt04		RAL		N155H	V151I	E11D, S17T, I72V, E198D, V201I, K211R, D270DA	B
	Pt09	Pt09		RAL		N155H		E11D, R20K, L28I, S39C, L101I, S119P, T122I, F181L, V201I, Y227F, L234V, D256E	B
	Pt11	Pt11		RAL				L28I, K34R, V37I, V201I, L234I, D253E	B
	Pt13	Pt13		RAL				Y15YN, S17N, N18D, A21T, M50R, G59E, I72V, L101I, S119T, T124N, V201I	B
	Pt15	Pt15		RAL				E13D, V31I, V79I, L101I, V201I	B
	Pt16	Pt16		RAL				V31VI, I72V, T112V, S119G, T122I, T124A, V201I, I203M, K219N, N222K	B
	Pt17	Pt17		RAL				E11ED, K14KR, V32I, S119P, V201I, K211R, K219N, N222K	B
Sichtig (2009)	Pt01	3-Koeln	FJ183691	RAL	31	G140GA, Q148QR		S119G, T122I, T125A, V201I, K215N	B
		4786	FJ183692	RAL	47	Y143R	L74M, T97A	E11D, R20K, V31I, H51HR, S119G, T122I, T125A, V201I, K215N	B
	Pt02	5068	FJ183700	RAL	35	G140S, Q148H	G163K	S17N, R20K, L28I, S39C, L45V, I113V, T124N, T125A, V201I, V259I	B
		5864	FJ183701	RAL	79	G140S, Q148H	G163EKQ	S17N, R20K, L28I, S39C, L45V, I113L, T124N, T125A, V201I	B
	Pt08	5255	FJ183703	RAL	76	N155H	V151VI, G163GR	T112I, T124N, M154I, V201I, D232DN	B
	Pt09	5358	FJ183704	RAL	106	N155H	V151I	K14KR, I72IV, T124A, I162V, E170AT, S195SR, I200L, V201I, I220L, L234I, I251IL	B
Wittkop (2009)	11	11_M3	GU358372	RAL	12			V31VM, L45Q, I72V, V201I, K211Q, P233PS	B
		11_M6	GU358373	RAL	25			A23V, V31I, I72V, V201I, K211Q	B
		11_M12	GU358374	RAL	52			A23V, I72V, V201I, K211Q	B
	2	2_M6	GU358401	RAL	25	G140S, Q148H		D3DN, E10ED, R20K, K160R, V201I	B
		2_M9	GU358402	RAL	39	G140S, Q148H		D3DN, R20K, K160R, V201I	B
Hatano (2010)	1	Virus3	GU121679	RAL				S17N, S24D, S39C, L101I, T124N, D167E, V201I, E212EA, R284RG, D286N	B
		Virus4	GU121680	RAL		G140S, Q148H		S17N, S24D, S39C, L45LQ, L101I, T124N, D167E, V201I, E212A, R284G, D286N	B
		Virus5	GU121681	RAL		G140S, Q148H		S17N, S24D, S39C, L45LQ, L101I, T124N, D167E, V201I, E212A, R284G, D286N	B
	3	Virus9	GU121685	RAL		N155H	V151I	D6E, E10D, A23S, V31I, L101I, T124A, K156N, V201I, D232N, M275V	B
		Virus10	GU121686	RAL		N155H	V151I	D6E, E10D, A23S, V31I, L101I, T124A, K156N, V201I, D232N, M275V	B
		Virus11	GU121687	RAL		N155H	V151I	D6E, E10D, A23S, V31I, L101I, T124A, K156N, V201I, D232N, M275V	B
		Virus12	GU121688	RAL		N155H	V151I	D6E, E10D, A23S, V31I, L101I, T124A, K156N, V201I, D232N, M275V	B
	4	Virus15	GU121691	RAL		Y143R	T97A	K7R, S17N, V31I, L101I, T112A, T125A, M154I, V201I	B
	15	Virus76	GU121752	EVG		E92EQ		K7KR, S17N, V31I, L101I, T112V, G193D, V201I, T218S, D256E, D279DG	B
		Virus79	GU121755	EVG		E92EQ	Q146QL	K7KR, S17N, V31I, I84IM, L101I, T112V, I135IV, G193D, V201I, T218S, D256E, D279DG	B
	5	Virus27	GU121703	RAL		G140S, Q148H		S17N, I72V, L101I, K156N, V201I, D207DG, I208L	B
		Virus28	GU121704	RAL		E138EK, G140GS, Q148QH		S17N, I72V, L101LI, K156N, V201I, I208L, D286DN	B
	8	Virus30	GU121706	RAL		G140GS, Q148QH		S17N, I72V, A98AT, L101I, K156KN, V201I, I208L, D286DN	B
		Virus32	GU121708	RAL		E138EK, G140GS, Q148QH	N155ND	S17N, I72V, L101LI, K156KN, V201I, I208L, D256DE, D286DN	B
		Virus34	GU121710	RAL		E138EA, G140GS, Q148QH		S17N, I72IV, L101I, K156KN, V201I, I208L	B
