Integrase Inhibitors

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Integrase Inhibitors

Subtype	B
Gene	IN
Mutation	E157Q
Rx	II-naive
IncludeMixtures	No

References	22
Patients	73
Isolates	73

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr)	Patient	Isolate	Acc#	INIs	INIMinorDRMs	OtherMut	Subtype
Liitsola (2000)	RU98001	RU98001	AF193277	None		E11A, L101V, T112V, T122I, T125A, E157Q, K160Q, V201I, T218I, L234I, S255N	B
	KAL153	KAL153	AF193276	None		S17G, L101V, T112I, T125A, E157Q, K160Q, I161T, V201I, T218I, L234I, S255N	B
Masharsky (2003)	Y10443	98BY10443	AF414006	None		E11A, L101V, T112I, T122I, T125A, E157Q, K160Q, V201I, T218I, L234I, S255N	B
Takebe (2003)	TY_pat5	TYmIDU106	AB097869	None		E10D, H51Q, V88I, L101I, G106A, K111R, T112V, T125A, E157Q, K160Q, K211R, S230N, R231K	B
Saad (2005)	SM_02YE519	02YE519	AY795908	None		E11D, A23V, S24N, I72V, L101I, T125V, K156R, E157Q, K160Q, K215N, D253E	B
Sanabani (2006)	02BR011	02BR011	DQ358809	None	V151I	D3E, L28I, P30A, I72V, L101I, V150A, E157Q, K160T, G163Q, V201I	B
Zarandia (2006)	03GEMZ019	03GEMZ019	DQ207943	None		S24G, L101V, K111R, T112I, T125A, E157Q, K160Q, S230N, L234I, A265V, D279G	B
Brennan (2007)	443592	443592	EF150612	None		M50I, L101I, E157Q, K160T, F181L, V201I, I208L, N222H, A265V, S283G	B
Lataillade (2007)	03-5355	ML_03-5355	EF472762	None		V31I, I72V, E96EG, S119T, V126M, E157Q, K160Q, G193D, S195C, V201I, K211R, N254X, D256E, A265V, I268L	B
Van Baelen (2007)	Pt12	12-1		None		E10D, S123G, T124A, T125A, K127R, I135V, E157Q, K160Q, D256E	B
	Pt13	13-1		None		E10D, M50L, L74I, L101I, S123G, T124A, T125A, K127R, I135V, E157Q, K160Q, V176L, D256E	B
Brumme (2009)	INT_3494	INT_3494	FJ812945	None	F121FS	S17N, M50I, I72IV, E157Q, K160Q, V201I, D256E, A265V, R269RK	B
	INT_3523	INT_3523	FJ812974	None		E11D, V31I, I72V, A91AT, L101I, S119ST, K156N, E157Q, F181L, V201I, K211R, A265AV, I268IL, R269RK	B
	INT_3603	INT_3603	FJ813054	None		E11D, S17ST, V37VI, M50MI, I60V, P90PS, T112V, S119SGR, T122TI, T125TA, E157Q, K160Q	B
	INT_3758	INT_3758	FJ813209	None		E10D, I72IV, T124A, E157Q, K160Q, S230N, D253DE, S255SR, R284G	B
	INT_3987	INT_3987	FJ813438	None		E11A, S39C, L45I, M50I, I72IV, L101I, K111T, T112A, T125A, E157Q, K160Q, V201I, T206S	B
	D7533	D7533	GQ371830	None		E11D, V31I, M50I, I72V, E96D, L101I, S119P, T122TI, K156N, E157Q, F181L, G193GE, V201I, T206S, I208IL, K211KQR, E212EA, S230N, D256E, I268IT	B
	E0549	E0549	GQ371837	None		S17N, V31I, A33AT, L45LI, M50MI, I113V, T124N, T125A, K156N, E157Q, K211Q, T218S, I220L, S230N, L242LF, D256E	B
	E6574	E6574	GQ371853	None		S17SN, V37VI, L101V, T125TA, E157Q, K160Q, G193D, S195C, S230N, L234I, D256E	B
	L5525	L5525	GQ371991	None		I72V, T124N, P142PR, E157Q, K160T, A175AG, R187K, V201VI, D232E, A265V, S283G	B
	O6535	O6535	GQ372066	None		E11D, K14R, V31I, E48Q, M50MIT, I72V, T124A, E157Q, K160Q, G193E, V201I, I220L, R262RK	B
