<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Integrase Inhibitors

Subtype B
Gene IN
Mutation E157Q
Rx II-naive
IncludeMixtures No
References 43
Patients 218
Isolates 218
 
Show mutation frequency as:
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# INIs WksINIMajorDRMs INIMinorDRMs OtherMutSubtype
Liitsola (2000)RU98001RU98001AF193277None   E11A, L101V, T112V, T122I, T125A, E157Q, K160Q, V201I, T218I, L234I, S255NB
 KAL153KAL153AF193276None   S17G, L101V, T112I, T125A, E157Q, K160Q, I161T, V201I, T218I, L234I, S255NB
Masharsky (2003)Y1044398BY10443AF414006None   E11A, L101V, T112I, T122I, T125A, E157Q, K160Q, V201I, T218I, L234I, S255NB
Saad (2005)SM_02YE51902YE519AY795908None   E11D, A23V, S24N, I72V, L101I, T125V, K156R, E157Q, K160Q, K215N, D253EB
Sanabani (2006)02BR01102BR011DQ358809None  V151ID3E, L28I, P30A, I72V, L101I, V150A, E157Q, K160T, G163Q, V201IB
Zarandia (2006)03GEMZ01903GEMZ019DQ207943None   S24G, L101V, K111R, T112I, T125A, E157Q, K160Q, S230N, L234I, A265V, D279GB
Brennan (2007)443592443592EF150612None   M50I, L101I, E157Q, K160T, F181L, V201I, I208L, N222H, A265V, S283GB
Lataillade (2007)03-5355ML_03-5355EF472762None   V31I, I72V, E96EG, S119T, V126M, E157Q, K160Q, G193D, S195C, V201I, K211R, N254NIST, D256E, A265V, I268LB
Van Baelen (2007)Pt1212-1 None   E10D, S123G, T124A, T125A, K127R, I135V, E157Q, K160Q, D256EB
 Pt1313-1 None   E10D, M50L, L74I, L101I, S123G, T124A, T125A, K127R, I135V, E157Q, K160Q, V176L, D256EB
Van Laethem (2008)AR07-2127AR07-2127EU882744None   V32I, L45I, I60M, I72V, E157Q, K160E, F181Y, I182V, T206S, Y227F, N254K, S255G, D256EB
Brumme (2009)INT_3494INT_3494FJ812945None  F121FSS17N, M50I, I72IV, E157Q, K160Q, V201I, D256E, A265V, R269RKB
 INT_3523INT_3523FJ812974None   E11D, V31I, I72V, A91AT, L101I, S119ST, K156N, E157Q, F181L, V201I, K211R, A265AV, I268IL, R269RKB
 INT_3603INT_3603FJ813054None   E11D, S17ST, V37VI, M50MI, I60V, P90PS, T112V, S119SGR, T122TI, T125TA, E157Q, K160QB
 INT_3758INT_3758FJ813209None   E10D, I72IV, T124A, E157Q, K160Q, S230N, D253DE, S255SR, R284GB
 INT_3987INT_3987FJ813438None   E11A, S39C, L45I, M50I, I72IV, L101I, K111T, T112A, T125A, E157Q, K160Q, V201I, T206SB
 D7533D7533GQ371830None   E11D, V31I, M50I, I72V, E96D, L101I, S119P, T122TI, K156N, E157Q, F181L, G193GE, V201I, T206S, I208IL, K211KQR, E212EA, S230N, D256E, I268ITB
 E0549E0549GQ371837None   S17N, V31I, A33AT, L45LI, M50MI, I113V, T124N, T125A, K156N, E157Q, K211Q, T218S, I220L, S230N, L242LF, D256EB
 E6574E6574GQ371853None   S17SN, V37VI, L101V, T125TA, E157Q, K160Q, G193D, S195C, S230N, L234I, D256EB
 L4530L4530GQ371988None   D25E, I72V, L101I, I113V, S119AT, T122TI, K156N, E157Q, I161IT, T206S, K219N, N222K, D256E, R262RK, A265V, D279DNB
 L5525L5525GQ371991None   I72V, T124N, P142PR, E157Q, K160T, A175AG, R187K, V201VI, D232E, A265V, S283GB
 O6535O6535GQ372066None   E11D, K14R, V31I, E48Q, M50MIT, I72V, T124A, E157Q, K160Q, G193E, V201I, I220L, R262RKB
 R2504R2504GQ372127None   S17N, I72V, L101I, T112R, T124S, T125V, E157Q, K160Q, D167E, D256E, A265V, R284GB