		Virus38	GU121714	RAL		E138EA, G140GS, Q148QH		S17N, I72IV, Y83YC, L101I, K156KN, V201I, I208L	B
	14	Virus142	GU121818	RAL		N155NH	T97TA, V151VI, G163GR	D6E, K14KR, S17N, R20K, D25E, S39C, L45AITV, L101I, S119SR, T124A, K160T, V201I, K211R, D288N	B
Blanco (2011)	CA4825	CA128619		RAL	21	N155H	G163K	E11D, S24N, V31I, L101I, I113V, S119P, T122I, T124N, T125A, V201I, K211KR	B
	CA14192	CA128613		RAL	35			T112V, M154L, V201I	B
	CA25140	CA153557		RAL	86			S17N, K34R, I72V, T124A, V201I, T206S, T218S, D270E	B
	JRM_04BL	JRM_04BL		RAL		G140S, Q148H		K14R, V32I, S39C, L101I, T112I, I135V, V201I, T206S, T218S, I220V, K240R, C280S, D286N	B
	GCC_10BL	GCC_10BL		RAL		N155H	V151I	A21S, M22I, A23V, S24G, I84V, M154I, V165I, V201I, D232N	B
Brenner (2011)	INT6	INT6_1	HQ207828	RAL		Y143C, N155H	S230R	S17N, M50I, L101I, T112I, T124N, G163E, A169S, V201I, T206S, I220L, Q221S, D279G	B
	092807.021	092807.021	HQ423434	RAL		G140S, Q148H		E11D, M50I, G193E, V201I, D232DN, D256E, D286DN	B
	093107.007	093107.007	HQ423436	RAL		G140S, Q148H	G163EK	V31I, L45I, L101I, S119G, T122I, E157Q, K160Q, V176L, V201I, I208M, K215N, L234I, D253H, D256E	B
	090808.001	090808.001	HQ423438	RAL		G140S, Q148H		E11D, V31VIM, L101I, K111AS, T125TA, I135V, K156N, R187K, V201I, I220IV, S283SG	B
Canducci (2011)	Pt3	Pt3W24	JN163887	RAL	26	Y143R		S17N, S24N, I113V, S119T, T124A, T125A, V165I, V201I, T206S, E212K, Q216H	B
	Pt4	Pt4W24	JN163889	RAL	26	G140S, Q148H	V54I	V31I, I113V, T124A, T125A, V201I, K215N, G277C	B
	Pt5	Pt5W12	JN163891	RAL	13		Y143S, S230R	Q9H, K14R, A23G, V32I, V37I, L101I, G163Q, V201I, D253E	B
		Pt5W48	JN163892	RAL	52		T97A, Y143S, S230R	Q9H, K14R, A23G, V32I, V37I, L101I, G163Q, V201I, D253E	B
	Pt8	Pt8w12	JN163901	RAL	13	Y143R, N155H		S17N, A49S, I72V, T124A, M154I, E170A, V201I, G277R	B
	Pt10	Pt10w20	JN163905	RAL	21	Q148R		S24N, L74I, L101I, T125A, V201I, Q216H	B
		Pt10w28	JN163906	RAL	30	G140S, Q148H		S24N, L101I, T125A, V201I, Q216H	B
		Pt10w32	JN163907	RAL	35	G140S, Q148H		S24N, D41N, L74I, A91T, L101I, T125A, V201I, Q216H, N254S	B
Armenia (2012)	PT_229	PT_229_MO_9	JN544121	RAL		Y143C, N155H	S230R	K7R, S17N, L101I, S119P, T122I, K156N, V165I, V201I, T206S, T218S, K219N, D256E, D278A, V281VM	B
		PT_229_MO_11	JN544122	RAL		Y143C, N155H	S230R	K7R, S17N, E69EQ, L101I, S119P, T122I, K156N, V165I, V201I, T206S, T218S, K219N, N222NK, D256DE, D278A, V281VM	B
	PT_141	PT_141_MO_6	JN544113	RAL		N155H	V151I, G163GR	D6T, K7E, E11D, K14R, V31I, M50I, I72IV, I113V, S119SR, T125A, V201I, D256E, V281VM	B
	PT_84	PT_84_MO_2	JN544107	RAL		Q148QR		D6S, K7E, S17N, I72V, V201I, D256E	B
		PT_84_MO_4	JN544109	RAL		G140S, Q148R		D6S, K7E, S17N, I72V, V201I, D256E	B
		PT_84_MO_5	JN544110	RAL		G140S, Q148QR		D6S, K7E, S17N, I72V, Q164QR, V201I, D256E, A276AT	B
		PT_84_MO_9s	JN544111	RAL				D6S, K7E, S17N, I72V, V201I, D256E	B
	PT_81	PT_81_MO_3	JN544105	RAL		N155H		H16P, L28I, T112I, S119P, K156N, V201I	B
Fransen (2012)	pt1	pt1		RAL		E92EQ, Y143YR, N155NH	V151VI, G163GK	S17N, S39C, L101I, T124N, V201I, L234V, W243L	B
	pt2	pt2		RAL		Y143YR, N155NH	Q95QK, V151I, G163GR	E10D, V31I, L101I, M154I, V165I, V201I	B
