<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Integrase Inhibitors

Subtype B
Gene IN
Mutation E157Q
Rx II-naive
IncludeMixtures No
References 30
Patients 99
Isolates 99
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# INIs WksINIMajorDRMs INIMinorDRMs OtherMutSubtype
Liitsola (2000)RU98001RU98001AF193277None   E11A, L101V, T112V, T122I, T125A, E157Q, K160Q, V201I, T218I, L234I, S255NB
 KAL153KAL153AF193276None   S17G, L101V, T112I, T125A, E157Q, K160Q, I161T, V201I, T218I, L234I, S255NB
Masharsky (2003)Y1044398BY10443AF414006None   E11A, L101V, T112I, T122I, T125A, E157Q, K160Q, V201I, T218I, L234I, S255NB
Saad (2005)SM_02YE51902YE519AY795908None   E11D, A23V, S24N, I72V, L101I, T125V, K156R, E157Q, K160Q, K215N, D253EB
Sanabani (2006)02BR01102BR011DQ358809None  V151ID3E, L28I, P30A, I72V, L101I, V150A, E157Q, K160T, G163Q, V201IB
Zarandia (2006)03GEMZ01903GEMZ019DQ207943None   S24G, L101V, K111R, T112I, T125A, E157Q, K160Q, S230N, L234I, A265V, D279GB
Brennan (2007)443592443592EF150612None   M50I, L101I, E157Q, K160T, F181L, V201I, I208L, N222H, A265V, S283GB
Lataillade (2007)03-5355ML_03-5355EF472762None   V31I, I72V, E96EG, S119T, V126M, E157Q, K160Q, G193D, S195C, V201I, K211R, N254X, D256E, A265V, I268LB
Van Baelen (2007)Pt1212-1 None   E10D, S123G, T124A, T125A, K127R, I135V, E157Q, K160Q, D256EB
 Pt1313-1 None   E10D, M50L, L74I, L101I, S123G, T124A, T125A, K127R, I135V, E157Q, K160Q, V176L, D256EB
Van Laethem (2008)AR07-2127AR07-2127EU882744None   V32I, L45I, I60M, I72V, E157Q, K160E, F181Y, I182V, T206S, Y227F, N254K, S255G, D256EB
Brumme (2009)INT_3494INT_3494FJ812945None  F121FSS17N, M50I, I72IV, E157Q, K160Q, V201I, D256E, A265V, R269RKB
 INT_3523INT_3523FJ812974None   E11D, V31I, I72V, A91AT, L101I, S119ST, K156N, E157Q, F181L, V201I, K211R, A265AV, I268IL, R269RKB
 INT_3603INT_3603FJ813054None   E11D, S17ST, V37VI, M50MI, I60V, P90PS, T112V, S119SGR, T122TI, T125TA, E157Q, K160QB
 INT_3758INT_3758FJ813209None   E10D, I72IV, T124A, E157Q, K160Q, S230N, D253DE, S255SR, R284GB
 INT_3987INT_3987FJ813438None   E11A, S39C, L45I, M50I, I72IV, L101I, K111T, T112A, T125A, E157Q, K160Q, V201I, T206SB
 D7533D7533GQ371830None   E11D, V31I, M50I, I72V, E96D, L101I, S119P, T122TI, K156N, E157Q, F181L, G193GE, V201I, T206S, I208IL, K211KQR, E212EA, S230N, D256E, I268ITB
 E0549E0549GQ371837None   S17N, V31I, A33AT, L45LI, M50MI, I113V, T124N, T125A, K156N, E157Q, K211Q, T218S, I220L, S230N, L242LF, D256EB
 E6574E6574GQ371853None   S17SN, V37VI, L101V, T125TA, E157Q, K160Q, G193D, S195C, S230N, L234I, D256EB
 L5525L5525GQ371991None   I72V, T124N, P142PR, E157Q, K160T, A175AG, R187K, V201VI, D232E, A265V, S283GB