 R5572R5572GQ372136None  P145PLI72IV, L74I, A91G, E96D, L101I, M154L, E157Q, K160Q, I182V, F185L, R187E, V201I, V225VG, D256E, R262RKB
 S5571S5571GQ372158None   I72V, K111R, T124A, E157Q, K160Q, F181L, V201I, A265VB
 T9524T9524GQ372194None   V31I, T125M, K156N, E157Q, V201I, I203M, K211R, I217VB
 V8518V8518GQ372213None   S17N, V31VI, A38AT, D41DN, M50I, T124A, T125A, K156N, E157Q, K211R, Y227F, D256EB
 W0546W0546GQ372221None   M50I, K111KR, K156N, E157Q, I203IM, I208L, T218SB
Garrido (2009)350INT-350GU217197None   E10D, L45I, L101I, S119R, N120Q, E157Q, K160Q, V201I, A265VB
 354INT-354GU217201None   E11D, S24N, L45I, I72V, L101I, I135V, E157Q, K160Q, L172I, V201I, K219N, N222K, A265VB
 369INT-369GU217216None   E11D, S24N, L45I, I72V, L101I, I135V, E157Q, K160Q, L172I, V201I, K219N, N222K, A265VB
Low (2009)ahi18ahi18_02FJ786285None   E11D, V37I, I60V, I72V, T112C, T122I, T125A, E157Q, K160Q, L172I, A205S, K211R, S230NB
 ahi21ahi21_03FJ786288None   P30A, V32I, T125A, K156N, E157Q, K188R, V201I, K215N, N222K, S230N, M275VB
 ahi41ahi41_06FJ786308None   V31I, S39C, T124A, E157Q, G163Q, V201I, D232EB
 ahi101ahi101_03FJ786369None   P30A, V32I, T125A, K156N, E157Q, K188R, V201I, K215N, N222K, S230N, M275VB
Nadai (2009)129805129805EU839604None   K7R, S17N, V31I, I72V, L101I, S119T, T124A, E157Q, K160Q, V201I, I220L, A265V, R284GB
 CRC50069CRC50069EU839608None   S39C, L45I, I72V, V88I, L101I, T112V, I113V, T115S, S119G, T124N, T125V, E157Q, K160E, D167E, V201I, K211R, Q221T, D256EB
Passaes (2009)BR.RJ.SB160BR.RJ.SB160HM026789None  V151IE11D, V31I, K111T, I113V, S119G, T122I, T124N, T125A, V126M, E157Q, K160Q, V260IB
Sichtig (2009)47784778FJ183631None   E11D, E13ED, L101I, T112TI, T124A, E157Q, K160Q, F181L, G193E, V201I, T218S, I220LB
 10561056FJ183679None   E10D, E11ED, K14KR, R20RK, L45I, I72V, L101I, T112I, T124A, E157Q, K160Q, S195T, N222K, S230NB
Wang (2009)PRLS08PRLS08FJ469757None   L45Q, I72V, K111R, E157Q, K160T, D256EB
Rangel (2010)HIV247pHIV247pGU797527None   Q53H, I72V, P90S, L101I, T112I, T124A, E157Q, K160QB
 HIV257pHIV257pGU797529None   M50I, I72V, T124A, T125A, E157Q, K160Q, V201I, D232E, A265VB
Kim (2011)p25p25HM051441None   V31I, I72V, L101I, T122I, T124N, E157Q, R187K, D232N, S255NB
 p33p33HM051449None   D6E, S17N, T124N, T125A, E157Q, K160Q, E198D, V201I, A265V, D288EB
 p39p39HM051455None   E10D, S39C, L101I, I135V, E157Q, K160Q, V201I, R284GB
 p59p59HM051475None   E11D, S17N, V31I, T124N, E157Q, V201I, A265VB
 p65p65HM051481None   V31I, I72V, L101I, T122I, T124N, E157Q, R187K, S255NB
Kousiappa (2011)CY266CY266JF683807None   E11D, S24N, V31I, I72V, S119P, E157Q, K160Q, D167E, V201I, T206S, T218S, S230N, D253E, D256E, R284GB
Sanabani (2011)BR2036BR2036JN692441None   D6E, E10D, V31I, I72V, S119P, T122I, T124A, E157Q, K160Q, G163E, R269K, D278N, D279N, D286N, E287KB
DeJesus (2012)70327032_1 None   S17C, A23AT, M50I, L101I, T112R, T124A, T125A, E157Q, K160Q, K219N, N222K, S230SNB
Molina (2012)32113211_1 None   S17SN, S24SN, M50MI, T124TA, T125A, K156N, E157Q, K211Q, D256E, S283SG, R284G, D288NB