	R2504	R2504	GQ372127	None		S17N, I72V, L101I, T112R, T124S, T125V, E157Q, K160Q, D167E, D256E, A265V, R284G	B
	S5571	S5571	GQ372158	None		I72V, K111R, T124A, E157Q, K160Q, F181L, V201I, A265V	B
	T9524	T9524	GQ372194	None		V31I, T125M, K156N, E157Q, V201I, I203M, K211R, I217V	B
	V8518	V8518	GQ372213	None		S17N, V31VI, A38AT, D41DN, M50I, T124A, T125A, K156N, E157Q, K211R, Y227F, D256E	B
	W0546	W0546	GQ372221	None		M50I, K111KR, K156N, E157Q, I203IM, I208L, T218S	B
Garrido (2009)	350	INT-350	GU217197	None		E10D, L45I, L101I, S119R, N120Q, E157Q, K160Q, V201I, A265V	B
	354	INT-354	GU217201	None		E11D, S24N, L45I, I72V, L101I, I135V, E157Q, K160Q, L172I, V201I, K219N, N222K, A265V	B
	369	INT-369	GU217216	None		E11D, S24N, L45I, I72V, L101I, I135V, E157Q, K160Q, L172I, V201I, K219N, N222K, A265V	B
Low (2009)	ahi18	ahi18_02	FJ786285	None		E11D, V37I, I60V, I72V, T112C, T122I, T125A, E157Q, K160Q, L172I, A205S, K211R, S230N	B
	ahi21	ahi21_03	FJ786288	None		P30A, V32I, T125A, K156N, E157Q, K188R, V201I, K215N, N222K, S230N, M275V	B
	ahi41	ahi41_06	FJ786308	None		V31I, S39C, T124A, E157Q, G163Q, V201I, D232E	B
	ahi101	ahi101_03	FJ786369	None		P30A, V32I, T125A, K156N, E157Q, K188R, V201I, K215N, N222K, S230N, M275V	B
Nadai (2009)	129805	129805	EU839604	None		K7R, S17N, V31I, I72V, L101I, S119T, T124A, E157Q, K160Q, V201I, I220L, A265V, R284G	B
	CRC50069	CRC50069	EU839608	None		S39C, L45I, I72V, V88I, L101I, T112V, I113V, T115S, S119G, T124N, T125V, E157Q, K160E, D167E, V201I, K211R, Q221T, D256E	B
Passaes (2009)	BR.RJ.SB160	BR.RJ.SB160	HM026789	None	V151I	E11D, V31I, K111T, I113V, S119G, T122I, T124N, T125A, V126M, E157Q, K160Q, V260I	B
Sichtig (2009)	4778	4778	FJ183631	None		E11D, E13ED, L101I, T112TI, T124A, E157Q, K160Q, F181L, G193E, V201I, T218S, I220L	B
	1056	1056	FJ183679	None		E10D, E11ED, K14KR, R20RK, L45I, I72V, L101I, T112I, T124A, E157Q, K160Q, S195T, N222K, S230N	B
Wang (2009)	PRLS08	PRLS08	FJ469757	None		L45Q, I72V, K111R, E157Q, K160T, D256E	B
Rangel (2010)	HIV247p	HIV247p	GU797527	None		Q53H, I72V, P90S, L101I, T112I, T124A, E157Q, K160Q	B
	HIV257p	HIV257p	GU797529	None		M50I, I72V, T124A, T125A, E157Q, K160Q, V201I, D232E, A265V	B
Kim (2011)	p25	p25	HM051441	None		V31I, I72V, L101I, T122I, T124N, E157Q, R187K, D232N, S255N	B
	p33	p33	HM051449	None		D6E, S17N, T124N, T125A, E157Q, K160Q, E198D, V201I, A265V, D288E	B
	p39	p39	HM051455	None		E10D, S39C, L101I, I135V, E157Q, K160Q, V201I, R284G	B
	p59	p59	HM051475	None		E11D, S17N, V31I, T124N, E157Q, V201I, A265V	B
	p65	p65	HM051481	None		V31I, I72V, L101I, T122I, T124N, E157Q, R187K, S255N	B
Sanabani (2011)	BR2036	BR2036	JN692441	None		D6E, E10D, V31I, I72V, S119P, T122I, T124A, E157Q, K160Q, G163E, R269K, D278N, D279N, D286N, E287K	B
Kijak (2012)	04TH601066	04TH601066	JN248329	None		V31I, I89M, L101I, S119R, T124N, T125S, K156N, E157Q, K160T, S230N	B
