<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Integrase Inhibitors

Subtype B
Gene IN
Mutation E157Q
Rx >=1 INI
IncludeMixtures No
References 7
Patients 20
Isolates 31
 
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# INIs WksINIMajorDRMs INIMinorDRMs OtherMutSubtype
Malet (2008)44_W8 RAL8  E11D, A21T, A23V, D25E, E157Q, V201IB
Garrido (2009)Pt01Pt01 RAL G140A, Q148R K14R, S24G, D25E, L45I, I113V, T124N, T125A, E157Q, K160S, V165VI, I220L, Y227F, L234V, D256EB
 Pt06Pt06 RAL N155HG163KS17N, A38AV, L101I, T112I, T124A, T125V, E157Q, K160Q, K211R, D256EB
Brenner (2011)INT21INT21HQ207822RAL G140S, Q148H L45V, L101I, E157Q, K160Q, K215N, D232N, D256EB
 093107.007093107.007HQ423436RAL G140S, Q148HG163EKV31I, L45I, L101I, S119G, T122I, E157Q, K160Q, V176L, V201I, I208M, K215N, L234I, D253H, D256EB
 091011.020091011.020HQ423439RAL G140GS, Q148QH L28LIM, L45I, L63LI, L101I, E157Q, K160Q, K215N, A265AV, D288NB
Garrido (2012)BAA295891BAA295891JQ716892RAL52G140A, Q148R K14R, S24G, D25E, L45I, I113V, T124N, T125A, E157Q, K160S, V165VI, I220L, Y227F, L234V, D256EB
Parczewski (2012)307307_18KC409156RAL196N155H E10D, L101I, T112I, T124N, T125A, E157Q, K160Q, K219T, I220L, S230N, L234I, D253E, D256E, D278GB
  307_xKC409158RAL201N155H E10D, L101I, T112I, T124N, T125A, E157Q, K160Q, K219T, I220L, S230N, L234I, D253E, D256E, D278GB
 549549_24KC409174RAL94  P90PS, L101I, T112I, E157Q, K160Q, K215KN, S230N, L234I, A265VB
  549_25KC409175RAL122  L101I, T112I, E157Q, K160Q, K215KN, S230N, L234I, A265V, S283SGB
 6060_40KC409182RAL246  L101I, T112I, E157Q, K160Q, K173R, I200L, V201I, S230N, L234I, L242LF, A265VB
  60_42KC409183RAL290  L101I, T112I, S119SN, E157Q, K160Q, K173R, I200L, V201I, S230N, L234I, A265V, G277GDB
  60_45KC409184RAL362  L101I, T112I, E157Q, K160Q, K173R, I200L, V201I, S230N, L234I, A265VB
 828828_7KC409201RAL82  E10D, M50I, L101I, T112I, E157Q, K160Q, S230N, L234I, D253E, D256EB
  828_8KC409202RAL107  E10D, M50I, L101I, T112I, E157Q, K160Q, S230N, L234I, D253E, D256EB
de Souza Cavalcanti (2014)BRSP08BRSP08 RAL  L74M, T97A, V151I, G163RK14R, V31I, I72A, L101I, I113L, S119G, T122I, T124TN, K156KN, E157Q, V201I, T206S, S283GB
 BRSP222BRSP222 RAL Y143RL74M, T97A, E138DE10D, V31I, M50I, L101I, T112V, S119P, T122I, T124N, T125A, I135V, E157Q, I203M, I208L, T218S, I220L, D253VB
 BRSP545BRSP545 RAL E92Q, N155H K14R, Y15H, V32I, S39C, M50I, I73IV, L101I, S119P, T124A, I135V, K136N, E157Q, K160Q, I162V, V201I, L234V, K240RB
 BRSP380BRSP380 RAL N155HE138D, V151IE11D, D25E, L28I, V37I, S39C, M50L, L74I, L101LF, T124A, E157Q, K160T, I203M, I208M, D232N, L234I, D253E, N254GB
 BRSP101BRSP101 RAL N155HV151IS17N, L101I, S119ST, T124TA, K136Q, E157Q, K160T, A169V, L172LI, I208M, D232N, L234I, D253E, D256EB
 BRSP268BRSP268 RAL N155HV151IS17N, L28I, T112I, S119G, T122I, T124N, T125A, E157Q, K160Q, V201IB
 BRSP318BRSP318 RAL E138K, G140C, Q148RV54I, L74MD6T, K7E, K14R, V31I, I72V, V79I, S119P, K156KN, E157Q, K160KT, V201I, T218S, R284GB
 BRSP710BRSP710 RAL Y143C, N155HS230RV31I, L101I, T112I, S119T, T124A, E157Q, K160Q, V201I, C280SB
Hardy (2014)Pt1INTPt1INT RAL16  R20RK, V31I, L45I, L101I, T122TI, I135IV, E157Q, K160Q, V201I, K215N, A265VB
  Pt1INT RAL22N155H R20K, V31I, L45I, L101I, I135IV, E157Q, K160Q, V201I, K215N, A265VB
  Pt1INT RAL28 V151VIR20K, V31I, L45I, L101I, I135V, E157Q, K160Q, V201I, K215NB
  Pt1INT RAL, DTG69N155HV151IR20K, V31I, L45I, L101I, S119SR, I135V, E157Q, K160Q, V201I, K215NB
  Pt1INT RAL, DTG110E138K, S147G, N155HT97A, V151ID6DN, R20RK, V31I, L45I, L101I, S119R, I135V, E157Q, K160Q, V201I, K215NB
  Pt1INT RAL, DTG157E138K, S147G, N155HT97A, V151IR20K, V31I, L45I, A49P, L101I, S119R, T122TAIV, I135V, E157Q, K160Q, V201I, K215N, L234VB
  Pt1INT RAL, DTG168E138K, S147G, N155HT97A, V151IR20RK, V31I, L45I, A49P, L68LF, L101I, S119R, T122TAIV, I135V, E157Q, K160Q, V201I, K215N, L234VB