 32413241_1 None   K14R, Y99H, L101I, I135V, E157Q, G193D, S195C, A265VB
 30623062_1 None   D6E, E11D, S17N, V31I, L63I, L74I, E96D, L101I, T112V, T124N, T125A, G134N, K136T, E157Q, K160N, V201I, T206S, K211R, L234I, R269K, S283G, D288NB
 31803180_1 None   K14KR, S17SN, V31VI, G106A, K111T, T124TA, E157Q, K160Q, V201I, D256EB
 40754075_1 None   S17N, V31I, I72IV, L101I, T124A, E157Q, K160Q, D232E, A265VB
Parczewski (2012)121_27121_27KC409143None   V32I, S39C, L101I, K111T, S119G, T124N, T125A, E157Q, K160Q, Q177L, V201I, S230N, L234I, D253DE, S255STB
 238_12238_12KC409151None   E10G, K14KR, S39C, L101I, T112I, T125A, E157Q, K160Q, V201I, S230N, L234I, D253E, N254D, D256E, V259VIB
 297_2297_2KC409154None   L101I, T112I, I113IV, T125M, E157Q, K160Q, G163V, V201VI, S230N, L234I, A265VB
 307307_12KC409155None   E10D, L101I, T112I, I113IV, T124N, T125A, E157Q, K160Q, K219T, I220L, S230N, L234I, D253E, D256E, D278GB
 414_18414_18KC409160None   E10D, L101I, T112I, T124TA, E157Q, K160Q, S230N, L234I, D253E, D256E, R284RGB
 431_30431_30KC409161None   D6E, E10D, V32I, S39SC, L101I, T112M, S119G, T124N, E157Q, K160Q, S230N, L234I, D288AB
 485_1485_1KC409162None   S17N, T124A, E157Q, K160Q, Q216QH, S230N, L234I, A265VB
 497_21497_21KC409164None   V31VIM, V32I, L101I, T112I, E157Q, K160Q, V201I, L234I, D253E, D256EB
 517_4517_4KC409168None   S17N, L101I, T112I, T125TA, E157Q, K160Q, S230N, L234I, A265VB
 518_4518_4KC409169None   E10ED, L101I, T112I, E157Q, K160Q, K211R, K219T, I220L, S230N, L234I, D253E, D256EB
 520_4520_4KC409170None   E11D, S17N, I84M, L101I, T112I, E157Q, K160Q, I220L, S230N, L234I, D253E, D256EB
 549549_18KC409173None   I72IT, L101I, T112I, E157Q, K160Q, K215KN, S230N, L234I, A265VB
 561_17561_17KC409176None   I72V, H78HY, T112V, T124A, E157Q, K160Q, R187K, S230NB
 573_2573_2KC409177None  T97TAS17N, I72V, L101V, T112I, T125A, E157Q, K160Q, V201I, K211Q, I217V, S230N, L234I, A265VB
 590_1590_1KC409180None  L68VL101I, T125TA, E157Q, K160Q, K188KR, G193GR, K211R, K219T, I220L, L234I, D253E, D256E, A265AVB
 6060_24KC409181None   L101I, T112I, E157Q, K160Q, I200L, S230N, L234I, A265VB
 682_12682_12KC409193None   K14R, L101I, E157Q, K160Q, G193D, I208M, L234I, N254NK, A265V, D278DE, D286NB
 828828_1KC409200None   E10D, M50I, L101I, T112I, E157Q, K160Q, S230N, L234I, D253E, D256EB
 874_2874_2KC409204None   V37I, E96D, L101V, T112I, T124N, T125A, E157Q, K160Q, S230N, L234I, D253EB
 893_1893_1KC409205None   K7KR, R20K, L101I, K111KR, T112I, T125A, V126A, E157Q, K160Q, G193E, S230N, L234I, D253EB
 916_1916_1KC409213None   S17N, S39C, L45I, L101I, T124N, T125A, I135V, E157Q, K160Q, G193E, A265V, D286NB
 921_1921_1KC409216None   S17N, L101I, T112I, E157Q, K160Q, R224RW, S230N, L234I, D253E, D256EB
 92_2092_20KC409220None   S57SG, L101V, T112IV, T125A, E157Q, K160Q, R187K, V201I, S230N, L234I, A265VB
 938_1938_1KC409222None   P30S, V32I, L101V, T112V, T125A, E157Q, K160Q, V201I, K215N, N222K, S230N, M275VB
Rolland (2012)AA010a_WG11AA010a_WG11JX446797None   S17N, L101I, T112I, D116DG, E157Q, K160Q, V201I, S230N, D253E, D256EB