Parczewski (2012)	121_27	121_27	KC409143	None		V32I, S39C, L101I, K111T, S119G, T124N, T125A, E157Q, K160Q, Q177L, V201I, S230N, L234I, D253DE, S255ST	B
	238_12	238_12	KC409151	None		E10G, K14KR, S39C, L101I, T112I, T125A, E157Q, K160Q, V201I, S230N, L234I, D253E, N254D, D256E, V259VI	B
	297_2	297_2	KC409154	None		L101I, T112I, I113IV, T125M, E157Q, K160Q, G163V, V201VI, S230N, L234I, A265V	B
	307	307_12	KC409155	None		E10D, L101I, T112I, I113IV, T124N, T125A, E157Q, K160Q, K219T, I220L, S230N, L234I, D253E, D256E, D278G	B
	414_18	414_18	KC409160	None		E10D, L101I, T112I, T124TA, E157Q, K160Q, S230N, L234I, D253E, D256E, R284RG	B
	431_30	431_30	KC409161	None		D6E, E10D, V32I, S39SC, L101I, T112M, S119G, T124N, E157Q, K160Q, S230N, L234I	B
	485_1	485_1	KC409162	None		S17N, T124A, E157Q, K160Q, Q216QH, S230N, L234I, A265V	B
	497_21	497_21	KC409164	None		V31VIM, V32I, L101I, T112I, E157Q, K160Q, V201I, L234I, D253E, D256E	B
	517_4	517_4	KC409168	None		S17N, L101I, T112I, T125TA, E157Q, K160Q, S230N, L234I, A265V	B
	518_4	518_4	KC409169	None		E10ED, L101I, T112I, E157Q, K160Q, K211R, K219T, I220L, S230N, L234I, D253E, D256E	B
	520_4	520_4	KC409170	None		E11D, S17N, I84M, L101I, T112I, E157Q, K160Q, I220L, S230N, L234I, D253E, D256E	B
	549	549_18	KC409173	None		I72IT, L101I, T112I, E157Q, K160Q, K215KN, S230N, L234I, A265V	B
	561_17	561_17	KC409176	None		I72V, H78HY, T112V, T124A, E157Q, K160Q, R187K, S230N	B
	573_2	573_2	KC409177	None	T97TA	S17N, I72V, L101V, T112I, T125A, E157Q, K160Q, V201I, K211Q, I217V, S230N, L234I, A265V	B
	590_1	590_1	KC409180	None	L68V	L101I, T125TA, E157Q, K160Q, K188KR, G193GR, K211R, K219T, I220L, L234I, D253E, D256E, A265AV	B
	60	60_24	KC409181	None		L101I, T112I, E157Q, K160Q, I200L, S230N, L234I, A265V	B
	682_12	682_12	KC409193	None		K14R, L101I, E157Q, K160Q, G193D, I208M, L234I, N254NK, A265V, D278DE, D286N	B
	828	828_1	KC409200	None		E10D, M50I, L101I, T112I, E157Q, K160Q, S230N, L234I, D253E, D256E	B
	874_2	874_2	KC409204	None		V37I, E96D, L101V, T112I, T124N, T125A, E157Q, K160Q, S230N, L234I, D253E	B
	893_1	893_1	KC409205	None		K7KR, R20K, L101I, K111KR, T112I, T125A, V126A, E157Q, K160Q, G193E, S230N, L234I, D253E	B
	916_1	916_1	KC409213	None		S17N, S39C, L45I, L101I, T124N, T125A, I135V, E157Q, K160Q, G193E, A265V, D286N	B
	921_1	921_1	KC409216	None		S17N, L101I, T112I, E157Q, K160Q, R224RW, S230N, L234I, D253E, D256E	B
	92_20	92_20	KC409220	None		S57SG, L101V, T112IV, T125A, E157Q, K160Q, R187K, V201I, S230N, L234I, A265V	B
	938_1	938_1	KC409222	None		P30S, V32I, L101V, T112V, T125A, E157Q, K160Q, V201I, K215N, N222K, S230N, M275V	B
Rolland (2012)	AA010a_WG11	AA010a_WG11	JX446797	None		S17N, L101I, T112I, D116DG, E157Q, K160Q, V201I, S230N, D253E, D256E	B

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