<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Integrase Inhibitors

Subtype B
Gene IN
Mutation G163E
Rx II-naive
IncludeMixtures No
References 35
Patients 171
Isolates 176
 
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# INIs WksINIMajorDRMs INIMinorDRMs OtherMutSubtype
Swanson (2003)TH1600TH1600AY214058None   S17C, S119R, T124N, T125S, G163E, K211R, I220V, K236KR, A265VB
Takebe (2003)TY_pat1TYmIDU103AB097873None   S17C, A91T, L101I, K111R, S119R, T124N, T125A, G163EB
 TY_pat4TYmSTD101AB097870None   D6E, E11D, S17C, V31I, A91T, L101I, S119R, T124N, T125S, I162V, G163E, K173E, K188E, K211R, S230NB
 TY_pat9TYmIDU502AB097865None   D6X, S17N, E35G, T112I, S119R, T124N, T125S, G163E, K211RB
McLaughlin (2004)98USHVTN3605c998_3605c9AY560108None   E10D, E11D, R20K, H78R, L101I, G163E, V201I, V281M, S283GB
Thomson (2004)99UFRJ_299UFRJ_2AY455780None   S17N, I72V, I84L, L101I, S119T, T124A, G163E, V165I, V201I, T206S, T218I, L234V, R284RG, D288NB
Brennan (2007)01CEB07801CEB078EF150588None   S24G, L28I, L101I, T122I, T124N, G163EB
Lataillade (2007)482-009ML_482-009EF472722None   S17N, M50IT, I72V, S123SG, T124A, T125V, G163E, Y227F, D253HY, S255N, D256EB
 482-079ML_482-079EF472724None   S17N, T124N, T125V, I135V, G163E, V201I, N254Q, D256EB
 03-5093ML_03-5093EF472783None   L45I, L101I, T124A, G163E, K211R, Q285XB
 63BML_63BEF472784None   S17N, T124N, T125V, I135V, G163E, V201I, N254Q, D256EB
Li (2007)PS40484048_d0DQ676886None   S17N, V31I, L101I, S119G, T122I, T124N, T125A, W131W*, G163E, F181L, V201I, D256EB
  4048_d143DQ676887None   S17N, V31I, G59GE, L101I, S119G, T122I, T124N, T125A, G163E, F181L, V201I, D256EB
Sa-Filho (2007)BREPM1026BREPM1026EF637055None   S17N, S57G, T124N, T125A, Q137H, G163E, V165I, V201I, I203M, T218I, L234V, D256E, S283GB
Struck (2007)luBF_10.03luBF_10.03EU170149None   E11D, R20K, L28I, V37I, S39C, I72V, I84L, L101I, T125V, G163E, V201I, L234VB
 luBF_03.03luBF_03.03EU170152None   E11D, R20K, L28I, V37I, S39C, I84L, L101I, T124TS, T125V, G163E, V201I, L234VB
Buzon (2008)Pt33Pt33Y1999EU883886None   K7KR, V31I, L74I, I84V, L101I, S119PT, T125A, G163E, H171Q, T206TS, S283GB
  Pt33Y2001EU883887None   V31I, L74I, I84IV, L101I, S119PT, T125A, G163E, A169AG, H171QB
  Pt33Y2004EU883888None   K7R, V31I, L74I, I84V, L101I, S119P, T125A, G163E, H171Q, S283GB
 Pt38Pt38Y1996EU883899None   V31I, M50IR, L101I, T124A, G163E, K188R, G193E, D232E, S255KB
  Pt38Y2006EU883900None   V31I, M50R, L101I, T124A, G163E, K188R, G193E, D232E, S255TB
Miura (2008)BEC108BEC108EU517891None   E10A, T124N, T125V, G163E, K211R, Q252LB
Brumme (2009)INT_3519INT_3519FJ812970None   S17N, T112TI, T122TI, T124N, T125TAIV, G163E, V201I, Y227F, D253Y, D256E, R284RGB
 INT_3534INT_3534FJ812985None   S17N, L74V, L101I, G163E, H171Q, V201I, I208L, D256EB
 INT_3675INT_3675FJ813126None   E11D, I72V, V88I, S119T, G163E, S195C, V201IB