 O6535O6535GQ372066None   E11D, K14R, V31I, E48Q, M50MIT, I72V, T124A, E157Q, K160Q, G193E, V201I, I220L, R262RKB
 R2504R2504GQ372127None   S17N, I72V, L101I, T112R, T124S, T125V, E157Q, K160Q, D167E, D256E, A265V, R284GB
 S5571S5571GQ372158None   I72V, K111R, T124A, E157Q, K160Q, F181L, V201I, A265VB
 T9524T9524GQ372194None   V31I, T125M, K156N, E157Q, V201I, I203M, K211R, I217VB
 V8518V8518GQ372213None   S17N, V31VI, A38AT, D41DN, M50I, T124A, T125A, K156N, E157Q, K211R, Y227F, D256EB
 W0546W0546GQ372221None   M50I, K111KR, K156N, E157Q, I203IM, I208L, T218SB
Garrido (2009)350INT-350GU217197None   E10D, L45I, L101I, S119R, N120Q, E157Q, K160Q, V201I, A265VB
 354INT-354GU217201None   E11D, S24N, L45I, I72V, L101I, I135V, E157Q, K160Q, L172I, V201I, K219N, N222K, A265VB
 369INT-369GU217216None   E11D, S24N, L45I, I72V, L101I, I135V, E157Q, K160Q, L172I, V201I, K219N, N222K, A265VB
Low (2009)ahi18ahi18_02FJ786285None   E11D, V37I, I60V, I72V, T112C, T122I, T125A, E157Q, K160Q, L172I, A205S, K211R, S230NB
 ahi21ahi21_03FJ786288None   P30A, V32I, T125A, K156N, E157Q, K188R, V201I, K215N, N222K, S230N, M275VB
 ahi41ahi41_06FJ786308None   V31I, S39C, T124A, E157Q, G163Q, V201I, D232EB
 ahi101ahi101_03FJ786369None   P30A, V32I, T125A, K156N, E157Q, K188R, V201I, K215N, N222K, S230N, M275VB
Nadai (2009)129805129805EU839604None   K7R, S17N, V31I, I72V, L101I, S119T, T124A, E157Q, K160Q, V201I, I220L, A265V, R284GB
 CRC50069CRC50069EU839608None   S39C, L45I, I72V, V88I, L101I, T112V, I113V, T115S, S119G, T124N, T125V, E157Q, K160E, D167E, V201I, K211R, Q221T, D256EB
Passaes (2009)BR.RJ.SB160BR.RJ.SB160HM026789None  V151IE11D, V31I, K111T, I113V, S119G, T122I, T124N, T125A, V126M, E157Q, K160Q, V260IB
Sichtig (2009)47784778FJ183631None   E11D, E13ED, L101I, T112TI, T124A, E157Q, K160Q, F181L, G193E, V201I, T218S, I220LB
 10561056FJ183679None   E10D, E11ED, K14KR, R20RK, L45I, I72V, L101I, T112I, T124A, E157Q, K160Q, S195T, N222K, S230NB
Wang (2009)PRLS08PRLS08FJ469757None   L45Q, I72V, K111R, E157Q, K160T, D256EB
Rangel (2010)HIV247pHIV247pGU797527None   Q53H, I72V, P90S, L101I, T112I, T124A, E157Q, K160QB
 HIV257pHIV257pGU797529None   M50I, I72V, T124A, T125A, E157Q, K160Q, V201I, D232E, A265VB
Kim (2011)p25p25HM051441None   V31I, I72V, L101I, T122I, T124N, E157Q, R187K, D232N, S255NB
 p33p33HM051449None   D6E, S17N, T124N, T125A, E157Q, K160Q, E198D, V201I, A265V, D288EB
 p39p39HM051455None   E10D, S39C, L101I, I135V, E157Q, K160Q, V201I, R284GB
 p59p59HM051475None   E11D, S17N, V31I, T124N, E157Q, V201I, A265VB
 p65p65HM051481None   V31I, I72V, L101I, T122I, T124N, E157Q, R187K, S255NB
Sanabani (2011)BR2036BR2036JN692441None   D6E, E10D, V31I, I72V, S119P, T122I, T124A, E157Q, K160Q, G163E, R269K, D278N, D279N, D286N, E287KB
