<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Integrase Inhibitors

Subtype B
Gene IN
Mutation E157Q
Rx >=1 INI
IncludeMixtures No
References 9
Patients 62
Isolates 76
 
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# INIs WksINIMajorDRMs INIMinorDRMs OtherMutSubtype
Malet (2008)44_W8 RAL8  E11D, A21T, A23V, D25E, E157Q, V201IB
Garrido (2009)Pt01Pt01 RAL G140A, Q148R K14R, S24G, D25E, L45I, I113V, T124N, T125A, E157Q, K160S, V165VI, I220L, Y227F, L234V, D256EB
 Pt06Pt06 RAL N155HG163KS17N, A38AV, L101I, T112I, T124A, T125V, E157Q, K160Q, K211R, D256EB
Brenner (2011)INT21INT21HQ207822RAL G140S, Q148H L45V, L101I, E157Q, K160Q, K215N, D232N, D256EB
 093107.007093107.007HQ423436RAL G140S, Q148HG163EKV31I, L45I, L101I, S119G, T122I, E157Q, K160Q, V176L, V201I, I208M, K215N, L234I, D253H, D256EB
 091011.020091011.020HQ423439RAL G140GS, Q148QH L28LIM, L45I, L63LI, L101I, E157Q, K160Q, K215N, A265AV, D288NB
Garrido (2012)BAA295891BAA295891JQ716892RAL52G140A, Q148R K14R, S24G, D25E, L45I, I113V, T124N, T125A, E157Q, K160S, V165VI, I220L, Y227F, L234V, D256EB
Molina (2012)32413241_2 EVG31  K14R, Y99H, L101I, T112TI, I135V, E157Q, G193D, S195C, A265VB
  3241_3 EVG45  K14R, Y99H, L101I, I135V, E157Q, I182IF, G193D, S195C, D232DN, L234LF, L241LF, L242LF, A265V, R269RGB
 30623062_2 EVG12E92EQ D6E, E11D, S17N, V31I, L63I, L74I, E96D, L101I, T112V, T124N, T125A, G134N, K136T, E157Q, K160N, V201I, T206S, T210TI, K211R, L234I, R269K, S283G, D288NB
  3062_3 EVG25E92EQ, G140GA, Q148QRL68LVD6E, E11D, S17N, V31I, L63I, L74I, E96D, L101I, T112V, T124N, T125A, G134N, K136T, E157Q, K160N, V201I, T206S, T210TI, K211R, L234I, R269K, S283G, D288NB
 31803180_2 EVG12 V151VIK14KR, S17SN, V31I, G106A, K111T, E157Q, K160Q, V201I, D256EB
  3180_3 EVG48  K14KR, S17SN, V31VI, G106A, K111T, T124TA, E157Q, K160Q, V201I, D256EB
 40754075_2 RAL28N155NH S17N, V31I, M50MI, I72IV, L101I, T124A, K136KN, E157Q, K160Q, D232E, A265VB
Parczewski (2012)307307_18KC409156RAL196N155H E10D, L101I, T112I, T124N, T125A, E157Q, K160Q, K219T, I220L, S230N, L234I, D253E, D256E, D278GB
  307_xKC409158RAL201N155H E10D, L101I, T112I, T124N, T125A, E157Q, K160Q, K219T, I220L, S230N, L234I, D253E, D256E, D278GB
 549549_24KC409174RAL94  P90PS, L101I, T112I, E157Q, K160Q, K215KN, S230N, L234I, A265VB
  549_25KC409175RAL122  L101I, T112I, E157Q, K160Q, K215KN, S230N, L234I, A265V, S283SGB
 6060_40KC409182RAL246  L101I, T112I, E157Q, K160Q, K173R, I200L, V201I, S230N, L234I, L242LF, A265VB
  60_42KC409183RAL290  L101I, T112I, S119SN, E157Q, K160Q, K173R, I200L, V201I, S230N, L234I, A265V, G277GDB
  60_45KC409184RAL362  L101I, T112I, E157Q, K160Q, K173R, I200L, V201I, S230N, L234I, A265VB
 828828_7KC409201RAL82  E10D, M50I, L101I, T112I, E157Q, K160Q, S230N, L234I, D253E, D256EB
  828_8KC409202RAL107  E10D, M50I, L101I, T112I, E157Q, K160Q, S230N, L234I, D253E, D256EB
de Souza Cavalcanti (2014)BRSP08BRSP08 RAL  L74M, T97A, V151I, G163RK14R, V31I, I72A, L101I, I113L, S119G, T122I, T124TN, K156KN, E157Q, V201I, T206S, S283GB
 BRSP222BRSP222 RAL Y143RL74M, T97A, E138DE10D, V31I, M50I, L101I, T112V, S119P, T122I, T124N, T125A, I135V, E157Q, I203M, I208L, T218S, I220L, D253VB