 INT_3746INT_3746FJ813197None   E11D, V31VI, V32I, I72V, V88I, L101I, I113V, G163E, S195C, V201IB
 INT_3748INT_3748FJ813199None  V151VIE11D, I72V, V88I, L101I, G106A, I113V, S119T, G163E, S195C, V201IB
 INT_3755INT_3755FJ813206None   E11D, V31I, L101I, S119P, T122I, G163E, R187K, D256E, S283SNB
 INT_3811INT_3811FJ813262None   E11D, P30PA, V88I, L101I, T112TA, G163E, S195C, V201IB
 INT_3823INT_3823FJ813274None   S17SN, L28I, L45V, L101I, G163EB
 INT_3824INT_3824FJ813275None   E11D, K14KR, I72V, V88I, L101I, G106A, I113V, S119T, G163E, S195C, V201I, Q216QHB
 INT_3827INT_3827FJ813278None   E11D, I72V, V79A, V88I, L101I, G106A, I113V, S119T, G163E, S195C, V201IB
 INT_3842INT_3842FJ813293None   E11D, R20K, S39SC, I72V, V88I, L101I, G106A, I113V, S119T, G163E, S195C, V201IB
 INT_3880INT_3880FJ813331None   E11D, V88I, L101I, T122I, T124N, G163E, G193E, V201I, N254K, S255SNB
 INT_3896INT_3896FJ813347None   S17N, I72IV, T125V, G163EB
 INT_3931INT_3931FJ813382None   E11D, V88I, L101I, K103KR, G163E, G193E, V201I, N254KB
 INT_3935INT_3935FJ813386None   E11ED, V88I, L101I, G163E, S195C, V201I, Q216HB
 INT_3946INT_3946FJ813397None   E10D, S17N, L101I, S119R, T122I, T124A, G163E, K173KR, G193D, S195C, K211R, D278NB
 INT_3965INT_3965FJ813416None   E11D, V31VI, V32VI, L45LV, I72V, V88I, L101I, G106A, I113V, S119T, T125A, G163E, S195C, V201IB
 INT_3982INT_3982FJ813433None  L74ME10A, S17N, V31I, D55N, I72V, L101V, K111R, T125A, G163E, H171Y, K211RB
 INT_4002INT_4002FJ813453None   I72IV, G163EB
 INT_4019INT_4019FJ813470None   L45I, L101I, G163E, H171HQ, S283SGB
 D9519D9519GQ371834None   L45V, T124A, G163E, H171Q, V201I, I220V, S283G, D286NB
 E6537E6537GQ371852None   E11D, M50I, T112I, G163E, K173KR, S195T, K211T, S230N, S283GB
 G3539G3539GQ371894None   R20K, M50I, L101I, T122I, T124N, G163E, V201I, S230SN, D232EB
 G8579G8579GQ371905None   S17N, S39N, L45V, M50I, I72V, L74I, L101I, T124N, T125A, A133AV, I162V, G163E, V176I, Q216H, Y227F, L234H, D256EB
 J4531J4531GQ371941None   S17N, L101I, I113V, T125V, G163E, H171Q, D256EB
 K6570K6570GQ371967None   E11D, V31I, I60M, L101I, S119P, T122I, T125A, G163E, A205TB
 L4509L4509GQ371987None   D6E, S17SN, V31I, S39C, L45V, L101I, T124N, G163EB
 L6514L6514GQ371992None   D6E, E11D, S17N, I72V, L101I, S119P, T122I, T124A, K136KN, G163E, T218S, A239APB
 L9528L9528GQ371998None   E10A, S17N, V31I, T97TI, G163E, V201I, I203IV, I220ILB
 P3502P3502GQ372080None  L68VS17N, D41N, M50I, P90S, S119R, T124N, M154I, G163E, K211R, D256EB
 P6539P6539GQ372091None   P30A, S39SC, L45R, T124A, G163E, V201I, S255SRB
 R4517R4517GQ372132None   D3N, S17N, I72V, L74I, L101M, T112V, G163E, F185X, V201I, E212A, Q216H, D256E, R262RKB
 R8512R8512GQ372139None   K14KR, L45I, M50I, C56CR, P90S, L101I, S119R, T124S, G163E, D256EB