DeJesus (2012)70327032_1 None   S17C, A23AT, M50I, L101I, T112R, T124A, T125A, E157Q, K160Q, K219N, N222K, S230SNB
Molina (2012)32113211_1 None   S17SN, S24SN, M50MI, T124TA, T125A, K156N, E157Q, K211Q, D256E, S283SG, R284G, D288NB
 32413241_1 None   K14R, Y99H, L101I, I135V, E157Q, G193D, S195C, A265VB
 30623062_1 None   D6E, E11D, S17N, V31I, L63I, L74I, E96D, L101I, T112V, T124N, T125A, G134N, K136T, E157Q, K160N, V201I, T206S, K211R, L234I, R269K, S283G, D288NB
 31803180_1 None   K14KR, S17SN, V31VI, G106A, K111T, T124TA, E157Q, K160Q, V201I, D256EB
 40754075_1 None   S17N, V31I, I72IV, L101I, T124A, E157Q, K160Q, D232E, A265VB
Parczewski (2012)121_27121_27KC409143None   V32I, S39C, L101I, K111T, S119G, T124N, T125A, E157Q, K160Q, Q177L, V201I, S230N, L234I, D253DE, S255STB
 238_12238_12KC409151None   E10G, K14KR, S39C, L101I, T112I, T125A, E157Q, K160Q, V201I, S230N, L234I, D253E, N254D, D256E, V259VIB
 297_2297_2KC409154None   L101I, T112I, I113IV, T125M, E157Q, K160Q, G163V, V201VI, S230N, L234I, A265VB
 307307_12KC409155None   E10D, L101I, T112I, I113IV, T124N, T125A, E157Q, K160Q, K219T, I220L, S230N, L234I, D253E, D256E, D278GB
 414_18414_18KC409160None   E10D, L101I, T112I, T124TA, E157Q, K160Q, S230N, L234I, D253E, D256E, R284RGB
 431_30431_30KC409161None   D6E, E10D, V32I, S39SC, L101I, T112M, S119G, T124N, E157Q, K160Q, S230N, L234I, D288AB
 485_1485_1KC409162None   S17N, T124A, E157Q, K160Q, Q216QH, S230N, L234I, A265VB
 497_21497_21KC409164None   V31VIM, V32I, L101I, T112I, E157Q, K160Q, V201I, L234I, D253E, D256EB
 517_4517_4KC409168None   S17N, L101I, T112I, T125TA, E157Q, K160Q, S230N, L234I, A265VB
 518_4518_4KC409169None   E10ED, L101I, T112I, E157Q, K160Q, K211R, K219T, I220L, S230N, L234I, D253E, D256EB
 520_4520_4KC409170None   E11D, S17N, I84M, L101I, T112I, E157Q, K160Q, I220L, S230N, L234I, D253E, D256EB
 549549_18KC409173None   I72IT, L101I, T112I, E157Q, K160Q, K215KN, S230N, L234I, A265VB
 561_17561_17KC409176None   I72V, H78HY, T112V, T124A, E157Q, K160Q, R187K, S230NB
 573_2573_2KC409177None  T97TAS17N, I72V, L101V, T112I, T125A, E157Q, K160Q, V201I, K211Q, I217V, S230N, L234I, A265VB
 590_1590_1KC409180None  L68VL101I, T125TA, E157Q, K160Q, K188KR, G193GR, K211R, K219T, I220L, L234I, D253E, D256E, A265AVB
 6060_24KC409181None   L101I, T112I, E157Q, K160Q, I200L, S230N, L234I, A265VB
 682_12682_12KC409193None   K14R, L101I, E157Q, K160Q, G193D, I208M, L234I, N254NK, A265V, D278DE, D286NB
 828828_1KC409200None   E10D, M50I, L101I, T112I, E157Q, K160Q, S230N, L234I, D253E, D256EB
 874_2874_2KC409204None   V37I, E96D, L101V, T112I, T124N, T125A, E157Q, K160Q, S230N, L234I, D253EB