 BRSP545BRSP545 RAL E92Q, N155H K14R, Y15H, V32I, S39C, M50I, I73IV, L101I, S119P, T124A, I135V, K136N, E157Q, K160Q, I162V, V201I, L234V, K240RB
 BRSP380BRSP380 RAL N155HE138D, V151IE11D, D25E, L28I, V37I, S39C, M50L, L74I, L101LF, T124A, E157Q, K160T, I203M, I208M, D232N, L234I, D253E, N254GB
 BRSP101BRSP101 RAL N155HV151IS17N, L101I, S119ST, T124TA, K136Q, E157Q, K160T, A169V, L172LI, I208M, D232N, L234I, D253E, D256EB
 BRSP268BRSP268 RAL N155HV151IS17N, L28I, T112I, S119G, T122I, T124N, T125A, E157Q, K160Q, V201IB
 BRSP318BRSP318 RAL E138K, G140C, Q148RV54I, L74MD6T, K7E, K14R, V31I, I72V, V79I, S119P, K156KN, E157Q, K160KT, V201I, T218S, R284GB
 BRSP710BRSP710 RAL Y143C, N155HS230RV31I, L101I, T112I, S119T, T124A, E157Q, K160Q, V201I, C280SB
Hardy (2014)Pt1INTPt1INT RAL16  R20RK, V31I, L45I, L101I, T122TI, I135IV, E157Q, K160Q, V201I, K215N, A265VB
  Pt1INT RAL22N155H R20K, V31I, L45I, L101I, I135IV, E157Q, K160Q, V201I, K215N, A265VB
  Pt1INT RAL28 V151VIR20K, V31I, L45I, L101I, I135V, E157Q, K160Q, V201I, K215NB
  Pt1INT RAL, DTG69N155HV151IR20K, V31I, L45I, L101I, S119SR, I135V, E157Q, K160Q, V201I, K215NB
  Pt1INT RAL, DTG110E138K, S147G, N155HT97A, V151ID6DN, R20RK, V31I, L45I, L101I, S119R, I135V, E157Q, K160Q, V201I, K215NB
  Pt1INT RAL, DTG157E138K, S147G, N155HT97A, V151IR20K, V31I, L45I, A49P, L101I, S119R, T122TAIV, I135V, E157Q, K160Q, V201I, K215N, L234VB
  Pt1INT RAL, DTG168E138K, S147G, N155HT97A, V151IR20RK, V31I, L45I, A49P, L68LF, L101I, S119R, T122TAIV, I135V, E157Q, K160Q, V201I, K215N, L234VB
Hurt (2014)IN_729IN_729 RAL N155HV151IE11D, K14R, V31I, D41DN, M50MI, I84LV, T97V, L101LV, I113V, S119R, K156KN, E157Q, K160KQ, V201I, T206S, I208M, T218S, R284RGB
 IN_1808IN_1808 RAL N155HV151I, G163KD6E, E11D, S24N, V31I, K42R, M50I, I73V, L74I, I84L, Q95H, L101I, I113L, T124HQ, E157Q, K160Q, V201I, T206S, K211R, L234LV, K240RB
 IN_1661IN_1661 RAL N155NHV151VIE11D, V31VI, L101I, V150A, E157Q, K160Q, V176L, S195T, D256DE, Q285RB
 IN_16IN_16 RAL T66TK, G140GS, Q148QRL74LIMS17N, V31I, I72IV, L101I, T124A, E157Q, K160Q, T206S, I208IM, S283SGB
 IN_1481IN_1481 RAL Y143YCHR P30S, S39C, L45LI, M50I, I60V, I72V, L101I, S119T, T124A, E157Q, K160Q, V201I, I220V, D253E, N254G, S283GB
 IN_2676IN_2676 RAL N155H D6E, E10D, R20K, V31I, M50I, L101I, I113V, S119P, T122TI, T124N, T125A, K156N, E157Q, V201I, A265VB
 IN_800IN_800 RAL Y143RL74M, T97AS17N, S119T, E157Q, K160Q, V201I, D256E, R284GB
 IN_2544IN_2544 RAL Y143YH, N155HT97TA, V151IS17N, M50I, G59GE, L101I, T112TR, S119R, T124A, I135IV, K156N, E157Q, V201I, T218TSB
 IN_920IN_920 RAL N155HV151IL45I, M50R, E69D, I72V, L74I, I84L, L101I, T112R, T125A, E157Q, K160Q, G163V, V201I, E212A, K215N, D256E, R284GB
 IN_385IN_385 RAL N155HV151IE11D, S24N, V31VI, M50I, L68F, L74I, T112R, I113V, S119P, T122I, T124N, E157Q, K160Q, V201I, I203IM, T206S, I208L, K211KR, E212AB
 IN_118IN_118 RAL N155HL68LV, V151VIE11D, K34R, S119T, T125A, K156N, E157Q, V180VI, V201VI, I208IL, S230N, E287EAB
 IN_212IN_212 RAL Y143RL74M, T97AS17N, R20K, V31I, T112S, I113V, S119ST, T124S, T125A, E157Q, K160Q, V201I, K211R, R284GB