	pt3	pt3		RAL		G140GS, Q148QHR, N155NH	V151I	E11D, A21T, A23AV, D25E, S119G, T122I, T125A, V201I, I203M, T218S, L234I, D253E, D278E	B
	pt5	pt5		RAL		G140GS, Y143YR, Q148QH, N155NH	V151I, G163GR	E10D, K14R, A23V, L28I, P30A, S39C, L101I, T124A, F185Y, V201I, T206S, Q216H	B
Garrido (2012)	BAA295958	BAA295958	JQ716866	RAL	52	G140A, Q148R		V31I, D41N, L101I, V201I, T206S, I268L, R269K	B
	BAA295879	BAA295879	JQ716868	RAL	52	E138EK		E11D, S24G, D25E, S39C, E69EK, I72V, L101I, R107RK, E152EK, M154MI, V201I, S283SG	B
	BAA295881	BAA295881	JQ716874	RAL	52			K14R, V31I, M50I, I72V, L101I, S119G, T122I, G163E, H171Q, V201I	B
	BAA295883	BAA295883	JQ716876	RAL	52			K14R, S17N, N18D, A21T, M50R, G59E, I72V, L101I, S119T, T124N, V201I, S283SG	B
	BAA295885	BAA295885	JQ716878	RAL	52			V31I, I72V, T112V, S119G, T122I, T124A, V201I, K219N, N222K	B
	BAA295856	BAA295856	JQ716880	RAL	52	Y143YH, N155H		S17N, E96N, L101I, S119P, T122I, T124A, K156N, V201I, T206S, I208L, Y227F, D253Y, D256E	B
	BAA295867	BAA295867	JQ716886	RAL	52			S17N, A23AV, V31I, I72V, K103R, T112I, T124N, T125V, K156N, V201I, T206S, S283G	B
	BAA295889	BAA295889	JQ716890	RAL	52	G140S, Q148H		D6E, K14R, S17SN, V31I, L101I, K111KE, A128AV, I135V, G163Q, G193E, V201I, D256E	B
	BAA295892	BAA295892	JQ716893	RAL	52			D6T, K7E, E13D, V31I, V79I, L101I, V201I	B
	BAA295899	BAA295899	JQ716895	RAL	52			E11D, V32I, S39C, L74I, V201I, I203M, I208L, K215N	B
	BAA295905	BAA295905	JQ716898	RAL	52	G140GS, Q148QH		E10D, V31I, I72V, L101I, S119G, T122I, T125A, K156N, V201I, T206S, Q216H, Q221R, D256E	B
	BAA295908	BAA295908	JQ716899	RAL	52		R263K	M50I, I72V, S119P, T124A, V201I, I220L	B
	BAA295912	BAA295912	JQ716901	RAL	52			K7R, S17N, V31I, S39C, L101I, G163E, K173R, V201I, D232E	B
Lee (2012)	3508	41205A.8	JQ666926	RAL	30	N155H	V151I	D6E, E10D, A23S, V31I, L101I, T124A, K156N, V201I, D232N, M275V	B
	3180	41193A.8	JQ666905	RAL	28	G140S, Q148H		S17N, S24D, S39C, L45LQ, L101I, T124N, D167E, V201I, E212A, R284G, D286N	B
	3242	41133A.3	JQ666890	RAL	48	E138EA, G140GS, Q148QH		S17N, I72IV, L101LI, K156KN, V201I, I208L, D286DN	B
Parczewski (2012)	60	60_40	KC409182	RAL	246			L101I, T112I, E157Q, K160Q, K173R, I200L, V201I, S230N, L234I, L242LF, A265V	B
		60_42	KC409183	RAL	290			L101I, T112I, S119SN, E157Q, K160Q, K173R, I200L, V201I, S230N, L234I, A265V, G277GD	B
		60_45	KC409184	RAL	362			L101I, T112I, E157Q, K160Q, K173R, I200L, V201I, S230N, L234I, A265V	B
Souza Cavalcanti (2012)	BRSP	BR10SP267C	JQ797720	RAL	74	F121Y	T97A, V151I	E11D, K14R, S24D, L28I, S39C, I72V, L74I, S119P, Q137H, Q164K, R187K, V201I, D232E, L234F	B
		BR10SP296	JQ797733	RAL	130	E138K, G140C, Q148R	V54I	E11D, V31I, V32I, V37I, D41N, V79I, L101I, T125A, K136Q, V201I, T206S, L234V, D270E	B
		BR11SP363B	JQ797725	RAL	135	Y143R	T97A	E11D, E13X, K14R, S24D, L28I, S39C, K42KR, L74I, S119P, Q164K, R187K, V201I, D232E, L234I	B
Underwood (2012)	14	Virus14	GU121690	RAL				D6E, E10D, A23S, V31I, L101I, T124A, K156N, V201I, M275V	B

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