 R9535R9535GQ372144None   D6E, E11D, D25DE, L45KT, I72V, G106A, S119G, T122I, S153A, G163E, V201I, D256EB
 S6507S6507GQ372160None   E11D, V32I, S39C, I72V, L74I, L101I, G163E, H171Q, V201I, I220V, K240RB
 T0530T0530GQ372172None   K34R, G70S, I72V, L101I, T122I, T124A, T125A, G163E, V201VI, L234IB
 T5529T5529GQ372184None   D6E, S17N, V31VE, L101I, S119P, T124N, T125A, G163E, V201I, A205S, R262RKB
 T9536T9536GQ372195None   D3E, S17N, I72V, L102LF, T124N, T125V, G163EB
 V9527V9527GQ372216None   S17N, L45I, L101I, K103KR, T124A, G163E, D256EB
 W5524W5524GQ372231None   R20RK, V31I, L45LI, L101I, G163E, F181FY, V201IB
 X7523X7523GQ372264None   S17N, V31I, T124A, T125A, V126L, G163E, V201I, S230NB
Garrido (2009)55INT-55GU216902None   K7KR, E11D, V31I, V37I, S39N, T124N, G163E, V201I, K211R, S230N, S255R, D279DNB
 93INT-93GU216940None   E11D, S17T, M50I, T124A, G163E, V165I, T218I, L234V, D256EB
 130INT-130GU216977None   E10D, L28I, L45LV, L74I, E152G, G163E, K188KR, V201I, L234H, D256E, G277GSB
 175INT-175GU217022None   E11D, N27G, V32I, M50T, I72V, T122I, T124N, T125A, G163E, V201I, I220VB
 204INT-204GU217051None   S17N, S39C, L45I, I113V, S119P, T124N, T125V, G163E, K211R, S230NB
 274INT-274GU217121None   K14R, V31I, I72V, S119P, T122I, T125A, G163E, V201I, I208L, S255RB
 281INT-281GU217128None   E10D, E11D, A21T, V32VI, M50I, G163E, V201I, S230N, L234HB
 302INT-302GU217149None   S24N, I73V, L101I, G163E, S230N, L234IB
 304INT-304GU217151None   S17N, I72V, T124H, T125A, V126M, G163E, D207N, K211T, T218S, N254KB
 331INT-331GU217178None   E10D, S39C, L45V, L101LI, S119SPRT, T122TI, T124N, G163E, V201I, S230N, R284RSB
 392INT-392GU217239None   E11D, S24R, V31I, L101I, S119P, T122I, G163E, V201IB
Low (2009)ahi34ahi34_05FJ786301None   D6E, E10D, T124N, T125M, G163EB
 ahi43ahi43_06FJ786310None   L45V, M50I, G163E, I208L, D286NB
 ahi45ahi45_02FJ786312None   E11D, V31I, M50I, L101I, G163E, F181L, V201I, A205S, T206S, T218S, S230NB
 ahi67ahi67_01FJ786334None   E11D, S17T, V31I, M50I, T124N, T125V, V126M, G163E, D256EB
 ahi70ahi70_01FJ786337None   E11D, V31I, M50I, L101I, G163E, F181L, V201I, A205S, T206S, T218S, S230NB
 ahi75ahi75_97FJ786342None   L45V, M50I, L101I, T124N, G163E, V201I, I208L, T218S, D256E, I267VB
 mdr1amdr1aFJ786380None  A128TS17N, I72V, T125M, G163E, I208L, K211Q, E212AB
 mdr1bmdr1bFJ786381None  A128TS17N, I72V, T125M, G163E, I208L, K211Q, E212A, I220LB
 mdr1cmdr1cFJ786382None  A128TS17N, I72V, T125M, G163E, I208L, K211Q, E212A, I220LB
 mdr1dmdr1dFJ786383None  A128TS17N, I72V, T125M, G163E, I208L, K211Q, E212AB
 mdr1emdr1eFJ786384None  A128TS17N, I72V, T125M, G163E, I208L, K211Q, E212AB
Nadai (2009)129389129389EU839602None   N27S, K34R, I72V, L101I, K111R, T124A, T125V, G163E, D167EB
 CRC08767CRC08767EU839606None   S17N, M50L, L101I, T112V, T124N, G163E, K211RB
