<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Integrase Inhibitors

Subtype B
Gene IN
Mutation G163E
Rx >=1 INI
IncludeMixtures No
References 6
Patients 30
Isolates 37
 
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# INIs WksINIMajorDRMs INIMinorDRMs OtherMutSubtype
Hatano (2010)18Virus19GU121695EVG   K7R, I72V, V88I, K111Q, I113V, T124A, T125A, G163E, I203M, I208L, L234IB
  Virus91GU121767EVG   K7R, I72V, V88I, K111Q, I113V, T124A, T125A, G163E, I203IM, I208L, L234IB
  Virus94GU121770EVG E92Q K7KR, D41DN, I72V, V88I, K111Q, I113V, T124A, T125A, G163E, I203M, I208L, E212EA, L234IB
  Virus95GU121771EVG E92Q, Q148QRL74LMK7KR, D41DN, I72IV, V88I, K111Q, I113V, T124A, T125A, G163E, I203M, I208L, E212EA, L234IB
  Virus97GU121773EVG E92QL68LV, L74LMK7KR, D41DN, I72IV, V88I, K111Q, I113V, T124A, T125A, G163E, I203M, I208L, E212EA, L234IB
 17Virus99GU121775EVG E138K, S147G, Q148R K7KR, I72V, V79VI, V88I, K111Q, I113V, T124A, T125A, G163E, I203M, I208L, L234IB
  Virus100GU121776EVG E138K, S147G, Q148RV54VIK7KR, I72V, V79I, V88I, K111Q, I113V, T124A, T125A, G163E, I203M, I208L, L234IB
  Virus103GU121779EVG E138K, S147G, Q148RV54VIK7KR, E35EQ, I72IV, V79I, V88I, K111Q, I113V, T124A, T125A, G163E, I203M, I208L, L234IB
  Virus20GU121696EVG E138K, S147G, Q148RV54IK7KR, E35EK, I72V, V79I, V88I, K111Q, I113V, T124A, T125A, G163E, I203M, I208L, L234IB
 11Virus104GU121780RAL G140GS, N155HA128AT, V151VIE10DG, E11D, V31I, S119P, T122I, T125A, V126M, G163E, S195C, L234V, D279DNB
Brenner (2011)INT6INT6_1HQ207828RAL Y143C, N155HS230RS17N, M50I, L101I, T112I, T124N, G163E, A169S, V201I, T206S, I220L, Q221S, D279GB
Garrido (2012)BAA295881BAA295881JQ716874RAL52  K14R, V31I, M50I, I72V, L101I, S119G, T122I, G163E, H171Q, V201IB
 BAA295912BAA295912JQ716901RAL52  K7R, S17N, V31I, S39C, L101I, G163E, K173R, V201I, D232EB
Molina (2012)33463346_2 EVG88E92EQ, N155NH S17N, M50I, E96EA, T124A, G163E, V201I, D256DEB
 32313231_2 EVG12  A91T, L101I, S119P, T122I, T124A, G163E, I208M, S255GB
 41214121_2 EVG42  L45LV, L101I, G163E, V165VI, S195C, Q216H, K219Q, D278AB
 40294029_2 RAL45  E11D, E13D, V31I, L101I, S119P, T122I, T124N, G163E, D256E, D286DNB
de Souza Cavalcanti (2014)BRSP148BRSP148 RAL G140S, Q148H S17N, A21S, D25E, V31I, L63LI, L74I, L101I, K111R, I113L, S119P, T122I, T125A, G163E, H171Q, T218S, S283GB
Hurt (2014)IN_1622IN_1622 RAL E138K, S147G, Q148RQ95KK14R, R20K, V32I, L45V, L101I, K103R, T124A, G163E, V201I, K215N, N222K, D270HB
 IN_192IN_192 RAL E138EK, Q148QR E11D, V31I, A38K, L45Q, I72V, I84V, T124N, G163E, G193E, V201I, D278AB
 IN_1304IN_1304 RAL N155H E11D, S17T, L45V, M50I, L101I, S119R, I135V, G163EB
 IN_1772IN_1772 RAL G140S, Q148H S17N, V31I, L45V, L101I, G163E, H171Q, V201I, T218S, L234IB
 IN_2024IN_2024 RAL N155H L74I, G163E, I208IM, Q216H, Q221R, L234H, S255SRB
 IN_947IN_947 RAL Q148QR S17N, M50MI, L101I, T112I, T124N, T125V, G163E, D232N, D256EB
 IN_548IN_548 RAL G140S, Q148H V31I, L101I, I161T, G163E, I182V, V201I, T218S, S230N, D256EB
 IN_914IN_914 RAL E138A, G140S, Q148H S17N, L45IT, L101I, T124A, T125A, V126VA, E157Q, K160Q, G163E, V165IB
 IN_3168IN_3168 RAL  N155NDK7R, L101I, G163E, G197GE, S230N, S283GB
 IN_430IN_430 RAL N155H L101I, I161IL, G163E, H171HR, V201I, T218I, D232DN, L234IB
 IN_852IN_852 RAL T66TI, Y143YC S17N, V75VI, L101I, T124N, T125V, I135V, G163E, E170EA, I208LB
 IN_101IN_101 RAL G140S, Q148H S17N, V31I, L45V, L101I, I113V, T124A, T125A, G163E, F181L, V201IB
 IN_1638IN_1638 RAL E138K, S147G, Q148RQ95KK14R, R20K, V32I, L45V, L101I, K103R, T124A, G163E, V201I, K215N, N222K, D270HB
 IN_2785IN_2785 RAL E92QT97A, V151IE11D, K14R, S24N, D41DN, L63I, L74I, L101I, T112S, T125A, G163E, V201I, I208M, L234V, D279GB
 IN_3198IN_3198 RAL E92QT97AD6E, E10D, V31I, L101I, S119G, T122I, T124N, G163EB
 IN_3296IN_3296 RAL E92EQT97TA, V151VIE11D, K14R, S24N, L63LI, L74I, L101I, T112TS, T125A, I135IV, G163E, R166RK, V201I, T210TI, L234V, D279G, D286DNB
 IN_3281IN_3281 RAL G140S, Q148H E10D, V32I, L45V, L101I, T125A, K159KE, G163E, Y227F, D253H, D256EB
 IN_254IN_254 RAL G140S, Q148H S17N, V31I, L101I, T112I, T124N, G163E, V201I, K211Q, I220V, D256EB
 IN_475IN_475 RAL G140S, Q148H S17N, M50ML, I72V, L101I, K111R, T124N, T125V, G163E, D167E, T218S, D256EB