Sax (2012)64696469_1 None   D6E, D25E, L101I, V110T, T112V, K156N, E157Q, K215N, D232E, L234H, D253E, D256E, D270NB
Capel (2013)130130KC238654None   E11D, V31I, G70E, L101I, T112I, S119R, T124N, K156N, E157Q, V201I, K215N, S230N, S283GB
Cho (2013)03LSH103LSH1JQ316127None   E11D, V31I, I72V, A91T, L101I, T124N, K156N, E157Q, G193EB
Kijak (2013)04TH60106604TH601066JN248329None   V31I, I89M, L101I, S119R, T124N, T125S, K156N, E157Q, K160T, S230NB
Reigadas (2013)4444JX425512None   S17N, I72V, L74I, S119T, T124A, T125A, E157Q, K160Q, G193E, V201I, D207N, K211T, D256E, R284G, D288NB
 203203JX425670None   S17N, L101I, E157Q, K160Q, G163E, S283GB
 230230JX425697None   R20K, D25E, S39N, L101I, K156N, E157Q, K160R, K188R, G193E, S195C, I220V, D279GB
Chikata (2014)KI-476KI-476AB873936None   E10D, K156N, E157Q, T218S, D256EB
 KI-960KI-960AB874244None   E11D, S24N, V31I, T125TA, I141IV, V150A, K156N, E157Q, V201I, L242LFB
 KI-637KI-637AB873998None   D6E, E10D, V32VI, L45I, L101I, K156N, E157Q, D256EB
 KI-874KI-874AB874182None   D6E, R20K, L45IV, K156N, E157Q, V281VMB
 KI-811KI-811AB874130None   E11D, A21AT, L28I, V37I, I72V, T112A, S119G, T122I, T124A, T125A, K156N, E157Q, K215N, Q221S, N222KB
 KI-680KI-680AB874032None   D6E, E10D, K14R, L101I, K156N, E157Q, I220L, D253EB
 KI-865KI-865AB874173None   D6E, E10D, K14R, R20K, L101I, K156N, E157Q, I220L, A265ATB
 KI-949KI-949AB874235None   E11D, K14R, S24N, L28I, L45I, T112I, K156N, E157Q, K211RB
 KI-750KI-750AB874080None   D6E, L101LI, K156N, E157Q, V201VI, I203IM, D256E, C280SB
 KI-996KI-996AB874266None   E11D, S24N, T112I, K156N, E157Q, V201I, K211R, T218S, I220LB
 KI-650KI-650AB874007None   E10D, S39C, S57N, I84M, L101I, S119P, E157Q, K160KEQ, Q177QL, V201I, T206SB
 KI-832KI-832AB874139None   E11D, S24N, L45I, T112I, K156N, E157Q, K211RB
Hardy (2014)Pt1INTPt1INT0908 None   R20K, V31I, L45I, L101I, K111KR, I135IV, E157Q, K160Q, V201I, K215N, A265AVB
Martin (2014)CHR6CHR6KJ869729None   L45Q, I72V, K111KR, E157Q, K160T, V176VI, D256DEB
Cuevas (2015)R14R14KT200350None   E11D, R20K, L28I, L101I, S119G, M154L, K156N, E157Q, V201I, T218S, Y227F, D256E, S283GB
Grossmann (2015)SE600057SE600057KP411828None   E11D, H16L, S17C, L63I, L101I, T112V, S119P, T124S, T125A, V126D, K156N, E157Q, K160Q, V201I, Q216H, L234I, A265VB
Hachiya (2015)94449444LC022303None   K7Q, E10A, E11D, K14R, S24SN, N27S, L28I, K34KR, T125A, K156N, E157QB
 94769476LC022228None   E10D, D41DN, I72IT, I84M, T124A, T125TA, K156N, E157Q, V201I, I203M, T218S, S283SGB
 96639663LC022148None   E11D, K14R, S24N, L28I, L45I, K111R, T112I, K156N, E157Q, K173R, K211R, T218SB
 92609260LC022378None   K14R, V31I, I60M, V88I, E96D, L101I, K111T, S119T, T124N, T125A, I135V, E157Q, V201I, T206S, I208L, I217S, S230NB
 92469246LC022362None   E11D, R20RK, D25DE, V31I, G106GA, T112TI, S119T, E157Q, K160Q, S195T, I203M, T206S, Q216H, S230N, A265V, S283GB
 96799679LC022212None   D6E, E10D, K14KR, S17N, I72T, I73IV, I84IM, P90PA, L101I, I113IV, T124A, T125TA, K156N, E157Q, A205S, I220LB