Passaes (2009)BR.RJ.FT24BR.RJ.FT24HM026763None   E10G, S17N, F26V, M50I, I113V, T124A, T125A, G163E, D232E, D256EB
Sichtig (2009)33083308FJ183504None   E11D, V31I, V32I, M50MI, L101I, K111Q, T124N, G163E, T218S, V259IB
 9-E9-EFJ183525None   K14R, S17SN, A23V, L45Q, L101I, T122I, T124A, G163E, K173R, V201I, L234LIRS, S255KB
 39-E39-EFJ183536None   L45V, L101I, S119P, T122I, T124TA, G163E, V201I, D256EB
 47654765FJ183649None   S17N, V31VI, L101I, T124N, T125A, I135V, G163E, L234H, K240KRB
 55065506FJ183667None   E11D, S24N, D25DE, P30PS, L45LI, I72V, L101I, S119P, T122I, G163E, K211R, T218I, N222K, L234VB
 55925592FJ183670None  L68VK34R, I72V, I113V, T124N, T125A, G163E, I220MB
 Pt025858FJ183684None   S17N, R20K, L28I, S39C, L45V, I113V, T124N, T125A, G163E, V201IB
van Hal (2009)W8W8FJ554681None   S17N, S119R, T125A, G163E, H171Q, S195CB
 W13W13FJ554686None   E11D, L28I, V37I, S39C, L101I, G163E, G193D, K211R, D279GB
 W14W14FJ554687None   E10D, N27G, V31I, I72V, L101I, I135V, E152K, G163E, R166K, R231K, D232NB
 W51W51FJ554724None   S17N, S119R, T125A, G163E, H171Q, S195C, V250IB
 W60W60FJ554733None   E11D, L28I, V37I, S39C, G163E, G193D, K211R, D279GB
 W62W62FJ554735None   E10D, N27G, V31I, I72V, L101I, I135V, E152K, G163E, R166K, V201I, S230G, R231K, D232N, D279GB
 W132W132FJ554805None   S17I, V31I, G70D, L101I, T112V, I113V, S119R, T124N, T125A, G163E, K211R, Q285RB
 W133W133FJ554806None   S17I, V31I, G70D, L101I, T112V, I113V, S119R, T124N, T125A, K160Q, G163E, K211R, Q285RB
Arruda (2010)EI065EI065GQ864207None   S17N, L28I, S39C, M50I, I72V, L101I, T124A, I135V, G163E, F181L, V201I, I220V, Y227FB
 EI089EI089GQ864229None   S17N, V31I, A91S, T124N, G163E, V201I, S255KRB
Hatano (2010)18Virus89GU121765None   K7KR, G59GE, I72V, V88I, K111Q, I113V, T124A, T125A, G163E, I203M, I208L, L234IB
Isarangkura-Na-Ayuthaya (2010)B-Int-40B-Int-40HM150815None   V31I, L45V, L101I, S119P, G163E, V201I, L234I, S283GB
 B-Int-112B-Int-112HM150833None   V31I, L45V, L101I, S119P, G163E, V201I, L234I, S283GB
Rangel (2010)N506pN506pGU797499None   V31I, L101I, G163E, E198D, V201I, T218SB
 HIV146pHIV146pGU797501None   L28I, V31I, V37I, L74I, L101I, G163E, T210I, D256E, S283G, Q285PB
 HIV238bHIV238bGU797520None   V31I, L74I, A91T, L101I, S119K, T125A, G163E, D256EB
 HIV238pHIV238pGU797521None   V31I, L74I, A91T, L101I, S119K, T125A, G163E, D256EB
 HIV239bHIV239bGU797522None   L101I, K111I, S119P, T124N, T125A, G163E, V201I, A205S, E212A, D256EB
Blanco (2011)CA4825CA124161 None   E11D, S24N, V31I, L101I, I113V, S119P, T122I, T124N, T125A, G163E, V201IB
Brenner (2011)63056305HQ207733None   S17N, S39C, L45LQ, I72V, L101I, G163E, H171Q, V201IB
 82148214HQ207772None   S17N, S39C, L45EV, I72V, L101I, G163E, H171Q, V201IB
 INT6INT6HQ207827None   S17N, M50I, L101I, T112I, T124N, G163E, A169S, V201I, T206S, I220L, Q221S, D279GB