 893_1893_1KC409205None   K7KR, R20K, L101I, K111KR, T112I, T125A, V126A, E157Q, K160Q, G193E, S230N, L234I, D253EB
 916_1916_1KC409213None   S17N, S39C, L45I, L101I, T124N, T125A, I135V, E157Q, K160Q, G193E, A265V, D286NB
 921_1921_1KC409216None   S17N, L101I, T112I, E157Q, K160Q, R224RW, S230N, L234I, D253E, D256EB
 92_2092_20KC409220None   S57SG, L101V, T112IV, T125A, E157Q, K160Q, R187K, V201I, S230N, L234I, A265VB
 938_1938_1KC409222None   P30S, V32I, L101V, T112V, T125A, E157Q, K160Q, V201I, K215N, N222K, S230N, M275VB
Rolland (2012)AA010a_WG11AA010a_WG11JX446797None   S17N, L101I, T112I, D116DG, E157Q, K160Q, V201I, S230N, D253E, D256EB
Sax (2012)64696469_1 None   D6E, D25E, L101I, V110T, T112V, K156N, E157Q, K215N, D232E, L234H, D253E, D256E, D270NB
Capel (2013)130130KC238654None   E11D, V31I, G70E, L101I, T112I, S119R, T124N, K156N, E157Q, V201I, K215N, S230N, S283GB
Kijak (2013)04TH60106604TH601066JN248329None   V31I, I89M, L101I, S119R, T124N, T125S, K156N, E157Q, K160T, S230NB
Reigadas (2013)4444JX425512None   S17N, I72V, L74I, S119T, T124A, T125A, E157Q, K160Q, G193E, V201I, D207N, K211T, D256E, R284G, D288NB
 203203JX425670None   S17N, L101I, E157Q, K160Q, G163E, S283GB
 230230JX425697None   R20K, D25E, S39N, L101I, K156N, E157Q, K160R, K188R, G193E, S195C, I220V, D279GB
 705705JX425872None   S17N, D25E, P30A, D41N, L45I, L101I, T112V, I113V, S119T, T125A, E157Q, K160Q, G163E, V201I, T206S, L234IB
Chikata (2014)KI-476KI-476AB873936None   E10D, K156N, E157Q, T218S, D256EB
 KI-960KI-960AB874244None   E11D, S24N, V31I, T125TA, I141IV, V150A, K156N, E157Q, V201I, L242LFB
 KI-637KI-637AB873998None   D6E, E10D, V32VI, L45I, L101I, K156N, E157Q, D256EB
 KI-874KI-874AB874182None   D6E, R20K, L45IV, K156N, E157Q, V281VMB
 KI-811KI-811AB874130None   E11D, A21AT, L28I, V37I, I72V, T112A, S119G, T122I, T124A, T125A, K156N, E157Q, K215N, Q221S, N222KB
 KI-680KI-680AB874032None   D6E, E10D, K14R, L101I, K156N, E157Q, I220L, D253EB
 KI-865KI-865AB874173None   D6E, E10D, K14R, R20K, L101I, K156N, E157Q, I220L, A265ATB
 KI-949KI-949AB874235None   E11D, K14R, S24N, L28I, L45I, T112I, K156N, E157Q, K211RB
 KI-750KI-750AB874080None   D6E, L101LI, K156N, E157Q, V201VI, I203IM, D256E, C280SB
 KI-996KI-996AB874266None   E11D, S24N, T112I, K156N, E157Q, V201I, K211R, T218S, I220LB
 KI-650KI-650AB874007None   E10D, S39C, S57N, I84M, L101I, S119P, E157Q, K160KEQ, Q177QL, V201I, T206SB
 KI-832KI-832AB874139None   E11D, S24N, L45I, T112I, K156N, E157Q, K211RB
Hardy (2014)Pt1INTPt1INT None   R20K, V31I, L45I, L101I, K111KR, I135IV, E157Q, K160Q, V201I, K215N, A265AVB
Grossmann (2015)SE600057SE600057KP411828None   E11D, H16L, S17C, L63I, L101I, T112V, S119P, T124S, T125A, V126D, K156N, E157Q, K160Q, V201I, Q216H, L234I, A265VB