 92809280LC022178None   V31I, E96D, L101V, K111T, S119T, T124N, T125A, I135V, E157Q, F181L, E198Q, V201I, T206S, I217S, S230NB
 95129512LC022355None   E11D, K14KR, S17ST, M22MI, A23V, S24SG, D25DE, L28I, V37I, A91T, L101I, S119G, T122I, T125A, K156N, E157Q, K211R, K215N, Q221S, N222K, D256E, V281VLB
 95319531LC022231None   E11D, A23V, S24N, L28I, V37I, I72V, L101I, S119G, T122I, T125A, E157Q, K160Q, I203M, K215N, Q221S, N222KB
 92729272LC022177None   K14R, V31I, I60M, V88I, E96D, L101I, K111T, S119T, T124N, T125A, I135V, E157Q, K160KQ, V201I, T206S, I208L, I217S, S230NB
 96139613LC022414None   S17N, A23V, L28I, L45LI, K156N, E157Q, I251V, D256E, S283SG, R284RGB
 96779677LC022360None   E11D, M22I, L28M, L45V, I72V, P90S, Y99YF, L101I, T124N, E157Q, K160Q, S195T, V201IB
 95689568LC022424None   D6E, K14R, R20K, M50MI, A76G, A91T, L101I, T124A, K156N, E157Q, V201I, I203M, I220L, S283GB
 N0803N0803LC022517None   K7Q, E10A, S17N, S39C, T125A, E157Q, K160QB
 N0690N0690LC022458None   D6DN, K7Q, E10ED, E11ED, L28LI, V37VIM, S39C, I113IV, T125TA, K156N, E157Q, V201VI, K211KR, K240KRB
 96479647LC022358None   K7Q, E10A, S17N, S39C, I113V, T125A, I141IT, E157Q, K160Q, T218TA, I220ILB
 N0711N0711LC022474None   E11D, R20K, S24G, D25E, L28I, I84V, G94GR, T112A, T125A, K156N, E157Q, M178MI, L234IB
 96199619LC022137None   E11D, V31I, L45LI, E48Q, S57G, I72IV, L74I, A91AT, L101LI, T124N, I135IV, E157Q, K160KPQT, K173KR, V201I, I203L, K215N, Q221S, N222K, D256E, R269K, S283DGB
 94739473LC022163None   E11D, L28I, V37I, I72V, S119G, T122I, T124A, T125A, K156N, E157Q, K215N, Q221S, N222KB
 94959495LC022164None   E11D, A23V, S24N, L28I, V37I, I72V, S119G, T122I, T125A, G134GE, E157Q, K160Q, I203M, K215N, Q221S, N222KB
 94609460LC022325None   E11D, K14R, R20RK, A23V, V31I, A91AT, L101IV, S119G, T122I, T125A, E157Q, K160Q, V201I, K215N, Q221S, N222K, S255SN, D256E, R269RK, D286DNB
 N550N550LC022674None   S39SC, L101I, E157Q, K160Q, I200ILM, V201I, T206TS, K215KN, R284RGB
Hora (2015)DEMB10US007DEMB10US007KC473828None   E10D, S24N, V31I, A91T, L101I, S119R, T125A, I135V, E157Q, K160E, V201I, K211R, K219N, N222K, D256EB
 DEMB10US009DEMB10US009KC473829None   K7R, L45I, I72V, L101I, I135V, V150A, K156N, E157Q, V201I, V281MB
Pessoa (2015)10BR_MG007MG007KJ849786None  T97AE10D, V31I, L45V, M50I, Q53R, L74I, L101I, S119T, E157Q, G163E, I200T, V201I, K211R, S255N, D256E, R269KB
Gashnikova (2016)Tyumen11Tyumen11KX640251None   E11D, S24N, V37I, I60V, I72V, L74I, T112I, T124A, T125A, E157Q, K160Q, V176T, A205S, K211R, N254S, S255GB
Li (2016)18601860KT191964None  L74IMVK14R, S17C, L68E, K71Q, A91T, L101I, S119R, T124N, T125A, K156N, E157Q, K211RB
 ZHP-36ZHP-36KT192005None  L68VE11D, S17C, V88I, A91T, E96D, L101I, P109S, S119R, T124N, T125A, K136N, K156N, E157Q, K211R, P261PSB
Pessoa (2016)10BR_PE01410BR_PE014KT427742None   L45I, I72V, T124N, T125A, V126L, I135V, E157Q, K160Q, G193R, V201I, D232E, A265VB
 10BR_PE08310BR_PE083KT427702None   S17N, R20K, V32I, I72V, I84V, T124N, T125A, I135V, E157Q, K160Q, T206S, I208L, T210I, D256EB
 10BR_PE11110BR_PE111KT427854None   S17N, L101I, T112A, S119T, T125A, E157Q, K160Q, K173R, G193D, E198D, T206S, D207E, D253E, D286NB