Kim (2011)p4p4HM051420None   E10D, V31I, L101I, T124N, T125V, G163E, D256EB
 p6p6HM051422None   E11D, V31I, L101I, I113V, T124N, T125A, I135V, G163E, H171Y, V201I, N222K, R224S, V225D, G245R, E246K, V249I, D256EB
 p7p7HM051423None   D6E, E11D, V31I, V37I, L101I, S119G, T122I, T124N, T125A, G163E, V201I, I203M, D256E, D278EB
 p8p8HM051424None   S17N, V31I, I60M, I72V, L74I, I84M, T124S, T125A, G163E, A205T, G277C, V281MB
 p10p10HM051426None   E11D, S24N, V31I, I72V, I113V, G163E, V201IB
 p17p17HM051433None   Q9P, K14R, V31I, S119G, T122I, T124N, T125A, G163E, S230N, Q252H, E287DB
 p18p18HM051434None   E11D, V31I, V32I, I72V, L101I, I113V, T122I, T124N, T125A, G163E, A205TB
 p21p21HM051437None   E11D, S24N, V31I, I72V, I113V, G163E, V201I, T218AB
 p27p27HM051443None   E11D, S24N, V31I, I72V, I113V, G163E, V201IB
 p37p37HM051453None   E10D, V31I, L101I, T124N, T125V, G163E, D256EB
 p42p42HM051458None   S24N, V31I, L45V, L101I, T124N, T125A, G163EB
 p46p46HM051462None   S17N, V31I, L101I, S119G, T122I, T125A, G163E, H171Q, S255RB
 p52p52HM051468None  L74MT124A, G163E, S283GB
 p54p54HM051470None   E11D, V31I, V37I, L101I, S119G, T122I, T124N, T125A, G163E, V201I, D256EB
 p73p73HM051489None   D6E, K14R, V31I, I113V, T124N, I162V, G163E, G193R, V201IB
 p74p74HM051490None   E10D, V31I, L101I, T124N, T125V, G163E, D256EB
Rolland (2011)0223consensus_0223JF320059None   S17N, S39C, M50I, L101I, I113V, T124S, T125V, G134E, G163E, T218SB
 2586consensus_2586JF320130None   M50I, K127R, G163E, I208LB
 2667consensus_2667JF320145None   S17N, V31I, L45Q, L74I, L101I, T124A, T125M, G163E, V201I, Q221K, N222K, S255KB
 2136consensus_2136JF320185None   D6E, E10D, R20K, L45R, L101I, T124A, G163E, N254K, S255G, I267V, R284G, D286NB
 1926consensus_1926JF320361None   E11D, D25E, L45V, I72V, S119G, T122I, G163E, V201VI, D256EB
 0897consensus_0897JF320493None   V31I, L101I, T112V, T124N, M154MI, G163E, R187K, K188RB
 0053consensus_0053JF320615None   S17N, L101I, K111R, T112V, S119G, T122I, T124N, T125A, G163E, K211R, Y227FB
Sanabani (2011)BR2036BR2036JN692441None   D6E, E10D, V31I, I72V, S119P, T122I, T124A, E157Q, K160Q, G163E, R269K, D278N, D279N, D286N, E287KB
 BR1097BR1097JN692472None   D6E, E11D, S24N, V31I, L74I, T122I, T124A, G163EB
Wilantho A (2011)SL0182SL0182JF928980None   S17N, V31VI, A91T, L101LI, I113IL, S119R, T124N, T125A, G163E, K211R, S255SN, D256EB
 711217711217JF928894None   V31VI, V88I, A91T, L101I, S119R, T124N, T125S, L158LF, G163E, K211R, K215KNB
 502407502407JF928833None   S17C, V32VG, Q53H, I113V, T124N, T125A, G163E, K211RB
Brockman (2012)AEHIV24AEHIV24JQ080108None   E10V, S119P, T122I, T124N, T125A, I135V, G163E, I182V, D256EB
 AEHIV29AEHIV29JQ080113None   K7R, V31I, L101I, G163E, T206S, D232EB
 AEHIV32AEHIV32JQ080116None   E11D, S17T, M22I, A23V, V31I, V37I, M50I, L101I, G163E, D167E, V201I, T206SB