 IN_713IN_713 RAL N155HV151I, G163KS17N, A21S, D25E, N27ND, L45I, L101I, G106A, K111R, T112R, T124A, E157Q, K160Q, I208L, D256E, D278A, S283GB
 IN_353IN_353 RAL N155HV151IS39C, M50I, T125A, V126M, E157Q, K160Q, G193E, I203M, I208IM, D232N, D286NB
 IN_477IN_477 RAL G140S, Q148H K7R, M50I, L101I, E157Q, K160Q, D167E, G193D, S195T, V201I, A265V, R269K, D270HB
 IN_81IN_81 RAL G140S, Q148RL74MS17SN, I72V, F100S, L101I, K111T, S119P, T124A, T125A, E157Q, K160KINB
 IN_216IN_216 RAL N155HV151I, G163RS17N, V31I, S39N, I84M, L101I, I113V, T124A, T125A, E157Q, K160T, I208IM, K211T, S230N, A265AV, R269RK, D270HB
 IN_1998IN_1998 RAL Y143YCHRT97TAV31I, I60IM, L74I, T112I, T124A, T125A, V126M, E157Q, K160Q, F181L, T206S, N254Q, S255SGB
 IN_914IN_914 RAL E138A, G140S, Q148H S17N, L45IT, L101I, T124A, T125A, V126VA, E157Q, K160Q, G163E, V165IB
 IN_1794IN_1794 RAL N155HV151VIS17N, I84L, L101I, K111T, T124A, T125A, E157Q, K160TB
 IN_1210IN_1210 RAL N155HV151IS17N, L101I, K111R, T112V, S119R, S123C, T124N, K156N, E157Q, Q177L, D256EB
 IN_1092IN_1092 RAL N155HV151IK7KR, S17N, V31I, M50I, I72IV, Q95P, L101I, T112A, S119R, K156N, E157Q, S283GB
 IN_2021IN_2021 RAL Y143RT97AV31I, I60M, L74I, T112I, T124A, T125A, V126M, E157Q, K160Q, F181L, T206S, N254QB
 IN_1905IN_1905 RAL N155H S17N, I72V, L101I, T124N, E157Q, K160Q, I203M, K211R, T218I, K219Q, N222K, D232N, A265VB
 IN_758IN_758 RAL Y143RT97AV31I, L74I, T112I, T124A, T125A, V126M, E157Q, K160Q, F181L, T206S, N254Q, S255SG, V259VI, S283SGB
 IN_341IN_341 RAL E92QL68V, L74M, T97AE10D, V31I, M50I, I73V, E96D, L101I, S119T, T124N, T125A, I135V, E157Q, K160T, I208M, S230N, D232E, L234F, D253E, D256E, E287EAB
 IN_770IN_770 RAL N155HV151IE11D, K14R, V31I, D41N, M50MI, I84IL, T97V, L101LV, I113V, S119R, E157Q, K160KQ, V201I, T206S, I208M, T218S, R284RGB
 IN_1550IN_1550 RAL N155NH S39SC, M50I, L74I, L101I, K111T, T124TA, E157Q, K160S, G193R, V201I, D253E, I268LB
 IN_302IN_302 RAL G140GS, Q148QH, N155NHV151VID25DE, V31I, E157Q, K160Q, V201I, A265V, R284GB
 IN_2789IN_2789 RAL N155HV151IV31I, M50MV, I72IV, L101I, T112I, I113V, K156N, E157Q, V201I, T218S, D229N, D253E, D256E, R284GB
 IN_787IN_787 RAL E92QL68V, L74M, T97AE10D, V31I, M50I, I73V, E96D, L101I, S119T, T124N, T125A, I135V, E157Q, K160KPQT, I208M, S230N, D232E, L234F, D253E, D256EB
 IN_2559IN_2559 RAL N155HL74LIM, A128T, E138D, V151IM50L, E157Q, K160Q, G163AB
 IN_1500IN_1500 RAL N155HL74LM, E138ED, V151ID3N, S17N, S39C, M50I, I72V, K156N, E157Q, K173R, D232NB
 IN_2350IN_2350 RAL N155HA128AT, V151IS17N, L28I, I72V, P90S, S119T, E157Q, K160Q, D232E, R284GB
 IN_1993IN_1993 RAL N155HV151IK14KR, V31VI, M50I, L74I, L101I, T124S, I135V, E157Q, K160T, F181L, Y194YC, V201I, T206S, K211KR, T218S, I220L, Y227F, D253Y, I268L, S283GB
 IN_286IN_286 RAL Y143CS230RE11D, R20RK, D25E, Q95N, L101I, G106A, S119T, I135V, E157Q, K160Q, G193E, I203M, I208L, D256E, D286NB
 IN_2269IN_2269 RAL N155HV151IK14KR, R20K, L101I, T124A, I135IV, E157Q, K160Q, G193E, V201I, D232N, D286NB
 IN_126IN_126 RAL E92Q, N155H R20K, M50I, E96ED, T124A, E157Q, K160T, G193E, V201I, T218S, I220V, D256E, D279DGB