Chen (2017)225510633225510633KY575003None   S17SN, V31I, L101I, K111A, T124A, I135IV, E157Q, K160Q, K188R, V201I, T206S, A265V, R269RKB
 225510459225510459KY575001None   K7R, A23V, S119P, E157Q, K160Q, V201I, I251IVB
 218511161218511161KY574937None   E10D, A21T, V31I, I72V, K111Q, T112A, T124A, T125A, V126M, E157Q, K160Q, T218S, S283GB
 218510295218510295KY574925None   L101I, S119T, T124A, E157Q, K160N, D167E, G193E, L234I, S255NB
 207510586207510586KY574901None   S17SN, I72V, T112V, S119P, T124A, T125A, K127R, E157Q, K160Q, G163V, A205T, K211R, D253E, N254GB
 207510466207510466KY574899None   S17N, T124A, E157Q, K160Q, G193E, V201I, I208L, E212A, D256EB
 248000813248000813KY369934None  T97AE10D, V31I, A49P, K71Q, P90A, L101I, S119R, K156N, E157Q, V201I, K236X, D256EB
 246000790246000790KY369928None   K14R, S17SN, L45I, M50I, S57N, G70GE, I72V, T112V, T124A, E157Q, K160Q, V201I, T206S, D256E, A265VB
 225510216225510216KY434655None   S17N, V31I, A91V, L101I, K111A, T124A, E157Q, K160Q, K188R, V201I, T206S, A265VB
Hachiya (2017)C12-00078834059LC160447LC160447None   E11D, S24N, D25E, T112V, K156N, E157Q, K215NB
 C13-000710639349LC160449LC160449None   E11D, S24N, L28I, L45I, L101I, K156N, E157Q, D253EB
 C13-00078464863LC160452LC160452None   E11S, A23V, L28I, S119G, T122I, T125A, E157Q, K160T, I203M, K215N, Q221S, N222K, D256EB
 C13-50584661524LC160469LC160469None   A23V, L28I, I72IT, I84L, T125A, K156N, E157Q, I203MB
 C14-50591987330LC160476LC160476None   D6E, E10D, K14R, S24N, L101I, K156N, E157Q, I220L, D253EB
 C14-209151LC160503LC160503None   S17N, V31I, S57N, L74I, I84M, L101I, S119T, E157Q, K160T, H171Q, A196P, V201I, T206SB
 C15-2091C27LC160509LC160509None   D6E, S17SN, S24G, L45V, I84M, E96D, L101I, K156N, E157Q, V201I, I208LB
 C13-2093GM3996LC160552LC160552None   E11D, R20K, D55DN, K156N, E157Q, V201I, K215N, L242LP, D256E, S283GB
 C14-2093GM4263LC160618LC160618None   E11D, S24N, L45I, I84V, T112I, K156N, E157Q, K173R, K211R, Q216H, T218SB
 C14-2066Y705LC160625LC160625None  V151IE11D, R20K, N27X, L28I, I72V, A91G, L101I, V150A, E157Q, K160KN, V201IB
 C15-2066GM4342LC160668LC160668None   D6E, E10D, K14R, R20K, V31I, L101I, K156N, E157Q, I220L, S230N, L242LF, A265AVB
 C13-51111444LC160701LC160701None   D6E, E10D, K14R, S24N, K156N, E157Q, I220L, D253EB
 C13-51111461LC160718LC160718None   D6E, S24G, L45V, I84M, E96D, L101I, K156N, E157Q, V201I, I208LB
 C13-51111463LC160720LC160720None   T112I, K156N, E157Q, K211RB
 C13-51111477LC160734LC160734None   E11D, A23V, S24N, L28I, V37I, L101I, S119G, T122I, T125A, E157Q, K160Q, D167E, I203M, K215N, Q221S, N222KB
 C13-51111487LC160744LC160744None   E11D, K14R, K156N, E157Q, R187K, V201I, D256EB
 C13-51111498LC160755LC160755None   E11D, R20K, K156N, E157Q, V201I, K215N, D256E, S283GB
 C13-51111507LC160764LC160764None   E11D, K14R, S24N, L28I, L45I, T112I, K156N, E157Q, K173R, K211R, T218SB
 C13-51111511LC160768LC160768None   E11D, A23V, L28I, V37I, L101I, S119G, T122I, T125A, K156N, E157Q, V201I, K215N, Q221S, N222K, D256E, R269KB