 AEHIV41AEHIV41JQ080125None  V151VIS17N, V31I, L101I, K136N, G163E, K188R, S230N, S283GB
 AEHIV53AEHIV53JQ080137None   L45V, I72V, V88I, L101I, I113V, S119P, T125A, G163E, S195C, V201I, V250VL, D256E, D270EB
 AEHIV57AEHIV57JQ080141None   E11D, V31I, D41DN, L101I, G163EB
 AEHIV59AEHIV59JQ080143None   E11D, I72V, V88I, L101I, I113V, S119P, G163E, S195C, V201IB
 AEHIV61AEHIV61JQ080145None   E11D, V32I, I72V, V88I, L101I, G163E, S195C, V201I, K240RB
Iamarino (2012)BF.BR.1433BF.BR.1433JN234062None   K7Q, A21S, V31I, D41N, E69D, T125V, V126M, G163E, K173E, S283GB
 B.BR.0645B.BR.0645JN234100None   S17N, V31I, S119G, T122I, T124N, T125A, G163E, V201I, D256EB
 B.BR.1069B.BR.1069JN234126None   S24G, L101I, G163EB
 B.BR.1542B.BR.1542JN234169None   D6T, K7Q, E11D, K14R, S17N, L28I, L45V, T124N, T125A, I135V, G163E, T206S, S230N, N254Q, S255G, K273NB
Parczewski (2012)502_17502_17KC409165None   A8AT, E11D, V31I, G47GR, L101I, S119P, T122I, T125A, G163E, H171L, I182V, T218S, I220L, Q221H, N222AB
Rolland (2012)AA115c04LAA115c04LJX448097None   R20K, I72V, L101I, T125A, I135V, G163E, F181L, I203M, N222H, L234I, D256EB
Kijak (2013)04TH80368604TH803686JN248333None   E11D, K14R, S17T, I72V, L101I, T124A, I135V, G163E, L234IB
Li (2013)hnqx88hnqx88KC987969None  L68VE11D, Y15YF, H16HCRY, S17C, A91T, L101I, S119R, T124N, T125S, Q137H, G163E, K211RB
 hnr141hnr141KC988164None  L68VV88I, A91T, L101I, W108*, S119R, T124N, T125S, G163E, V201I, I208M, K211R, E212AB
 hnsx26hnsx26KC988130None  L68VV88I, A91T, L101I, K111R, S119R, T124N, T125P, S153A, K156N, G163E, R187K, K211RB
Reigadas (2013)1515JX425483None   V31I, M50I, Y99F, L101I, K111KR, T124TA, G163E, V201I, S230N, D256DE, S283SGB
 2828JX425496None   D6E, E10D, V31I, V32I, L74I, L101I, G163E, Q216HB
 4545JX425513None   E11D, S17T, M50T, L101I, T124N, T125V, G163E, E212A, D256EB
 8181JX425549None   S17N, M50T, I72V, L101I, S119P, T122I, T124A, T125M, G163E, Q209P, C280R, S283GB
 100100JX425568None   S17N, V31I, L45V, K111R, I113V, T124N, T125V, G163E, R187R_NILKQQYKW, K211R, D256E, V281M, Q285PB
 105105JX425573None  L68VK14R, S17N, V31I, S39C, L74I, L101I, S119T, T125A, G163E, H171Q, V201I, Q216HB
 107107JX425575None  V151IR20K, L101I, S119P, T124A, T125A, G163E, D167E, V201I, I208L, K211R, I220M, Y227FB
 117117JX425585None   E10D, E13EV, L45LV, L101I, S119P, T122TI, T124N, T125A, I135V, G163E, V201I, E212EA, S283SGB
 174174JX425641None   V31I, I72V, T112I, T122I, T124TADN, T125V, K127KR, G163E, K211RB
 175175JX425642None  L74LME11D, L28I, V31VI, M50I, I72V, T125AV, G163E, A205T, K211RB
 203203JX425670None   S17N, L101I, E157Q, K160Q, G163E, S283GB
 705705JX425872None   S17N, D25E, P30A, D41N, L45I, L101I, T112V, I113V, S119T, T125A, E157Q, K160Q, G163E, V201I, T206S, L234IB
 101165101165JX451951None   K7R, E11D, D41N, I113IV, S119SR, G163E, S195C, K211R, L234H, N254QB