 C13-51111516LC160773LC160773None   I72T, P90S, K156N, E157Q, I203MB
 C14-51111602LC160859LC160859None   D6E, E10D, K14R, R20K, S57G, L74I, A80S, L101I, K156N, E157Q, H171Q, I220L, R269KB
 C14-51111605LC160862LC160862None   E11D, A23V, L28I, V37I, L101I, S119G, T122I, T125A, K156N, E157Q, V201I, K215N, Q221S, N222K, D256E, R269KB
 C14-51111607LC160864LC160864None   E11D, R20K, L28I, V37I, I72V, L101I, S119G, T122I, T124A, T125A, M154I, K156N, E157Q, K215N, Q221S, N222KB
 C14-51111616LC160873LC160873None   E11D, A23V, S24N, L28I, V37I, I72V, S119G, T122I, T125A, E157Q, K160Q, I203M, K215N, Q221S, N222KB
 C14-51111640LC160897LC160897None   D6E, E11D, E13D, R20K, S24G, D25E, L45I, L101I, T124S, K156N, E157Q, I204V, K211Q, D256EB
 C14-51111648LC160905LC160905None   T125A, K156N, E157Q, K211R, K215NB
 C14-51111652LC160909LC160909None   E10D, E11D, L28I, V31I, A91T, L101I, V150A, K156N, E157Q, I200M, V201I, K211RB
 C15-51111671LC160928LC160928None   E11D, A23V, S24N, L28I, V37I, I72V, S119G, T122I, T125A, E157Q, K160Q, I203M, K215N, Q221S, N222KB
 C15-51111698LC160955LC160955None   E11D, R20K, L28I, V37I, I72V, S119G, T122I, T125A, K156N, E157Q, K215N, Q221S, N222KB
 C15-51111715LC160972LC160972None   E11D, R20K, L28I, V37I, I72V, L101I, S119G, T122I, T125A, K156N, E157Q, K215N, Q221S, N222KB
 C15-51111727LC160984LC160984None   S17N, L45I, T112V, K156N, E157Q, K173R, K211RB
 C14-555539LC161074LC161074None   E11D, S24N, V31VI, L45I, I84IV, T112I, K156N, E157Q, K173R, K211R, Q216H, T218SB
 C14-5555057LC161082LC161082None   K7KQ, E11D, D25DE, V31I, K156N, E157Q, V201VI, K215N, D256E, D278DE, S283SGB
 C14-55550007LC161087LC161087None   E11D, K14KR, S24N, D25DE, L101LI, I113IV, T125TA, V150VA, K156N, E157Q, V201VI, D256EB
 C15-555521960711LC161122LC161122None   E11D, S24N, D25E, V31I, V77VA, T112V, K156N, E157Q, K211R, K215N, R284RG, D286NB
 C15-55550011LC161139LC161139None   D6DE, K7KR, E10ED, E11ED, K14KR, V31VI, L101I, K156N, E157Q, K211Q, D256EB
 C15-5555073LC161174LC161174None   E11D, A21T, V31I, I72IV, I84M, T93S, L101I, T124TA, K136X, E157Q, K160Q, V201VI, I203IM, K215N, D288NB
 C15-555515004LC161198LC161198None   D6DE, M22L, V37I, S39C, L45I, A91AS, T124TN, T125A, E157Q, K160Q, V165VI, V201I, A205S, K211R, K215NB
 C15-6000470LC161213LC161213None   E11D, A23V, S24N, L28I, V37I, I72V, S119G, T122I, T125A, E157Q, K160Q, I203M, K215N, Q221S, N222KB
 C15-2019595LC161340LC161340None   D6E, S17SN, R20K, L45I, L101I, K156N, E157Q, G163E, V201I, I203V, K211KRB
 H15-2060174LC161353LC161353None   E10D, R20K, A23V, L28I, L45I, K156N, E157Q, V201I, T218SB
 H15-2060175LC161354LC161354None   D6E, S17N, I84L, L101I, T124TA, T125TA, E157Q, K160Q, V201VI, A205S, K215N, D256E, R284RGB
 E14-50911625LC161383LC161383None   K7Q, E10A, S17N, S39C, T125A, E157Q, K160QB
 E15-50911656LC161404LC161404None   K14R, L101X, T112TA, T124A, T125A, I135V, E157Q, K160T, I200M, V201I, T206S, K215KN, I217IV, T218TS, S283SGB
 E15-50911722LC161448LC161448None   E11D, R20RK, L28I, V37I, T125TA, K156N, E157Q, V201I, K211R, D256E, R284RGB
 E15-50911765LC161480LC161480None  L68VE10D, D25E, V31VI, I72V, I73V, I84M, L101I, I113V, T125A, E157Q, K160Q, G190GE, T206S, T218S, D253E, N254K, S255G, C280SB
 F14-20082259LC161517LC161517None   E11D, S17N, D25E, L101I, S119G, T122I, T125A, E157Q, K160Q, K215N, Q221S, N222K, V281LB
 H13-201127LC161567LC161567None   L68LM, V150A, K156N, E157Q, V201VIB
 H13-201130LC161570LC161570None   E11D, S24N, D25E, T112V, K156N, E157Q, V201I, K211R, K215NB
 H14-20116LC161588LC161588None   E10D, L101I, K156N, E157Q, D256E, R284GB
 H14-201115LC161597LC161597None   E10D, L101I, K156N, E157Q, V201VIB
 H15-201123LC161638LC161638None   D6E, E10D, K14KR, R20K, L101I, T124TA, K156N, E157Q, I220LB
 C13-2069020LC170963LC170963None   D6E, E10D, S57SN, L101I, K156N, E157Q, I220L, D253EB
 C13-2069039LC170982LC170982None   D6E, S24SG, N27ND, L45X, I84M, E96D, L101I, K156N, E157Q, V201I, I208LB
 C13-2069048LC170988LC170988None   D6E, E10D, K14R, R20K, L101I, K156N, E157Q, I220LB
 C13-2069052LC170992LC170992None   E11D, A23V, S24N, L28I, V37I, L101I, S119G, T122I, T125A, E157Q, K160Q, D167E, I203M, K215N, Q221S, N222KB
 C13-2069065LC171003LC171003None   E11D, S24N, D25E, T112V, K156N, E157Q, K211R, K215NB
 C13-2069081LC171016LC171016None   S24G, L45I, T112I, K156N, E157Q, K173R, K211R, T218S, I220LB
 C13-2069082LC171017LC171017None   E11D, A23V, L28I, V31VI, V37I, L101I, S119G, T122I, T125A, K156N, E157Q, V201I, K215N, Q221S, N222K, D256E, R269KB
 C13-2069084LC171019LC171019None   E11D, K14R, S24N, L28I, L45I, T112I, K156N, E157Q, K173R, K211KR, T218X, Y227YSB
 C13-2069088LC171022LC171022None   D6E, E10D, I84M, L101I, K156N, E157Q, V201I, I208L, S283GB
 C14-2069049LC171073LC171073None   D6E, M22I, A23V, S24G, L45V, L101I, K156N, E157Q, V281MB
 C14-2069063LC171085LC171085None   E11D, R20K, L28I, V37I, I72V, L101I, S119G, T122I, T124A, T125A, M154I, K156N, E157Q, K215N, Q221S, N222KB
 C14-2069075LC171097LC171097None   E11D, K14R, S24N, L28I, L45I, T112I, K156N, E157Q, K173R, R187K, A196AP, K211R, T218SB
 C15-2069073LC171188LC171188None   E11D, S24N, V31I, T125A, V126L, K156N, E157Q, I203M, T218S, I220LB
 C15-2069085LC171196LC171196None   E11D, W19L, A23V, S24N, L28I, V37I, S119G, T122I, T125A, E157Q, K160Q, I203M, K215N, Q221S, N222KB
Meixenberger (2017)86-0164186-01641KM677348None  V151VIE10D, K34KR, I72V, T112I, T124A, K136KR, E157Q, K160Q, V201VI, K211RB
 86-0256186-02561KM677351None   S17N, I72V, T112I, T124A, I135IV, E152EK, E157Q, K160Q, V201I, A265VB
 92-0011692-00116KM677424None   E10D, L45I, I72V, L101I, T112M, S119T, T124A, T125A, E157Q, K160QB
 95-0491595-04915KM677490None   E11D, D25E, M50I, K111T, T122I, T124A, E157Q, K160Q, I220LB
 95-0558595-05585KM677494None   E11D, D25E, M50I, K111T, S119SG, T122I, T124TA, T125TA, E157Q, K160Q, I220LB
 01-0025801-00258KM677541None   R20K, S39C, E157Q, G193E, V201I, L234IB
 03-0003403-00034KM677569None   S17N, S24G, L45I, L101I, T124A, T125A, I135V, E157Q, K160Q, A205S, T206S, K211T, E212N, I251V, D256EB
 05-0049805-00498KM677614None   E11D, K14R, P90Q, L101I, T112I, T124A, E157Q, K160Q, G193E, V201I, S230NB